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5121por Bachelet, T., Bourdenx, J.P., Martinez, C., Mucha, S., Perier, V., Martin, L., Pommereau, A.“…RÉSULTATS: Nous montrons qu’une campagne de vaccination proactive avec information personnelle à chaque patient est efficace pour convaincre la plupart des patients de se faire vacciner (95 %, vs 78 % pour la campagne de vaccination grippale) et initie fréquemment une réponse en anticorps spécifique anti-Spike RBD (182/193, 94,3 %). Seul le statut immunodéprimé est associé à une absence de séroconversion (OR 7,6 [1,5-38,2], p = 0,02). …”
Publicado 2021
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5122por Ren, Huiling, Yin, Xin, Su, Chao, Guo, Miaomiao, Wang, Xue-Feng, Na, Lei, Lin, Yuezhi, Wang, Xiaojun“…Abbreviations:3-MA: 3-methyladenine; AA: amino acid; ACTB: actin beta; AD: activation domain; ATG: autophagy related; Baf A1: bafilomycin A(1); BD: binding domain; BECN1: beclin 1; BH3: BCL2-homology-3 domain; BiFC: bimolecular fluorescence complementation; CCD: coiled-coil domain; class III PtdIns3K: class III phosphatidylinositol 3-kinase; CQ: chloroquine; Co-IP: co-immunoprecipitation; dNTPase: dGTP-stimulated deoxynucleoside triphosphate triphosphohydrolase; ECD: evolutionarily conserved domain; EIAV: equine infectious anemia virus; eMDMs: equine monocyte-derived macrophages; GFP: green fluorescent protein; HD: histidine-aspartic; HIV-1: human immunodeficiency virus-1; hpi: hours post infection; hpt: hours post transfection; KO: knockout; LAMP2: lysosomal associated membrane protein 2; LMB: leptomycin B; PMA: phorbol 12-myristate 13-acetate; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; ND: unknown non-essential domain; NES: nuclear export signal; NLS: localization signal; NS: statistically non-significant; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; RBD: RNA binding domain; RT: reverse transcriptase; siRNAs: small interfering RNAs; SAMHD1: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1; SIV: simian immunodeficiency virus; VN: C-terminal residues of Venus 174 to 238; VC: N-terminal residues 2 to 173 of Venus…”
Publicado 2020
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5123por Chiem, Kevin, Morales Vasquez, Desarey, Silvas, Jesus A., Park, Jun-Gyu, Piepenbrink, Michael S., Sourimant, Julien, Lin, Michelle J., Greninger, Alexander L., Plemper, Richard K., Torrelles, Jordi B., Walter, Mark R., de la Torre, Juan C., Kobie, James K., Ye, Chengjin, Martinez-Sobrido, Luis“…Here, we report the generation and use of a recombinant (r)SARS-CoV-2 USA/WA1/2020 (WA-1) strain expressing Venus and an rSARS-CoV-2 strain expressing mCherry and containing mutations K417N, E484K, and N501Y found in the receptor binding domain (RBD) of the spike (S) glycoprotein of the South African (SA) B.1.351 (beta [β]) VoC in bifluorescent-based assays to rapidly and accurately identify human monoclonal antibodies (hMAbs) able to neutralize both viral infections in vitro and in vivo. …”
Publicado 2021
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5124por Kubale, John, Balmaseda, Angel, Frutos, Aaron M, Sanchez, Nery, Plazaola, Miguel, Ojeda, Sergio, Saborio, Saira, Lopez, Roger, Barilla, Carlos, Vasquez, Gerald, Moreira, Hanny, Gajewski, Anna, Campredon, Lora, Maier, Hannah, Chowdhury, Mahboob, Cerpas, Cristhiam, Harris, Eva, Kuan, Guillermina, Gordon, Aubree“…EXPOSURES: Prior COVID-19 infection as confirmed by positive anti SARS-CoV-2 antibodies (receptor binding domain [RBD] and spike protein) or real time RT-PCR confirmed COVID-19 infection ≥60 days prior to current COVID-19. …”
Publicado 2022
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5125por Ryan, Feargal J., Hope, Christopher M., Masavuli, Makutiro G., Lynn, Miriam A., Mekonnen, Zelalem A., Yeow, Arthur Eng Lip, Garcia-Valtanen, Pablo, Al-Delfi, Zahraa, Gummow, Jason, Ferguson, Catherine, O’Connor, Stephanie, Reddi, Benjamin A. J., Hissaria, Pravin, Shaw, David, Kok-Lim, Chuan, Gleadle, Jonathan M., Beard, Michael R., Barry, Simon C., Grubor-Bauk, Branka, Lynn, David J.“…RESULTS: Anti-Spike and anti-RBD IgG responses were largely stable up to 24 wpi and correlated with disease severity. …”
Publicado 2022
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5126por Yeo, Kee Thai, Chia, Wan Ni, Tan, Chee Wah, Ong, Chengsi, Yeo, Joo Guan, Zhang, Jinyan, Poh, Su Li, Lim, Amanda Jin Mei, Sim, Kirsten Hui Zhi, Sutamam, Nursyuhadah, Chua, Camillus Jian Hui, Albani, Salvatore, Wang, Lin-Fa, Chua, Mei Chien“…Post the second vaccine dose, all (35/35, 100%) mothers had detectable breastmilk SARS-CoV-2 spike RBD-specific IgG1 and IgA antibody and 32/35 (88.6%) mothers with IgM. …”
Publicado 2022
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5127por Drews, Steven J., Hu, Queenie, Samson, Reuben, Abe, Kento T., Rathod, Bhavisha, Colwill, Karen, Gingras, Anne-Claude, Yi, Qi-Long, O’Brien, Sheila F.“…A tiered testing approach analyzed 4,500 Canadian blood donor specimens for potential evidence of a signal for anti-spike (anti-S), anti-receptor-binding domain (anti-RBD), and anti-nucleocapsid protein (anti-N). Specimens were stratified based on donor-declared vaccination history and then stratified on the presence or absence of anti-N as follows: (i) “vaccinated plus anti-N” (n = 5), (ii) “vaccinated and no anti-N” (n = 20), (iii) “unvaccinated plus anti-N” (n = 20), and (iv) “unvaccinated and no anti-N” (n = 20). …”
Publicado 2022
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5128por Ettich, Julia, Werner, Julia, Weitz, Hendrik T., Mueller, Eva, Schwarzer, Roland, Lang, Philipp A., Scheller, Jürgen, Moll, Jens M.“…Here, in analogy to bispecific antibodies (bsAbs), we developed the first bispecific IL-6 trans-signaling inhibitor, c19s130Fc, which blocks viral infection and IL-6 trans-signaling. c19s130Fc is a designer protein of the IL-6 trans-signaling inhibitor cs130 fused to a single-domain nanobody directed against the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. c19s130Fc binds with high affinity to IL-6:sIL-6R complexes as well as the spike protein of SARS-CoV-2, as shown by surface plasmon resonance. …”
Publicado 2022
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5129por Medigeshi, Guruprasad R, Batra, Gaurav, Murugesan, Deepika Rathna, Thiruvengadam, Ramachandran, Chattopadhyay, Souvick, Das, Bhabatosh, Gosain, Mudita, Ayushi, Singh, Janmejay, Anbalagan, Anantharaj, Shaman, Heena, Pargai, Kamal, Mehdi, Farha, Das, Soon Jyoti, Kahlon, Namrata, Singh, Savita, Kshetrapal, Pallavi, Wadhwa, Nitya, Pandey, Anil K, Bhatnagar, Shinjini, Garg, Pramod Kumar“…The 50% neutralisation titre against omicron demonstrated moderate correlation with serum anti-RBD IgG levels [Spearman r: 0·58 (0·41, 0·71)]. …”
Publicado 2022
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5130por Dolci, Maria, Signorini, Lucia, Cason, Carolina, Campisciano, Giuseppina, Kunderfranco, Paolo, Pariani, Elena, Galli, Cristina, Petix, Vincenzo, Ferrante, Pasquale, Delbue, Serena, Comar, Manola“…SARS-CoV-2 variants were identified by in vitro viral isolation, amplification, automatic sequencing of the receptor binding domain (RBD) of the SARS-CoV-2 spike coding gene, and subsequent next-generation sequencing. …”
Publicado 2022
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5131por Westendorf, Kathryn, Žentelis, Stefanie, Wang, Lingshu, Foster, Denisa, Vaillancourt, Peter, Wiggin, Matthew, Lovett, Erica, van der Lee, Robin, Hendle, Jörg, Pustilnik, Anna, Sauder, J. Michael, Kraft, Lucas, Hwang, Yuri, Siegel, Robert W., Chen, Jinbiao, Heinz, Beverly A., Higgs, Richard E., Kallewaard, Nicole L., Jepson, Kevin, Goya, Rodrigo, Smith, Maia A., Collins, David W., Pellacani, Davide, Xiang, Ping, de Puyraimond, Valentine, Ricicova, Marketa, Devorkin, Lindsay, Pritchard, Caitlin, O’Neill, Aoise, Dalal, Kush, Panwar, Pankaj, Dhupar, Harveer, Garces, Fabian A., Cohen, Courtney A., Dye, John M., Huie, Kathleen E., Badger, Catherine V., Kobasa, Darwyn, Audet, Jonathan, Freitas, Joshua J., Hassanali, Saleema, Hughes, Ina, Munoz, Luis, Palma, Holly C., Ramamurthy, Bharathi, Cross, Robert W., Geisbert, Thomas W., Menachery, Vineet, Lokugamage, Kumari, Borisevich, Viktoriya, Lanz, Iliana, Anderson, Lisa, Sipahimalani, Payal, Corbett, Kizzmekia S., Yang, Eun Sung, Zhang, Yi, Shi, Wei, Zhou, Tongqing, Choe, Misook, Misasi, John, Kwong, Peter D., Sullivan, Nancy J., Graham, Barney S., Fernandez, Tara L., Hansen, Carl L., Falconer, Ester, Mascola, John R., Jones, Bryan E., Barnhart, Bryan C.“…Using a high-throughput B cell screening pipeline, we isolated LY-CoV1404 (bebtelovimab), a highly potent SARS-CoV-2 spike glycoprotein receptor binding domain (RBD)-specific antibody. LY-CoV1404 potently neutralizes authentic SARS-CoV-2, B.1.1.7, B.1.351, and B.1.617.2. …”
Publicado 2022
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5132por Chiang, Chen-Yi, Chen, Mei-Yu, Hsu, Chia-Wei, Liu, Chia-Yeh, Tsai, Yu-Wen, Liao, Hung-Chun, Yan, Jia-Ying, Chuang, Zih-Shiuan, Wang, Hsin-I., Pan, Chien-Hsiung, Yu, Chia-Yi, Yu, Guann-Yi, Liao, Ching-Len, Liu, Shih-Jen, Chen, Hsin-Wei“…Furthermore, the identified neutralizing epitopes of monoclonal antibodies are all located in the receptor-binding domain (RBD) of the spike protein but in different regions. …”
Publicado 2022
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5133por Leone, Vincenza, Meisinger, Christa, Temizel, Selin, Kling, Elisabeth, Gerstlauer, Michael, Frühwald, Michael C., Burkhardt, Katrin“…The Roche® ECLIA test is used to detect SARS-CoV-2 spike protein, and the recomLine Blot test is used to rule out the possibility of infection by seasonal SARS-viruses and to test for specific SARS-CoV-2 proteins (NP, RBD and S1). In addition, one parent each (n = 336), and 4–5 teachers/caregivers (n = 90) per institution were tested for IgG antibodies from capillary blood samples. …”
Publicado 2022
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5134por Gan, Jinghuan, Chen, Zhichao, Liu, Shuai, Shi, Zhihong, Liu, Yiming, Wang, Xiao-Dan, Liu, Chunyan, Ji, Yong“…We also found that the APOE ε4 allele was significantly associated with hyperhidrosis (OR = 3.472, 95%CI: 1.082–11.144, p = 0.036) and depression (OR = 3.002, 95%CI: 1.079–8.353, p = 0.035) in DLB patients, while there were no significant associations between APOE ε4 allele and the age at visit, the age at onset, scores of MDS-UPDRS III, H&Y stage, ADL, MMSE, MOCA and NPI, as well as the presences of fluctuating cognition, VH, parkinsonism and RBD in both groups. CONCLUSION: The presence and co-incidence of geriatric symptoms are common in patients with mild-moderate LBD. …”
Publicado 2022
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5135por Gan, Jinghuan, Chen, Zhichao, Shi, Zhihong, Li, Xudong, Liu, Shuai, Liu, Yiming, Zhu, Hongcan, Shen, Lu, Zhang, Guili, You, Yong, Guo, Qihao, Zhang, Nan, Lv, Yang, Gang, Baozhi, Yuan, Junliang, Ji, Yong“…Men had more parkinsonism (p = 0.000) and less fluctuating cognition (p = 0.024) in MCI-LB, and those with PD-MCI had more RBD (p = 0.001). Women with PD-MCI had lower MMSE scores (β ± standard error = − 1.24 ± 0.58, p = 0.04), more irritability (0.95 ± 0.46, p = 0.04) and fluctuating cognition (− 3.41 ± 1.31, p = 0.01), and less parkinsonism (− 2.10 ± 0.97, p = 0.03) than men after adjusting for demographic and cardiometabolic conditions. …”
Publicado 2022
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5136por Schumann, Vic-Fabienne, de Castro Cuadrat, Rafael Ricardo, Wyler, Emanuel, Wurmus, Ricardo, Deter, Aylina, Quedenau, Claudia, Dohmen, Jan, Faxel, Miriam, Borodina, Tatiana, Blume, Alexander, Freimuth, Jonas, Meixner, Martin, Grau, José Horacio, Liere, Karsten, Hackenbeck, Thomas, Zietzschmann, Frederik, Gnirss, Regina, Böckelmann, Uta, Uyar, Bora, Franke, Vedran, Barke, Niclas, Altmüller, Janine, Rajewsky, Nikolaus, Landthaler, Markus, Akalin, Altuna“…Lastly, using a targeted sequencing dataset from New York City (receptor-binding-domain (RBD) only), we could reproduce the results recovering the proportions of the so-called cryptic lineages shown in the original study. …”
Publicado 2022
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5137por Rubio, Rocío, Aguilar, Ruth, Bustamante, Mariona, Muñoz, Erica, Vázquez-Santiago, Miquel, Santano, Rebeca, Vidal, Marta, Melero, Natalia Rodrigo, Parras, Daniel, Serra, Pau, Santamaria, Pere, Carolis, Carlo, Izquierdo, Luis, Gómez-Roig, Maria Dolores, Dobaño, Carlota, Moncunill, Gemma, Mazarico, Edurne“…We measured IgM, IgG and IgA levels to 6 SARS-CoV-2 antigens (spike [S], S1, S2, receptor-binding domain [RBD], nucleocapsid [N] full-length and C-terminus), IgG to N from 4 human coronaviruses (OC43, HKU1, 229E and NL63), and the concentrations of 30 cytokines, chemokines and growth factors by Luminex. …”
Publicado 2022
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5138por Padilla-Blanco, Miguel, Vega, Santiago, Enjuanes, Luis, Morey, Alfonso, Lorenzo, Teresa, Marín, Clara, Ivorra, Carmen, Maiques, Elisa, Rubio, Vicente, Rubio-Guerri, Consuelo“…Remarkably, the sequence revealed the Ile402Val substitution in the spike protein (S), of potential concern because it mapped in the receptor binding domain (RBD) that mediates virus interaction with the cell. …”
Publicado 2022
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5139por Vangeti, Sindhu, Periasamy, Sivakumar, Sun, Peifang, Balinsky, Corey A., Mahajan, Avinash S., Kuzmina, Natalia A., Soares-Schanoski, Alessandra, Cooper, Elizabeth, Beckett, Charmagne, Marayag, Jan, Marrone, Amethyst, Nunez, Edgar, Ge, Yongchao, Porter, Chad K., Goforth, Carl W., Lizewski, Stephen E., Lizewski, Rhonda, Jani, Vihasi, Sugiharto, Victor A., Schilling, Megan, Yu, Xuechen B., Marjanovic, Nada, George, Mary Catherine, Bukreyev, Alexander, Sealfon, Stuart C., Letizia, Andrew G., Ramos, Irene“…Antibody binding to S1 and RBD of Beta, Gamma, Delta (1.7 to 2.3-fold decrease), and Omicron (10 to 16-fold decrease) variants was also significantly reduced compared to the ancestral SARS-CoV-2 strain. …”
Publicado 2022
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5140por Singh, Pushpendra, Sharma, Kuldeep, Shaw, Dipika, Bhargava, Anudita, Negi, Sanjay Singh“…The spike gene showed the signature mutations of T19I and V213G in the N-terminal domain (NTD), S373P, S375F, T376A, and D405N in receptor-binding domain (RBD), D614G, H655Y, N679K, and P681H at the furin cleavage site, N764K and D796K in fusion peptide, and Q954H and N969K in heptapeptide repeat sequence (HR)1. …”
Publicado 2023
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