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5141por Islam, Md. Aminul, Shahi, Shatila, Marzan, Abdullah Al, Amin, Mohammad Ruhul, Hasan, Mohammad Nayeem, Hoque, M. Nazmul, Ghosh, Ajit, Barua, Abanti, Khan, Abbas, Dhama, Kuldeep, Chakraborty, Chiranjib, Bhattacharya, Prosun, Wei, Dong-Qing“…Mutations affecting spike proteins are mostly found in RBD regions for Omicron, whereas most of the Delta variant mutations drawn to focus on amino acid regions ranging from 911 to 924 in the context of epitope prediction (B cell & T cell) and mutational stability impact analysis protruding that Omicron is more transmissible. …”
Publicado 2023
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5142por Shree, Tanaya, Shankar, Vishnu, Czerwinski, Debra K., Rodriguez, Gladys, Beygi, Sara, Schroers-Martin, Joseph G, Advani, Ranjana, Maeda, Lauren S., Gupta, Neel K., Khodadoust, Michael S., Kurtz, David M., Corbelli, Karen S., Gabriel, Etelka, Kanegai, Alyssa M., Alizadeh, Ash A., Levy, Ronald“…B-cell responses are being profiled by measuring anti-Spike serum IgG, RBD-ACE2 blocking activity, and spike-specific memory B cells. …”
Publicado 2021
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5143por Madsen, Johannes Roth, Holm, Bettina Eide, Pérez-Alós, Laura, Bayarri-Olmos, Rafael, Rosbjerg, Anne, Fogh, Kamille, Pries-Heje, Mia Marie, Møller, Dina Leth, Hansen, Cecilie Bo, Heftdal, Line Dam, Hasselbalch, Rasmus Bo, Hamm, Sebastian Rask, Frikke-Schmidt, Ruth, Hilsted, Linda, Nielsen, Susanne Dam, Iversen, Kasper Karmark, Bundgaard, Henning, Garred, Peter“…BNT162b2 vaccination induced a detectable IgG anti-SARS-CoV-2 RBD response in saliva at both 2 and 6 months after vaccination, being more prominent in previously infected than infection-naive individuals. …”
Publicado 2023
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5144por Lu, Mengjia, Yao, Weitong, Li, Yujun, Ma, Danting, Zhang, Zhaoyong, Wang, Haimin, Tang, Xiaojuan, Wang, Yanqun, Li, Chao, Cheng, Dechun, Lin, Hua, Yin, Yandong, Zhao, Jincun, Zhong, Guocai“…These data suggest that extensively mutating ACE2 residues near the receptor binding domain (RBD)-binding interface should be avoided or performed with extra caution. …”
Publicado 2023
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5145“…We estimated the association between a known SARS-CoV-2 serostatus (reported positive PCR test or vaccination) and self-reported PPM behavior (hand hygiene, physical distancing, wearing face mask), just as the association of PPM compliance with seropositivity against nucleocapsid (NC), receptor-binding domain (RBD), and spike protein (S) antigens. We identified relevant variables and deduced adjustment sets with directed acyclic graphs (DAG), and applied mixed logistic regression. …”
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5146por Cirks, Blake T, Parsons, Emily, Samuels, Emily, Laing, Eric D, Rajnik, Michael, Malloy, Allison M“…Total SARS-CoV-2 spike (S) and receptor binding domain (RBD)-specific IgG antibodies, as well as endemic coronavirus (eCoV) antibodies, were measured using a multiplex microsphere immunoassay. …”
Publicado 2023
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5147por Goel, Rishi R., Apostolidis, Sokratis A., Painter, Mark M., Mathew, Divij, Pattekar, Ajinkya, Kuthuru, Oliva, Gouma, Sigrid, Kuri-Cervantes, Leticia, Meng, Wenzhao, Adamski, Sharon, Baxter, Amy E., Giles, Josephine R., Weirick, Madison E., McAllister, Christopher M., Hicks, Amanda, Korte, Scott, Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., Prak, Eline T Luning, Betts, Michael R., Bates, Paul, Hensley, Scott E., Greenplate, Allison R., Wherry, E. John“…In this study, we evaluated antibody responses and antigen-specific memory B cell responses over time in 33 SARS-CoV2 naïve and 11 SARS-CoV2 recovered subjects. mRNA vaccination induced significant antibody and memory B cell responses against full-length SARS-CoV2 spike protein and the spike receptor binding domain (RBD). SARS-CoV2 naïve individuals benefitted from both doses of mRNA vaccine with additional increases in antibodies and memory B cells following booster immunization. …”
Publicado 2021
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5148por Goubet, Anne-Gaëlle, Dubuisson, Agathe, Geraud, Arthur, Danlos, François-Xavier, Terrisse, Safae, Silva, Carolina Alves Costa, Drubay, Damien, Touri, Lea, Picard, Marion, Mazzenga, Marine, Silvin, Aymeric, Dunsmore, Garett, Haddad, Yacine, Pizzato, Eugenie, Ly, Pierre, Flament, Caroline, Melenotte, Cléa, Solary, Eric, Fontenay, Michaela, Garcia, Gabriel, Balleyguier, Corinne, Lassau, Nathalie, Maeurer, Markus, Grajeda-Iglesias, Claudia, Nirmalathasan, Nitharsshini, Aprahamian, Fanny, Durand, Sylvère, Kepp, Oliver, Ferrere, Gladys, Thelemaque, Cassandra, Lahmar, Imran, Fahrner, Jean-Eudes, Meziani, Lydia, Ahmed-Belkacem, Abdelhakim, Saïdani, Nadia, La Scola, Bernard, Raoult, Didier, Gentile, Stéphanie, Cortaredona, Sébastien, Ippolito, Giuseppe, Lelouvier, Benjamin, Roulet, Alain, Andre, Fabrice, Barlesi, Fabrice, Soria, Jean-Charles, Pradon, Caroline, Gallois, Emmanuelle, Pommeret, Fanny, Colomba, Emeline, Ginhoux, Florent, Kazandjian, Suzanne, Elkrief, Arielle, Routy, Bertrand, Miyara, Makoto, Gorochov, Guy, Deutsch, Eric, Albiges, Laurence, Stoclin, Annabelle, Gachot, Bertrand, Florin, Anne, Merad, Mansouria, Scotte, Florian, Assaad, Souad, Kroemer, Guido, Blay, Jean-Yves, Marabelle, Aurélien, Griscelli, Frank, Zitvogel, Laurence, Derosa, Lisa“…When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 1063 patients (58% with cancer), we found that malignant disease favors the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies. Cancer patients with a prolonged SARS-CoV-2 RNA detection exhibited the typical immunopathology of severe COVID-19 at the early phase of infection including circulation of immature neutrophils, depletion of nonconventional monocytes, and a general lymphopenia that, however, was accompanied by a rise in plasmablasts, activated follicular T-helper cells, and non-naive Granzyme B(+)FasL(+), Eomes(high)TCF-1(high), PD-1(+)CD8(+) Tc1 cells. …”
Publicado 2021
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5149por Sil, Bijon Kumar, Jamiruddin, Mohd Raeed, Haq, Md Ahsanul, Khondoker, Mohib Ullah, Jahan, Nowshin, Khandker, Shahad Saif, Ali, Tamanna, Oishee, Mumtarin Jannat, Kaitsuka, Taku, Mie, Masayasu, Tomizawa, Kazuhito, Kobatake, Eiry, Haque, Mainul, Adnan, Nihad“…However, the overall efficacies were assessed with sera that seroconverted against either nucleocapsid (NCP) or receptor-binding domain (RBD). RESULTS: In-house ELISA selected a total of 81 true seropositive and 100 seronegative samples. …”
Publicado 2021
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5150por Rathore, Avinash Chandra, Mehta, Harsh, Jayaprakash, J., Singh, Charan, Gupta, Anand Kumar, Kumar, Pawan, Islam, Sadikul, Kar, Saswat Kumar, Patra, Sridhar, Chand, Lekh, Doharey, Vijay Kumar, Ojasvi, Prabhat Ranjan, Yadav, Ram Swaroop, Madhu, M.“…There were five treatments laid in a randomized block design (RBD) with three replications; T(1) [Farmer practice on the flatbed with RDF @ N(120):P(60):K(60) + FYM @6.0 t ha(−1) without mulch], T(2) [T(1) + Polythene mulch (50 microns)], T(3) [Tomato plants grown on the raised bed with polythene mulch + FYM @ 8.0 t ha(−1) + Single shoot trellis system + Side shoot pruning + Liquid Fertilizer (LF(1)—N(19):P(19):K(19)) @ 2.0 g l(–1) for vegetative growth + Liquid Fertilizer (LF(2)—N(0): P(52): K(34)) @ 1.5 g l(–1) for improving fruit quality], T(4) [Tomato plants grown on the raised bed with polythene mulch + FYM @ 8.0 t ha(−1) + Single shoot trellis system + Side shoot pruning + LF(1) @ 4.0 g l(–1) + LF(2) @ 3.0 g l(–1)], and T(5) [Tomato plants grown on the raised bed with polythene mulch + FYM @ 10.0 t ha(−1) + Single shoot trellis system + Side shoot pruning + LF(1) @ 6.0 g l(–1) + LF(2) @ 4.5 g l(–1)]. …”
Publicado 2021
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5151por Hoornaert, Ellen, Dachy, François, Hansenne, Amandine, Lagneaux, Eugénie, Gruson, Damien, Bailly, Sarah, Vekemans, Marie“…We then collected the serological status at day 30, of the first 129 patients that completed vaccination. 97 were affected by MM, 19 by SMM, 3 by MGRS, 10 by AL amyloidosis. 118 developed regular antibodies confirmed by the presence of the receptor binding domain of the spike protein (RBD) antibodies, while 7 presented nucleocapsid protein (N) antibodies, suggesting a previous contact with the virus in the absence of any clinical manifestation. 11 patients failed to develop any immunization, all had received immunosuppressive therapies (renal transplantation in 1, long-term corticosteroid in 1, cyclophosphamide in 7, anti-CD20 monoclonal antibodies in 2) or multiple previous lines of therapies. …”
Publicado 2021
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5152por Mathema, Barun, Chen, Liang, Chow, Kar Fai, Zhao, Yanan, Zody, Michael C., Mediavilla, Jose R., Cunningham, Marcus H., Composto, Kaelea, Lee, Annie, Oschwald, Dayna M., Germer, Soren, Fennessey, Samantha, Patel, Kishan, Wilson, David, Cassell, Ann, Pascual, Lauren, Ip, Andrew, Corvelo, André, Dar, Sophia, Kramer, Yael, Maniatis, Tom, Perlin, David S., Kreiswirth, Barry N.“…We did not detect an increased frequency of any receptor-binding domain (RBD)/N-terminal domain (NTD) polymorphism between groups (P > 0.05). …”
Publicado 2021
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5153por Poglajen, G., Ihan, A., Žorž, N., Frljak, S., Petek, S., Pohar, K., Cerar, A., Zemljič, G., Okrajšek, R., Šebeštjen, M., Kneževič, I., Vrtovec, B.“…At the end of follow-up we measured humoral response to SARS-CoV2 by assessing total antibody levels to the receptor-binding domain of SARS-CoV2 spike (S) protein using anti-RBD immunoassay. Anti-S antibody serum levels ≥250 BAU/mL were considered protective. …”
Publicado 2022
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5154por Wang, Chang Yi, Hwang, Kao-Pin, Kuo, Hui-Kai, Peng, Wen-Jiun, Shen, Yea-Huei, Kuo, Be-Sheng, Huang, Juin-Hua, Liu, Hope, Ho, Yu-Hsin, Lin, Feng, Ding, Shuang, Liu, Zhi, Wu, Huan-Ting, Huang, Ching-Tai, Lee, Yuarn-Jang, Liu, Ming-Che, Yang, Yi-Ching, Lu, Po-Liang, Tsai, Hung-Chin, Lee, Chen-Hsiang, Shi, Zhi-Yuan, Liu, Chun-Eng, Liao, Chun-Hsing, Chang, Feng-Yee, Chen, Hsiang-Cheng, Wang, Fu-Der, Hou, Kuo-Liang, Cheng, Jennifer, Wang, Min-Sheng, Yang, Ya-Ting, Chiu, Han-Chen, Jiang, Ming-Han, Shih, Hao-Yu, Shen, Hsuan-Yu, Chang, Po-Yen, Lan, Yu-Rou, Chen, Chi-Tian, Lin, Yi-Ling, Liang, Jian-Jong, Liao, Chun-Che, Chou, Yu-Chi, Morris, Mary Kate, Hanson, Carl V., Guirakhoo, Farshad, Hellerstein, Michael, Yu, Hui-Jing, King, Chwan-Chuen, Kemp, Tracy, Heppner, D. Gray, Monath, Thomas P.“…We report phase I/II trial results of UB-612, a multitope subunit vaccine containing S1-RBD-sFc protein and rationally designed promiscuous peptides representing sarbecovirus conserved helper T cell and cytotoxic T lymphocyte epitopes on the nucleocapsid (N), membrane (M), and spike (S2) proteins. …”
Publicado 2022
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5155por Espi, M., Charmetant, X., Mathieu, C., Koppe, L., Pelletier, C., Kalbacher, E., Mezaache, S., Fauvel, J.P., Fouque, D., Thaunat, O.“…DESCRIPTION: L’évolution de la réponse humorale (titre d’IgG anti-RBD et capacité de seroneutralisation virale in vitro) et cellulaire (interferon gamma releasing assay, IGRA) a été évaluée chez 62 patients hémodialysés naïfs pour le virus (HD_naïf) entre le pic de la réponse vaccinal et 6 mois après la dernière dose. …”
Publicado 2022
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5156por Valim, Valéria, Martins-Filho, Olindo Assis, Gouvea, Maria da Penha Gomes, Camacho, Luiz Antônio Bastos, Villela, Daniel Antunes Maciel, de Lima, Sheila Maria Barbosa, Azevedo, Adriana Souza, Neto, Lauro Ferreira Pinto, Domingues, Carla Magda Allan Santos, de Medeiros Junior, Nésio Fernandes, Moulaz, Isac Ribeiro, Dias, Laiza Hombre, Miyamoto, Samira Tatiyama, Teixeira-Carvalho, Andréa, Mill, José Geraldo“…The anti-SARS-CoV-2 spike (S) protein receptor binding domain (RBD) by chemiluminescence and the neutralizing antibodies by plaque reduction neutralization test (PRNT) were titrated. …”
Publicado 2022
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5157por Zedan, Hadeel T., Yassine, Hadi M., Al-Sadeq, Duaa W., Liu, Na, Qotba, Hamda, Nicolai, Eleonora, Pieri, Massimo, Bernardini, Sergio, Abu-Raddad, Laith J., Nasrallah, Gheyath K.“…Correlation with anti-SARS-CoV-2 binding antibodies was variable, but the strongest correlations were observed between anti-RBD IgG antibodies and Mindray (r = 0.952, R(2) = 0.907). …”
Publicado 2022
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5158por Achiron, Anat, Mandel, Mathilda, Dreyer-Alster, Sapir, Magalashvili, David, Menascu, Shay, Warszawer, Yehuda, Dolev, Mark, Didikin, Maria, Harari, Gil, Sonis, Polina, Falb, Rina, Gurevich, Michael“…METHODS: We prospectively measured SARS-COV-2 IgG, memory B-cells specific for SARS-CoV-2 RBD, and memory T-cells secreting IFN-γ and/or IL-2, in MS patients vaccinated with BNT162b2-COVID-19 vaccine before, 1, 3 and 6 months after the second vaccine dose, and 3–6 months following vaccine booster. …”
Publicado 2023
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5159por Cavalcanti, Ernesta, Isgrò, Maria Antonietta, Rea, Domenica, Di Capua, Lucia, Trillò, Giusy, Russo, Luigi, Botti, Gerardo, Miscio, Leonardo, Buonaguro, Franco Maria, Bianchi, Attilio Antonio Montano“…METHODS: We determined specific anti-RBD (receptor-binding domain) titers against trimeric spike glycoprotein (S) of SARS-CoV-2 by Roche Elecsys Anti-SARS-CoV-2 S immunoassay in serum samples of 35 healthcare workers with a previous documented history of SARS-CoV-2 infection and 158 healthcare workers without, after 1 and 2 doses of vaccine, respectively. …”
Publicado 2021
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5160por Speich, Benjamin, Chammartin, Frédérique, Smith, Daniel, Stoeckle, Marcel P., Amico, Patrizia, Eichenberger, Anna L., Hasse, Barbara, Schuurmans, Macé M., Müller, Thomas, Tamm, Michael, Dickenmann, Michael, Abela, Irene A., Trkola, Alexandra, Hirsch, Hans H., Manuel, Oriol, Cavassini, Matthias, Hemkens, Lars G., Briel, Matthias, Mueller, Nicolas J., Rauch, Andri, Günthard, Huldrych F., Koller, Michael T., Bucher, Heiner C., Kusejko, Katharina“…The primary clinical outcome will be change in pan-lg antibody response (pan-Ig anti-S1-RBD; baseline vs. 3 months after first vaccination; binary outcome, considering ≥ 0.8 units/ml as a positive antibody response). …”
Publicado 2021
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