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5161por Chen, Yuxin, Yin, Shengxia, Tong, Xin, Tao, Yue, Ni, Jun, Pan, Jie, Li, Ming, Wan, Yawen, Mao, Minxin, Xiong, Yali, Yan, Xiaomin, Yang, Yue, Huang, Rui, Wu, Chao, Shen, Han“…SARS-CoV-2 memory CD4(+) T cells were strongly associated with both receptor binding domain (RBD)-specific memory B cells (r 0.87, p <0.0001) and SARS-CoV-2-specific memory CD8(+) T cells (r 0.48, p <0.0001). …”
Publicado 2022
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5162por Paguntalan, Helen, Magyarics, Zoltán, Connolly, Lynn E, Hershberger, Ellie, Narayan, Kristin, Gupta, Deepali, Ambrose, Paul G, Engler, Frank, Campanaro, Ed, Das, Anita F, Schmidt, Pete“…BACKGROUND: ADG20 is a fully human IgG1 monoclonal antibody engineered to have high potency and broad neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-like CoVs with pandemic potential by binding to a highly conserved epitope in the receptor-binding domain (RBD) of the spike protein. The Fc region of ADG20 has been modified to provide an extended half-life. …”
Publicado 2021
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5163por Chaves, Ana Paula Cunha, Moreira, Luiz Vinicius Leão, Luna, Luciano Kleber de Souza, Barbosa, Gabriela Rodrigues, Bellei, Nancy Cristina Junqueira“…Os níveis de anticorpos contra a porção RBD (Receptor Binding Domain) da proteína S foram detectados e quantificados utilizando o kit ACCESS SARS-CoV-2 IgG (1st IS) (Beckman Coulter, EUA). …”
Publicado 2022
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5164por Neuhann, Julia M., Stemler, Jannik, Carcas, Antonio, Frías-Iniesta, Jesús, Bethe, Ullrich, Heringer, Sarah, Tischmann, Lea, Zarrouk, Marouan, Cüppers, Arnd, König, Franz, Posch, Martin, Cornely, Oliver A.“…The primary endpoint of the trial is to assess the rate of 2-fold antibody titre increase 14 days after vaccination measured by quantitative enzyme-linked immunosorbent assay (Anti-RBD-ELISA) against wild-type virus. Secondary endpoints include the changes in neutralising antibody titres (Virus Neutralisation Assay) against wild-type as well as against Variants of Concern (VOC) at 14 days and up to 12 months. …”
Publicado 2022
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5165por Silva, MB, Boehm, RE, Cohen, CR, Bonacina, F, Farinon, J, Correa, GG, Fontana, C, Corrêa, JARA, Mattos, EMA, Arbo, BD, Sekine, L“…Essas amostras foram triadas para pesquisa de anticorpos IgG e IgM contra o epítopo RBD da proteína Spike do SARS-CoV-2 no Teste Rápido (TR) qualitativo Kit One Step COVID-2019 (CELER). …”
Publicado 2022
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5166por Aweda, Tolulope A., Cheng, Shih-Hsun, Lenhard, Stephen C., Sepp, Armin, Skedzielewski, Tinamarie, Hsu, Chih-Yang, Marshall, Shelly, Haag, Heather, Kehler, Jonathan, Jagdale, Prabhas, Peter, Alessia, Schmid, Michael A., Gehman, Andrew, Doan, Minh, Mayer, Andrew P., Gorycki, Peter, Fanget, Marie, Colas, Christophe, Smith, Brenda, Maier, Curtis C., Alsaid, Hasan“…PURPOSE: Sotrovimab (VIR-7831), a human IgG1κ monoclonal antibody (mAb), binds to a conserved epitope on the SARS-CoV-2 spike protein receptor binding domain (RBD). The Fc region of VIR-7831 contains an LS modification to promote neonatal Fc receptor (FcRn)–mediated recycling and extend its serum half-life. …”
Publicado 2022
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5167por Gholami, Fatemeh, Hamidi Farahani, Ramin, Karimi Rahjerdi, Ahmad, Ahi, Mohammadreza, Sheidaei, Ali, Gohari, Kimiya, Rahimi, Zahra, Ansarifar, Akram, Basiri, Pouria, Moradi, Milad, Jahangiri, Arash, Naderi, Kosar, Ghasemi, Soheil, Khatami, Pezhman, Honari, Mohsen, Khodaverdloo, Samane, Shooshtari, Mohammad, Mehr Azin, Hajar, Moradi, Sohrab, Shafaghi, Batool, Allahyari, Hossein, Monazah, Arina, Khodaei Poor, Ali, Taghva, Zahra, Bakhshande, Hooman, Karimi Nia, Mohammad, Solaymani Dodaran, Masoud, Forooghizade, Mohsen“…Specific ELIZA antibody response against a combination of S1 and RBD antigens 4 weeks after the second injection increased more than three times in the vaccine compared to the placebo group (GMR = 3.34, 95% CI 2.5–4.47, N:142). …”
Publicado 2023
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5168por van Dam, Koos P. J., Volkers, Adriaan G., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y. L., van Kempen, Zoé L. E., Killestein, Joep, Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Takkenberg, R. Bart, D’Haens, Geert R. A. M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A. C. M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J. G. M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C. F., Teng, Y. K. Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B. P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R. G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B. D., Cristianawati, Olvi, ten Brinke, Anja, Verstegen, Niels J. M., van Ham, S. Marieke, Rispens, Theo, Kuijpers, Taco W., Löwenberg, Mark, Eftimov, Filip“…A serum sample was collected before first vaccination to measure SARS-CoV-2 anti-receptor-binding domain (RBD) antibodies. RESULTS: In total, 193 IMID patients on ISP and 113 controls were included. …”
Publicado 2023
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5169por Bae, Seongman, Ko, Jae-Hoon, Choi, Ju-Yeon, Park, Woo-Jung, Lim, So Yun, Ahn, Jin Young, Song, Kyoung-Ho, Lee, Kyoung Hwa, Song, Young Goo, Chan Kim, Yong, Park, Yoon Soo, Choi, Won Suk, Jeong, Hye Won, Kim, Shin-Woo, Kwon, Ki Tae, Kang, Eun-Suk, Kim, Ah-Ra, Jang, Sundong, Kim, Byoungguk, Kim, Sung Soon, Jang, Hee-Chang, Choi, Jun Yong, Kim, Sung-Han, Peck, Kyong Ran“…Immunogenicity was assessed by measuring antibody titers against receptor-binding domain (RBD) of SARS-CoV-2 spike protein in all participants and neutralizing antibody titer in 100 participants per group. …”
Publicado 2022
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5170por Schrag, Anette, Bohlken, Jens, Dammertz, Lotte, Teipel, Stefan, Hermann, Wiebke, Akmatov, Manas K., Bätzing, Jörg, Holstiege, Jakob“…Consistent with previous reports, risk factors and prodromal features associated with PD included traumatic brain injury, odds ratio (OR), 1.62; 95% CI, 1.36-1.92; alcohol misuse, OR, 1.32; 95% CI, 1.21-1.44; hypertension, OR, 1.29; 95% CI, 1.26-1.31; anosmia, OR, 2.16; 95% CI, 1.59-2.93; and parasomnias (including RBD), OR, 1.62; 95% CI, 1.42-1.84. In addition, there were associations with restless legs syndrome (OR, 4.19; 95% CI, 3.91-4.50), sleep apnea (OR, 1.45; 95% CI, 1.37-1.54), epilepsy (OR, 2.26; 95% CI, 2.07-2.46), migraine (OR, 1.21; 95% CI, 1.12-1.29), bipolar disorder (OR, 3.81; 95% CI, 3.11-4.67), and schizophrenia (OR, 4.48; 95% CI, 3.82-5.25). …”
Publicado 2022
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5171por Volk, Andreas, Covini-Souris, Caroline, Kuehnel, Denis, De Mey, Christian, Römisch, Jürgen, Schmidt, Torben“…METHODS: Final containers of IVIG/SCIG and CP donations were analyzed by commercial ELISA for anti-SARS-CoV-2 S1-receptor binding domain (RBD) IgG as well as microneutralization assay using a patient-derived SARS-CoV-2 (D614G) isolate. …”
Publicado 2021
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5172por Schultheis, Katherine, Reed, Charles C, Andrade, Viviane M, Kalia, Richa, Tur, Jared, Schouest, Blake, Elwood, Dustin, Maricic, Igor, Doan, Arthur, Eblimit, Zeena, Pezzoli, Patrick, Amante, Dinah, yang, maria, Fader, Joseph g, Ferrer, Roi, Weiner, David, Kim, J Joseph, Humeau, Laurent, Ramos, Stephanie, Smith, Trevor R F, Broderick, Kate“…METHODS: The synthetic consensus (SynCon®) sequence for INO-4802 SARS-CoV-2 spike with focused RBD changes and dual proline mutations was codon-optimized (Figure 1). …”
Publicado 2021
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5173por Jin, Pengfei, Guo, Xiling, Chen, Wei, Ma, Shihua, Pan, Hongxing, Dai, Lianpan, Du, Pan, Wang, Lili, Jin, Lairun, Chen, Yin, Shi, Fengjuan, Liu, Jingxian, Xu, Xiaoyu, Zhang, Yanan, Gao, George F., Chen, Cancan, Feng, Jialu, Li, Jingxin, Zhu, Fengcai“…TRIAL REGISTRATION: Study on Heterologous Prime-boost of Recombinant COVID-19 Vaccine (Ad5 Vector) and RBD-based Protein Subunit Vaccine; ClinicalTrial.gov NCT04833101.…”
Publicado 2022
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5174“…The studies on the molecular mechanisms of EGCG in inhibition of SARS-CoV-2 infection in host cells reveal that EGCG blocks the entry of the virus particles by interaction with the receptor binding domain (RBD) of viral spike (S) protein to host cell surface receptor protease angiotensin-converting enzyme 2 (ACE2) as well as suppression of the expressions of host proteases, ACE2, TMPRSS2 and GRP78, required for viral entry, by Nrf2 activation in host cells. …”
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5175por Claudiani, Simone, Rosadas, Carolina, McClure, Myra, Khan, Maryam, Tedder, Richard S., Innes, Andrew J., Milojkovic, Dragana, Apperley, Jane“…The Imperial Hybrid DABA, a two-step double antigen binding assay (DABA) for the detection and measurement of total antibody directed to the receptor binding domain (RBD) of SARS-CoV-2 was used for analysis. The cut-off (CO) for positivity is established by adding 0.1 to the average of optical density (OD) obtained for the negative controls. …”
Publicado 2020
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5176por Saraceni, Francesco, Fiorentini, Alessandro, Morè, Sonia, Guerzoni, Selene, Puglisi, Bruna, Corvaro, Benedetta, Caucci, Sara, Menzo, Stefano, Costantini, Andrea, Butini, Luca, Viola, Nadia, Scortechini, Ilaria, Mancini, Giorgia, Dubbini, Maria Vittoria, Federici, Irene, Kordasti, Shahram, Offidani, Massimo, Patriarca, Francesca, Battista, Marta Lisa, Chiarucci, Martina, Visani, Giuseppe, Falcioni, Sadia, Galieni, Piero, Natale, Annalisa, Vaddinelli, Doriana, Santarone, Stella, Colasante, Fabrizia, Carella, Angelo Michele, Battipaglia, Giorgia, Pane, Fabrizio, Olivieri, Attilio“…IgG antibodies to the receptor-binding domain (RBD) of the S1 subunit of the spike protein of SARS-CoV-2 were analyzed by SARS-CoV-2 IgG II Quant (Abbott, Ireland). …”
Publicado 2021
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5177por Christodoulou, Ilias, Rahnama, Ruyan, Ravich, Wesley J., Seo, Jaesung, Zolov, Sergey, Marple, Andrew, Markovitz, David M, Bonifant, Challice L.“…The SARS-CoV-2 spike (S) protein is decorated with high mannose N-glycosites that are in close proximity to the viral receptor binding domain (RBD). Our goal was to use the H84T-BanLec as the extracellular targeting domain of a chimeric antigen receptor (CAR). …”
Publicado 2021
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5178por Valim, Valéria, Gouvea, Maria da Penha Gomes, Filho, Olindo Assis Martins, Carvalho, Andrea Teixeira, Camacho, Luiz Antônio Bastos, Villela, Daniel A. Maciel, Neto, Lauro Ferreira Pinto, Domingues, Carla, Moulaz, Isac Ribeiro, Thompson, Beatriz Paoli, Lança, Karen Evelin Monlevade, Lacerda, Gabriela Curto Cristianes, Lenzi, João Pedro Gonçalvez, Ramos, Sabrina de Souza, Miossi, João Pedro Moraes, Rassele, Matheus Leite, Pimentel, Felipe de Castro, Henriques, Allan Gonçalves, Amaral, Maria Eduarda Moraes Hibner, Silva, Lucas Santos, Pasti, Laís, Vieira, Gabriel Smith Sobral, Roza, Thais Luma de Oliveira, Ramos, Alessandro Demoner, Surlo, Heitor Filipe, Grillo, Luiza Lorenzoni, Aguiar, Laura Gonçalves Rodrigues, Rosi, Matheus Pereira, Rizzi, Ramon Borge, Athayde, Paula dos Santos, Lorencini, Pietra Zava, Silva, Adriana Santos, Reuter, Tania, Jubini, Jaquelini, Lyra, Danielle Grillo Pacheco, Rodrigues, Rodrigo Ribeiro, da Silva, Cristiano Soares, Reblin, Luís Carlos, Cardoso, Orlei, Miyamoto, Samira T., Machado, Ketty Lysie Libardi Lira, Forechi, Ludimila, Strauss, Carolina, Percio, Jadher, Barrera, Lely Stella Guzmán, Junior, Nésio Fernandes de Medeiros, Mill, José Geraldo“…Foram estudados a incidência novos casos, número de mortes, internações e admissões em UTI, anticorpos neutralizantes por teste de neutralização em placa (PRNT) e quimioluminescência contra a porção RBD da fração S1 da proteína Spike, anticorpos totais IgG específico para SARS-Cov2, fatores solúveis sistêmicos, imunidade celular por estimulação antígeno-específica de células mononucleares do sangue periférico in vitro e investigação de Linfócitos T e B de memória e de citocinas intracitoplasmáticas. …”
Publicado 2022
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5179por Guo, Li, Wang, Geng, Wang, Yeming, Zhang, Qiao, Ren, Lili, Gu, Xiaoying, Huang, Tingxuan, Zhong, Jingchuan, Wang, Ying, Wang, Xinming, Huang, Lixue, Xu, Liuhui, Wang, Conghui, Chen, Lan, Xiao, Xia, Peng, Yanchun, Knight, Julian C, Dong, Tao, Cao, Bin, Wang, Jianwei“…N-IgG (899 [82·0%]), S-IgG (1043 [95·2%]), RBD-IgG (1032 [94·2%]), and neutralising (115 [81·6%] of 141) antibodies were detectable 12 months after initial infection in most individuals. …”
Publicado 2022
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5180por Isgrò, Maria Antonietta, Trillò, Giusy, Russo, Luigi, Tornesello, Anna Lucia, Buonaguro, Luigi, Tornesello, Maria Lina, Miscio, Leonardo, Normanno, Nicola, Bianchi, Attilio Antonio Montano, Buonaguro, Franco Maria, Cavalcanti, Ernesta“…METHODS: Specific anti-RBD (receptor-binding domain) titers against trimeric spike glycoprotein (S) of SARS-CoV-2 by Roche Elecsys Anti-SARS-CoV-2 S ECLIA immunoassay were determined in serum samples of 27 healthcare workers with a previously documented history of SARS-CoV-2 infection and 123 healthcare workers without, during antibody titers’ monitoring. …”
Publicado 2022
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