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501por Caruso, Teresita, Salani, Francesca, Catanese, Silvia, Pratesi, Federico, Mercinelli, Chiara, Motta, Giuseppe, Genovesi, Virginia, Bonato, Adele, Sara, Galimberti, Masi, Gianluca, Migliorini, PaolaEnlace del recurso
Publicado 2023
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502por Wu, Shiheng, Wang, Xiaolin, Feng, Mingyang, Liu, Xiaoman, Fan, Xinxing, Ran, Xiangui, Wang, Baogui, Wang, HuiEnlace del recurso
Publicado 2023
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503por da Costa, Hernan H. M., Orts, Diego J. B., Moura, Andrew D., Duarte-Neto, Amaro N., Cirqueira, Cinthya S., Réssio, Rodrigo A., Kanamura, Cristina T., Miguita, Karen, Ferreira, Jerenice E., Santos, Raimunda T. M., Adriani, Patricia P., Cunha-Junior, Jair P., Astray, Renato M., Catarino, Regina M., Lancelotti, Marcelo, Prudencio, Carlos R.“…We demonstrated that three doses of DNA plasmid carrying the gene encoding the full-length spike protein (S) or the receptor binding domain (RBD) of SARS-CoV-2 induced a time-dependent increase in IgG antibody avidity maturation. …”
Publicado 2023
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504por Watanabe, Yoshihiro, Hosokawa, Natsuko, Yoshida, Misaki, Miura, Tomoyuki, Kawano, Mitsuhiro“…We identified closed linear epitopes of the SARS-CoV-2 Spike molecule that induced neutralizing Abs (nAbs) against both S1-RBD, responsible for attachment to hACE2, and S2-HR1/2, in convalescents and vaccine recipients. …”
Publicado 2023
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505por Nanishi, Etsuro, Borriello, Francesco, Seo, Hyuk-Soo, O’Meara, Timothy R., McGrath, Marisa E., Saito, Yoshine, Chen, Jing, Diray-Arce, Joann, Song, Kijun, Xu, Andrew Z., Barman, Soumik, Menon, Manisha, Dong, Danica, Caradonna, Timothy M., Feldman, Jared, Hauser, Blake M., Schmidt, Aaron G., Baden, Lindsey R., Ernst, Robert K., Dillen, Carly, Yu, Jingyou, Chang, Aiquan, Hilgers, Luuk, Platenburg, Peter Paul, Dhe-Paganon, Sirano, Barouch, Dan H., Ozonoff, Al, Zanoni, Ivan, Frieman, Matthew B., Dowling, David J., Levy, OferEnlace del recurso
Publicado 2023
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506por Phoolcharoen, Waranyoo, Shanmugaraj, Balamurugan, Khorattanakulchai, Narach, Sunyakumthorn, Piyanate, Pichyangkul, Sathit, Taepavarapruk, Pornnarin, Praserthsee, Wanlapa, Malaivijitnond, Suchinda, Manopwisedjaroen, Suwimon, Thitithanyanont, Arunee, Srisutthisamphan, Kanjana, Jongkaewwattana, Anan, Tomai, Mark, Fox, Christopher B., Taychakhoonavudh, Suthira“…This vaccine formulation, named Baiya SARS-CoV-2 Vax 2, induced significant levels of RBD-specific IgG and neutralizing antibody responses in mice. …”
Publicado 2023
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507por Koopman, Gerrit, Amacker, Mario, Stegmann, Toon, Verschoor, Ernst J., Verstrepen, Babs E., Bhoelan, Farien, Bemelman, Denzel, Böszörményi, Kinga P., Fagrouch, Zahra, Kiemenyi-Kayere, Gwendoline, Mortier, Daniella, Verel, Dagmar E., Niphuis, Henk, Acar, Roja Fidel, Kondova, Ivanela, Kap, Yolanda S., Bogers, Willy M. J. M., Mooij, Petra, Fleury, Sylvain“…Here, vaccine efficacy was evaluated in non-human primates with a COVID-19 virosome-based vaccine containing a low dose of RBD protein (15 µg) and the adjuvant 3M-052 (1 µg), displayed together on virosomes. …”
Publicado 2023
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508por Kang, Eun Song, Oh, Ji Seon, Lee, Eun-Ju, Hong, Seokchan, Ahn, Soo Min, Lee, Chang-Keun, Yoo, Bin, Kim, Yong-GilEnlace del recurso
Publicado 2023
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509por Liu, Zezhong, Zhou, Jie, Wang, Xinling, Xu, Wei, Teng, Zheng, Chen, Hongyou, Chen, Min, Zhang, Guangxu, Wang, Yuanzhou, Huang, Jinghe, Wang, Qian, Jiang, Shibo, Lu, Lu“…Here, we found that the human IgG Fc-conjugated RBD of the original SARS-CoV-2 strain (WA1) plus a novel STING agonist-based adjuvant CF501 (CF501/RBD-Fc) could induce highly potent and durable broad-neutralizing antibody (bnAb) responses against Omicron subvariants, including BQ.1.1 and XBB in rhesus macaques with NT50s ranging from 2,118 to 61,742 after three doses. …”
Publicado 2023
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510por Bajoria, Sakshi, Kumru, Ozan S., Doering, Jennifer, Berman, Katherine, Slyke, Greta Van, Prigodich, Anneka, Rodriguez-Aponte, Sergio A., Kleanthous, Harry, Love, J. Christopher, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.“…Previously, we demonstrated that a recombinant receptor-binding domain (RBD)-based COVID-19 vaccine candidate (RBD-J; RBD-L452K-F490W) formulated with aluminum hydroxide (Alhydrogel(®); AH) and CpG 1018™ (CpG) adjuvants induced potent neutralizing antibody responses in mice yet displayed instability during storage. …”
Publicado 2023
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511por Kaewchim, Kanasap, Glab-ampai, Kittirat, Mahasongkram, Kodchakorn, Saenlom, Thanatsaran, Thepsawat, Watayagorn, Chulanetra, Monrat, Choowongkomon, Kiattawee, Sookrung, Nitat, Chaicumpa, WanpenEnlace del recurso
Publicado 2023
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512por Yang, Songhao, Duan, Liangwei, Wang, Chan, Zhang, Cuiying, Hou, Siyu, Wang, Hao, Song, Jiahui, Zhang, Tingting, Li, Zihua, Wang, Mingxia, Tang, Jing, Zheng, Qianqian, Wang, Hui, Wang, Qi, Zhao, Wei“…However, the immunologic mechanism of Tfh cells in SARS-CoV-2 receptor binding domain (RBD) vaccine strategy is limited. In this study, we expressed and purified recombinant SARS-CoV-2 RBD protein in Drosophila S2 cells for the first time and explored the mechanism of Tfh cells induced by RBD vaccine in humoral immune response. …”
Publicado 2023
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513“…One of these linkers, Linker 2 between RBD2 and RBD3, is conserved in length, predicted to be structured and contains conserved clusters of amino acid residues. …”
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514por Chen, Wen-Hsiang, Chag, Shivali M., Poongavanam, Mohan V., Biter, Amadeo B., Ewere, Ebe A., Rezende, Wanderson, Seid, Christopher A., Hudspeth, Elissa M., Pollet, Jeroen, McAtee, C. Patrick, Strych, Ulrich, Bottazzi, Maria Elena, Hotez, Peter J.“…When adjuvanted with aluminum hydroxide, this protein elicited high neutralizing antibody titers and high RBD-specific antibody titers. However, the yield of RBD219-N1 (60 mg RBD219-N1 per liter of fermentation supernatant; 60 mg/L FS) still required improvement to reach our target of >100 mg/L FS. …”
Publicado 2017
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515por Ankush Jagtap, Pravin Kumar, Müller, Marisa, Masiewicz, Pawel, von Bülow, Sören, Hollmann, Nele Merret, Chen, Po-Chia, Simon, Bernd, Thomae, Andreas W, Becker, Peter B, Hennig, Janosch“…Here, we determined the solution NMR structure of dsRBD1 and dsRBD2 of MLE in tandem and investigated its role in double-stranded RNA (dsRNA) binding. …”
Publicado 2019
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516por Othman, Houcemeddine, Bouslama, Zied, Brandenburg, Jean-Tristan, da Rocha, Jorge, Hamdi, Yosr, Ghedira, Kais, Srairi-Abid, Najet, Hazelhurst, Scott“…Finally, we studied the impact of eight different variants located at the interaction surface of ACE2, on the complex formation with SARS-CoV-2 RBD. We found that none of them is likely to disrupt the interaction with the viral RBD of SARS-CoV-2.…”
Publicado 2020
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517“…Pro-to-Ala475 substitution and Gly482 insertion in the AGSTPCNGV-loop of RBD possibly hinders neutralization of SARS-CoV-2 by anti-SARS-CoV mAbs. …”
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518por Arokiyaraj, Selvaraj, Stalin, Antony, Kannan, Balakrishnan Senthamarai, Shin, Hakdong“…The SARS-CoV-2 receptor-binding domain (RBD), 3CL(pro) (Replicase polyprotein 1ab), and the cell surface receptor glucose-regulated protein 78 (GRP78) were chosen as target proteins. …”
Publicado 2020
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519“…Here we completely map all mutations to the SARS-CoV-2 spike receptor binding domain (RBD) that escape binding by a leading monoclonal antibody, LY-CoV555, and its cocktail combination with LY-CoV016. …”
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520“…Here, we completely map all of the mutations to the SARS-CoV-2 spike receptor-binding domain (RBD) that escape binding by a leading monoclonal antibody, LY-CoV555, and its cocktail combination with LY-CoV016. …”
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