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521por Gao, Xiangzheng, Liang, Keying, Mei, Shengsheng, Peng, Shanshan, Vong, Eu Gene, Zhan, JinbiaoEnlace del recurso
Publicado 2021
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522por Lee, Jungsoon, Liu, Zhuyun, Chen, Wen-Hsiang, Wei, Junfei, Kundu, Rakhi, Adhikari, Rakesh, Rivera, Joanne Altieri, Gillespie, Portia M., Strych, Ulrich, Zhan, Bin, Hotez, Peter J., Bottazzi, Maria Elena“…ABSTRACT: A SARS-CoV-2 RBD219-N1C1 (RBD219-N1C1) recombinant protein antigen formulated on Alhydrogel® has recently been shown to elicit a robust neutralizing antibody response against SARS-CoV-2 pseudovirus in mice. …”
Publicado 2021
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523por Zhang, Yunwen, Yang, Zhengrong, Tian, Sicheng, Li, Baisheng, Feng, Tiejian, He, Jianfan, Jiang, Min, Tang, Xiujuan, Mei, Shujiang, Li, Hao, Zhong, Yifan, Li, Guilian, Tang, Mingyuan, Liu, Sijing, Tang, Tian, Wang, Chuan, Wang, Xiaohui“…RESULTS: Two B cell linear epitopes, P104 and P82, located in non-RBD region of SARS-CoV-2 S protein were identified by indirect ELISA screening of an overlapping peptide library of the S protein with COVID-19 patients’ convalescent serum. …”
Publicado 2021
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524por Tan, Enqing, Frew, Erica, Cooper, Jeff, Humphrey, John, Holden, Matthew, Mand, Amanda Restell, Li, Jun, Anderson, Shaya, Bi, Ming, Hatler, Julia, Person, Anthony, Mortari, Frank, Gould, Kevin, Barry, Shelly“…We characterized seven anti-SARS-CoV-2 receptor binding domain (RBD) antibodies for binding activity, pairing capability, and neutralization activity to SARS-CoV-2 and three variant RBDs via lateral flow immunoassays. …”
Publicado 2021
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525por Liao, Baolin, Chen, Zhao, Zheng, Peiyan, Li, Linghua, Zhuo, Jianfen, Li, Fang, Li, Suxiang, Chen, Dingbin, Wen, Chunyan, Cai, Weiping, Wu, Shanhui, Tang, Yanhong, Duan, Linwei, Wei, Peilan, Chen, Fangli, Yuan, Jinwei, Yang, Jinghong, Feng, Jiaxin, Zhao, Jingxian, Zhao, Jincun, Sun, Baoqing, Zhu, Airu, Li, Yimin, Tang, Xiaoping“…In contrast to symptomatic patients, asymptomatic patients showed a dominant IgG-response towards the RBD protein, but not IgM and IgA. Neutralizing antibody titers had linear correlations with IgA/IgM/IgG levels against SARS-CoV-2-RBD, as well as with IgG levels against multiple SARS-CoV-2 structural proteins, especially with anti-RBD or anti-S2 IgG. …”
Publicado 2021
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526por Alves, Juliano, Engel, Laurie, de Vasconcelos Cabral, Renata, Rodrigues, Eduardo L., de Jesus Ribeiro, Liane, Higa, Luiza M., da Costa Ferreira Júnior, Orlando, Castiñeiras, Terezinha Marta P. P., de Carvalho Leitão, Isabela, Tanuri, Amilcar, Goueli, Said A., Zegzouti, Hicham“…Studying the effect of RBD mutations on ACE2 binding showed that the N501Y mutation increased RBD apparent affinity toward ACE2 tenfold that resulted in escaping inhibition by some anti-RBD antibodies. …”
Publicado 2021
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527por He, Yunjiao, Qu, Jing, Wei, Lan, Liao, Shumin, Zheng, Nianzhen, Liu, Yingzi, Wang, Xingyun, Jing, Yue, Shen, Clifton Kwang-Fu, Ji, Chong, Luo, Guxun, Zhang, Yiyun, Xiang, Qi, Fu, Yang, Li, Shuo, Fan, Yunping, Fang, Shisong, Wang, Peng, Li, Liang“…In this study, we generated anti–receptor-binding domain (anti-RBD) pAbs from rabbit serum and tested their safety and efficacy in response to SARS-CoV-2 infection both in vivo and ex vivo. …”
Publicado 2021
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528por Wu, Jing, Liu, Xingxiang, Shao, Jianguo, Zhang, Yuanyuan, Lu, Renfei, Xue, Hong, Xu, Yunfang, Wang, Lijuan, Zhou, Hui, Yu, Lugang, Yue, Ming, Dong, Chen“…METHODS: Expression profiles of 12 plasma ISR-miRNAs in COVID-19 patients and healthy controls were analyzed using RT-qPCR. The level of RBD-IgG antibody was determined using the competitive ELISA. …”
Publicado 2021
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529“…These peptides are screened based on their binding with the RBD of the spike protein and aqueous stability, obtained using several atomistic molecular dynamic simulations. …”
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530“…Simultaneously, serum Ab were determined by Maglumi 2000 plus (anti S-RBD CLIA assay, Snibe Diagnostics, Shenzhen, China) and SARS-CoV-2 “Neutralizing” Ab Chorus ELISA (DIESSE, Siena, Italy). …”
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531por Schubert, Maren, Bertoglio, Federico, Steinke, Stephan, Heine, Philip Alexander, Ynga-Durand, Mario Alberto, Maass, Henrike, Sammartino, Josè Camilla, Cassaniti, Irene, Zuo, Fanglei, Du, Likun, Korn, Janin, Milošević, Marko, Wenzel, Esther Veronika, Krstanović, Fran, Polten, Saskia, Pribanić-Matešić, Marina, Brizić, Ilija, Baldanti, Fausto, Hammarström, Lennart, Dübel, Stefan, Šustić, Alan, Marcotte, Harold, Strengert, Monika, Protić, Alen, Piralla, Antonio, Pan-Hammarström, Qiang, Čičin-Šain, Luka, Hust, Michael“…In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially more mutations in the spike protein than any previous variant, especially in the receptor-binding domain (RBD). We analyzed the binding of the Omicron RBD to the human angiotensin-converting enzyme-2 receptor (ACE2) and the ability of human sera from COVID-19 patients or vaccinees in comparison to Wuhan, Beta, or Delta RBD variants. …”
Publicado 2022
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532“…The proposed aptasensor had a good selectivity to SARS-CoV-2-RBD in the presence of human serum albumin; human immunoglobulins G, A, and M, hemagglutinin, and neuraminidase. …”
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533por Hod, Tammy, Ben-David, Aharon, Olmer, Liraz, Scott, Noa, Ghinea, Ronen, Mor, Eytan, Levy, Itzchak, Indenbaum, Victoria, Lustig, Yaniv, Grossman, Ehud, Rahav, Galia“…Methods: To reveal predictors for humoral response to third vaccine, patients were stratified to positive (N = 85) and negative (N = 14) response groups based on receptor-binding domain (RBD) IgG ≥1.1 and neutralizing antibodies (NA) ≥ 16 dilution versus RBD IgG <1.1 or NA < 16, respectively. …”
Publicado 2022
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534por Sokal, Aurélien, Broketa, Matteo, Barba-Spaeth, Giovanna, Meola, Annalisa, Fernández, Ignacio, Fourati, Slim, Azzaoui, Imane, de La Selle, Andrea, Vandenberghe, Alexis, Roeser, Anais, Bouvier-Alias, Magali, Crickx, Etienne, Languille, Laetitia, Michel, Marc, Godeau, Bertrand, Gallien, Sébastien, Melica, Giovanna, Nguyen, Yann, Zarrouk, Virginie, Canoui-Poitrine, Florence, Noizat-Pirenne, France, Megret, Jérôme, Pawlotsky, Jean-Michel, Fillatreau, Simon, Simon-Lorière, Etienne, Weill, Jean-Claude, Reynaud, Claude-Agnès, Rey, Félix A., Bruhns, Pierre, Chappert, Pascal, Mahévas, Matthieu“…Compared with other variants of concern, Omicron evaded recognition by a larger proportion of MBC-derived antibodies, with only 30% retaining high affinity against the Omicron RBD, and the reduction in neutralization potency was even more pronounced. …”
Publicado 2022
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535por Conzentino, Marcelo S., Gonçalves, Ana C. A., Paula, Nigella M., Rego, Fabiane G. M., Zanette, Dalila L., Aoki, Mateus N., Nardin, Jeanine M., Huergo, Luciano Fernandes“…A 6xHis-tagged Spike S1 RBD was expressed in E. coli and purified by affinity chromatography. …”
Publicado 2022
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536por Gumanova, Nadezhda G., Gorshkov, Alexander U., Bogdanova, Natalya L., Korolev, Andrew I., Drapkina, Oxana M.“…We investigated seroprevalence of anti-SARS-CoV-2-S1 receptor-binding domain (RBD)-specific antibodies in the serum samples in 2011–2021, including a cohort study of 2019–2021, to evaluate the vaccination and anti-IgG-SARS-CoV-2–S1 RBD-positive statuses to assess the resistance and severity of COVID-19. …”
Publicado 2022
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537por Shi, Juan, Zheng, Jian, Zhang, Xiujuan, Tai, Wanbo, Odle, Abby E., Perlman, Stanley, Du, Lanying“…Particularly, RBD-mRNA vaccine completely protected mice from challenge with a virulent mouse-adapted SARS-CoV-2 variant. …”
Publicado 2022
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538por Shafiq, Athar, Zubair, Farrukh, Ambreen, Amna, Suleman, Muhammad, Yousafi, Qudsia, Rasul Niazi, Zahid, Anwar, Zeeshan, Khan, Abbas, Mohammad, Anwar, Wei, Dong-Qing“…The higher TBE for the A.30 RBD complex signifies a more robust interaction between A.30 variant RBD with ACE2 than the wild type, allowing the variant to bind and spread more promptly. …”
Publicado 2022
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539por Chang, Matthew R., Ke, Hanzhong, Coherd, Christian D., Wang, Yufei, Mashima, Kiyomi, Kastrunes, Gabriella M., Huang, Chiung-Yu, Marasco, Wayne A.“…FINDINGS: Forty-eight COVID convalescent donors with post-infection vaccination (hybrid immunity) were studied to evaluate the levels of cross-reactive antibodies pre- and post- vaccination against various SARS-CoV-2 Spike and RBD proteins. Vaccination with BNT162b2, mRNA-1273 or Ad26.COV2.S led to a 6.3 to 7.8 fold increase in anti-Spike antibody titers and a 7·0 to 7·4 fold increase in anti-WT, Alpha and Delta RBD antibody. …”
Publicado 2022
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540por Goswami, Pritam, Chatterjee, Debasmita, Ghosh, Sayak, Paira, Krishnendu, Das, Satadal“…In this experiment, we studied cytokine changes by diluted Bryonia alba extract in Delta SARS-CoV-2 spike protein RBD-induced pathogenesis, in fertilized chick (Gallus gallus domesticus) embryos. …”
Publicado 2022
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