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561por Balkrishna, Acharya, Pokhrel, Subarna, Singh, Hoshiyar, Joshi, Monali, Mulay, Vallabh Prakash, Haldar, Swati, Varshney, Anurag“…The two intrachain salt bridge interactions (K31-E35) and the interchain long-range ion-pair (K31-E484), at the ACE2-RBD interface were completely abolished by withanone, in the 50 ns simulation. …”
Publicado 2021
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562por Chang, Chih-Chao, Vlad, George, Vasilescu, Elena-Rodica, Husain, Syed A., Liu, Ya Nan, Sun, Wei-Zen, Chang, Ming-Fu, Suciu-Foca, Nicole, Mohan, SumitEnlace del recurso
Publicado 2021
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563“…The high transmissibility rate of the disease is related to the strong interaction between the virus spike receptor-binding domain (RBD) and the human angiotensin-converting enzyme 2 (ACE2) as documented in several reports. …”
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564por Routhu, Nanda Kishore, Cheedarla, Narayanaiah, Bollimpelli, Venkata Satish, Gangadhara, Sailaja, Edara, Venkata Viswanadh, Lai, Lilin, Sahoo, Anusmita, Shiferaw, Ayalnesh, Styles, Tiffany M., Floyd, Katharine, Fischinger, Stephanie, Atyeo, Caroline, Shin, Sally A., Gumber, Sanjeev, Kirejczyk, Shannon, Dinnon, Kenneth H., Shi, Pei-Yong, Menachery, Vineet D., Tomai, Mark, Fox, Christopher B., Alter, Galit, Vanderford, Thomas H., Gralinski, Lisa, Suthar, Mehul S., Amara, Rama Rao“…The receptor binding domain (RBD) of the spike protein is a primary target of neutralizing antibodies. …”
Publicado 2021
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565por Law, John Lok Man, Logan, Michael, Joyce, Michael A., Landi, Abdolamir, Hockman, Darren, Crawford, Kevin, Johnson, Janelle, LaChance, Gerald, Saffran, Holly A., Shields, Justin, Hobart, Eve, Brassard, Raelynn, Arutyunova, Elena, Pabbaraju, Kanti, Croxen, Matthew, Tipples, Graham, Lemieux, M. Joanne, Tyrrell, D. Lorne, Houghton, Michael“…Our results show that RBD induces high titers of neutralizing antibodies and activates strong cellular immune responses. …”
Publicado 2021
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566por Kumar Paul, Gobindo, Mahmud, Shafi, Aldahish, Afaf A, Afroze, Mirola, Biswas, Suvro, Briti Ray Gupta, Swagota, Hasan Razu, Mahmudul, Zaman, Shahriar, Salah Uddin, Md., Nahari, Mohammed H, Merae Alshahrani, Mohammed, Abdul Rahman Alshahrani, Mohammed, Khan, Mala, Abu Saleh, Md.“…In this work, we extracted phytochemicals from two mangrove plants, Pistacia integerrima and Pandanus odorifer, assessing their potential actions against the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. The antioxidant activities of Pistacia integerrima leaves and fruits were 142.10 and 97.13 µg/mL, respectively, whereas Pandanus odorifer leaves and fruits were 112.50 and 292.71 µg/mL, respectively. …”
Publicado 2022
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567por Pugliese, Maria Elena, Battaglia, Riccardo, Cerasa, Antonio, Raso, Maria Girolama, Coschignano, Francesco, Pagliuso, Angela, Bruschetta, Roberta, Pugliese, Giovanni, Scola, Paolo, Tonin, Paolo“…Objective: In the last year, a large amount of research has investigated the anti-spike protein receptor-binding domain (S-RBD) antibody responses in patients at high risk of developing severe acute respiratory syndrome because of COVID-19 infection. …”
Publicado 2021
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568por Wongso, Hendris, Mahendra, Isa, Arnafia, Wyanda, Idar, Idar, Yusuf, Muhammad, Achmad, Arifudin, Holik, Holis A., Kurniawan, Ahmad, Halimah, Iim, Sriyani, Maula E., Wibawa, Teguh H. A., Febrian, Muhamad B., Setiadi, Yanuar, Widyasari, Eva M., Daruwati, Isti, Kusumaningrum, Crhisterra E., Subroto, Toto“…For the purpose of preclinical studies, we radiolabeled IgY anti-RBD spike SARS-CoV-2 with radionuclide iodine-131. …”
Publicado 2022
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569por Sim, Kyu-Young, Ko, Gwang-Hoon, Bae, So-Eun, Choi, Kyu Yeong, Lee, Jung Sup, Kim, Byeong C., Lee, Kun Ho, Song, Mi-Ryoung, Park, Sung-Gyoo“…Instead, SARS-CoV-2 pseudovirus infection was neutralized by some RBD-reactive plasma samples (n = 9, neutralization ≥ 25%, P ≤ 0.05), but enhanced by other RBD-reactive plasma samples (n = 4, neutralization ≤ -25%, P ≤ 0.05). …”
Publicado 2022
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570“…Furthermore, RBD from the omicron variant (B.1.1.529) was also produced. …”
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571por Wang, Xiaofei, Hu, Ao, Chen, Xiangyu, Zhang, Yixin, Yu, Fei, Yue, Shuai, Li, Arong, Zhang, Junsong, Pan, Zhiwei, Yang, Yang, Lin, Yao, Gao, Leiqiong, Zhou, Jing, Zhao, Jing, Li, Fang, Shi, Yaling, Huang, Feng, Yang, Xiaofan, Peng, Yi, Tu, Luoyang, Zhang, Huan, Zheng, Huanying, He, Jun, Zhang, Hui, Xu, Lifan, Huang, Qizhao, Zhu, Yongqun, Deng, Kai, Ye, Lilin“…The neutralizing monoclonal antibodies (mAbs) targeting the receptor-binding domain (RBD) of SARS-CoV-2 are among the most promising strategies to prevent and treat COVID-19. …”
Publicado 2022
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572por Zhou, Bing, Song, Shuo, Guo, Huimin, Zhou, Xinrong, Fan, Qing, Liu, Weilong, Cheng, Lin, Ge, Xiangyang, Ju, Bin, Zhang, Zheng“…These results demonstrated that the booster of Omicron RBD vaccine could be a rational strategy to enhance the broadly nAb response.…”
Publicado 2022
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573por Hassan, Heba Ali, Hassan, Ahmed R., Mohamed, Eslam A.R., Al-Khdhairawi, Ahmad, Karkashan, Alaa, Attar, Roba, Allemailem, Khaled S., Al Abdulmonem, Waleed, Shimizu, Kuniyoshi, Abdel-Rahman, Iman A. M., Allam, Ahmed E.“…Recently, a new SARS-CoV-2 B.1.1.529 variant has spread in many countries, which has raised awareness of the role of natural constituents in attempts to contribute to therapeutic protocols. (2) Methods: Using various chromatographic techniques, triterpenes (1–7), phenolics (8–11), and flavonoids (12–17) were isolated from Euphorbia dendroides and computationally screened against the receptor-binding domain (RBD) of the SARS-CoV-2 Omicron variant. As a first step, molecular docking calculations were performed for all investigated compounds. …”
Publicado 2022
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574por Pino, Maria, Abid, Talha, Pereira Ribeiro, Susan, Edara, Venkata Viswanadh, Floyd, Katharine, Smith, Justin C., Latif, Muhammad Bilal, Pacheco-Sanchez, Gabriela, Dutta, Debashis, Wang, Shelly, Gumber, Sanjeev, Kirejczyk, Shannon, Cohen, Joyce, Stammen, Rachelle L., Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Pollet, Jeroen, Chen, Wen-Hsiang, Wei, Junfei, Zhan, Bin, Lee, Jungsoon, Liu, Zhuyun, Strych, Ulrich, Shenvi, Neeta, Easley, Kirk, Weiskopf, Daniela, Sette, Alessandro, Pollara, Justin, Mielke, Dieter, Gao, Hongmei, Eisel, Nathan, LeBranche, Celia C., Shen, Xiaoying, Ferrari, Guido, Tomaras, Georgia D., Montefiori, David C., Sekaly, Rafick P., Vanderford, Thomas H., Tomai, Mark A., Fox, Christopher B., Suthar, Mehul S., Kozlowski, Pamela A., Hotez, Peter J., Paiardini, Mirko, Bottazzi, Maria Elena, Kasturi, Sudhir Pai“…Here, we report the efficacy of a rapidly scalable, novel yeast-expressed SARS-CoV-2–specific receptor binding domain (RBD)–based vaccine in rhesus macaques. We formulated the RBD immunogen in alum, a licensed and an emerging alum-adsorbed TLR-7/8-targeted, 3M-052-alum adjuvant. …”
Publicado 2021
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575por de Oliveira, Camille F., Neto, Walter F. F., da Silva, Carla P., Ribeiro, Ana Claudia S., Martins, Lívia C., de Sousa, Alana W., Freitas, Maria N. O., Chiang, Jannifer O., Silva, Franko A., dos Santos, Eder B., Medeiros, Daniele B. A., Pinheiro, Gleiciane S., Brandão, Gleiciane F., Carvalho, Valéria L., Azevedo, Raimunda S. S., Vasconcelos, Pedro F. C., Costa, Igor B., Costa, Iran B., dos Santos, Mirleide C., Soares, Luana S., Bedran, Rayssa L. S., Ferreira, James L., Amarilla, Alberto A., Modhiran, Naphak, McMillan, Christopher L. D., Freney, Morgan E., Muller, David A., Watterson, Daniel, Casseb, Lívia M. N., Henriques, Daniele F.“…Within the vaccinated cohort, some individuals had a history of infection by SARS-CoV-2 prior to immunization, while others did not. We analyzed RBD-specific and neutralizing-antibodies. Anti-RBD antibodies were detected in both cohorts, with a peak between 45–90 days post infection or vaccination, followed by a steady decline over time. …”
Publicado 2022
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576por Zhu, Yichao, Zhou, Wenzhao, Niu, Zubiao, Sun, Jiayi, Zhang, Zhengrong, Li, Qinqin, Zheng, You, Wang, Chenxi, Gao, Lihua, Sun, Qiang“…N501Y in the receptor-binding domain (RBD) of Spike protein is the key mutation dictating the mouse infectivity, on which the neighboring mutations within RBD have profound impacts. …”
Publicado 2022
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577“…The receptor-binding domain (RBD) of SARS-CoV-2 attaches to the human ACE2 to initiate binding of SARS-CoV-2 to human cell and leads to the infection process afterwards. …”
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578“…Here, we summarized 21 RBD mutations and their human angiotensin-converting enzyme 2 (hACE2) and/or neutralizing antibodies' binding characteristics. …”
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579por Martínez-Barnetche, Jesús, Carnalla, Martha, Gaspar-Castillo, Carlos, Basto-Abreu, Ana, Lizardi, Ricardo, Antonio, Rodrigo Aparicio, Martinez, Irma López, Escamilla, Anais Cortes, Ramirez, Octavio T., Palomares, Laura A., Barreto-Cabrera, Daniel, Rivera-Castro, Juan Carlos, Segura-Sánchez, Carlos, Ávila, Mauricio Hernández, Barrientos-Gutiérrez, Tonatiuh, Aranda, Celia M. Alpuche“…We adapted a two-step ELISA protocol as a single-step protocol for detection of IgG against the Receptor Binding Domain (RBD) of SARS-CoV-2 spike protein and compared its diagnostic accuracy with a commercial immunoassay anti-nucleoprotein IgG. …”
Publicado 2022
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580por Bajoria, Sakshi, Kaur, Kawaljit, Kumru, Ozan S., Van Slyke, Greta, Doering, Jennifer, Novak, Hayley, Rodriguez Aponte, Sergio A., Dalvie, Neil C., Naranjo, Christopher A., Johnston, Ryan S., Silverman, Judith Maxwell, Kleanthous, Harry, Love, J. Christopher, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.“…Here, a yeast-produced recombinant RBD antigen (RBD-L452K-F490W or RBD-J) was formulated with various combinations of aluminum-salt (Alhydrogel®, AH; AdjuPhos®, AP) and CpG 1018 adjuvants. …”
Publicado 2022
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