Mostrando 41 - 60 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.18s Limitar resultados
  1. 41
    “…OBJECTIVE: To describe the prevalence, natural history, and risk factors for impulse control behaviors (ICBs) among people with Parkinson disease (PD), those with REM sleep behavior disorder (RBD), and controls. METHODS: Participants with early PD (within 3.5 years of diagnosis), those with RBD, and controls were clinically phenotyped and screened for ICBs longitudinally (with the Questionnaire for Impulsivity in Parkinson's Disease). …”
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    Impulse control disorders in Parkinson disease and RBD: A longitudinal study of severity
  2. 42
    “…However, the immunogenicity of RBD monomers is not strong enough. In this study, we fused the RBD-monomer with a modified Fc fragment of human IgG1 to form an RBD-Fc fusion protein. …”
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    Development of a Recombinant RBD Subunit Vaccine for SARS-CoV-2
  3. 43
    “…Given a predominance for elicitation of neutralizing antibodies (nAbs) that target RBD following natural infection or vaccination, a key biomarker of protection, there is merit for selection of RBD as a sole vaccine immunogen. …”
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    Scientific rationale for developing potent RBD-based vaccines targeting COVID-19
  4. 44
    “…REM sleep without atonia (RSWA) is the polysomnographic (PSG) hallmark of rapid eye movement (REM) sleep behavior disorder (RBD), a feature essential for the diagnosis of this condition. …”
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    Neurophysiological Aspects of REM Sleep Behavior Disorder (RBD): A Narrative Review
  5. 45
    “…Together, these results suggest mosaic-8 RBD-nanoparticles could protect against SARS-CoV-2 variants and future sarbecovirus spillovers.…”
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    Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models
  6. 46
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    Jigsaw puzzle of SARS-CoV-2 RBD evolution and immune escape
  7. 47
    “…Together, these results suggest mosaic-8 RBD-nanoparticles could protect against SARS-CoV-2 variants and future sarbecovirus spillovers.…”
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    Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
  8. 48
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    Odor identification predicts the transition of patients with isolated RBD: A retrospective study
  9. 49
    “…Herein, a Chlamydomonas-made SARS-CoV-2 RBD was evaluated as an oral immunogen in mice to explore the feasibility of developing an oral algae-based vaccine. …”
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    An Algae-Made RBD from SARS-CoV-2 Is Immunogenic in Mice
  10. 50
    “…Up on invasion, the Receptor Binding Domain (RBD) of Spike protein plays a crucial role in the entry of the virus into the host cell. …”
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    Antibodies Produced Toward Recombinant RBD and Nucleocapsid Neutralize SARS-COV-2
  11. 51
    “…Our previous study has demonstrated that vaccination with adeno-associated virus encoding RBD (RBD-rAAV) induces high titer of neutralizing antibodies. …”
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    Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection
  12. 52
    “…Three vaccine candidates were developed against SARS-CoV-2 using adenoviral vectors, including the prime-boost (rAd5-S/rAd5 RBD-N), heterologous prime-boost (rAd5-S/ SOBERANA vaccine), and prime only (mixture of rAd5-S and rAd5 RBD-N). …”
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    Potency, toxicity and protection evaluation of PastoCoAd candidate vaccines: Novel preclinical mix and match rAd5 S, rAd5 RBD-N and SOBERANA dimeric-RBD protein
  13. 53
    “…Hence, the current study uses computational drug screening and molecular dynamics simulation approaches (replicated) to identify novel drugs that can inhibit the binding of the receptor-binding domain (RBD) with hACE2. Screening of the North African, East African and North-East African medicinal compound databases by employing a multi-step screening approach revealed four compounds, namely (−)-pipoxide (C1), 2-(p-hydroxybenzyl) benzofuran-6-ol (C2), 1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (C3), and Rhein (C4), with excellent anti-viral properties against the RBD of the omicron variant. …”
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    Blocking key mutated hotspot residues in the RBD of the omicron variant (B.1.1.529) with medicinal compounds to disrupt the RBD-hACE2 complex using molecular screening and simulation approaches
  14. 54
    “…The results showed that the tag-free RBD protein had a higher affinity for binding with hACE2 receptors than His-tag RBD proteins (EC(50): 1.78 µM vs. 7.51 µM). …”
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    Tag-Free SARS-CoV-2 Receptor Binding Domain (RBD), but Not C-Terminal Tagged SARS-CoV-2 RBD, Induces a Rapid and Potent Neutralizing Antibody Response
  15. 55
    por Freyermuth, Oliver
    Publicado 2019
    “…Operational experience with CephFS and exporting it via NFS Ganesha to users' desktop machines, upgrade experiences, and design decisions e.g. concerning the quota setup will be presented. Additionally, Ceph RBD is used as backend for a libvirt/KVM based virtualisation infrastructure operated by two institutes replicated across multiple buildings. …”
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    CephFS in an HTC cluster and VMs on Ceph RBD with TRIM and differential backups in Bonn
  16. 56
    “…We previously developed a protein subunit COVID-19 vaccine, termed ZF2001, based on an aluminium hydroxide-adjuvanted tandem-repeat dimeric receptor-binding domain (RBD) of the viral spike (S) protein. Here, we described the use of a squalene-based oil-in-water adjuvant, Sepivac SWE™ (abbreviated to SWE), to further improve the immunogenicity of this RBD-dimer-based subunit vaccines. …”
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    Effect of adjuvanting RBD-dimer-based subunit COVID-19 vaccines with Sepivac SWE™
  17. 57
    “…It is known that the receptor-binding domain (RBD) in the S protein of SARS-CoV-2 is an important vaccine target, but subunit vaccines usually have lower immunogenicity and efficacy. …”
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    Screening of Efficient Adjuvants for the RBD-Based Subunit Vaccine of SARS-CoV-2
  18. 58
    “…We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. …”
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    SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
  19. 59
    “…The S-RBD from SARS-CoV-2 Delta was fused to the headless HA from H1N1 (H1Delta), creating a chimera that forms trimers in solution. …”
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    Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD
  20. 60
    “…Viral infection is caused by the interaction between the SARS-CoV-2 receptor binding domain (RBD) and the human ACE2 receptor (hACE2). Previous computational studies have identified repurposed small molecules that target the RBD, but very few have screened drugs in the RBD–hACE2 interface. …”
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    Exploring the disruption of SARS-CoV-2 RBD binding to hACE2
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