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41por Baig, Fahd, Kelly, Mark J., Lawton, Michael A., Ruffmann, Claudio, Rolinski, Michal, Klein, Johannes C., Barber, Thomas, Lo, Christine, Ben-Shlomo, Yoav, Okai, David, Hu, Michele T.“…OBJECTIVE: To describe the prevalence, natural history, and risk factors for impulse control behaviors (ICBs) among people with Parkinson disease (PD), those with REM sleep behavior disorder (RBD), and controls. METHODS: Participants with early PD (within 3.5 years of diagnosis), those with RBD, and controls were clinically phenotyped and screened for ICBs longitudinally (with the Questionnaire for Impulsivity in Parkinson's Disease). …”
Publicado 2019
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42por Sun, Yi-Sheng, Zhou, Jing-Jing, Zhu, Han-Ping, Xu, Fang, Zhao, Wen-Bin, Lu, Hang-Jing, Wang, Zhen, Chen, Shu-Qing, Yao, Ping-Ping, Jiang, Jian-Min, Zhou, Zhan“…However, the immunogenicity of RBD monomers is not strong enough. In this study, we fused the RBD-monomer with a modified Fc fragment of human IgG1 to form an RBD-Fc fusion protein. …”
Publicado 2021
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43por Kleanthous, Harry, Silverman, Judith Maxwell, Makar, Karen W., Yoon, In-Kyu, Jackson, Nicholas, Vaughn, David W.“…Given a predominance for elicitation of neutralizing antibodies (nAbs) that target RBD following natural infection or vaccination, a key biomarker of protection, there is merit for selection of RBD as a sole vaccine immunogen. …”
Publicado 2021
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44por Figorilli, Michela, Lanza, Giuseppe, Congiu, Patrizia, Lecca, Rosamaria, Casaglia, Elisa, Mogavero, Maria P., Puligheddu, Monica, Ferri, Raffaele“…REM sleep without atonia (RSWA) is the polysomnographic (PSG) hallmark of rapid eye movement (REM) sleep behavior disorder (RBD), a feature essential for the diagnosis of this condition. …”
Publicado 2021
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45por Cohen, Alexander A., van Doremalen, Neeltje, Greaney, Allison J., Andersen, Hanne, Sharma, Ankur, Starr, Tyler N., Keeffe, Jennifer R., Fan, Chengcheng, Schulz, Jonathan E., Gnanapragasam, Priyanthi N.P., Kakutani, Leesa M., West, Anthony P., Saturday, Greg, Lee, Yu E., Gao, Han, Jette, Claudia A., Lewis, Mark G., Tan, Tiong K., Townsend, Alain R., Bloom, Jesse D., Munster, Vincent J., Bjorkman, Pamela J.“…Together, these results suggest mosaic-8 RBD-nanoparticles could protect against SARS-CoV-2 variants and future sarbecovirus spillovers.…”
Publicado 2022
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47por Cohen, Alexander A., van Doremalen, Neeltje, Greaney, Allison J., Andersen, Hanne, Sharma, Ankur, Starr, Tyler N., Keeffe, Jennifer R., Fan, Chengcheng, Schulz, Jonathan E., Gnanapragasam, Priyanthi N. P., Kakutani, Leesa M., West, Anthony P., Saturday, Greg, Lee, Yu E., Gao, Han, Jette, Claudia A., Lewis, Mark G., Tan, Tiong K., Townsend, Alain R., Bloom, Jesse D., Munster, Vincent J., Bjorkman, Pamela J.“…Together, these results suggest mosaic-8 RBD-nanoparticles could protect against SARS-CoV-2 variants and future sarbecovirus spillovers.…”
Publicado 2022
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49por Govea-Alonso, Dania O., Malla, Ashwini, Bolaños-Martínez, Omayra C., Vimolmangkang, Sornkanok, Rosales-Mendoza, Sergio“…Herein, a Chlamydomonas-made SARS-CoV-2 RBD was evaluated as an oral immunogen in mice to explore the feasibility of developing an oral algae-based vaccine. …”
Publicado 2022
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50por Rezaei, Amir, Nazarian, Shahram, Samiei Abianeh, Hossein, Kordbacheh, Emad, Alizadeh, Zahra, Mousavi Gargari, Seyed Latif“…Up on invasion, the Receptor Binding Domain (RBD) of Spike protein plays a crucial role in the entry of the virus into the host cell. …”
Publicado 2022
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51por Du, Lanying, Zhao, Guangyu, Lin, Yongping, Chan, Chris, He, Yuxian, Jiang, Shibo, Wu, Changyou, Jin, Dong-Yan, Yuen, Kwok-Yung, Zhou, Yusen, Zheng, Bo-Jian“…Our previous study has demonstrated that vaccination with adeno-associated virus encoding RBD (RBD-rAAV) induces high titer of neutralizing antibodies. …”
Publicado 2008
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52por Pouriayevali, Mohammad Hassan, Teimoori, Ali, Esmaeili, Saber, Abdoli, Asghar, Doroud, Delaram, Salehi-Vaziri, Mostafa, Shahali, Maryam, Kadkhodazadeh, Maryam, Sabouni, Talieh, Khosravi, Mohammad Ali, Panahi, Mohammad, Khoshroo, Fereidoon, Bahmanjeh, Anahita, Valdes-Balbin, Yury, Garcia-Rivera, Dagmar, Verez-Bencomo, Vicente, Biglari, Alireza, Baesi, Kazem“…Three vaccine candidates were developed against SARS-CoV-2 using adenoviral vectors, including the prime-boost (rAd5-S/rAd5 RBD-N), heterologous prime-boost (rAd5-S/ SOBERANA vaccine), and prime only (mixture of rAd5-S and rAd5 RBD-N). …”
Publicado 2022
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53por Khan, Abbas, Randhawa, AsfandYar Waheed, Balouch, Ali Raza, Mukhtar, Naila, Sayaf, Abrar Mohammad, Suleman, Muhammad, Khan, Taimoor, Ali, Shahid, Ali, Syed Shujait, Wang, Yanjing, Mohammad, Anwar, Wei, Dong-Qing“…Hence, the current study uses computational drug screening and molecular dynamics simulation approaches (replicated) to identify novel drugs that can inhibit the binding of the receptor-binding domain (RBD) with hACE2. Screening of the North African, East African and North-East African medicinal compound databases by employing a multi-step screening approach revealed four compounds, namely (−)-pipoxide (C1), 2-(p-hydroxybenzyl) benzofuran-6-ol (C2), 1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (C3), and Rhein (C4), with excellent anti-viral properties against the RBD of the omicron variant. …”
Publicado 2022
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54por Lin, Ting-Wei, Huang, Ping-Han, Liao, Bo-Hung, Chao, Tai-Ling, Tsai, Ya-Min, Chang, Shih-Chung, Chang, Sui-Yuan, Chen, Hui-Wen“…The results showed that the tag-free RBD protein had a higher affinity for binding with hACE2 receptors than His-tag RBD proteins (EC(50): 1.78 µM vs. 7.51 µM). …”
Publicado 2022
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55por Freyermuth, Oliver“…Operational experience with CephFS and exporting it via NFS Ganesha to users' desktop machines, upgrade experiences, and design decisions e.g. concerning the quota setup will be presented. Additionally, Ceph RBD is used as backend for a libvirt/KVM based virtualisation infrastructure operated by two institutes replicated across multiple buildings. …”
Publicado 2019
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56por Xu, Senyu, Duan, Huixin, An, Yaling, Jin, Xiyue, Duan, Minrun, Dubois, Patrice M., Huang, Yan, Xu, Kun, Du, Heng, Kleanthous, Harry, Dai, Lianpan, Gao, George F.“…We previously developed a protein subunit COVID-19 vaccine, termed ZF2001, based on an aluminium hydroxide-adjuvanted tandem-repeat dimeric receptor-binding domain (RBD) of the viral spike (S) protein. Here, we described the use of a squalene-based oil-in-water adjuvant, Sepivac SWE™ (abbreviated to SWE), to further improve the immunogenicity of this RBD-dimer-based subunit vaccines. …”
Publicado 2023
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57por Shi, Juan, Zhao, Yu, Peng, Min, Zhu, Suyue, Wu, Yandan, Ji, Ruixue, Shen, Chuanlai“…It is known that the receptor-binding domain (RBD) in the S protein of SARS-CoV-2 is an important vaccine target, but subunit vaccines usually have lower immunogenicity and efficacy. …”
Publicado 2023
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58por Love, J., Rodriguez-Aponte, Sergio, Tostanoski, Lisa, Dalvie, Neil, Johnston, Ryan, Jacob-Dolan, Catherine, Powers, Olivia, Hachmann, Nicole, Miller, Jessica, Hall, Kevin, Siamatu, Mazuba, Mazurek, Camille, Surve, Nehalee, Barouch, Dan“…We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. …”
Publicado 2023
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59por Li, Yulei, Liu, Peipei, Hao, Tianjiao, Liu, Sheng, Wang, Xi, Xie, Yufeng, Xu, Ke, Lei, Wenwen, Zhang, Cheng, Han, Pu, Li, Ying, Jin, Xiyue, Huan, Yu, Lu, Yafei, Zhang, Rong, Li, Xiaoyan, Zhao, Xin, Xu, Kun, Liao, Pu, Lu, Xuancheng, Bi, Yuhai, Song, Hao, Wu, Guizhen, Zhu, Baoli, Gao, George F.“…The S-RBD from SARS-CoV-2 Delta was fused to the headless HA from H1N1 (H1Delta), creating a chimera that forms trimers in solution. …”
Publicado 2023
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60“…Viral infection is caused by the interaction between the SARS-CoV-2 receptor binding domain (RBD) and the human ACE2 receptor (hACE2). Previous computational studies have identified repurposed small molecules that target the RBD, but very few have screened drugs in the RBD–hACE2 interface. …”
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