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581por Starr, Tyler N., Greaney, Allison J., Stewart, Cameron M., Walls, Alexandra C., Hannon, William W., Veesler, David, Bloom, Jesse D.“…SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. …”
Publicado 2022
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582por Lovell, Jonathan F., Baik, Yeong Ok, Choi, Seuk Keun, Lee, Chankyu, Lee, Jeong-Yoon, Miura, Kazutoyo, Huang, Wei-Chiao, Park, Young-Shin, Woo, Sun-Je, Seo, Sang Hwan, Kim, Jae-Ouk, Song, Manki, Kim, Chung-Jong, Choi, Jae-Ki, Kim, Jieun, Choo, Eun Ju, Choi, Jung-Hyun“…Of the participants who received two vaccine doses according to protocol, 100 received high-dose ECV19 (20 μg RBD), 96 received low-dose ECV19 (10 μg RBD), and 27 received placebo. …”
Publicado 2022
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583por Yaghoobizadeh, Fatemeh, Ardakani, Mohammad Roayaei, Ranjbar, Mohammad Mehdi, Galehdari, Hamid, Khosravi, MohammadEnlace del recurso
Publicado 2023
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584por Brindha, Subbaian, Yoshizue, Takahiro, Wongnak, Rawiwan, Takemae, Hitoshi, Oba, Mami, Mizutani, Tetsuya, Kuroda, Yutaka“…A large-scale Escherichia coli (E. coli) production of the receptor-binding domain (RBD) of the SARS-CoV-2 could yield a versatile and low-cost antigen for a subunit vaccine. …”
Publicado 2022
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585por Shi, Deling, Bu, Changkai, He, Peng, Song, Yuefan, Dordick, Jonathan S., Linhardt, Robert J., Chi, Lianli, Zhang, Fuming“…The binding affinity of Omicron S protein RBD to heparin was further investigated by surface plasmon resonance (SPR). …”
Publicado 2022
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586por Viste, Rannveig, Follin, Louise F, Kornum, Birgitte R, Lie, Benedicte A, Viken, Marte K, Thorsby, Per M, Rootwelt, Terje, Christensen, Julie A E, Knudsen-Heier, Stine“…In siblings, REM and NREM sleep muscle activity indices were not associated with RBD symptoms, other narcolepsy symptoms, or HLA-DQB1*06:02-positivity. …”
Publicado 2022
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587por Cai, Jian-Piao, Luo, Cuiting, Wang, Kun, Cao, Hehe, Chen, Lin-Lei, Zhang, Xiaojuan, Han, Yuting, Yin, Feifei, Zhang, Anna Jinxia, Chu, Hin, Yuan, Shuofeng, Kok, Kin-Hang, To, Kelvin Kai-Wang, Chen, Honglin, Chen, Zhiwei, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-WooEnlace del recurso
Publicado 2023
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588por Murdocca, Michela, Citro, Gennaro, Centanini, Eleonora, Giannini, Rosalinda, Latini, Andrea, Centofanti, Federica, Piano Mortari, Eva, Cocciadiferro, Dario, Novelli, Antonio, Bernardini, Sergio, Novelli, Giuseppe, Sangiuolo, Federica“…Subject T-cells were cultured and infected with pseudotype particles bearing the S proteins and in parallel stimulated with two S-peptides designed on the RBD region of the spike protein. Our results showed that one of these peptides, RBD 484–508, induces a significant increase in IFN-γ gene expression and protein production in T-cells, comparable to those obtained in cells infected by SARS-CoV-2 pseudovirus. …”
Publicado 2023
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589por Thimmiraju, Syamala Rani, Adhikari, Rakesh, Villar, Maria Jose, Lee, Jungsoon, Liu, Zhuyun, Kundu, Rakhi, Chen, Yi-Lin, Sharma, Suman, Ghei, Karm, Keegan, Brian, Versteeg, Leroy, Gillespie, Portia M., Ciciriello, Allan, Islam, Nelufa Y., Poveda, Cristina, Uzcategui, Nestor, Chen, Wen-Hsiang, Kimata, Jason T., Zhan, Bin, Strych, Ulrich, Bottazzi, Maria Elena, Hotez, Peter J., Pollet, Jeroen“…(1) Background: We previously reported the development of a recombinant protein SARS-CoV-2 vaccine, consisting of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, adjuvanted with aluminum hydroxide (alum) and CpG oligonucleotides. …”
Publicado 2023
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590por Zhu, Fengcai, Huang, Shoujie, Liu, Xiaohui, Chen, Qi, Zhuang, Chunlan, Zhao, Hui, Han, Jinle, Jaen, Anjuli May, Do, Thai Hung, Peter, Jonathan Grant, Dorado, Alexander Gonzalez, Tirador, Louie S, Zabat, Gelza Mae A, Villalobos, Ralph Elvi M, Gueco, Gemalyn Pineda, Botha, Lauren Livia Greta, Iglesias Pertuz, Shirley Patricia, Tan, Jiaxiang, Zhu, Kongxin, Quan, Jiali, Lin, Hongyan, Huang, Yue, Jia, Jizong, Chu, Xiafei, Chen, Junyu, Chen, Yixin, Zhang, Tianying, Su, Yingying, Li, Changgui, Ye, Xiangzhong, Wu, Ting, Zhang, Jun, Xia, Ningshao“…BACKGROUND: The live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine (dNS1-RBD, Pneucolin; Beijing Wantai Biological Pharmacy Enterprise, Beijing, China) confers long-lasting and broad protection in animal models and is, to our knowledge, the first COVID-19 mucosal vaccine to enter into human trials, but its efficacy is still unknown. …”
Publicado 2023
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591“…This competition arises because the interaction between the RBD and K-Ras is strong while the linker between the RBD and CRD is short. …”
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592por Alexpandi, Rajaiah, De Mesquita, Joelma Freire, Pandian, Shunmugiah Karutha, Ravi, Arumugam Veera“…Moreover, as SARS-CoV-2 Spike-glycoprotein uses human ACE2-receptor for viral entry, targeting the Spike-RBD-ACE2 has been viewed as a promising strategy to control the infection. …”
Publicado 2020
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593por Zhang, Liqun, Ghosh, Santosh K., Basavarajappa, Shrikanth C., Muller-Greven, Jeannine, Penfield, Jackson, Brewer, Ann, Ramakrishnan, Parameswaran, Buck, Matthias, Weinberg, Aaron“…Our comprehensive in-silico studies demonstrate that hBD-2 binds the site on the CoV-2-RBD that docks with the ACE2 receptor. Biophysical and biochemical assays confirm that hBD-2 indeed binds to the CoV-2-receptor binding domain (RBD) (K(D) ~ 300 nM), preventing it from binding to ACE2 expressing cells. …”
Publicado 2021
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594por Sinegubova, Maria V., Orlova, Nadezhda A., Kovnir, Sergey V., Dayanova, Lutsia K., Vorobiev, Ivan I.“…Recombinant SARS-CoV-2 RBD is widely used as a highly specific minimal antigen for serological tests. …”
Publicado 2021
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595por Márquez-Ipiña, Alan Roberto, González-González, Everardo, Rodríguez-Sánchez, Iram Pablo, Lara-Mayorga, Itzel Montserrat, Mejía-Manzano, Luis Alberto, Sánchez-Salazar, Mónica Gabriela, González-Valdez, José Guillermo, Ortiz-López, Rocio, Rojas-Martínez, Augusto, Trujillo-de Santiago, Grissel, Alvarez, Mario Moisés“…The antigen performances of S-RBD(N318-V510) and a commercial full-length spike protein were compared in ELISAs. …”
Publicado 2021
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596por Ashoor, Dana, Ben Khalaf, Noureddine, Marzouq, Maryam, Jarjanazi, Hamdi, Chlif, Sadok, Fathallah, M. Dahmani“…We observed that out of 351 RBD point mutations, 83% destabilizes the complex according to free energy (ΔΔG) differences. …”
Publicado 2021
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597por Coghi, Paolo, Yang, Li Jun, Ng, Jerome P. L., Haynes, Richard K., Memo, Maurizio, Gianoncelli, Alessandra, Wong, Vincent Kam Wai, Ribaudo, Giovanni“…Virtual screening indicated pyronaridine as the most promising RBD and ACE2 ligand, and molecular dynamics simulations confirmed the stability of the predicted complex with the RBD. …”
Publicado 2021
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598por Esparza, Thomas J., Chen, Yaozong, Martin, Negin P., Bielefeldt-Ohmann, Helle, Bowen, Richard A., Tolbert, William D., Pazgier, Marzena, Brody, David L.“…The structure of NIH-CoVnb-112 bound to SARS-CoV-2 RBD reveals a large contact surface area overlapping the angiotensin converting enzyme 2 (ACE2) binding site, which is largely unencumbered by the common RBD mutations. …”
Publicado 2021
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599por Malipiero, Giacomo, D'Agaro, Pierlanfranco, Segat, Ludovica, Moratto, Anna, Villalta, Danilo“…BACKGROUND AND AIMS: Long-term kinetics of anti-RBD IgG and neutralizing antibodies were analyzed in a cohort of COVID-19 naïve health care workers (HCW) undergoing SARS-CoV-2 vaccination. …”
Publicado 2022
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600por Hakami, Abdulrahim R.“…SIMPLE SUMMARY: The current study based on virtual drugs screening and simulations identified novel drugs to target the RBD of the spike protein from Omicron variant of SARS-CoV-2. …”
Publicado 2022
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