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601por Shurrab, Farah M., Younes, Nadin, Al-Sadeq, Duaa W., Liu, Na, Qotba, Hamda, Abu-Raddad, Laith J., Nasrallah, Gheyath K.“…Recently, a novel fluorescence-based lateral flow immunoassay (LFIA) test was developed for quantitative measurement of the total binding antibody units (BAUs) (BAU/mL) against SARS-CoV-2 spike protein receptor-binding domain (S-RBD). AIM: This study aimed to evaluate the performance of the fluorescence LFIA Finecare(TM) 2019-nCoV S-RBD test along with its reader (Model No.: FS-113). …”
Publicado 2022
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602por Esparza, Thomas J., Chen, Yaozong, Martin, Negin P., Bielefeldt-Ohmann, Helle, Bowen, Richard A., Tolbert, William D., Pazgier, Marzena, Brody, David L.“…The structure of NIH-CoVnb-112 bound to SARS-CoV-2 RBD reveals a large contact surface area overlapping the angiotensin converting enzyme 2 (ACE2) binding site, which is largely unencumbered by the common RBD mutations. …”
Publicado 2022
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603por Khan, Abbas, Gui, Jianjun, Ahmad, Waqar, Haq, Inamul, Shahid, Marukh, Khan, Awais Ahmed, Shah, Abdullah, Khan, Arsala, Ali, Liaqat, Anwar, Zeeshan, Safdar, Muhammad, Abubaker, Jehad, Uddin, N. Nizam, Cao, Liqiang, Wei, Dong-Qing, Mohammad, Anwar“…Structural variants reported in the RBD and NTD may play essential roles in the increased pathogenicity of this SARS-CoV-2 new variant. …”
Publicado 2021
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604por Ramot, Yuval, Kronfeld, Noam, Ophir, Yakir, Ezov, Nati, Friedman, Sheli, Saloheimo, Markku, Vitikainen, Marika, Ben-Artzi, Hanna, Avigdor, Avi, Tchelet, Ronen, Valbuena Crespo, Noelia, Emalfarb, Mark, Nyska, Abraham“…ELISA studies revealed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G antibodies in the sera of C1-RBD-treated animals starting from day 13 post injection, that were further elevated. …”
Publicado 2022
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605por Brodowski, Mateusz, Pierpaoli, Mattia, Janik, Monika, Kowalski, Marcin, Ficek, Mateusz, Slepski, Pawel, Trzaskowski, Bartosz, Swain, Greg, Ryl, Jacek, Bogdanowicz, Robert“…We present extended statistical studies of the multisine dynamic electrochemical impedance spectroscopy (DEIS) revealing interactions between Spike RBD and cellular receptors ACE2 and CD147, and a reference anti-RBD antibody (IgG2B) based on a functionalised boron-doped diamond (BDD) electrode. …”
Publicado 2022
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606por Meyers, Eline, Coen, Anja, De Sutter, An, Padalko, Elizaveta, Callens, Steven, Vandekerckhove, Linos, Witkowski, Wojciech, Heytens, Stefan, Cools, PietEnlace del recurso
Publicado 2022
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607“…We modeled in silico the interaction between Spike RBDs of Wuhan-Hu-1, Delta, and Omicron BA.1 variants and ACE2 at different pHs (pH 5 and pH 7) and showed that the strength of this interaction was higher for the Omicron BA.1 RBD compared to Wuhan-Hu-1 or Delta RBDs and that the effect was more profound at pH 5. …”
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609por Yang, Jing-Xing, Tseng, Jen-Chih, Tien, Chih-Feng, Lee, Chia-Yin, Liu, Yi-Ling, Lin, Jhe-Jhih, Tsai, Pei-Ju, Liao, Hung-Chun, Liu, Shih-Jen, Su, Yu-Wen, Hsu, Li-Chung, Chen, Jen-Kun, Huang, Ming-Hsi, Yu, Guann-Yi, Chuang, Tsung-HsienEnlace del recurso
Publicado 2023
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610por Sirisreetreerux, Supamas, Porntharukchareon, Thachanun, Dechates, Bothamai, Rangsrisaeneepitak, Vimonsri, Therawit, Phonthip, Worawitchawong, Supanat, Sornsamdang, Gaidganok, Soonklang, Kamonwan, Tawinprai, Kriangkrai“…In both groups, the GMC of anti-RBD was persistently high without decline 12 weeks after the first vaccination. …”
Publicado 2023
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611por Muslimah, Amila Hanifan, Tiara, Marita Restie, Djauhari, Hofiya, Dewantara, Muhammad Hafizh, Susandi, Evan, Indrati, Agnes Rengga, Alisjahbana, Bachti, Soeroto, Arto Yuwono, Wisaksana, RudiEnlace del recurso
Publicado 2023
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612por Kong, Xiaomu, Gao, Peng, Jiang, Yongwei, Lu, Lixia, Zhao, Meimei, Liu, Yi, Deng, Guoxiong, Zhu, Haoyan, Cao, Yongtong, Ma, Liang“…BACKGROUND: The SARS-CoV-2 Omicron strain has multiple immune-escape mutations in the spike protein receptor-binding domain (RBD). Rapid detection of these mutations to identify Omicron and its lineages is essential for guiding public health strategies and patient treatments. …”
Publicado 2023
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613por Zhang, Jikai, Hu, Zhongyu, He, Jianfeng, Liao, Yuyi, Li, Yuan, Pei, Rongjuan, Fang, Xin, Zeng, Peiyu, Fan, Renfeng, Ou, Zhiqiang, Deng, Jinglong, Zhou, Jian, Guan, Wuxiang, Min, Yuanqin, Deng, Fei, Peng, Hua, Zhang, Zheng, Feng, Chunyan, Xin, Baobao“…Recently, we developed a recombinant COVID-19 vaccine (V-01) containing fusion protein (IFN-PADRE-RBD-Fc dimer) as antigen verified to induce protective immunity against SARS-CoV-2 challenge in pre-clinical study, which supported progression to Phase I clinical trials in humans. …”
Publicado 2021
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614por Mariotti, Sabrina, Capocefalo, Antonio, Chiantore, Maria Vincenza, Iacobino, Angelo, Teloni, Raffaela, De Angelis, Maria Laura, Gallinaro, Alessandra, Pirillo, Maria Franca, Borghi, Martina, Canitano, Andrea, Michelini, Zuleika, Baggieri, Melissa, Marchi, Antonella, Bucci, Paola, McKay, Paul F., Acchioni, Chiara, Sandini, Silvia, Sgarbanti, Marco, Tosini, Fabio, Di Virgilio, Antonio, Venturi, Giulietta, Marino, Francesco, Esposito, Valeria, Di Bonito, Paola, Magurano, Fabio, Cara, Andrea, Negri, Donatella, Nisini, Roberto“…We produced the recombinant RBD (rRBD) of SARS-CoV-2 spike glycoprotein from the Wuhan-Hu 1 reference sequence in a mammalian system, for mice immunization to isolate new mAbs with neutralizing activity. …”
Publicado 2021
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615por Ai, Jingwen, Zhang, Haocheng, Zhang, Qiran, Zhang, Yi, Lin, Ke, Fu, Zhangfan, Song, Jieyu, Zhao, Yuanhan, Fan, Mingxiang, Wang, Hongyu, Qiu, Chao, Zhou, Yang, Zhang, WenhongEnlace del recurso
Publicado 2021
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616por Muhseen, Ziyad Tariq, Kadhim, Salim, Yahiya, Yahiya Ibrahim, Alatawi, Eid A., Aba Alkhayl, Faris F., Almatroudi, Ahmad“…SIMPLE SUMMARY: The current study provides an insight into the binding and dynamic differences between wild-type RBD and B.1.620, which harbor S477N-E484K mutations in the spike protein’s receptor-binding domain (RBD). …”
Publicado 2021
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617por Zhou, Wenhao, He, Ping, Li, Junhua, Liu, Huan, Shi, Mengjuan, Yu, Junping, Wei, Hongping“…The results showed that the Omicron variant may evade antibodies induced by the ancestral strain and by the inactivated vaccine, with significant reduction in the binding capability of its RBD much greater than that of the Delta variant.…”
Publicado 2022
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618por Kulemzin, Sergey V., Sergeeva, Maria V., Baranov, Konstantin O., Gorchakov, Andrey A., Guselnikov, Sergey V., Belovezhets, Tatyana N., Volkova, Olga Yu., Najakshin, Alexander M., Chikaev, Nikolai A., Danilenko, Daria M., Taranin, Alexander V.“…Both nAbs were found to bind the Omicron RBD with a nanomolar affinity, yet they displayed contrasting functional features. …”
Publicado 2022
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619por Kim, Young Soo, Kwon, Eun-Bin, Kim, Buyun, Chung, Hwan-Suck, Choi, Garam, Kim, Yeoun-Hee, Choi, Jang-Gi“…Molecular interaction studies using competitive ELISA and the BLItz system revealed that KC targets both the spike S1 RBD and the ACE2 receptor, successfully disrupting their interaction, as supported by the in silico docking simulation. …”
Publicado 2022
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620por Nabati, Farzan, kamyabiamineh, Ayshin, Kosari, Ramin, Ghasemi, Faezeh, Seyedebrahimi, Seyedehmasoumeh, Mohammadi, Sobhan, Moradi, MohammadEnlace del recurso
Publicado 2022
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