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621por Wey, Leoni, Masetto, Thomas, Spaeth, Alexander, Brehm, Jessica, Kochem, Christian, Reinhart, Marco, Müller, Holger, Kempin, Uwe, Lorenz, Franziska, Peter, Christoph, Grimmler, Matthias“…To confirm bioinformatical assumptions, an S-RBD- and a Nucleocapsid-based PETIA were produced. …”
Publicado 2023
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622por Cimas, Francisco J., Torres, Javier, Ontañón, Jesús, de Cabo, Carlos, Lozano, Julia, Requena, María Ángeles, Blas, Joaquín, Rodríguez-García, José Luis, Mas, Antonio, Solera, Javier“…CONCLUSION: Two parsimonious models can explain the anti-RBD IgG antibody titer waning after vaccination. …”
Publicado 2023
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623por Fernandes, Edgar Ruz, Taminato, Monica, de Souza Apostolico, Juliana, Gabrielonni, Maria Cristina, Lunardelli, Victoria Alves Santos, Maricato, Juliana Terzi, Andersen, Monica Levy, Tufik, Sergio, Rosa, Daniela SantoroEnlace del recurso
Publicado 2023
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624por Oluka, Gerald Kevin, Namubiru, Patricia, Kato, Laban, Ankunda, Violet, Gombe, Ben, Cotten, Matthew, Musenero, Monica, Kaleebu, Pontiano, Fox, Julie, Serwanga, Jennifer“…ROC-derived cut-offs for S-, RBD-, and N-directed IgG, IgM, and IgA were 0.432, 0.356, 0.201 (S), 0.214, 0.350, 0.303 (RBD), and 0.395, 0.229, 0.188 (N). …”
Publicado 2023
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625por Yoshizue, Takahiro, Brindha, Subbaian, Wongnak, Rawiwan, Takemae, Hitoshi, Oba, Mami, Mizutani, Tetsuya, Kuroda, Yutaka“…We immunized 5-week-old Jcl-ICR female mice by injecting RBD (30 µg) and S1 subunit (5 µg) according to four schemes: two injections 8 weeks apart with RBD (RBD/RBD), two injections with S1 (S1/S1), one injection with RBD, and the second one with S1 (RBD/S1), and vice versa (S1/RBD). …”
Publicado 2023
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626por Chansaenroj, Jira, Suntronwong, Nungruthai, Kanokudom, Sitthichai, Assawakosri, Suvichada, Vichaiwattana, Preeyaporn, Klinfueng, Sirapa, Wongsrisang, Lakana, Thongmee, Thanunrat, Aeemjinda, Ratchadawan, Khanarat, Nongkanok, Srimuan, Donchida, Thatsanathorn, Thaksaporn, Yorsaeng, Ritthideach, Katanyutanon, Apirat, Thanasopon, Wichai, Bhunyakitikorn, Wichan, Sonthichai, Chaninan, Angsuwatcharakorn, Piyada, Withaksabut, Withak, Wanlapakorn, Nasamon, Sudhinaraset, Natthinee, Poovorawan, Yong“…All serum samples were tested for anti-N total Ig and anti-RBD IgG. The interviewer-administered questionnaires queried information on infection history and vaccination records. …”
Publicado 2023
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627por Li, Rong, Ma, Xiancai, Deng, Jieyi, Chen, Qier, Liu, Weiwei, Peng, Zhilin, Qiao, Yidan, Lin, Yingtong, He, Xin, Zhang, HuiEnlace del recurso
Publicado 2021
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628por Pham, Thang L., He, Jiucheng, Kakazu, Azucena H., Calandria, Jorgelina, Do, Khanh V., Nshimiyimana, Robert, Lam, Ting F., Petasis, Nicos A., Bazan, Haydee E. P., Bazan, Nicolas G.“…We explore ways to block the receptor-binding domain (RBD) of SARS-CoV-2 Spike (S) protein to angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2021
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629“…The tighter binding interface and the new hydrogen bonds formation also contribute to the improved binding affinity of RBD to the receptor hACE2. In addition, six neutralizing antibodies and nanobodies complexed with RBD were selected to explore the effects of E484K mutation on the recognition of these antibodies to RBD. …”
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630por Kratzer, Bernhard, Trapin, Doris, Gattinger, Pia, Oberhofer, Teresa, Sehgal, Al Nasar Ahmed, Waidhofer-Söllner, Petra, Rottal, Arno, Körmöczi, Ulrike, Grabmeier-Pfistershammer, Katharina, Kopetzky, Gerhard H., Tischer, Franz, Valenta, Rudolf, Pickl, Winfried F.“…However, despite suspension of immunosuppression and administration of in total four consecutive heterologous SARS-CoV-2 vaccine shots, the patient did not develop neutralizing RBD-specific antibodies. Conclusions: Despite immunomonitoring-based adjustment of vaccination and/or therapy schedules vaccination success, with clear correlates of protection, the development of RBD-specific antibodies could not be achieved in the immunocompromised patient with current SARS-CoV-2 vaccines. …”
Publicado 2022
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631por Cameron, Andrew, Bohrhunter, Jessica L., Porterfield, Claire A., Mangat, Rupinder, Karasick, Michael H., Pearson, Zachary, Angeloni, Stephen, Pecora, Nicole D.“…Specific antibodies against the SARS-CoV-2 spike (S), receptor binding domain (RBD), and nucleocapsid (N) proteins were investigated in 310 symptomatic case patients using a fluorescent microsphere immunoassay and simultaneous detection of IgM and IgG. …”
Publicado 2022
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632por Deeba, Elie, Krashias, George, Constantinou, Astero, Koptides, Dana, Lambrianides, Anastasia, Christodoulou, Christina“…Both vaccines induced S1RBD-specific antibodies after the second dose. A significant increase in S1RBD-specific IgG median levels 3 weeks following the second dose was detected (BNT162b2, 118.0 BAU/mL to 2018.0 BAU/mL; ChAdOx1-S, 38.1 BAU/mL to 182.1 BAU/mL). …”
Publicado 2022
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633“…Competitive docking suggests ten H-bonding (1.3–2.4 Å) with highly favorable energy values/Van-der-Walls-force/Haddock score for more stable-binding of Omicron-RBD with ACE2. Blind docking of different CUTs (wild/mutants) and Omicron to ACE2 completely rejected the Omicron-RBD from ACE2-target. …”
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634“…The SARS-CoV-2 infectivity is established via the association of spike (S) protein receptor binding domain (RBD) with host angiotensin I converting enzyme 2 (hACE2) receptor. …”
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635por del Pino Molina, Lucía, Bravo Gallego, Luz Yadira, Nozal, Pilar, Soto-Serrano, Yolanda, Martínez-Feito, Ana, Reche-Yebra, Keren, González-Torbay, Andrea, Cuesta-Martín de la Cámara, Ricardo, Gianelli, Carla, Cámara, Carmen, González-García, J., González-Muñoz, Miguel, Rodríguez-Pena, Rebeca, López Granados, Eduardo“…RESULTS AND DISCUSSION: We first analyzed the percentage of specific RBD+ IgG+ MBCs in healthy healthcare workers. Within the control group, there was an increase in the percentage of specific IgG+ RBD+ MBCs 21 days after the second dose, which was consistent with S-specific IgG antibodies.Thirty-one patients with IEI were included for the pre- and post-vaccination study; IgG+ RBD+ MBCs were not evaluated in 6 patients due to an absence of B cells in peripheral blood. …”
Publicado 2023
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636por Villoutreix, Bruno O., Calvez, Vincent, Marcelin, Anne-Geneviève, Khatib, Abdel-Majid“…Here we used the experimental structure of the Spike RBD domain co-crystallized with part of the ACE2 receptor, several in silico methods and numerous experimental data reported recently to analyze the possible impacts of three amino acid replacements (Spike K417N, E484K, N501Y) with regard to ACE2 binding. …”
Publicado 2021
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637por Ou, Junxian, Zhou, Zhonghua, Dai, Ruixue, Zhang, Jing, Zhao, Shan, Wu, Xiaowei, Lan, Wendong, Ren, Yi, Cui, Lilian, Lan, Qiaoshuai, Lu, Lu, Seto, Donald, Chodosh, James, Wu, Jianguo, Zhang, Gong, Zhang, Qiwei“…The SARS-CoV-2 spike protein receptor-binding domain (RBD) is the critical determinant of viral tropism and infectivity. …”
Publicado 2021
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638por Hernández-Bernal, Francisco, Ricardo-Cobas, Maria C., Martín-Bauta, Yenima, Navarro-Rodríguez, Zadis, Piñera-Martínez, Marjoris, Quintana-Guerra, Joel, Urrutia-Pérez, Karen, Urrutia-Pérez, Klaudia, Chávez-Chong, Cristina O., Azor-Hernández, Jorge L., Rodríguez-Reinoso, José L., Lobaina-Lambert, Leonardo, Colina-Ávila, Elizabeth, Bizet-Almeida, Jacqueline, Rodríguez-Nuviola, Jeniffer, del Valle-Piñera, Sergio, Ramírez-Domínguez, Mayara, Tablada-Ferreiro, Elisangela, Alonso-Valdés, Marel, Lemos-Pérez, Gilda, Guillén-Nieto, Gerardo E., Palenzuela-Díaz, Ariel, Noa-Romero, Enrique, Limonta-Fernández, Miladys, Fernández-Ávila, Juan M., Ali-Mros, Nabil A., del Toro-Lahera, Lianne, Remedios-Reyes, Rossana, Ayala-Ávila, Marta, Muzio-González, Verena L.“…Subjects were randomly assigned (1:1:1, in blocks) to three groups: placebo, 25 µg and 50 µg RBD vaccine (Abdala). The product was administered intramuscularly, 0·5 mL in the deltoid region. …”
Publicado 2022
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639por Chakraborty, Chiranjib, Sharma, Ashish Ranjan, Bhattacharya, Manojit, Mallik, Bidyut, Nandi, Shyam Sundar, Lee, Sang-Soo“…Our receptor binding analysis showed a similar indication pattern for hACE2-RBD of these two variants. However, B.1.617.2 offers slightly better stability in the hACE2-RBD binding pattern through MD simulation than B.1.1.7. …”
Publicado 2022
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640por Zhu, Zhitong, Ma, Xiaoming, Zhu, Lin, Luo, Qiong, Lin, Nan, Chen, Zhonghui, Zhao, Xingchen, Lin, Zhenyu, Cai, Zongwei“…Using gold nanoparticle (AuNR) as an immunosensor, we have established a semi-quantitative, instrument-free assay for measuring antibody level against SRAS-CoV-2 spike1 (S1) receptor binding domain (RBD) from fingertip blood samples. The testing results by the developed method correlated well with those obtained from conventional ELISA assay, indicating reliable quantitation could be achieved without use of plate reader. …”
Publicado 2022
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