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661“…Through a commercial surrogate virus neutralization test (sVNT), we aimed to evaluate the production of SARS-CoV-2 NAbs in a set of vaccinated healthcare workers and to correlate these NAbs with the SARS-CoV-2 IgG anti-S1, anti-RBD and anti-S2 serological titers. We found that 6 months after vaccination, only 74% maintain NAbs for the Wuhan strain/UK variant (V1) and 47% maintain NAbs for the South African and Brazil variants (V2). …”
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662por Gerges, Daniela, Kapps, Sebastian, Hernández-Carralero, Esperanza, Freire, Raimundo, Aiad, Monika, Schmidt, Sophie, Winnicki, Wolfgang, Reiter, Thomas, Pajenda, Sahra, Schmidt, Alice, Sunder-Plassmann, Gere, Wagner, Ludwig“…The cohort was continuously monitored by SARS-CoV-2 testing and commercial nucleocapsid IgG ELISA. RBD IgG ELISA showed significantly lower reactivity against the Omicron-RBD compared to the Alpha variant in all individuals (p < 0.001). …”
Publicado 2022
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663por De Marco Verissimo, Carolina, López Corrales, Jesús, Dorey, Amber L., Cwiklinski, Krystyna, Lalor, Richard, Calvani, Nichola Eliza Davies, Jewhurst, Heather L., Flaus, Andrew, Doyle, Sean, Dalton, John P.“…In addition, we assessed the ability of our 3CL-pro to function as a carrier for the receptor binding domain (RBD) of the Spike protein. The co-expressed chimeric protein, 3CLpro-RBD, did not exhibit 3CL-pro activity, but its enhanced solubility made purification easier and improved RBD antigenicity when tested against serum from vaccinated individuals in ELISAs. …”
Publicado 2022
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664“…AIMS: Lewy Body Dementia (LBD) is predicted to be under-diagnosed in the general population. RBD is one of the four core clinical criteria for the diagnosis of LBD. …”
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665por Nešić, Andrijana, Stojsavljević, Aleksandar, Jagodić, Jovana, Čavić, Milena, Stefanović, Aleksandra, Manojlović, Dragan, Gavrović-Jankulović, Marija“…The main aim was to explore links between ETE levels and IgG antibodies produced against Spike glycoprotein's Receptor-Binding Domain (RBD). RESULTS: A recombinant protein of SARS-CoV-2 comprising the receptor binding domain was successfully expressed in HEK-293 T cells. …”
Publicado 2022
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666“…A quartz crystal microbalance (QCM) analysis confirmed the binding activity of RBD-C9R with ACE2, the host cell’s receptor. In addition, RBD-C9R elicited a Th-2 immune response with a high IgG titer in Jcl: ICR mice. …”
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667por Brandys, Pascal, Montagutelli, Xavier, Merenkova, Irena, Barut, Güliz T., Thiel, Volker, Schork, Nicholas J., Trüeb, Bettina, Conquet, Laurine, Deng, Aihua, Antanasijevic, Aleksandar, Lee, Hyun-Ku, Valière, Martine, Sindhu, Anoop, Singh, Gita, Herold, Jens“…A construct encoding the RBD of the Delta variant elicits robust neutralizing antibody response, and also provides protective immunity against the Delta variant in a widely used transgenic mouse model. …”
Publicado 2022
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668por Nechooshtan, Ram, Ehrlich, Sharon, Vitikainen, Marika, Makovitzki, Arik, Dor, Eyal, Marcus, Hadar, Hefetz, Idan, Pitel, Shani, Wiebe, Marilyn, Huuskonen, Anne, Cherry, Lilach, Lupu, Edith, Sapir, Yehuda, Holtzman, Tzvi, Aftalion, Moshe, Gur, David, Tamir, Hadas, Yahalom-Ronen, Yfat, Ramot, Yuval, Kronfeld, Noam, Zarling, David, Vallerga, Anne, Tchelet, Ronen, Nyska, Abraham, Saloheimo, Markku, Emalfarb, Mark, Ophir, Yakir“…The RBD-C-tag antigen strongly binds ACE2 receptors in vitro. …”
Publicado 2022
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669por Kudriavtsev, Aleksandr V., Vakhrusheva, Anna V., Kryuchkov, Nickolay A., Frolova, Maria E., Blagodatskikh, Konstantin A., Ivanishin, Taras V., Djonovic, Milana, Romanovskaya-Romanko, Ekaterina A., Kovalenko, Anton N., Lioznov, Dmitry A., Zubkova, Tatiana G., Teplykh, Svetlana V., Oseshnyuk, Rodion A., Stukova, Marina A., Isaev, Artur A., Krasilnikov, Igor V.“…Open, double-blinded, placebo-controlled, randomized phase I/II clinical trial of the “Betuvax-CoV-2,” recombinant protein subunit vaccine based on the S-protein RBD fused with the Fc-fragment of IgG, was conducted to evaluate safety and immunogenicity in response to the vaccination. …”
Publicado 2023
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670por Pollet, Jeroen, Chen, Wen-Hsiang, Versteeg, Leroy, Keegan, Brian, Zhan, Bin, Wei, Junfei, Liu, Zhuyun, Lee, Jungsoon, Kundu, Rahki, Adhikari, Rakesh, Poveda, Cristina, Villar, Maria Jose, de Araujo Leao, Ana Carolina, Altieri Rivera, Joanne, Momin, Zoha, Gillespie, Portia M., Kimata, Jason T., Strych, Ulrich, Hotez, Peter J., Bottazzi, Maria Elena“…After introducing two modifications into the wild-type RBD gene to reduce yeast-derived hyperglycosylation and improve stability during protein expression, we show that the recombinant protein, RBD219-N1C1, is equivalent to the wild-type RBD recombinant protein (RBD219-WT) in an in vitro ACE-2 binding assay. …”
Publicado 2021
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671por Kitro, Amonrphat, Sirikul, Wachiranun, Thongkum, Weeraya, Soponpong, Suthinee, Yasamut, Umpa, Kiratipaisarl, Wuttipat, Kosai, Apiradee, Kasinrerk, Watchara, Tayapiwatana, Chatchai, Srithanaviboonchai, Kriengkrai“…Anti-SARS-CoV-2 IgG antibodies levels and short-term side effects were assessed. The anti-RBD level was determined using Architect SARS-CoV-2 IgG II Quant (Abbott). …”
Publicado 2022
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672por Younes, Nadin, Al-Sadeq, Duaa W., Shurrab, Farah M., Zedan, Hadeel T., Abou-Saleh, Haissam, Abo-Halawa, Bushra Y., AlHamaydeh, Fatima M., Elsharafi, Amira E., Daas, Hanin I., Thomas, Swapna, Aboalmaaly, Sahar, Al Farsi, Afra, Al-Buainain, Reeham, Ataelmannan, Samar, Paul, Jiji, Al Saadi, Amana Salih, Yassine, Hadi M., Majdalawieh, Amin F., Ismail, Ahmed, Abu-Raddad, Laith J., Nasrallah, Gheyath K.“…Background: Limited commercial LFA assays are available to provide a reliable quantitative measurement of the total binding antibody units (BAU/mL) against the receptor-binding domain of the SARS-CoV-2 spike protein (S-RBD). Aim: This study aimed to evaluate the performance of the fluorescence LFA FinecareTM 2019-nCoV S-RBD test along with its reader (Model No.: FS-113) against the following reference methods: (i) the FDA-approved GenScript surrogate virus-neutralizing assay (sVNT); and (ii) three highly performing automated immunoassays: BioMérieux VIDAS(®)3, Ortho VITROS(®), and Mindray CL-900i(®). …”
Publicado 2022
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673por Zalewska, Marzena, Fus, Wiktoria, Konka, Adam, Wystyrk, Karolina, Bochenek, Aneta, Botor, Hanna, Fronczek, Martyna, Zembala-John, Joanna, Adamek, BrygidaEnlace del recurso
Publicado 2022
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674por Dawood, Ali Adel“…Proteins (ORF9b, ORF8, nsp9, and RBD) were affected by unfavorable donor or acceptor bonds that impact the degree of docking. …”
Publicado 2023
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675por Dawood, Ali Adel“…Proteins (ORF9b, ORF8, nsp9, and RBD) were affected by unfavorable donor or acceptor bonds that impact the degree of docking. …”
Publicado 2023
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676por DeMarco, Jennifer K., Royal, Joshua M., Severson, William E., Gabbard, Jon D., Hume, Steve, Morton, Josh, Swope, Kelsi, Simpson, Carrie A., Shepherd, John W., Bratcher, Barry, Palmer, Kenneth E., Pogue, Gregory P.“…CoV-RBD121-NP elicits strong antibody responses in C57BL/6 mice and is stable for up to 12 months at 2–8 or 22–28 °C. …”
Publicado 2021
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677por Coria, Lorena M., Saposnik, Lucas M., Pueblas Castro, Celeste, Castro, Eliana F., Bruno, Laura A., Stone, William B., Pérez, Paula S., Darriba, Maria Laura, Chemes, Lucia B., Alcain, Julieta, Mazzitelli, Ignacio, Varese, Augusto, Salvatori, Melina, Auguste, Albert J., Álvarez, Diego E., Pasquevich, Karina A., Cassataro, Juliana“…In this work, we evaluated recombinant receptor binding domain (RBD)-based vaccine formulation prototypes with potential for further clinical development. …”
Publicado 2022
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678por Cinza-Estévez, Zurina, Resik-Aguirre, Sonia, Figueroa-Baile, Nelvis L., Oquendo-Martínez, Rachel, Campa-Legrá, Ivan, Tejeda-Fuentes, Alina, Rivero-Caballero, Marila, González-García, Gloria, Chávez-Chong, Cristina O., Alonso-Valdés, Marel, Hernández-Bernal, Francisco, Lemos-Pérez, Gilda, Campal-Espinosa, Ana, Freyre-Corrales, Giselle, Benítez-Gordillo, Delia, Gato-Orozco, Evelyn, Pérez Bartutis, Greter Susana, Mesa-Pedroso, Iliana, Bueno-Alemani, Nilda, Infante-Aguilar, Elizabeth, Rodríguez Reinoso, José Luis, Melo-Suarez, Grettel, Limonta-Fernández, Miladys, Ayala-Ávila, Marta, Muzio-González, Verena L.“…ISMAELILLO study aimed to evaluate safety and immunogenicity of two strengths of a new recombinant receptor-binding domain (RBD) protein vaccine (Abdala) in paediatric population. …”
Publicado 2023
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679“…In vitro transfection experiments in multiple cell lines demonstrated that W4P-RBD vs. wild-type RBD protein (W-RBD) led to enhanced production of IL-6 and TNFα at the transcription and translation levels, suggesting the adjuvant potential of N-terminal HBV preS1 sequences for DNA vaccines against SARS-CoV-2. …”
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680por Yip, Ka Man, Lee, Kwan Ming, Ng, Tzi Bun, Xu, Shujun, Yung, Ken Kin Lam, Qu, Shaogang, Cheung, Allen Ka Loon, Sze, Stephen Cho Wing“…Furthermore, ARND was confirmed to have a strong binding affinity with ACE2 and SARS-CoV-2 spike-RBD (Delta) by ELISA. Finally, inflammatory and fibrotic cell models were used in conjunction in this study. …”
Publicado 2022
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