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721Publicado 2022“…When the particles ratio of RBD to BLS units was high (6–7 RBD molecules per BLS decamer in average), the humoral immune response was significantly higher than that elicited by RBD alone or by RBD-BLS particles with a lower RBD to BLS ratio (1–2 RBD molecules per BLS decamer). …”
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722por Zhang, Zhi-Bi, Xia, Yuan-Ling, Shen, Jian-Xin, Du, Wen-Wen, Fu, Yun-Xin, Liu, Shu-Qun“…The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein (RBD(CoV2)) has a higher binding affinity to the human receptor angiotensin-converting enzyme 2 (ACE2) than the SARS-CoV RBD (RBD(CoV)). …”
Publicado 2022
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723por Byun, Jung-Ick, Yang, Tae-Won, Sunwoo, Jun-Sang, Shin, Won Chul, Kwon, Oh-Young, Jung, Ki-Young“…The investigations included 204 iRBD, 295 PD with RBD (PDwtRBD), 187 PD without RBD (PDwoRBD), 42 MSAwtRBD, 9 DLBwtRBD patients, and 246 controls. …”
Publicado 2023
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724por Nishiwaki, Hiroshi, Hamaguchi, Tomonari, Ito, Mikako, Ishida, Tomohiro, Maeda, Tetsuya, Kashihara, Kenichi, Tsuboi, Yoshio, Ueyama, Jun, Shimamura, Teppei, Mori, Hiroshi, Kurokawa, Ken, Katsuno, Masahisa, Hirayama, Masaaki, Ohno, Kinji“…Gut dysbiosis has been repeatedly reported in Parkinson’s disease (PD) but only once in idiopathic rapid-eye-movement sleep behavior disorder (iRBD) from Germany. Abnormal aggregation of α-synuclein fibrils causing PD possibly starts from the intestine, although this is still currently under debate. iRBD patients frequently develop PD. …”
Publicado 2020
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725por Giannini, Giulia, Provini, Federica, Cortelli, Pietro, Calandra-Buonaura, Giovanna“…REM sleep behaviour disorder (RBD) is one of the most robust markers of an underlying alpha-synucleinopathy. …”
Publicado 2021
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726“…In this study, we report the transient expression of RBD alone, RBD coupled with four copies of M2e, and fusions of RBD and RBD-4M2e with flagellin in Nicotiana benthamiana plants using the self-replicating potato virus X-based vector pEff. …”
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727por Urso, Daniele, Nigro, Salvatore, Tafuri, Benedetta, Gnoni, Valentina, Filardi, Marco, De Blasi, Roberto, Ray Chaudhuri, K., Logroscino, Giancarlo“…We investigated the association between the Magnetic Resonance Parkinsonism Index (MRPI) and REM sleep behavior disorder (RBD). We included 226 de novo PD patients (82 PD-RBD and 144 PD-noRBD) and 19 idiopathic RBD patients. …”
Publicado 2022
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728por Shi, Juan, Jin, Xiaoxiao, Ding, Yan, Liu, Xiaotao, Shen, Anran, Wu, Yandan, Peng, Min, Shen, Chuanlai“…In this study, nine receptor-binding domain (RBD) proteins of the SARS-CoV-2 variants (B.1.1.7, B.1.351 and P.1 lineages) were constructed and fused with the Fc fragment of human IgG (RBD-Fc). …”
Publicado 2021
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729“…REM sleep behavior disorder (RBD) is closely associated with Parkinson's disease (PD), however, the influence of dopaminergic replacement therapy (DRT) on the clinical course of RBD in PD remains less understood. …”
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730por Su, Siao-Chu, Chen, Rou-Shayn, Chen, Yi-Chieh, Weng, Yi-Hsin, Hung, June, Lin, Yi-Ying“…INTRODUCTION: REM Sleep Behavior Disorder (RBD) has been highlighted to identify a patient with prodromal Parkinson’s disease (PD). …”
Publicado 2023
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731por Volpatti, Lisa R., Wallace, Rachel P., Cao, Shijie, Raczy, Michal M., Wang, Ruyi, Gray, Laura T., Alpar, Aaron T., Briquez, Priscilla S., Mitrousis, Nikolaos, Marchell, Tiffany M., Sasso, Maria Stella, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Solanki, Ani, Watkins, Elyse A., Schnorenberg, Mathew R., Tremain, Andrew C., Reda, Joseph W., Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Yu, Shann S., Manicassamy, Balaji, LaBelle, James L., Tirrell, Matthew V., Randall, Glenn, Kwissa, Marcin, Swartz, Melody A., Hubbell, Jeffrey A.“…We evaluated the humoral and cellular responses of mice immunized with these surface-decorated polymersomes (RBD(surf)) compared to RBD-encapsulated polymersomes (RBD(encap)) and unformulated RBD (RBD(free)), using monophosphoryl lipid A-encapsulated polymersomes (MPLA PS) as an adjuvant. …”
Publicado 2021
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732por Jung, Bo-Kyoung, An, Yong Hee, Jang, Jin-Ju, Jeon, Joo Hee, Jang, Sung Hoon, Jang, Hyun“…The RBD protein concentrations on the viral surface were measured by the sandwich ELISA method. 10(6.7) TCID(50)/ml of LVP-K1-RBD19 has a 0.17 μg of RBD protein. …”
Publicado 2022
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733por Byun, Jung-Ick, Cha, Kwang Su, Kim, Minah, Lee, Woo-Jin, Lee, Han Sang, Sunwoo, Jun-Sang, Shin, Jung-Won, Kim, Tae-Joon, Jun, Jin-Sun, Kim, Han-Joon, Shin, Won Chul, Schenck, Carlos H., Lee, Sang Kun, Jung, Ki-Young“…Thirteen of the iRBD patients had mild cognitive impairment (iRBD-MCI), and the others were age-matched patients with normal cognition (iRBD-NC). …”
Publicado 2022
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734por Liu, Haolin, Wei, Pengcheng, Aviszus, Katja, Zhang, Qianqian, Linderberger, Jared, Yang, John, Liu, Junfeng, Chen, Zhongzhou, Waheed, Hassan, Reynoso, Lyndon, Downey, Gregory P., Frankel, Stephen K., Kappler, John W., Marrack, Philippa, Zhang, Gongyi“…The protective anti-wild type RBD antibody Bamlanivimab binds very poorly to the Delta RBD and not at all to the Lambda RBD. …”
Publicado 2022
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735por Pavelka, Lukas, Rauschenberger, Armin, Landoulsi, Zied, Pachchek, Sinthuja, Marques, Taina, Gomes, Clarissa P.C., Glaab, Enrico, May, Patrick, Krüger, Rejko“…Multiple regression models were applied to explore (i) the effect of pRBD on clinical outcomes adjusted for disease duration and age, (ii) the effect of sex on pRBD, and (iii) the association of APOE ɛ4 and pRBD. …”
Publicado 2022
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736por During, Emmanuel H, Hernandez, Beatriz, Miglis, Mitchell G, Sum-Ping, Oliver, Hekmat, Anahid, Cahuas, Ana, Ekelmans, Adrian, Yoshino, Fuyumi, Mignot, Emmanuel, Kushida, Clete A“…Patients were adults with definite iRBD or Parkinson’s disease and probable RBD (PD-RBD), and persistence of ≥ 2 weekly episodes despite standard therapy. …”
Publicado 2023
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737por Chen, Amei, Li, Yuting, Wang, Zhaoxiu, Huang, Junxiang, Ruan, Xiuhang, Cheng, Xiaofang, Huang, Xiaofei, Liang, Dan, Chen, Dandan, Wei, Xinhua“…The patients were divided into two groups, PD with probable RBD (PD-pRBD, n = 74) and PD without probable RBD (PD-npRBD, N = 97), according to the RBD screening questionnaire (RBDSQ). …”
Publicado 2022
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738“…Fifty iRBD patients, 19 with mild cognitive impairment (MCI) (RBD-MCI) and 31 without MCI (RBD-nonMCI), were prospectively enrolled. …”
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739por Ding, Yan, Hu, Yue-Qing, Zhan, Shu-Qin, Li, Cun-Jiang, Wang, Hong-Xing, Wang, Yu-Ping“…METHODS: Totally, 46 MSA-C patients (23 with RBD, and 23 without RBD) were enrolled in this study. …”
Publicado 2016
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740por Luo, Deyan, Liu, Xuechao, Xing, Li, Sun, Yakun, Huang, Jie, Zhang, Liangyan, Li, Jiajia, Wang, Hui“…The immunogenicity and protection of the vaccine candidates RBD-TcdA, RBD-TcdB, and RBD-TcdA/B was evaluated by ELISA and survival assays. …”
Publicado 2019
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