“…We found that tRBD binds to the ACE2 with 58-fold higher affinity than monomeric RBD (mRBD) and blocks spike-dependent pseudoviral infection over 4-fold more effectively compared to the mRBD. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cellular and humoral responses were detected at 1, 3, and 6 months, including IgG antibody against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein (anti-RBD-IgG), neutralizing antibodies (NAbs), the positive rate of NAbs and anti-RBD-IgG, RBD-atypical memory B cells (MBCs) (CD3 − CD19 + RBD + CD21 − CD27−), RBD-activated MBCs (CD3 − CD19 + RBD + CD21 − CD27+), RBD-resting MBCs (CD3 − CD19 + RBD + CD21 + CD27+), and RBD-intermediate MBCs (CD3 − CD19 + RBD + CD21 + CD27−). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND AND OBJECTIVES: Mild cognitive impairment (MCI) in isolated REM sleep behavior disorder (iRBD) is a risk factor for subsequent neurodegeneration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Binding free energies computed by Molecular Mechanics Generalised Born Surface Area (MM-GBSA) algorithm predicted the binding affinity of MW06 for RBD BA.1 (−53 kcal/mol) as strong as RBD wildtype (−58 kcal/mol) while deterioration was observed for RBD BA.2 (−43 kcal/mol). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We evaluated the vaccination efficacy of these surface-decorated polymersomes (RBD(surf)) in mice compared to RBD-encapsulated polymersomes (RBD(encap)) and unformulated RBD (RBD(free)), using monophosphoryl-lipid-A-encapsulated polymersomes (MPLA PS) as an adjuvant. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: The subjects included 169 patients with Parkinson’s disease (Parkinson’s disease with RBD [PD-RBD] = 69 subjects; Parkinson’s disease without RBD [PD-nRBD] = 100 subjects). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Parkinson disease (PD) patients with rapid eye movement (REM) sleep behavior disorder (RBD) have worse motor symptoms and non-motor symptoms than patients without RBD. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In 2012, we determined pRBD status using a validated RBD questionnaire‐Hong Kong (RBDQ‐HK). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We divided the patients into 3 groups: PD with clinical RBD (n = 32), PD with subclinical RBD (n = 11), and PD with normal REM sleep (n = 19). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Vaccination protects against COVID-19 via the spike protein receptor-binding domain (RBD)-specific antibody formation, but it also affects the innate immunity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We previously identified the receptor-binding domain (RBD) of S protein as a major target of neutralizing antibodies in animal models and thus proposed a RBD-based vaccine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by excessive muscle activity and undesirable motor events during REM sleep. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we describe the production of a recombinant RBD protein using prokaryotic (pRBD) and mammalian (mRBD) expression systems, and compare the immunogenicity of prokaryotic and mammalian-expressed RBD using a BALB/c mice model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…INTRODUCTION: The earliest stages of alpha-synucleinopathies are accompanied by non-specific prodromal symptoms such as diminished sense of smell, constipation and depression, as well as more specific prodromal conditions including REM Sleep Behaviour Disorder (RBD). While the majority of RBD patients will develop an alpha-synucleinopathy, one of the greatest clinical challenges is determining whether and when individual patients will phenoconvert. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…AD group distributions were AD-Likely=71%, LBD-Likely=4%, Normal+AD=14%, Normal+iRBD=4%, Normal-Likely=7%. iRBD patients were characterized with iRBD-Likely=37%, LBD-Likely=5%, AD-Likely=5%, Normal+iRBD=27%, Normal-Likely=26%. …”
Enlace del recurso
Enlace del recurso

“…RESULTS: The purified rlipoA-RBD was characterized immunologically and found to have the following properties: (a) mice, hamsters and rabbits vaccinated with 3 μg of rlipoA-RBD produced strong antibody responses that neutralized TcdA toxicity in Vero cell cytotoxicity assays; furthermore, the neutralization titer was comparable to those obtained from antisera immunized either with 10 μg of TcdA toxoid or 30 μg of A-rRBD; (b) rlipoA-RBD elicited immune responses and protected mice from TcdA challenge, but offered insignificant protection (10 to 20 %) against C. difficile spores challenge in hamster models; (c) only rlipoA-RBD formulated with B-rRBD consistently confers protection (90 to 100 %) in the hamster challenge model; and (d) rlipoA-RBD was found to be 10-fold more potent than A-rRBD as an adjuvant to enhancing immune responses against a poor antigen such as ovalbumin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…NRH comparisons to consensus physician agreement yielded one false-positive and one false-negative iRBD finding. Physician2 classified: a) iRBD in two cases that were negative by Physician1 and NRH, and b) one negative case that Physician1 and NRH characterized as iRBD. …”
Enlace del recurso
Enlace del recurso

“…SARS-CoV-2 relies on its spike protein, in particular the receptor-binding domain (RBD), to bind human cell receptor angiotensin-converting enzyme 2 (ACE2) for viral entry, and thus targeting RBD holds the promise for preventing SARS-CoV-2 infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…STUDY OBJECTIVES: The differentiation of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) or its prodromal phase (prodromal RBD) from other disorders with motor activity during sleep is critical for identifying α-synucleinopathy in an early stage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Angiotensin-converting enzyme 2 (ACE2) and neuropilin 1, a vascular endothelial growth factor (VEGF) receptor, were identified to bind to the SARS-CoV-2 spike receptor-binding domain (spike RBD). In silico analysis based on 3D structure, multiple sequence alignment, and molecular docking of second domain of soluble Flt-1 (sFlt-1) and spike RBD revealed structural similarities, sequence homology, and protein-protein interaction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso