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781por Huang, Jun-Ying, Zhang, Jin-Ru, Shen, Yun, Zhang, Hui-Jun, Cao, Yu-Lan, Mao, Cheng-Jie, Yang, Ya-Ping, Chen, Jing, Liu, Chun-Feng, Li, Jie“…BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). …”
Publicado 2018
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782por Prabakaran, Ponraj, Gan, Jianhua, Feng, Yang, Zhu, Zhongyu, Choudhry, Vidita, Xiao, Xiaodong, Ji, Xinhua, Dimitrov, Dimiter S.“…However, the structural basis of RBD immunogenicity, RBD-mediated neutralization, and the role of RBD in entry steps following its binding to ACE2 have not been elucidated. …”
Publicado 2006
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783por Oltra, Javier, Segura, Barbara, Uribe, Carme, Monté-Rubio, Gemma C., Campabadal, Anna, Inguanzo, Anna, Pardo, Jèssica, Marti, Maria J., Compta, Yaroslau, Valldeoriola, Francesc, Iranzo, Alex, Junque, Carme“…We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and without probable RBD (pRBD). METHODS: Magnetic resonance imaging and cognition data were obtained for 274 participants from the Parkinson's Progression Marker Initiative database: 79 PD with pRBD (PD-pRBD; male/female, 54/25), 126 PD without pRBD (PD-non pRBD; male/female, 73/53), and 69 healthy controls (male/female, 40/29). …”
Publicado 2021
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784“…Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors. …”
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785por Halsband, Claire, Zapf, Antonia, Sixel‐Döring, Friederike, Trenkwalder, Claudia, Mollenhauer, Brit“…OBJECTIVES: To test the validity of the RBD‐Screening Questionnaire (RBDSQ) in assessing RBD in early PD. …”
Publicado 2018
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786por Kanjo, Kawkab, Chattopadhyay, Gopinath, Malladi, Sameer Kumar, Singh, Randhir, Jayatheertha, Sowrabha, Varadarajan, Raghavan“…We have previously reported the design and characterization of a mammalian cell expressed RBD derivative, mRBD1-3.2, that has higher thermal stability and greatly enhanced immunogenicity relative to the wild type mRBD. …”
Publicado 2023
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787por Barber, Thomas R, Lawton, Michael, Rolinski, Michal, Evetts, Samuel, Baig, Fahd, Ruffmann, Claudio, Gornall, Aimie, Klein, Johannes C, Lo, Christine, Dennis, Gary, Bandmann, Oliver, Quinnell, Timothy, Zaiwalla, Zenobia, Ben-Shlomo, Yoav, Hu, Michele TM“…OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is the most specific marker of prodromal alpha-synucleinopathies. …”
Publicado 2017
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788por Pandey, Manisha, Ozberk, Victoria, Eskandari, Sharareh, Shalash, Ahmed O, Joyce, Michael A, Saffran, Holly A, Day, Christopher J, Lepletier, Ailin, Spillings, Belinda L, Mills, Jamie‐Lee, Calcutt, Ainslie, Fan, Fan, Williams, James T, Stanisic, Danielle I, Hattingh, Laetitia, Gerrard, John, Skwarczynski, Mariusz, Mak, Johnson, Jennings, Michael P, Toth, Istvan, Tyrrell, D Lorne, Good, Michael F“…Immune sera were tested for binding to the RBD and for their ability to block the interaction of the RBD and ACE2. …”
Publicado 2021
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789por Zhang, Xinyuan, Molsberry, Samantha A., Pavlova, Milena, Schwarzschild, Michael A., Ascherio, Alberto, Gao, Xiang“…RESULTS: Of the 25 694 studied men (mean [SD] age, 75.6 [7.4] years), 223 (0.9%) had probable SW, 2720 (10.6%) had probable RBD, and 257 (1.0%) had PD. After adjusting for potential confounders (eg, age, smoking, caffeine intake, chronic disease status, and other sleep disorders), compared with individuals without probable SW and probable RBD, participants with probable SW, probable RBD, and both probable SW and probable RBD had higher odds of PD, (probable SW: odds ratio [OR], 4.80; 95% CI, 1.61-14.26; probable RBD: OR, 6.36; 95% CI, 4.83-8.37; both probable SW and probable RBD: OR, 8.44; 95% CI, 3.90-18.27). …”
Publicado 2021
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790por Fujita, Hiroaki, Shiina, Tomohiko, Sakuramoto, Hirotaka, Nozawa, Narihiro, Ogaki, Keitaro, Suzuki, Keisuke“…Patients with Parkinson’s disease (PD) complicated with rapid eye movement sleep behavior disorder (RBD) present with distinct clinical features. The purpose of this study was to determine the clinical features of sleep and autonomic symptoms in PD patients with probable RBD (pRBD). …”
Publicado 2022
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791por Fulda, Stephany“…REM sleep behavior disorder (RBD) is a parasomnia characterized by dream-enacting behavior and loss of muscle atonia during REM sleep. …”
Publicado 2011
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792por Ahmad, Javeed, Jiang, Jiansheng, Boyd, Lisa F., Zeher, Allison, Huang, Rick, Xia, Di, Natarajan, Kannan, Margulies, David H.“…Combating the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of new variants demands understanding of the structural basis of the interaction of antibodies with the SARS-CoV-2 receptor-binding domain (RBD). Here, we report five X-ray crystal structures of sybodies (synthetic nanobodies) including those of binary and ternary complexes of Sb16–RBD, Sb45–RBD, Sb14–RBD–Sb68, and Sb45–RBD–Sb68, as well as unliganded Sb16. …”
Publicado 2021
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793por Stroylova, Yulia, Konstantinova, Anastasiia, Stroylov, Victor, Katrukha, Ivan, Rozov, Fedor, Muronetz, Vladimir“…The formation of the RBD complex with the alpha-synuclein monomer was confirmed immunochemically by immobilization of RBD on its specific receptor ACE2. …”
Publicado 2023
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794por Huang, Bei, Chau, Steven W. H., Liu, Yaping, Chan, Joey W. Y., Wang, Jing, Ma, Suk Ling, Zhang, Jihui, Chan, Paul K. S., Yeoh, Yun Kit, Chen, Zigui, Zhou, Li, Wong, Sunny Hei, Mok, Vincent C. T., To, Ka Fai, Lai, Hei Ming, Ng, Simon, Trenkwalder, Claudia, Chan, Francis K. L., Wing, Yun Kwok“…Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. …”
Publicado 2023
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795por Huang, Si-Fei, Chen, Kui, Wu, Jian-Jun, Liu, Feng-Tao, Zhao, Jue, Lin, Wei, Guo, Si-Si, Wang, Yi-Xuan, Wang, Ying, Luo, Su-Shan, Sun, Yi-Min, Ding, Zheng-Tong, Yu, Huan, Wang, Jian“…However, a few studies have conflicting results when comparing dysosmia in the patients with iRBD and PD. There is no study investigating the olfactory function in Chinese patients with iRBD. …”
Publicado 2016
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796Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorderpor Liu, Ye, Zhu, Xiao-Ying, Zhang, Xiao-Jin, Kuo, Sheng-Han, Ondo, William G., Wu, Yun-Cheng“…BACKGROUND: Rapid eye movement sleep behavior disorder (RBD) and Parkinson’s disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. …”
Publicado 2017
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797por Gabryelska, A., Roguski, A., Simpson, G., Maschauer, E. L., Morrison, I., Riha, Renata L.“…The aims of this study were to determine the prevalence of obstructive sleep apnoea (OSA) in RBD patients and determine whether continuous positive airway pressure (CPAP) therapy improved RBD symptoms in patients with concomitant RBD and OSA. …”
Publicado 2017
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798“…Here, we used RBD-Fc, a fusion protein containing the RBD and human IgG1 Fc, as a model in the studies and found that a single amino acid substitution in the RBD (R441A) could abolish the immunogenicity of RBD to induce neutralizing antibodies in immunized mice and rabbits. …”
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799por Borgoyakova, M. B., Karpenko, L. I., Rudometov, A. P., Shanshin, D. V., Isaeva, A. A., Nesmeyanova, V. S., Volkova, N. V., Belenkaya, S. V., Murashkin, D. E., Shcherbakov, D. N., Volosnikova, E. A., Starostina, E. V., Orlova, L. A., Danilchenko, N. V., Zaikovskaya, A. V., Pyankov, O. V., Ilyichev, A. A.“…In particular, RBD-specific antibody titers were shown in ELISA to be no higher than 1 : 1000 in the animals from the pVAX-RBD group and 1 : 42 000, in the pVAX-RBD-PGS group. …”
Publicado 2021
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800por Jia, Xiuqin, Fan, Wentao, Wang, Zhijiang, Liu, Yuehong, Li, Ying, Li, Haibin, Li, Hui, Ma, Ting, Wang, Jing, Yang, Qi“…Of these, 46 patients who completed 1- and 3-year fMRI follow-up examinations were categorized as PD with probable RBD (PD-pRBD(+)) and without (PD-pRBD(−)). The left dorsolateral prefrontal cortex (DLPFC) seed-to-voxel functional connectivity analysis was conducted to evaluate the progressive neural alterations specific to PD-pRBD(+) compared with PD-pRBD(−) over time. …”
Publicado 2022
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