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801por König-Beihammer, Julia, Vavra, Ulrike, Shin, Yun-Ji, Veit, Christiane, Grünwald-Gruber, Clemens, Gillitschka, Yasmin, Huber, Jasmin, Hofner, Manuela, Vierlinger, Klemens, Mitteregger, Dieter, Weinhäusel, Andreas, Strasser, Richard“…Analysis of sera from RBD-positive and RBD-negative individuals revealed further that non-infected RBD-negative blood group O individuals have antibodies that strongly bind to RBD modified with blood group A antigen structures. …”
Publicado 2022
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802por Tragni, Vincenzo, Preziusi, Francesca, Laera, Luna, Onofrio, Angelo, Mercurio, Ivan, Todisco, Simona, Volpicella, Mariateresa, De Grassi, Anna, Pierri, Ciro Leonardo“…By using our pipeline, we built 3D comparative models of the SARS-CoV-2 spike RBD/ACE2 protein complexes for the VoC B.1.1.7-United Kingdom (carrying the mutations of concern/interest N501Y, S494P, E484K at the RBD), P.1-Japan/Brazil (RBD mutations: K417T, E484K, N501Y), B.1.351-South Africa (RBD mutations: K417N, E484K, N501Y), B.1.427/B.1.429-California (RBD mutations: L452R), the B.1.141 (RBD mutations: N439K), and the recent B.1.617.1-India (RBD mutations: L452R; E484Q) and the B.1.620 (RBD mutations: S477N; E484K). …”
Publicado 2022
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803por Michos, Athanasios, Tatsi, Elizabeth-Barbara, Filippatos, Filippos, Dellis, Charilaos, Koukou, Dimitra, Efthymiou, Vasiliki, Kastrinelli, Evangelia, Mantzou, Aimilia, Syriopoulou, Vasiliki“…METHODS: We prospectively measured the total (TAbs-RBD) and the neutralizing antibodies (NAbs-RBD) against the receptor binding domain (RBD) of SARS-CoV-2 spike protein in a cohort of 268 Healthcare workers before immunization, 20 days after the 1(st) dose and 30 days after the 2(nd) dose of the BNT162b2 vaccine. …”
Publicado 2021
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804por Valli, Mikaeel, Cho, Sang Soo, Uribe, Carme, Masellis, Mario, Chen, Robert, Mihaescu, Alexander, Strafella, Antonio P.“…Beyond the brainstem, it is unclear if RBD patients comorbid with PD have more affected striatal dopamine denervation compared to PD patients unaffected by RBD (PD-RBD−). …”
Publicado 2021
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805“…Rapid Eye Movement (REM) Behaviour Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis during REM sleep, leading to the enactment of dream content. …”
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806por Du, Lanying, Zhao, Guangyu, Li, Lin, He, Yuxian, Zhou, Yusen, Zheng, Bo-Jian, Jiang, Shibo“…Here we used CHO-K1 cells to establish a cell line for stable expression of a 193-mer (residues 318–510) RBD (RBD193-CHO) and determined its antigenicity and immunogenicity. …”
Publicado 2009
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807por Mahajan, Abhimanyu, Rosenthal, Liana S., Gamaldo, Charlene, Salas, Rachel E., Pontone, Gregory M., McCoy, Arita, Umeh, Chizoba, Mari, Zoltan“…DISCUSSION: PD patients with RBD symptoms had worse motor findings than those unlikely to have RBD. …”
Publicado 2014
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808“…We hypothesized that SNCA variants conferring risk of Parkinson’s disease would also predispose to an RBD phenotype. METHODS: We assessed possible RBD (pRBD) status using the RBD screening questionnaire and investigated known susceptibility variants for Parkinson’s disease located in the α-synuclein (SNCA) and tau (MAPT) gene loci in 325 Parkinson’s disease patients. …”
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809“…We adopted the latest Seed-based d Mapping with Permutation of Subject Images technique to quantitatively estimate the difference of regional GM volume between PD patients with and without RBD. Results: We included five studies comprising 105 PD patients with RBD and 140 PD patients without RBD. …”
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810por Cooray, Navin, Andreotti, Fernando, Lo, Christine, Symmonds, Mkael, Hu, Michele T.M., De Vos, Maarten“…OBJECTIVE: Rapid-Eye-Movement (REM) sleep behaviour disorder (RBD) is an early predictor of Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. …”
Publicado 2021
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811por Calderón-Garcidueñas, Lilian, Rajkumar, Ravi Philip, Stommel, Elijah W., Kulesza, Randy, Mansour, Yusra, Rico-Villanueva, Adriana, Flores-Vázquez, Jorge Orlando, Brito-Aguilar, Rafael, Ramírez-Sánchez, Silvia, García-Alonso, Griselda, Chávez-Franco, Diana A., Luévano-Castro, Samuel C., García-Rojas, Edgar, Revueltas-Ficachi, Paula, Villarreal-Ríos, Rodolfo, Mukherjee, Partha S.“…This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale–Revised (IES-R) and pRBD symptoms using the RBD Single-Question. …”
Publicado 2021
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812por Peng, Anjiao, Ji, Shuming, Li, Wanling, Lai, Wanlin, Qiu, Xiangmiao, He, Shixu, Dong, Bosi, Huang, Cheng, Chen, Lei“…Background: Subjective gastrointestinal complaints have been repeatedly reported in patients with REM sleep behavior disorder (RBD), but objective evidence is scarce. We aimed to objectively investigate the gastrointestinal dysfunction in individuals with probable RBD (pRBD) using an electrogastrogram. …”
Publicado 2021
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813por Li, Dan, Ding, Jin, Liu, Te-li, Wang, Feng, Meng, Xiang-xi, Liu, Song, Yang, Zhi, Zhu, Hua“…The dissociation constant of (124)I-RBD binding to hACE2 was 75.7 nM. The uptake of (124)I-RBD by HeLa(ACE+) cells at 2 h was 2.96% ± 0.35%, which could be substantially blocked by an excessive amount of RBD, and drop to 1.71% ± 0.23%. …”
Publicado 2021
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814por Chaouat, Abigael Eva, Achdout, Hagit, Kol, Inbal, Berhani, Orit, Roi, Gil, Vitner, Einat B., Melamed, Sharon, Politi, Boaz, Zahavy, Eran, Brizic, Ilija, Lenac Rovis, Tihana, Alfi, Or, Wolf, Dana, Jonjic, Stipan, Israely, Tomer, Mandelboim, Ofer“…Here, we generated fusion proteins composed of the extracellular portions of ACE2 and RBD fused to the Fc portion of human IgG1 (ACE2-Ig and RBD-Ig, respectively). …”
Publicado 2021
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815por Hatzakis, Angelos, Karabinis, Andreas, Roussos, Sotirios, Pantazis, Nikos, Degiannis, Dimitrios, Chaidaroglou, Antigoni, Petsios, Konstantinos, Pavlopoulou, Ioanna, Tsiodras, Sotirios, Paraskevis, Dimitrios, Sypsa, Vana, Psichogiou, Mina“…Several lines of evidence suggest that binding SARS-CoV-2 antibodies such as anti-SARS-CoV-2 RBD IgG (anti-RBD) and neutralising antibodies (NA) are correlates of protection against SARS-CoV-2, and the correlation of anti-RBD and NA is very high. …”
Publicado 2022
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816por Klausberger, Miriam, Kienzl, Nikolaus F., Stadlmayr, Gerhard, Grünwald‐Gruber, Clemens, Laurent, Elisabeth, Stadlbauer, Katharina, Stracke, Florian, Vierlinger, Klemens, Hofner, Manuela, Manhart, Gabriele, Gerner, Wilhelm, Grebien, Florian, Weinhäusel, Andreas, Mach, Lukas, Wozniak‐Knopp, Gordana“…The authors aimed to optimize RBD produced in HEK293‐6E cells towards a stable homogeneous preparation and addressed its O‐glycosylation as well as the unpaired cysteine residue 538 in the widely used RBD (319‐541) sequence. …”
Publicado 2022
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817por Golcuk, Mert, Hacisuleyman, Aysima, Yilmaz, Sema Zeynep, Taka, Elhan, Yildiz, Ahmet, Gur, Mert“…Among these nanobodies H11-H4 and H11-D4 bind RBD without overlapping ACE2. They were unable to dislocate ACE2 from RBD(Delta) when bound side by side with ACE2 on RBD. …”
Publicado 2022
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818“…We identified two mutated aptamers, namely, RBD-1CM1 and RBD-1CM2, which presented better docking results against the S protein compared with the RBD-1C aptamer. …”
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819“…Intranasal immunization using the receptor-binding domain (RBD) of MERS-CoV spike protein (S-RBD) recombined with LL-37 (S-RBD-LL-37) induced an efficient mucosal IgA and systemic IgG response with virus-neutralizing activity, compared with S-RBD. …”
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820“…Among the novel mutations distinguishing SARS-CoV-2 from similar coronaviruses is a K403R substitution in the receptor-binding domain (RBD) of the viral spike (S) protein within its S1 region. …”
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