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841por Omotuyi, Olaposi, Olubiyi, Olujide, Nash, Oyekanmi, Afolabi, Elizabeth, Oyinloye, Babatunji, Fatumo, Segun, Femi-Oyewo, Mbang, Bogoro, Suleiman“…Analyses of trajectories showed that Om-RBD has evolved into an efficient ACE2 binder, via pi-pi (Om-RBD-Y501/ACE2-Y41) and salt-bridge (Om-RBD-K493/ACE2-Y41) interactions. …”
Publicado 2022
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842por Carreño, Juan Manuel, Mendu, Damodara Rao, Simon, Viviana, Shariff, Masood A., Singh, Gagandeep, Menon, Vidya, Krammer, Florian“…Current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests are based on the full-length spike (S), the receptor-binding domain (RBD), or the nucleoprotein (NP) as substrates. Here, we used samples from healthcare workers (HCWs) to perform a longitudinal analysis of the antibody responses using a research-grade RBD and spike-based enzyme-linked immunosorbent assay (ELISA), a commercial RBD and spike-based ELISA, and a commercial NP-based chemiluminescent microparticle immunoassay. …”
Publicado 2021
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843por Hu, Ye-Fan, Hu, Jing-Chu, Chu, Hin, Yau, Thomas, Zhang, Bao-Zhong, Huang, Jian-Dong“…In our database, 132 epitopes of the 120 antibodies are classified into five groups, namely NTD, RBD-1, RBD-2, RBD-3, and RBD-4. The Omicron mutations impact all epitopes in NTD, RBD-1, RBD-2, and RBD-3, with no antibody epitopes spared by these mutations. …”
Publicado 2022
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844por Dokainish, Hisham M, Re, Suyong, Mori, Takaharu, Kobayashi, Chigusa, Jung, Jaewoon, Sugita, Yuji“…Reduced interactions between RBD(A) and RBD(B) in one-Up induce RBD(B) motions toward two-Up. …”
Publicado 2022
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845por Boucetta, Soufiane, Salimi, Ali, Dadar, Mahsa, Jones, Barbara E., Collins, D. Louis, Dang-Vu, Thien Thanh“…Characterized by dream-enactment motor manifestations arising from rapid eye movement (REM) sleep, REM sleep behavior disorder (RBD) is frequently encountered in Parkinson’s disease (PD). …”
Publicado 2016
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846“…During the 4-year follow-up, patients in the PD-pRBD+ group consistently exhibited greater DAT loss than patients in the PD-pRBD− group with comparable disease duration in all four striatal subregions. …”
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847“…The positive relationship was reduced in patients with RBD and PD with RBD, and the relationship was found to be negative in PD patients. …”
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848por Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Lee, Yu E., Hoffman, Pauline R., Ou, Susan, Kakutani, Leesa M., Keeffe, Jennifer R., Wu, Hung-Jen, Howarth, Mark, West, Anthony P., Barnes, Christopher O., Nussenzweig, Michel C., Bjorkman, Pamela J.“…We made homotypic nanoparticles displaying the receptor-binding domain (RBD) of SARS-CoV-2 or co-displaying SARS-CoV-2 RBD along with RBDs from animal betacoronaviruses that represent threats to humans (mosaic nanoparticles; 4–8 distinct RBDs). …”
Publicado 2021
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849por Tian, Fang, Tong, Bei, Sun, Liang, Shi, Shengchao, Zheng, Bin, Wang, Zibin, Dong, Xianchi, Zheng, Peng“…Taken together, these results suggest that the reinforced RBD–ACE2 interaction that results from the N501Y mutation in the RBD should play an essential role in the higher rate of transmission of SARS-CoV-2 variants, and that future mutations in the RBD of the virus should be under surveillance.…”
Publicado 2021
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850“…Methods: We enrolled 22 participants with RBD and 46 healthy controls (HCs) with age and gender-matched. …”
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851por Tallei, Trina Ekawati, Fatimawali, Adam, Ahmad Akroman, Elseehy, Mona M., El-Shehawi, Ahmed M., Mahmoud, Eman A., Tania, Adinda Dwi, Niode, Nurdjannah Jane, Kusumawaty, Diah, Rahimah, Souvia, Effendi, Yunus, Idroes, Rinaldi, Celik, Ismail, Hossain, Md. Jamal, Emran, Talha Bin“…Hence, this RBD is a critical target for the development of antiviral agents. …”
Publicado 2022
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852por Shi, Yuejun, Shi, Jiale, Sun, Limeng, Tan, Yubei, Wang, Gang, Guo, Fenglin, Hu, Guangli, Fu, Yanan, Fu, Zhen F., Xiao, Shaobo, Peng, Guiqing“…The spike (S) homotrimers bind to their receptors via the receptor-binding domain (RBD), which is a major target to block viral entry. …”
Publicado 2021
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853por Koch, Julia, Willemsen, Kira, Dogan, Imis, Rolke, Roman, Schulz, Jörg B., Schiefer, Johannes, Reetz, Kathrin, Maier, Andrea“…INTRODUCTION: Studies have reported autonomic impairment in patients with idiopathic REM sleep behaviour disorder (iRBD), which is considered a prodromal stage of alpha-synucleinopathies. …”
Publicado 2021
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854“…Therefore, it is important to investigate the binding and interaction of ACE2 with different RBD variants. A comparative study using all-atom MD simulations was conducted on ACE2 binding with 8 different RBD variants, including N501Y, E484K, P479S, T478I, S477N, N439K, K417N and N501Y-E484K-K417N on RBD. …”
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855por Vasconcelos, Larissa de Carvalho Medrado, Leony, Leonardo Maia, Camelier, Aquiles Assunção, Meireles, André Costa, Oliveira Júnior, André Luiz Freitas de, Bandeira, Antônio Carlos, Macedo, Yasmin Santos Freitas, Duarte, Alan Oliveira, Van Voorhis, Wesley, Siqueira, Isadora Cristina de, Santos, Fred Luciano Neves“…OBJECTIVES: This study evaluated the performance of recombinant receptor binding domain (RBD) protein-based enzyme-linked immunosorbent assays (RBD-ELISAs) for detecting anti-SARS-CoV-2 immunoglobulin (Ig) G and IgM antibodies. …”
Publicado 2023
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856por Patil, Hemangi, Cho, Kyoung-in, Lee, James, Yang, Yi, Orry, Andrew, Ferreira, Paulo A.“…The RBD(2), kinesin-binding domain (KBD) and RBD(3) comprise a tripartite domain (R(2)KR(3)) of RanBP2 that causes the unfolding, microtubule binding and biphasic activation of kinesin-1, a crucial anterograde motor of mitochondrial motility. …”
Publicado 2013
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857por Uguccioni, Ginevra, Pallanca, Olivier, Golmard, Jean-Louis, Dodet, Pauline, Herlin, Bastien, Leu-Semenescu, Smaranda, Arnulf, Isabelle“…Two RBD patients with dementia were studied separately. …”
Publicado 2013
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858“…The expression of chemokines capable of recruiting leukocytes, including monocytes/macrophages, natural killer cells, granulocytes, T cells, and dendritic cells, was also increased following HBD 2-conjugated S RBD treatment. More important, immunization of mice with HBD 2-conjugated S RBD enhanced the immunogenicity of the S RBD and elicited a higher S RBD-specific neutralizing antibody response than S RBD alone. …”
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859por Pereira, Joana B., Weintraub, Daniel, Chahine, Lana, Aarsland, Dag, Hansson, Oskar, Westman, Eric“…The aim of this study is to determine whether structural MRI measures are associated with clinical impairment and progression to a Lewy body disease in patients with idiopathic REM sleep behavior disorder (iRBD). Twenty-seven patients with iRBD in addition to patients with de novo PD and healthy controls were included from the Parkinson’s Progression Markers Initiative. …”
Publicado 2019
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860por Lee, Jee-Young, Yoon, Eun Jin, Kim, Yu Kyeong, Shin, Chae Won, Nam, Hyunwoo, Jeong, Jae Min, Kim, Han-Joon, Jeon, Beomseok“…The iRBD group was divided into two groups based on olfactory testing results. …”
Publicado 2019
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