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861por Barber, Thomas R., Griffanti, Ludovica, Bradley, Kevin M., McGowan, Daniel R., Lo, Christine, Mackay, Clare E., Hu, Michele T., Klein, Johannes C.“…OBJECTIVES: Rapid eye movement sleep behavior disorder (RBD) patients have a high risk of developing a Parkinsonian disorder, offering an opportunity for neuroprotective intervention. …”
Publicado 2019
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862por Aatif, Mohammad, Muteeb, Ghazala, Alsultan, Abdulrahman, Alshoaibi, Adil, Khelif, Bachir Yahia“…Analysis of the RBD–DK07 interaction suggested the formation of hydrogen bonds, electrostatic interactions, and hydrophobic interactions with key residues mediating the ACE2–RBD interaction. …”
Publicado 2021
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863“…INTRODUCTION: The structural and functional damages of the striatum were evident in idiopathic REM sleep behavior disorder (iRBD). With the research on iRBD deepens, cognitive impairment in iRBD is getting increasing attention. …”
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864“…These data suggest that it is unlikely for neutralization/RBD antibody binding to be significantly impacted, as a whole, in the presence of RBD point mutations that conserve the RBD structure.…”
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865por Gao, Fengxia, Huang, Jingjing, Li, Tingting, Hu, Chao, Shen, Meiying, Mu, Song, Luo, Feiyang, Song, Shuyi, Hao, Yanan, Wang, Wang, Han, Xiaojian, Qian, Chen, Wang, Yingming, Wu, Ruixin, Li, Luo, Li, Shenglong, Jin, Aishun“…Immunization with RBD9.1 can successfully induce the production of the receptor-binding domain (RBD)-specific antibodies in Balb/c mice. …”
Publicado 2021
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866por Mendoza-Salazar, Ivette, Gómez-Castellano, Keyla M., González-González, Edith, Gamboa-Suasnavart, Ramsés, Rodríguez-Luna, Stefany D., Santiago-Casas, Giovanni, Cortés-Paniagua, María I., Pérez-Tapia, Sonia M., Almagro, Juan C.“…After three rounds of panning with SARS-CoV-2 receptor-binding domain wildtype (RBD-WT) 34 unique scFvs, were identified, with 27 cross-reactive for the RBD-WT and RBD Delta (RBD-DT), and seven specifics for the RBD-WT. …”
Publicado 2022
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867“…The mode of the interaction between Omicron’s RBD with the hACE2 receptor is similar to the original SARS-CoV-2 RBD except for a few key differences. …”
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868“…SARS-CoV-2 infection is initiated by binding of the receptor-binding domain (RBD) of its spike glycoprotein to the peptidase domain (PD) of angiotensin-converting enzyme 2 (ACE2) receptors in host cells. …”
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869por Yang, Kai, Liu, Shiyun, Yan, Han, Lu, Wenju, Shan, Xiaoqian, Chen, Haixia, Bao, Changlei, Feng, Huazhuo, Liao, Jing, Liang, Shuxin, Xu, Lei, Tang, Haiyang, Yuan, Jason X.-J., Zhong, Nanshan, Wang, Jian“…Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. …”
Publicado 2023
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870por Sumi, Yukiyoshi, Nakayama, Chikao, Kadotani, Hiroshi, Matsuo, Masahiro, Ozeki, Yuji, Kinoshita, Takafumi, Goto, Yuki, Kano, Manabu, Yamakawa, Toshitaka, Hasegawa-Ohira, Masako, Ogawa, Keiko, Fujiwara, Koichi“…The subjects were divided into three groups: healthy controls (HC), OH-negative iRBD [OH (–) iRBD], and OH-positive iRBD [OH (+) iRBD]. …”
Publicado 2020
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871“…We investigated the adjuvanticity of Aluminum (alum) in combination with rASP-1, a protein adjuvant, using the Middle East respiratory syndrome coronavirus MERS-CoV receptor-binding-domain (RBD) vaccine antigen. A highly enhanced anti-MERS-CoV neutralizing antibody response was induced when mice were immunized with rASP-1 and the alum-adjuvanted RBD vaccine in two separate injection sites as compared to mice immunized with RBD + rASP-1 + alum formulated into a single inoculum. …”
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872“…The Receptor Binding Domain (RBD) of SARS-CoV-2, located on the S1 subunit, plays a vital role in the virus binding and its entry into the host cell through angiotensin-converting enzyme 2 (ACE2) receptor. …”
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873por Weidmann, Chase A., Raynard, Nathan A., Blewett, Nathan H., Van Etten, Jamie, Goldstrohm, Aaron C.“…Rather, we determined that the poly(A) is necessary for repression by the RBD. Our results reveal that poly(A)-dependent repression by the RBD requires the poly(A) binding protein, pAbp. …”
Publicado 2014
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874“…OBJECTIVE: REM sleep behavior disorder (RBD) is associated with psychiatric symptoms, such as anxiety and alexithymia. …”
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875por Song, Wenfei, Wang, Ying, Wang, Nianshuang, Wang, Dongli, Guo, Jianying, Fu, Lili, Shi, Xuanling“…Based on the RBD–hDPP4 crystal structure we reported, the mutated residues were located at the interface between RBD and hDPP4, which potentially changed the polarity, hydrophobic or hydrophilic properties of hDPP4, thereby interfering or disrupting their interaction with RBD. …”
Publicado 2014
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876“…Constipation and REM sleep behaviour disorder (RBD) are the earliest non-motor manifestations of Parkinson’s disease (PD). …”
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877por Kim, Young-Il, Kim, Dokyun, Yu, Kwang-Min, Seo, Hogyu David, Lee, Shin-Ae, Casel, Mark Anthony B., Jang, Seung-Gyu, Kim, Stephanie, Jung, WooRam, Lai, Chih-Jen, Choi, Young Ki, Jung, Jae U.“…RBD-ferritin protein purified from mammalian cells efficiently assembled into 24-mer nanoparticles. 16–20 months-old ferrets were vaccinated with RBD-ferritin nanoparticles (RBD-nanoparticles) by intramuscular or intranasal inoculation. …”
Publicado 2021
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878por Cohen, Alexander A., Gnanapragasam, Priyanthi N. P., Lee, Yu E., Hoffman, Pauline R., Ou, Susan, Kakutani, Leesa M., Keeffe, Jennifer R., Wu, Hung-Jen, Howarth, Mark, West, Anthony P., Barnes, Christopher O., Nussenzweig, Michel C., Bjorkman, Pamela J.“…We made homotypic nanoparticles displaying the receptor binding domain (RBD) of SARS-CoV-2 or co-displaying SARS-CoV-2 RBD along with RBDs from animal betacoronaviruses that represent threats to humans (mosaic nanoparticles with four to eight distinct RBDs). …”
Publicado 2021
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879por Kim, Young-Il, Kim, Dokyun, Yu, Kwang-Min, Seo, Hogyu David, Lee, Shin-Ae, Casel, Mark Anthony B., Jang, Seung-Gyu, Kim, Stephanie, Jung, WooRam, Lai, Chih-Jen, Choi, Young Ki, Jung, Jae U.“…Sixteen- to 20-month-old ferrets were vaccinated with RBD-ferritin nanoparticles (RBD nanoparticles) by intramuscular or intranasal inoculation. …”
Publicado 2021
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880“…Immunoblotting showed that rSA11 viruses containing the smaller NTD, RBD, ExRBD, and CR coding sequences expressed S-protein products of expected size, with ExRBD expressed at highest levels. …”
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