Mostrando 881 - 900 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.26s Limitar resultados
  1. 881
    “…Sera (N=98) from infected individuals were tested with ELISAs based on the NP, receptor-binding domain (RBD), or both proteins. The AUROCs were 0.958 (NP), 0.991 (RBD), and 0.992 (NP/RBD). …”
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    Performance of a SARS CoV-2 antibody ELISA based on simultaneous measurement of antibodies against the viral nucleoprotein and receptor-binding domain
  2. 882
    “…BACKGROUND: Motor impairments in those with isolated REM sleep behaviour disorder (iRBD) significantly increases the likelihood of developing Lewy body disease (e.g. …”
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    Narrow doorways alter brain connectivity and step patterns in isolated REM sleep behaviour disorder
  3. 883
    “…In this study, we combine all-atom MD simulations and comprehensive mutational scanning of S-RBD complexes with the angiotensin-converting enzyme 2 (ACE2) host receptor in the native form as well as the S-RBD Delta and Omicron variants to (a) examine the differences in the dynamic signatures of the S-RBD complexes and (b) identify the critical binding hotspots and sensitivity of the mutational positions. …”
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    Computer Simulations and Network-Based Profiling of Binding and Allosteric Interactions of SARS-CoV-2 Spike Variant Complexes and the Host Receptor: Dissecting the Mechanistic Effects of the Delta and Omicron Mutations
  4. 884
    “…We employed protein structure modeling using Rosetta to compare the effects of all single mutants at the RBD-NAb and RBD-ACE2 interfaces for the wild type and Delta, Gamma, and Omicron variants. …”
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    Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape
  5. 885
    “…We also found that pramipexole had different effects on idiopathic RBD (iRBD) and secondary RBD (sRBD). These results will help to guide the clinical use of medication in patients with RBD.…”
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    The treatment efficacy of pharmacotherapies for rapid eye movement sleep behavior disorder with polysomnography evaluation: A systematic review and meta-analysis
  6. 886
    “…This study aimed to develop a model using ML algorithms to identify iRBD patients and test its accuracy. Methods: Data were acquired from 32 participants (20 iRBD patients and 12 controls). …”
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    A Machine Learning Approach for Detecting Idiopathic REM Sleep Behavior Disorder
  7. 887
    “…Compared with homologous immunization of RNA‐RBD or PS‐RBD, heterologous prime‐boost strategies for mRNA and protein subunit vaccines failed to simultaneously enhance neutralizing antibody (NAb) and Th1 cellular response in this study, showing modestly higher serum neutralizing activity and antibody‐dependent cell‐mediated cytotoxicity for “PS‐RBD prime, RNA‐RBD boost” and robust Th1 type cellular response for “RNA‐RBD prime, PS‐RBD boost”. …”
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    Mixed formulation of mRNA and protein‐based COVID‐19 vaccines triggered superior neutralizing antibody responses
  8. 888
    “…CONCLUSIONS: Altered diffusivity in the CST seems to be associated with RBD. The combination of RBD, hyposmia, and CST alterations may be related to later development of PD with comorbid RBD.…”
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    Aberrant corticospinal tract characteristics in prodromal PD: A diffusion tensor imaging study
  9. 889
    “…Wrist actigraphy can detect characteristic features in individuals with RBD; however, high‐frequency actigraphy has been rarely used. …”
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    Ambulatory Detection of Isolated Rapid‐Eye‐Movement Sleep Behavior Disorder Combining Actigraphy and Questionnaire
  10. 890
    “…RESULTS: The participants with pRBD had smaller pineal parenchyma volume (VPP) than those without pRBD (p <  0.001). …”
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    Smaller pineal gland is associated with rapid eye movement sleep behavior disorder in Alzheimer’s disease
  11. 891
    “…Here, we characterized the memory B-cell repertoire of COVID-19 convalescent donors and analyzed their RBD and non-RBD nAbs. We found that many of the non-RBD-targeting nAbs were specific to the N-terminal domain (NTD). …”
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    A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants
  12. 892
    “…We report four X-ray crystal structures of three synthetic nanobodies (sybodies) (Sb16, Sb45 and Sb68) bind to the receptor-binding domain (RBD) of SARS-CoV-2: binary complexes of Sb16–RBD and Sb45–RBD; a ternary complex of Sb45–RBD–Sb68; and Sb16 unliganded. …”
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    Synthetic nanobody–SARS-CoV-2 receptor-binding domain structures identify distinct epitopes
  13. 893
    “…Additionally, isolated RBD (iRBD) represents a prodromal stage of neurodegeneration preceding the development of α-synucleinopathies. …”
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    Dreaming in Parasomnias: REM Sleep Behavior Disorder as a Model
  14. 894
    por Gao, Bin, Zhu, Shunyi
    Publicado 2023
    “…In this study, we report two microbe-derived antibacterial defensins with RBD-binding activity. These two naturally occurring binders bind wild-type RBD (WT RBD) and RBDs from various variants with moderate-to-high affinity (7.6–1,450 nM) and act as activators that enhance the ACE2-binding activity of RBDs. …”
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    Enhancement of SARS-CoV-2 receptor-binding domain activity by two microbial defensins
  15. 895
    “…Here, the mechanism by which Msi1 recognizes the target RNA sequence using its Ribonucleoprotein (RNP)-type RNA-binding domains (RBDs), RBD1 and RBD2 has been revealed on identification of the minimal binding RNA for each RBD and determination of the three-dimensional structure of the RBD1:RNA complex. …”
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    Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions
  16. 896
    “…Isothermal titration calorimetry (ITC) experiments for each of the Rnd proteins with Plexin-B1-RBD and Plexin-B2-RBD showed similar association constants for all six interactions, although Rnd1 displayed a small preference for Plexin-B1-RBD and Rnd3 for Plexin-B2-RBD. …”
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    Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins
  17. 897
    “…Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability of developing PD in future. …”
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    Apathy in rapid eye movement sleep behaviour disorder is common and under‐recognized
  18. 898
    “…Rapid eye movement sleep behavior disorder (RBD) is a parasomnia characterized by dream-enactment behaviors that emerge during a loss of REM sleep atonia. …”
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    The “respiratory REM sleep without atonia benefit” on coexisting REM sleep behavior disorder - obstructive sleep apnea
  19. 899
    “…Aptamers inhibited the binding of the RBD to ACE2 in an ELISA assay. Inhibition, on a per weight basis, was similar to neutralizing antibodies that were specific for RBD. …”
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    Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding
  20. 900
    “…Viral infection initiates when the SARS-CoV-2 receptor-binding domain (RBD) binds to the ACE2 receptor, and thus, inhibiting RBD is a promising therapeutic for blocking viral entry. …”
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    Computational Design of Miniproteins as SARS-CoV-2 Therapeutic Inhibitors
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