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881por Reiners, Nina, Schnurra, Carolin, Trawinski, Henning, Kannenberg, Judith, Hermsdorf, Thomas, Aebischer, Andrea, Schöneberg, Torsten, Reiche, Sven, Jassoy, Christian“…Sera (N=98) from infected individuals were tested with ELISAs based on the NP, receptor-binding domain (RBD), or both proteins. The AUROCs were 0.958 (NP), 0.991 (RBD), and 0.992 (NP/RBD). …”
Publicado 2021
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882por Ehgoetz Martens, Kaylena A., Matar, Elie, Phillips, Joseph R., Shine, James M., Grunstein, Ron R., Halliday, Glenda M., Lewis, Simon J.G.“…BACKGROUND: Motor impairments in those with isolated REM sleep behaviour disorder (iRBD) significantly increases the likelihood of developing Lewy body disease (e.g. …”
Publicado 2022
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883“…In this study, we combine all-atom MD simulations and comprehensive mutational scanning of S-RBD complexes with the angiotensin-converting enzyme 2 (ACE2) host receptor in the native form as well as the S-RBD Delta and Omicron variants to (a) examine the differences in the dynamic signatures of the S-RBD complexes and (b) identify the critical binding hotspots and sensitivity of the mutational positions. …”
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884por Rochman, Nash D., Faure, Guilhem, Wolf, Yuri I., Freddolino, Peter L., Zhang, Feng, Koonin, Eugene V.“…We employed protein structure modeling using Rosetta to compare the effects of all single mutants at the RBD-NAb and RBD-ACE2 interfaces for the wild type and Delta, Gamma, and Omicron variants. …”
Publicado 2022
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885por Que, Zhiqiang, Zheng, Cuifeng, Zhao, Zhenhua, Weng, Yanhong, Zhu, Zhibao, Zeng, Yuqi, Ye, Qinyong, Lin, Fabin, Cai, Guoen“…We also found that pramipexole had different effects on idiopathic RBD (iRBD) and secondary RBD (sRBD). These results will help to guide the clinical use of medication in patients with RBD.…”
Publicado 2022
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886por Salsone, Maria, Quattrone, Andrea, Vescio, Basilio, Ferini-Strambi, Luigi, Quattrone, Aldo“…This study aimed to develop a model using ML algorithms to identify iRBD patients and test its accuracy. Methods: Data were acquired from 32 participants (20 iRBD patients and 12 controls). …”
Publicado 2022
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887por Zhang, Jialu, He, Qian, Yan, Xujia, Liu, Jianyang, Bai, Yu, An, Chaoqiang, Cui, Bopei, Gao, Fan, Mao, Qunying, Wang, Junzhi, Xu, Miao, Liang, Zhenglun“…Compared with homologous immunization of RNA‐RBD or PS‐RBD, heterologous prime‐boost strategies for mRNA and protein subunit vaccines failed to simultaneously enhance neutralizing antibody (NAb) and Th1 cellular response in this study, showing modestly higher serum neutralizing activity and antibody‐dependent cell‐mediated cytotoxicity for “PS‐RBD prime, RNA‐RBD boost” and robust Th1 type cellular response for “RNA‐RBD prime, PS‐RBD boost”. …”
Publicado 2022
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888por Pimer, Laura J., Leslie, Ronald A., Phillips, Gosia, Newman, Aaron J., Rusak, Benjamin, Rolheiser, Tyler M., Schoffer, Kerrie, Khan, M. Naeem, McKelvey, J. Roger, Robertson, Harold A., Good, Kimberley P.“…CONCLUSIONS: Altered diffusivity in the CST seems to be associated with RBD. The combination of RBD, hyposmia, and CST alterations may be related to later development of PD with comorbid RBD.…”
Publicado 2022
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889por Brink‐Kjaer, Andreas, Gupta, Niraj, Marin, Eric, Zitser, Jennifer, Sum‐Ping, Oliver, Hekmat, Anahid, Bueno, Flavia, Cahuas, Ana, Langston, James, Jennum, Poul, Sorensen, Helge B.D., Mignot, Emmanuel, During, Emmanuel“…Wrist actigraphy can detect characteristic features in individuals with RBD; however, high‐frequency actigraphy has been rarely used. …”
Publicado 2022
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890por Park, Jeongbin, Suh, Seung Wan, Kim, Grace Eun, Lee, Subin, Kim, Jun Sung, Kim, Hye Sung, Byun, Seonjeong, Bae, Jong Bin, Kim, Jae Hyoung, Kim, Sang Eun, Han, Ji Won, Kim, Ki Woong“…RESULTS: The participants with pRBD had smaller pineal parenchyma volume (VPP) than those without pRBD (p < 0.001). …”
Publicado 2020
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891por Haslwanter, Denise, Dieterle, M. Eugenia, Wec, Anna Z., O’Brien, Cecilia M., Sakharkar, Mrunal, Florez, Catalina, Tong, Karen, Rappazzo, C. Garrett, Lasso, Gorka, Vergnolle, Olivia, Wirchnianski, Ariel S., Bortz, Robert H., Laudermilch, Ethan, Fels, J. Maximilian, Mengotto, Amanda, Malonis, Ryan J., Georgiev, George I., Quiroz, Jose A., Wrapp, Daniel, Wang, Nianshuang, Dye, Kathryn E., Barnhill, Jason, Dye, John M., McLellan, Jason S., Daily, Johanna P., Lai, Jonathan R., Herbert, Andrew S., Walker, Laura M., Chandran, Kartik, Jangra, Rohit K.“…Here, we characterized the memory B-cell repertoire of COVID-19 convalescent donors and analyzed their RBD and non-RBD nAbs. We found that many of the non-RBD-targeting nAbs were specific to the N-terminal domain (NTD). …”
Publicado 2021
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892por Ahmad, Javeed, Jiang, Jiansheng, Boyd, Lisa F., Natarajan, Kannan, Margulies, David H.“…We report four X-ray crystal structures of three synthetic nanobodies (sybodies) (Sb16, Sb45 and Sb68) bind to the receptor-binding domain (RBD) of SARS-CoV-2: binary complexes of Sb16–RBD and Sb45–RBD; a ternary complex of Sb45–RBD–Sb68; and Sb16 unliganded. …”
Publicado 2021
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893por Fasiello, Elisabetta, Scarpelli, Serena, Gorgoni, Maurizio, Alfonsi, Valentina, De Gennaro, Luigi“…Additionally, isolated RBD (iRBD) represents a prodromal stage of neurodegeneration preceding the development of α-synucleinopathies. …”
Publicado 2022
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894“…In this study, we report two microbe-derived antibacterial defensins with RBD-binding activity. These two naturally occurring binders bind wild-type RBD (WT RBD) and RBDs from various variants with moderate-to-high affinity (7.6–1,450 nM) and act as activators that enhance the ACE2-binding activity of RBDs. …”
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895por Ohyama, Takako, Nagata, Takashi, Tsuda, Kengo, Kobayashi, Naohiro, Imai, Takao, Okano, Hideyuki, Yamazaki, Toshio, Katahira, Masato“…Here, the mechanism by which Msi1 recognizes the target RNA sequence using its Ribonucleoprotein (RNP)-type RNA-binding domains (RBDs), RBD1 and RBD2 has been revealed on identification of the minimal binding RNA for each RBD and determination of the three-dimensional structure of the RBD1:RNA complex. …”
Publicado 2012
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896“…Isothermal titration calorimetry (ITC) experiments for each of the Rnd proteins with Plexin-B1-RBD and Plexin-B2-RBD showed similar association constants for all six interactions, although Rnd1 displayed a small preference for Plexin-B1-RBD and Rnd3 for Plexin-B2-RBD. …”
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897por Barber, T. R., Muhammed, K., Drew, D., Lawton, M., Crabbe, M., Rolinski, M., Quinnell, T., Zaiwalla, Z., Ben‐Shlomo, Y., Husain, M., Hu, M. T. M.“…Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability of developing PD in future. …”
Publicado 2017
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898“…Rapid eye movement sleep behavior disorder (RBD) is a parasomnia characterized by dream-enactment behaviors that emerge during a loss of REM sleep atonia. …”
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899“…Aptamers inhibited the binding of the RBD to ACE2 in an ELISA assay. Inhibition, on a per weight basis, was similar to neutralizing antibodies that were specific for RBD. …”
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900“…Viral infection initiates when the SARS-CoV-2 receptor-binding domain (RBD) binds to the ACE2 receptor, and thus, inhibiting RBD is a promising therapeutic for blocking viral entry. …”
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