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961por Wang, Shunxin, Guo, Feng, Liu, Kangtai, Wang, Hongliang, Rao, Shuan, Yang, Peng, Jiang, Chengyu“…The RBD-Fc protein was purified by affinity chromatography. …”
Publicado 2008
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962por Liu, Xianglei, Drelich, Aleksandra, Li, Wei, Chen, Chuan, Sun, Zehua, Shi, Megan, Adams, Cynthia, Mellors, John W., Tseng, Chien-Te, Dimitrov, Dimiter S.“…RBD-Fc elicited a higher neutralizing antibodies titer than RBD as evaluated by a pseudovirus neutralization assay and a live virus based microneutralization assay. …”
Publicado 2020
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963por Beauchamp, Leah C., Villemagne, Victor L., Finkelstein, David I., Doré, Vincent, Bush, Ashley I., Barnham, Kevin J., Rowe, Christopher C.“…Together, these findings suggest that RBD subjects have prodromal parkinsonism supporting the concept of conducting neuroprotective therapeutic trials in RBD-enriched cohorts. …”
Publicado 2020
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964por Jette, Claudia A., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Muecksch, Frauke, Lee, Yu E., Huey-Tubman, Kathryn E., Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., West, Anthony P., Keeffe, Jennifer R., Bjorkman, Pamela J., Barnes, Christopher O.“…C118-RBD and C022-RBD structures revealed CDRH3 mainchain H-bond interactions that extended an RBD β-sheet, thus reducing sensitivity to RBD sidechain changes, and epitopes that extended from the cryptic epitope to occlude ACE2 binding. …”
Publicado 2021
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965por Pratesi, Federico, Caruso, Teresita, Testa, Davide, Tarpanelli, Tiziano, Gentili, Alessandra, Gioè, Davide, Migliorini, Paola“…IgM, IgG, and IgA anti-receptor binding domain (RBD) were tested by ELISA. Neutralizing antibodies were evaluated testing the inhibition of RBD binding to ACE2. …”
Publicado 2021
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966por Shin, Yun-Ji, König-Beihammer, Julia, Vavra, Ulrike, Schwestka, Jennifer, Kienzl, Nikolaus F., Klausberger, Miriam, Laurent, Elisabeth, Grünwald-Gruber, Clemens, Vierlinger, Klemens, Hofner, Manuela, Margolin, Emmanuel, Weinhäusel, Andreas, Stöger, Eva, Mach, Lukas, Strasser, Richard“…We found that a truncated RBD variant (RBD-215) consisting of amino acids Arg319-Leu533 can be efficiently expressed as a secreted soluble protein. …”
Publicado 2021
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967por Zheng, Luping, Ma, Yingxin, Chen, Minghai, Wu, Guoqiang, Yan, Chuang, Zhang, Xian-En“…However, the role of SARS-CoV-2 RBD N-glycosylation in viral entry remains elusive. …”
Publicado 2021
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968“…OBJECTIVES: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by abnormal and potentially violent behaviors during REM sleep, typically observed in older adult subjects. …”
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969por Bozdaganyan, Marine E., Shaitan, Konstantin V., Kirpichnikov, Mikhail P., Sokolova, Olga S., Orekhov, Philipp S.“…Further analysis of the existing RBD variants pointed to the trade-off between ACE2 binding and antigenic escape as a key limiting factor for the emergence of novel SAR-CoV-2 strains, as the naturally occurring mutations in RBD tend to reduce its binding affinity to Abs but not to ACE2. …”
Publicado 2022
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970por Sugiyama, Kazuo, Suzuki, Chouji, Aoyama, Masanori, Toyota, Nobuhiko, Nakagawa, Nozomi, Shozu, Makio, Nakai, Kanji, Iwano, Keiji“…METHODS: Serum anti-RBD antibody titers were measured monthly and the decay curve of the antibody was analyzed. …”
Publicado 2022
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971por Xu, Buzhou, Tang, Hao, Weng, Yiming, Jones, Valerie Sloane, Luo, Shuhong, Cho, Chih Yun, Lin, Yongping, Fang, Jianmin, Song, Xuedong, Huang, Ruo‐Pan“…The device emits a fluorescent signal in the presence of S1‐RBD, which can be captured by an automated TRF instrument. …”
Publicado 2022
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972por La Morgia, Chiara, Romagnoli, Martina, Pizza, Fabio, Biscarini, Francesco, Filardi, Marco, Donadio, Vincenzo, Carbonelli, Michele, Amore, Giulia, Park, Jason C., Tinazzi, Michele, Carelli, Valerio, Liguori, Rocco, Plazzi, Giuseppe, Antelmi, Elena“…OBJECTIVES: To quantitatively compare PLR and mRGC‐mediated contribution to PLR in 16 iRBD patients and 16 healthy controls. METHODS: iRBD and controls underwent extensive neuro‐ophthalmological evaluation and chromatic pupillometry. …”
Publicado 2021
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973“…In this study, we constructed a recombinant Vaccinia virus (VV) harboring trimeric receptor-binding domain (RBD) of SARS-CoV-2 spike protein (VV(-tRBD)), and evaluated the immune responses towards RBD following intranasal immunization against mice and rabbits. …”
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974por Yao, Xiangyu, Zhang, Zhichao, Mei, Qingmin, Li, Shenwei, Xing, Li, Long, Yali, Zhang, Demei, Wang, Jing, Wang, Xiedong, Xie, Bin, Yang, Bo, Gao, Yong, Wu, Changxin, Meng, Qinglai“…Herein, we established a bead-based flow cytometric CB assay and tested the detection performance of six combination models, i.e. immobilized ACE2 and soluble Fc-tagged S1 subunit of S protein (iACE2/S1-Fc), immobilized ACE2 and soluble Fc-tagged receptor binding domain (RBD) of S protein (iACE2/RBD-Fc), immobilized S1 and soluble Fc-tagged ACE2 (iS1/ACE2-Fc), immobilized S1 and soluble His-tagged ACE2 (iS1/ACE2-His), immobilized RBD and soluble Fc-tagged ACE2 (iRBD/ACE2-Fc), and immobilized RBD and soluble His-tagged ACE2 (iRBD/ACE2-His). …”
Publicado 2022
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975por Zheng, Bin, Xiao, Yuelong, Tong, Bei, Mao, Yutong, Ge, Rui, Tian, Fang, Dong, Xianchi, Zheng, Peng“…[Image: see text] A cluster of several newly occurring mutations on Omicron is found at the β-core region of the spike protein’s receptor-binding domain (RBD), where mutation rarely happened before. Notably, the binding of SARS-CoV-2 to human receptor ACE2 via RBD happens in a dynamic airway environment, where mechanical force caused by coughing or sneezing occurs. …”
Publicado 2023
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976“…The lead pentasaccharide with the highest affinity for RBD was analyzed via drug-likeness calculations, showing better predicted druggable profiles than those currently reported for RBD-binding HS mimetics. …”
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977por Blanas, Athanasios, Karsjens, Haiko, de Ligt, Aafke, Huijbers, Elisabeth J.M., van Loon, Karlijn, Denisov, Stepan S., Durukan, Canan, Engbersen, Diederik J.M., Groen, Jan, Hennig, Sven, Hackeng, Tilman M., van Beijnum, Judy R., Griffioen, Arjan W.“…Immunization studies in mice showed that the conjugation of CDP to RBD induced superior immune responses compared to RBD alone. …”
Publicado 2022
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978por Augusto, Gilles, Mohsen, Mona O., Zinkhan, Simon, Liu, Xuelan, Vogel, Monique, Bachmann, Martin F.“…METHODS: To this end, we produced recombinant wild‐type RBD, as well as RBD containing each of the mutations L452R/E484Q, N440K, or E484K (the latest present in variants of concern B.1.351 and P.1), as well as the ectodomain of ACE2. …”
Publicado 2021
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979por Horn, Michael P., Jonsdottir, Hulda R., Brigger, Daniel, Damonti, Lauro, Suter‐Riniker, Franziska, Endrich, Olga, Froehlich, Tanja K., Fiedler, Martin, Largiadèr, Carlo R., Marschall, Jonas, Weber, Benjamin, Eggel, Alexander, Nagler, Michael“…Sensitivity was 84.7% in anti‐S1/S2 CLIA, 84.0% in anti‐RBD+LFI, 81.0% in anti‐N CLIA, 79.2% in anti‐RBD ELISA, and 65.6% in anti‐N ELISA. …”
Publicado 2022
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980por Lan, Jiaming, Deng, Yao, Chen, Hong, Lu, Guangwen, Wang, Wen, Guo, Xiaojuan, Lu, Zhuozhuang, Gao, George F., Tan, Wenjie“…Some studies have indicated the receptor-binding domain (RBD) protein of MERS-CoV spike (S) is a good candidate antigen for a MERS-CoV subunit vaccine. …”
Publicado 2014
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