Mostrando 81 - 100 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.19s Limitar resultados
  1. 81
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    High Heterogeneity of Virus-Neutralizing and RBD-Binding Activities of COVID-19 Convalescent Sera
  2. 82
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    Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding
  3. 83
    “…INTRODUCTION: Rapid Eye Movement Sleep Behavior Disorder (RBD) and hyposmia are common in synucleinopathies and they tend to occur in connection to the prodromal development of these disorders. …”
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    RBD and hyposmia in Moroccan patients with a synucleinopathy: prevalence and the timing of occurrence in a large cohort
  4. 84
    “…Most vaccination strategies against COVID-19 have targeted the spike protein of SARS-CoV-2 to generate neutralizing antibodies. P1, a truncated RBD-derived spike protein, has been shown to induce virus-neutralizing antibodies in preclinical studies. …”
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    A Recombinant RBD-Based Phage Vaccine Report: A Solution to the Prevention of New Diseases?
  5. 85
    “…Here, we generated an IgG-like bispecific antibody (bsAb), Bi-Nab, based on a pair of human neutralizing antibodies targeting multiple and invariant sites of the spike receptor binding domain (RBD): 35B5 and 32C7. We demonstrated that Bi-Nab exhibited higher binding affinity to the Delta spike protein than its parental antibodies and presented an extended inhibition breadth of preventing RBD binding to angiotensin-converting enzyme 2 (ACE2), the cellular receptor of SARS-CoV-2. …”
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    An RBD bispecific antibody effectively neutralizes a SARS-CoV-2 Omicron variant
  6. 86
    por Song, Siyuan, Shi, Qinghong
    Publicado 2023
    “…Molecular docking was performed using HADDOCK software, and three potential Z(RBD) affibodies, Z(RBD)-02, Z(RBD)-04, and Z(RBD)-07, were obtained. …”
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    Interface-Based Design of High-Affinity Affibody Ligands for the Purification of RBD from Spike Proteins
  7. 87
    “…This information can prove very useful in providing mechanistic information and insights about the mechanism of interactions between ACE2 and SARS-CoV-2 RBD or similar systems.…”
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    Advanced Analysis of Biosensor Data for SARS-CoV-2 RBD and ACE2 Interactions
  8. 88
    “…The spike (S) protein, and particularly its receptor-binding domain (RBD), mediates the interaction with the angiotensin-converting enzyme 2 (ACE2) receptor on host cells and may be modulated by its structural features. …”
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    Structural and Functional Characterization of SARS-CoV-2 RBD Domains Produced in Mammalian Cells
  9. 89
    “…BLI assay further confirmed that corilagin exhibits a relatively strong binding affinity to SARS-CoV-2-RBD and hACE2 protein. In addition, corilagin dose-dependently blocks SARS-CoV-2-RBD binding and abolishes the infectious property of RBD-pseudotyped lentivirus in hACE2 overexpressing HEK293 cells, which mimicked the entry of SARS-CoV-2 virus in human host cells. …”
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    Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding
  10. 90
    “…Since anti-spike mAbs, used individually, might be unable to block the virus entry in the case of resistant mutations, we designed an innovative strategy for the isolation of multiple novel human scFvs specific for the binding domain (RBD) of Spike. By panning a large phage display antibody library on immobilized RBD, we obtained specific binders by eluting with ACE2 in order to identify those scFvs recognizing the epitope of Spike interacting with its receptor. …”
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    Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2
  11. 91
    “…Many efforts have been made to design or repurpose therapeutics to deactivate the RBD or ACE2 and prevent the initial binding. In addition to direct inhibition strategies, small chemical compounds might be able to interfere and destabilize the metastable, prefusion complex of ACE2-RBD. …”
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    Small molecule therapeutics to destabilize the ACE2-RBD complex: A molecular dynamics study
  12. 92
    “…Here we use a yeast-display system to map all mutations to the viral spike receptor-binding domain (RBD) that escape binding by representatives of three potently neutralizing classes of anti-RBD antibodies with high-resolution structures. …”
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    Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies
  13. 93
    por Schenck, Carlos H.
    Publicado 2021
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    RBD, sexsomnia, sleepwalking, and sleep paralysis comorbidities: relevance to pulmonary, dental, and behavioral sleep medicine
  14. 94
    “…We employed protein structure modeling using Rosetta to compare the effects of all single mutants at the RBD-NAb and RBD-ACE2 interfaces for the WT, Delta, Gamma, and Omicron variants. …”
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    Epistasis at the SARS-CoV-2 RBD Interface and the Propitiously Boring Implications for Vaccine Escape
  15. 95
    “…The more neutralizing mAb, 2B04, binds the receptor-binding motif (RBM) of the receptor-binding domain (RBD) and competes with angiotensin-converting enzyme 2 (ACE2). …”
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    Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD
  16. 96
    “…Deep-mutational scanning experiments identify the potential binding epitopes of the Nbs on the RBD and demonstrate that biparatopic Nb1–Nb2 has a strong escape-resistant feature against more than 60 tested RBD amino acid substitutions. …”
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    An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants
  17. 97
    “…This effective protocol for the RBD production in transient eukaryotic system can be immediately extended to the production of RBD mutants.…”
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    Expression, purification and characterization of SARS-CoV-2 spike RBD in ExpiCHO cells
  18. 98
    “…Additionally, we observed that anti-RBD avidity increased similarly after SARS-CoV-2 mRNA vaccination and after SARS-CoV-2 infection. …”
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    Evolution of Anti-RBD IgG Avidity following SARS-CoV-2 Infection
  19. 99
    “…Rapid eye movement sleep behavior disorder (RBD) is associated with high likelihood of prodromal Parkinson’s disease (PD) and is common in de novo PD. …”
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    Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment
  20. 100
    “…The Microblot-Array COVID-19 IgG assay was used to detect antibodies against three major SARS-CoV-2 antigens: nucleocapsid (NCP), RBD, and Spike 2 (S2). The aim of our study was to determine the seroprevalence and titer of anti-SARS-CoV-2 IgG antibodies—NCP, RBD, and S2—as markers of the humoral response in vaccinated and unvaccinated HCWs. …”
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    Antibodies to NCP, RBD and S2 SARS-CoV-2 in Vaccinated and Unvaccinated Healthcare Workers
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