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81por Astakhova, E. A., Byazrova, M. G., Yusubalieva, G. M., Larichev, V. F., Baklaushev, V. P., Filatov, A. V.Enlace del recurso
Publicado 2022
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82por Lin, Sheng, Chen, Zimin, Zhang, Xindan, Wen, Ao, Yuan, Xin, Yu, Chongzhang, Yang, Jing, He, Bin, Cao, Yu, Lu, GuangwenEnlace del recurso
Publicado 2022
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83por El Otmani, Hicham, Daghi, Mohamed, Maghfour, Manal, Haddouali, Kamal, Bellakhdar, Salma, El Moutawakil, Bouchra, Tahiri Jouti, Nadia, Rafai, Mohammed Abdoh“…INTRODUCTION: Rapid Eye Movement Sleep Behavior Disorder (RBD) and hyposmia are common in synucleinopathies and they tend to occur in connection to the prodromal development of these disorders. …”
Publicado 2023
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84“…Most vaccination strategies against COVID-19 have targeted the spike protein of SARS-CoV-2 to generate neutralizing antibodies. P1, a truncated RBD-derived spike protein, has been shown to induce virus-neutralizing antibodies in preclinical studies. …”
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85por Yuan, Mengqi, Zhu, Yanzhi, Liu, Guanlan, Wang, Yujie, Wang, Guanxi, Zhang, Guozhong, Ye, Lilin, Qian, Zhaohui, Liu, Pinghuang“…Here, we generated an IgG-like bispecific antibody (bsAb), Bi-Nab, based on a pair of human neutralizing antibodies targeting multiple and invariant sites of the spike receptor binding domain (RBD): 35B5 and 32C7. We demonstrated that Bi-Nab exhibited higher binding affinity to the Delta spike protein than its parental antibodies and presented an extended inhibition breadth of preventing RBD binding to angiotensin-converting enzyme 2 (ACE2), the cellular receptor of SARS-CoV-2. …”
Publicado 2023
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86“…Molecular docking was performed using HADDOCK software, and three potential Z(RBD) affibodies, Z(RBD)-02, Z(RBD)-04, and Z(RBD)-07, were obtained. …”
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87“…This information can prove very useful in providing mechanistic information and insights about the mechanism of interactions between ACE2 and SARS-CoV-2 RBD or similar systems.…”
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88por Gstöttner, Christoph, Zhang, Tao, Resemann, Anja, Ruben, Sophia, Pengelley, Stuart, Suckau, Detlev, Welsink, Tim, Wuhrer, Manfred, Domínguez-Vega, Elena“…The spike (S) protein, and particularly its receptor-binding domain (RBD), mediates the interaction with the angiotensin-converting enzyme 2 (ACE2) receptor on host cells and may be modulated by its structural features. …”
Publicado 2021
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89por Yang, Li Jun, Chen, Rui Hong, Hamdoun, Sami, Coghi, Paolo, Ng, Jerome P.L., Zhang, David Wei, Guo, Xiaoling, Xia, Chenglai, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai“…BLI assay further confirmed that corilagin exhibits a relatively strong binding affinity to SARS-CoV-2-RBD and hACE2 protein. In addition, corilagin dose-dependently blocks SARS-CoV-2-RBD binding and abolishes the infectious property of RBD-pseudotyped lentivirus in hACE2 overexpressing HEK293 cells, which mimicked the entry of SARS-CoV-2 virus in human host cells. …”
Publicado 2021
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90por Passariello, Margherita, Gentile, Chiara, Ferrucci, Veronica, Sasso, Emanuele, Vetrei, Cinzia, Fusco, Giovanna, Viscardi, Maurizio, Brandi, Sergio, Cerino, Pellegrino, Zambrano, Nicola, Zollo, Massimo, De Lorenzo, Claudia“…Since anti-spike mAbs, used individually, might be unable to block the virus entry in the case of resistant mutations, we designed an innovative strategy for the isolation of multiple novel human scFvs specific for the binding domain (RBD) of Spike. By panning a large phage display antibody library on immobilized RBD, we obtained specific binders by eluting with ACE2 in order to identify those scFvs recognizing the epitope of Spike interacting with its receptor. …”
Publicado 2021
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91“…Many efforts have been made to design or repurpose therapeutics to deactivate the RBD or ACE2 and prevent the initial binding. In addition to direct inhibition strategies, small chemical compounds might be able to interfere and destabilize the metastable, prefusion complex of ACE2-RBD. …”
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92por Greaney, Allison J., Starr, Tyler N., Barnes, Christopher O., Weisblum, Yiska, Schmidt, Fabian, Caskey, Marina, Gaebler, Christian, Cho, Alice, Agudelo, Marianna, Finkin, Shlomo, Wang, Zijun, Poston, Daniel, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J., Bloom, Jesse D.“…Here we use a yeast-display system to map all mutations to the viral spike receptor-binding domain (RBD) that escape binding by representatives of three potently neutralizing classes of anti-RBD antibodies with high-resolution structures. …”
Publicado 2021
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94por Rochman, Nash D., Faure, Guilhem, Wolf, Yuri I., Freddolino, Peter L., Zhang, Feng, Koonin, Eugene V.“…We employed protein structure modeling using Rosetta to compare the effects of all single mutants at the RBD-NAb and RBD-ACE2 interfaces for the WT, Delta, Gamma, and Omicron variants. …”
Publicado 2021
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95por Errico, John M., Zhao, Haiyan, Chen, Rita E., Liu, Zhuoming, Case, James Brett, Ma, Meisheng, Schmitz, Aaron J., Rau, Michael J., Fitzpatrick, James A.J., Shi, Pei-Yong, Diamond, Michael S., Whelan, Sean P.J., Ellebedy, Ali H., Fremont, Daved H.“…The more neutralizing mAb, 2B04, binds the receptor-binding motif (RBM) of the receptor-binding domain (RBD) and competes with angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2021
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96por Chi, Xiaojing, Zhang, Xinhui, Pan, Shengnan, Yu, Yanying, Shi, Yujin, Lin, Tianli, Duan, Huarui, Liu, Xiuying, Chen, Wenfang, Yang, Xuehua, Chen, Lan, Dong, Xiaoqian, Ren, Lili, Ding, Qiang, Wang, Jianwei, Yang, Wei“…Deep-mutational scanning experiments identify the potential binding epitopes of the Nbs on the RBD and demonstrate that biparatopic Nb1–Nb2 has a strong escape-resistant feature against more than 60 tested RBD amino acid substitutions. …”
Publicado 2022
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97por De March, Matteo, Terdoslavich, Michela, Polez, Sulena, Guarnaccia, Corrado, Poggianella, Monica, Marcello, Alessandro, Skoko, Nataša, de Marco, Ario“…This effective protocol for the RBD production in transient eukaryotic system can be immediately extended to the production of RBD mutants.…”
Publicado 2022
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98por Tauzin, Alexandra, Gendron-Lepage, Gabrielle, Nayrac, Manon, Anand, Sai Priya, Bourassa, Catherine, Medjahed, Halima, Goyette, Guillaume, Dubé, Mathieu, Bazin, Renée, Kaufmann, Daniel E., Finzi, Andrés“…Additionally, we observed that anti-RBD avidity increased similarly after SARS-CoV-2 mRNA vaccination and after SARS-CoV-2 infection. …”
Publicado 2022
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99por Oltra, Javier, Uribe, Carme, Segura, Barbara, Campabadal, Anna, Inguanzo, Anna, Monté-Rubio, Gemma C., Pardo, Jèssica, Marti, Maria J., Compta, Yaroslau, Valldeoriola, Francesc, Junque, Carme, Iranzo, Alex“…Rapid eye movement sleep behavior disorder (RBD) is associated with high likelihood of prodromal Parkinson’s disease (PD) and is common in de novo PD. …”
Publicado 2022
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100por Błaszczuk, Agata, Michalski, Aleksander, Malm, Maria, Drop, Bartłomiej, Polz-Dacewicz, Małgorzata“…The Microblot-Array COVID-19 IgG assay was used to detect antibodies against three major SARS-CoV-2 antigens: nucleocapsid (NCP), RBD, and Spike 2 (S2). The aim of our study was to determine the seroprevalence and titer of anti-SARS-CoV-2 IgG antibodies—NCP, RBD, and S2—as markers of the humoral response in vaccinated and unvaccinated HCWs. …”
Publicado 2022
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