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981por Stefani, Ambra, Heidbreder, Anna, Brandauer, Elisabeth, Guaita, Marc, Neier, Lisa-Marie, Mitterling, Thomas, Santamaria, Joan, Iranzo, Alex, Videnovic, Aleksander, Trenkwalder, Claudia, Sixel-Döring, Friederike, Wenning, Gregor K, Chade, Anabel, Poewe, Werner, Gershanik, Oscar S, Högl, Birgit“…STUDY OBJECTIVES: To evaluate the utility of multimodal low-cost approaches including actigraphy, a wrist-worn device monitoring rest/activity cycles, in identifying patients with idiopathic REM sleep behavior disorder (iRBD). METHODS: Seventy patients diagnosed with sleep disorders causing different motor manifestations during sleep (iRBD, sleep apnea, restless legs syndrome) and 20 subjects without any relevant motor manifestation during sleep, underwent video-polysomnography (vPSG) and 2 week actigraphy, completed six validated RBD screening questionnaires, and sleep apps use was assessed. …”
Publicado 2018
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982por Arora, Siddharth, Baig, Fahd, Lo, Christine, Barber, Thomas R., Lawton, Michael A., Zhan, Andong, Rolinski, Michal, Ruffmann, Claudio, Klein, Johannes C., Rumbold, Jane, Louvel, Amandine, Zaiwalla, Zenobia, Lennox, Graham, Quinnell, Tim, Dennis, Gary, Wade-Martins, Richard, Ben-Shlomo, Yoav, Little, Max A., Hu, Michele T.“…For the 3 pairwise discriminatory comparisons, (1) controls vs iRBD, (2) controls vs PD, and (3) iRBD vs PD, the mean sensitivity and specificity values ranged from 84.6% to 91.9%. …”
Publicado 2018
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983por de Natale, Edoardo Rosario, Ginatempo, Francesca, Laccu, Ilaria, Figorilli, Michela, Manca, Andrea, Mercante, Beniamina, Puligheddu, Monica, Deriu, Franca“…Results: Compared with controls, iRBD had higher rates of abnormalities both in the VEMP battery (iRBD 75%, Controls 23%; p < 0.01) as well as in each single VEMP (cVEMP: 45 vs. 5%; mVEMP: 65 vs. 13.6%; oVEMP: 50 vs. 5%; p < 0.01), which exhibited significantly lower amplitudes (cVEMP and oVEMP: p < 0.0001; mVEMP: p = 0.001) in iRBD. …”
Publicado 2018
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984por Han, Xian-Hua, Li, Xiu-Ming, Tang, Wei-Jun, Yu, Huan, Wu, Ping, Ge, Jing-Jie, Wang, Jian, Zuo, Chuan-Tao, Shi, Kuang-Yu“…Idiopathic rapid eye movement sleep behavior disorder (iRBD) is often a precursor to neurodegenerative disease. …”
Publicado 2019
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985por Yoon, Eun Jin, Lee, Jee-Young, Nam, Hyunwoo, Kim, Han-Joon, Jeon, Beomseok, Jeong, Jae Min, Kim, Yu Kyeong“…BACKGROUND AND PURPOSE: To identify a metabolic network reflecting neurodegeneration in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). METHODS: We recruited a prospective cohort comprising patients with de novo Parkinson's disease (PD) with probable REM sleep behavior disorder (PDRBD, n=21), polysomnography-confirmed iRBD patients (n=28), and age-matched healthy controls (HC) (n=24). …”
Publicado 2019
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986por Hussain, Arif, Hasan, Anwarul, Nejadi Babadaei, Mohammad Mahdi, Bloukh, Samir Haj, Chowdhury, Muhammad E.H., Sharifi, Majid, Haghighat, Setareh, Falahati, Mojtaba“…Afterwards, the mechanism of interaction of RBD and different mAbs were explained and it was suggested that one of the SARS-CoV-specific human mAbs, namely CR3022, could show the highest binding affinity with SARS-CoV2 S-protein RBD. …”
Publicado 2020
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987por Deng, Fang, Zhang, Yanan, Zhang, Ran, Tang, Qi, Guo, Zhenni, Lv, Yudan, Wang, Zan, Yang, Yi“…Results: The overall PD of the IH, NT1-RBD, and NT1 + RBD groups were lower than that of the control group (P < 0.001). …”
Publicado 2021
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988por Ma, Lin, Liu, Shu-Ying, Cen, Shan-Shan, Li, Yuan, Zhang, Hui, Han, Chao, Gu, Zhu-Qin, Mao, Wei, Ma, Jing-Hong, Zhou, Yong-Tao, Xu, Er-He, Chan, Piu“…Patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at high risk for conversion to synucleinopathy and Parkinson disease (PD). …”
Publicado 2021
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989por Tanaka, Shiho, Nelson, Gard, Olson, C. Anders, Buzko, Oleksandr, Higashide, Wendy, Shin, Annie, Gonzalez, Marcos, Taft, Justin, Patel, Roosheel, Buta, Sofija, Richardson, Ashley, Bogunovic, Dusan, Spilman, Patricia, Niazi, Kayvan, Rabizadeh, Shahrooz, Soon-Shiong, Patrick“…The ACE2 Triple Decoy maintains high affinity for mutated S RBD, displays enhanced affinity for S RBD N501Y or L452R, and has the highest affinity for S RBD with both E484K and N501Y mutations, making it a viable therapeutic option for the prevention or treatment of SARS-CoV-2 infection with a high likelihood of efficacy against variants.…”
Publicado 2021
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990“…The assembly processes of GNPs@MUA, anti-RBD antibodies and RBD antigens were characterized electrochemical, chemical and morphological techniques. …”
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991por Jette, Claudia A., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Muecksch, Frauke, Lee, Yu E., Huey-Tubman, Kathryn E., Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., West, Anthony P., Keeffe, Jennifer R., Bjorkman, Pamela J., Barnes, Christopher O.“…C118-RBD and C022-RBD structures reveal orientations that extend from the cryptic epitope to occlude ACE2 binding and CDRH3-RBD main-chain H-bond interactions that extend an RBD β sheet, thus reducing sensitivity to RBD side-chain changes. …”
Publicado 2021
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992por Schwestka, Jennifer, König-Beihammer, Julia, Shin, Yun-Ji, Vavra, Ulrike, Kienzl, Nikolaus F., Grünwald-Gruber, Clemens, Maresch, Daniel, Klausberger, Miriam, Laurent, Elisabeth, Stadler, Maria, Manhart, Gabriele, Huber, Jasmin, Hofner, Manuela, Vierlinger, Klemens, Weinhäusel, Andreas, Swoboda, Ines, Binder, Christoph J., Gerner, Wilhelm, Grebien, Florian, Altmann, Friedrich, Mach, Lukas, Stöger, Eva, Strasser, Richard“…The RBD is a major target for neutralizing antibodies, whilst recombinant RBD is commonly used as an antigen in serological assays. …”
Publicado 2021
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993por Gattinger, Pia, Niespodziana, Katarzyna, Stiasny, Karin, Sahanic, Sabina, Tulaeva, Inna, Borochova, Kristina, Dorofeeva, Yulia, Schlederer, Thomas, Sonnweber, Thomas, Hofer, Gerhard, Kiss, Renata, Kratzer, Bernhard, Trapin, Doris, Tauber, Peter A., Rottal, Arno, Körmöczi, Ulrike, Feichter, Melanie, Weber, Milena, Focke‐Tejkl, Margarete, Löffler‐Ragg, Judith, Mühl, Bernhard, Kropfmüller, Anna, Keller, Walter, Stolz, Frank, Henning, Rainer, Tancevski, Ivan, Puchhammer‐Stöckl, Elisabeth, Pickl, Winfried F., Valenta, Rudolf“…Twenty percent of patients selectively lacked RBD‐specific IgG. Only immunization with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus‐neutralizing activity. …”
Publicado 2021
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994“…Ag-specific mucosal immunoglobulin (Ig) A and systemic IgG, together with virus-neutralizing activities, were highly induced in mice immunized with Co4B-conjugated S-RBD (S-RBD-Co4B) compared to those immunized with unconjugated S-RBD. …”
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995“…The cell-surface Glucose Regulated Protein 78 (GRP78) attached to the mutated ACE2-SARS-CoV-2 Spike RBD complex is modeled. The results showed that GRP78 β-substrate-binding domain weakly binds to the wild-type RBD combined with angiotensin-converting enzyme 2 (ACE2) within the SARS-CoV-2 Spike RBD-ACE2 complex. …”
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996por Yu, Yunkai, Esposito, Dominic, Kang, Zhigang, Lu, Jianming, Remaley, Alan T., De Giorgi, Valeria, Chen, Leonard N., West, Kamille, Cao, Liang“…Those with mutations in the angiotensin-converting enzyme (ACE2) receptor binding domain (RBD) are associated with increased transmission and severity. …”
Publicado 2022
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997por Amoghavarsha, Chittaragi, Pramesh, Devanna, Sridhara, Shankarappa, Patil, Balanagouda, Shil, Sandip, Naik, Ganesha R., Naik, Manjunath K., Shokralla, Shadi, El-Sabrout, Ahmed M., Mahmoud, Eman A., Elansary, Hosam O., Nayak, Anusha, Prasannakumar, Muthukapalli K.“…Rice is a globally important crop and highly vulnerable to rice blast disease (RBD). We studied the spatial distribution of RBD by considering the 2-year exploratory data from 120 sampling sites over varied rice ecosystems of Karnataka, India. …”
Publicado 2022
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998por Zhou, Li, Chau, Steven W. H., Liu, Yaping, Wang, Jing, Zhang, Jihui, Chan, Ngan Yin, Chan, Joey W. Y., Huang, Bei, Chen, Sijing, Li, Shirley Xin, Mok, Vincent Chung Tong, Wing, Yun Kwok“…We aimed to investigate the personality profile and its association with future neurodegenerative phenoconversion in iRBD patients. One hundred and eighty-five video-polysomnography confirmed iRBD patients and 91 age- and sex-matched controls underwent personality assessment using the NEO five-factor inventory, and 171 iRBD patients were followed up. …”
Publicado 2022
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999por Prados de la Torre, Esther, Obando, Ignacio, Vidal, Marta, de Felipe, Beatriz, Aguilar, Ruth, Izquierdo, Luis, Carolis, Carlo, Olbrich, Peter, Capilla-Miranda, Ana, Serra, Pau, Santamaria, Pere, Blanco-Lobo, Pilar, Moncunill, Gemma, Rodríguez-Ortega, Manuel J., Dobaño, Carlota“…Comparison of antibody levels against RBD-Wuhan versus RBD-VoCs indicated that the strongest positive correlations for all three isotypes were with RBD-Alpha, while the lowest correlations were with RBD-Delta for IgG, RBD-Gamma for IgM, and RBD-Beta for IgA. …”
Publicado 2022
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1000por Sekhon, Simranjeet Singh, Shin, Woo‐Ri, Kim, Sang Yong, Jeong, Dong‐Seok, Choi, Wooil, Choi, Bong‐Keun, Min, Jiho, Ahn, Ji‐Young, Kim, Yang‐Hoon“…The emergence of new SARS‐CoV‐2 variants with key mutations in RBD had a negligible effect on the binding of the RBD variants to hCypA, indicating an effective mitigation strategy for SARS‐CoV‐2 variants. …”
Publicado 2022
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