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1021“…BACKGROUND: Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health controls. …”
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1022por Wang, Qihui, Qi, Jianxun, Yuan, Yuan, Xuan, Yifang, Han, Pengcheng, Wan, Yuhua, Ji, Wei, Li, Yan, Wu, Ying, Wang, Jianwei, Iwamoto, Aikichi, Woo, Patrick C.Y., Yuen, Kwok-Yung, Yan, Jinghua, Lu, Guangwen, Gao, George F.“…The structure of the HKU4-RBD/hCD26 complex revealed a hCD26-binding mode similar overall to that observed for MERS-RBD. …”
Publicado 2014
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1023por Sunwoo, Jun-Sang, Kim, Young Ji, Byun, Jung-Ick, Kim, Tae-Joon, Jun, Jin-Sun, Lee, Soon-Tae, Jung, Keun-Hwa, Park, Kyung-Il, Chu, Kon, Kim, Manho, Lee, Sang Kun, Kim, Han-Joon, Schenck, Carlos H., Jung, Ki-Young“…We aimed to identify the association between depression and treatment response in patients with idiopathic RBD (iRBD). METHODS: We reviewed the medical records of 123 consecutive patients (76 males; age, 66.0±7.7 years; and symptom duration, 4.1±4.0 years) with iRBD who were treated with clonazepam and/or melatonin. …”
Publicado 2020
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1024por Shang, Jian, Wan, Yushun, Luo, Chuming, Ye, Gang, Geng, Qibin, Auerbach, Ashley, Li, Fang“…Our findings have identified key cell entry mechanisms of SARS-CoV-2. First, SARS-CoV-2 RBD has higher hACE2 binding affinity than SARS-CoV RBD, supporting efficient cell entry. …”
Publicado 2020
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1025por Dai, Lianpan, Zheng, Tianyi, Xu, Kun, Han, Yuxuan, Xu, Lili, Huang, Enqi, An, Yaling, Cheng, Yingjie, Li, Shihua, Liu, Mei, Yang, Mi, Li, Yan, Cheng, Huijun, Yuan, Yuan, Zhang, Wei, Ke, Changwen, Wong, Gary, Qi, Jianxun, Qin, Chuan, Yan, Jinghua, Gao, George F.“…Structure-guided design further yielded a stable version of RBD-dimer as a tandem repeat single-chain (RBD-sc-dimer) which retained the vaccine potency. …”
Publicado 2020
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1026“…Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is a predictor of neurodegeneration, yet there have been limited studies evaluating the relationship between cognitive decline and amyloid accumulation in iRBD patients. …”
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1027“…In the current study, we simulate the complex ACE2-SARS-CoV-2 spike RBD system in which the RBD is in the wild-type and mutated isoforms. …”
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1028“…In this work, we first constructed RBD-encoding mRNA (RBD-mRNA) formulated in liposomes (LPX/RBD-mRNA) and investigated the influence of administration routes on the immunogenicity. …”
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1029por Singh, Rahul, Bhardwaj, Vijay Kumar, Sharma, Jatin, Kumar, Dinesh, Purohit, Rituraj“…The Spike receptor binding domain (S-RBD) from SARS-CoV-2, a crucial protein for the entrance of the virus into target cells is known to cause infection by binding to a cell surface protein. …”
Publicado 2021
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1030por Koonpaew, Surapong, Kaewborisuth, Challika, Srisutthisamphan, Kanjana, Wanitchang, Asawin, Thaweerattanasinp, Theeradej, Saenboonrueng, Janya, Poonsuk, Sukontip, Jengarn, Juggragarn, Viriyakitkosol, Ratchanont, Kramyu, Jarin, Jongkaewwattana, Anan“…The C-terminus of the RBD was designed to link with the cytoplasmic domain of the influenza virus hemagglutinin (HA) to anchor the RBD on the surface of producing cells and virus envelope. …”
Publicado 2021
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1031por Basit, Abdul, Karim, Asad Mustafa, Asif, Muhammad, Ali, Tanveer, Lee, Jung Hun, Jeon, Jeong Ho, Rehman, Shafiq ur, Lee, Sang Hee“…SARS-CoV-2 enters human cells by interacting with human angiotensin-converting enzyme 2 (ACE2) receptor expressed on human cell surface through utilizing receptor-binding domain (RBD) of its spike glycoprotein. The RBD is highly conserved and is also a potential target for blocking its interaction with human cell surface receptor. …”
Publicado 2021
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1032por Geng, Qibin, Tai, Wanbo, Baxter, Victoria K., Shi, Juan, Wan, Yushun, Zhang, Xiujuan, Montgomery, Stephanie A., Taft-Benz, Sharon A., Anderson, Elizabeth J., Knight, Audrey C., Dinnon, Kenneth H., Leist, Sarah R., Baric, Ralph S., Shang, Jian, Hong, Sung-Wook, Drelich, Aleksandra, Tseng, Chien-Te K., Jenkins, Marc, Heise, Mark, Du, Lanying, Li, Fang“…Here we have developed a novel virus-like nanoparticle (VLP) vaccine that displays 120 copies of SARS-CoV-2 RBD on its surface. This VLP-RBD vaccine mimics virus-based vaccines in immunogen display, which boosts its efficacy, while maintaining the safety of protein-based subunit vaccines. …”
Publicado 2021
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1033por Das, Jayanta Kumar, Thakuri, Bikash, MohanKumar, Krishnan, Roy, Swarup, Sljoka, Adnan, Sun, Gui-Quan, Chakraborty, Amit“…Despite the hundreds of apparently neutral mutations observed in the domains other than the RBD, we have shown that each RBD mutation site is differentially engaged in an interdomain allosteric network involving mutation sites from a distant domain, affecting interactions with the human receptor angiotensin-converting enzyme-2 (ACE2). …”
Publicado 2021
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1034Immunogenicity of the COVID-19 BNT162b2 vaccine in adolescents and young adults with cystic fibrosispor Michos, Athanasios, Filippatos, Filippos, Tatsi, Elizabeth-Barbara, Dellis, Charilaos, Efthymiou, Vasiliki, Zarkada, Ioanna, Troupi, Evgenia, Syriopoulou, Vasiliki, Loukou, Ioanna“…We prospectively measured total (TAbs-RBD; U/ml) and neutralizing (NAbs-RBD; %) antibodies of SARS-CoV-2 spike-receptor binding domain (RBD) protein in 33 CF patients and 66 healthy controls with median age (IQR): 19.6 (17.6–24.3) years and 31 (29–36) years, respectively and investigated possible associations with epidemiological and clinical parameters. …”
Publicado 2022
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1035por Windsor, Ian W., Tong, Pei, Lavidor, Olivia, Sanjari Moghaddam, Ali, McKay, Lindsay G.A., Gautam, Avneesh, Chen, Yuezhou, MacDonald, Elizabeth A., Yoo, Duck Kyun, Griffiths, Anthony, Wesemann, Duane R., Harrison, Stephen C.“…The ACE2 binding surface (“RBD-2”) harbored the binding sites of the neutralizing antibodies with highest potency but with the greatest sensitivity to viral escape; two other epitopic regions on the RBD (“RBD-1 and “RBD-3”) bound antibodies of more modest potency but greater breadth. …”
Publicado 2022
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1036por Stalls, Victoria, Lindenberger, Jared, Gobeil, Sophie M.-C., Henderson, Rory, Parks, Rob, Barr, Maggie, Deyton, Margaret, Martin, Mitchell, Janowska, Katarzyna, Huang, Xiao, May, Aaron, Speakman, Micah, Beaudoin, Esther, Kraft, Bryan, Lu, Xiaozhi, Edwards, Robert J., Eaton, Amanda, Montefiori, David C., Williams, Wilton B., Saunders, Kevin O., Wiehe, Kevin, Haynes, Barton F., Acharya, Priyamvada“…BA.2 receptor-binding domain (RBD) mutations induce remodeling of the RBD structure, resulting in tighter packing and improved thermostability. …”
Publicado 2022
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1037por Sakamoto, Atsuhiko, Yoshimura, Michinobu, Itoh, Ryota, Ozuru, Ryo, Ishii, Kazunari, Sechi, Yusuke, Nabeshima, Shigeki, Hiromatsu, Kenji“…The decay in anti-RBD IgG started from 1 M after the second dose of BNT162b2 and anti-RBD IgG titers dropped to nearly one-tenth at 6 M after the second vaccination. …”
Publicado 2022
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1038por Darai, Nitchakan, Mahalapbutr, Panupong, Wolschann, Peter, Lee, Vannajan Sanghiran, Wolfinger, Michael T., Rungrotmongkol, Thanyada“…MSI proteins contain two ribonucleoprotein-like RNA-binding domains, RBD1 and RBD2, that bind single-stranded RNA motifs with a central UAG trinucleotide with high affinity and specificity. …”
Publicado 2022
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1039por Ramirez-Acosta, Kendra, Rosales-Fuerte, Ivan A, Perez-Sanchez, J Eduardo, Nuñez-Rivera, Alfredo, Juarez, Josue, Cadena-Nava, Ruben D“…SARS-CoV-2 infection begins with the recognition of the cellular receptor angiotensin converting enzyme-2 by its spike glycoprotein receptor-binding domain (RBD). Thus, the use of small peptides to neutralize the infective mechanism of SARS-CoV-2 through the RBD is an interesting strategy. …”
Publicado 2022
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1040“…Here, we dissect the mechanism underlying the increased binding affinity of the N501Y mutant for ACE2 using molecular dynamics (MD) simulations of the available ACE2-S1-RBD complex structure (6M0J) and show a prolonged and stable interfacial interaction of the N501Y mutant S1-RBD with ACE2 compared to the wild type S1-RBD. …”
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