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1101por Farnós, Omar, Venereo-Sánchez, Alina, Xu, Xingge, Chan, Cindy, Dash, Shantoshini, Chaabane, Hanan, Sauvageau, Janelle, Brahimi, Fouad, Saragovi, Uri, Leclerc, Denis, Kamen, Amine A.“…The monosaccharide and sialic acid content was similar in the RBD protein from the two production approaches. …”
Publicado 2020
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1102“…SARS-CoV-2 is a recently emerged coronavirus that binds angiotensin-converting enzyme 2 (ACE2) for cell entry via its receptor-binding domain (RBD) on a surface-expressed spike glycoprotein. …”
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1103por Byazrova, Maria, Yusubalieva, Gaukhar, Spiridonova, Anna, Efimov, Grigory, Mazurov, Dmitriy, Baranov, Konstantin, Baklaushev, Vladimir, Filatov, Alexander“…METHODS: The frequencies of RBD‐binding plasmablasts and RBD‐specific antibody‐secreting cells (ASCs) in the peripheral blood samples collected from patients with COVID‐19 were measured using flow cytometry and the ELISpot assay. …”
Publicado 2021
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1104por Farouk, Abd-ElAziem, Baig, Mohammad Hassan, Khan, Mohd Imran, Park, Taehwan, Alotaibi, Saqer S., Dong, Jae-June“…The SARS-CoV-2 spike receptor-binding domain (RBD) is the region mediating the binding of the virus to host cells via Angiotensin-converting enzyme 2 (ACE2), a critical step of viral. …”
Publicado 2021
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1105por Tan, Hyon-Xhi, Juno, Jennifer A., Lee, Wen Shi, Barber-Axthelm, Isaac, Kelly, Hannah G., Wragg, Kathleen M., Esterbauer, Robyn, Amarasena, Thakshila, Mordant, Francesca L., Subbarao, Kanta, Kent, Stephen J., Wheatley, Adam K.“…Boosting S-primed mice with either S or RBD significantly augments neutralising titres, with RBD-focussing driving moderate improvement in serum neutralisation. …”
Publicado 2021
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1106“…Binding modes of the antibody were investigated and compared with RBD bound receptor ACE2. Key epitopes were revealed and a distal motif of RBD (residue numbers 473–488) was demonstrated by analyzing dynamic trajectories. …”
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1107por Liu, Lin, Chopra, Pradeep, Li, Xiuru, Bouwman, Kim M., Tompkins, S. Mark, Wolfert, Margreet A., de Vries, Robert P., Boons, Geert-Jan“…Microarray binding experiments showed that ACE2 and HS can simultaneously engage with the RBD, and it is likely no dissociation between HS and RBD is required for binding to ACE2. …”
Publicado 2021
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1108por Barone, Daniel A., Wang, Fei, Ravdin, Lisa, Vo, Mary, Lee, Andrea, Sarva, Harini, Hellmers, Natalie, Krieger, Ana C., Henchcliffe, Claire“…We propose the term RBD+ to be used to identify such individuals. For the quality of life in patients diagnosed with RBD, a closer look by the clinician should be enacted, with appropriate referrals and workup.…”
Publicado 2020
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1109“…BACKGROUND: Clinical observations reveal that rapid eye movement (REM) sleep behavior disorder (RBD) often develops prior to alpha-synucleinopathies including Parkinson’s disease (PD). …”
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1110por Flisiak, Robert, Pawłowska, Małgorzata, Rogalska-Płońska, Magdalena, Bociąga-Jasik, Monika, Kłos, Krzysztof, Piekarska, Anna, Zarębska-Michaluk, Dorota“…The levels of anti-SARS-CoV-2 S1S2 IgG (anti-S) and, in some cases, anti-SARS-CoV-S-RBD IgG (anti-S-RBD) were determined six months after complete vaccination. …”
Publicado 2021
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1111por Gale, Emily C., Powell, Abigail E., Roth, Gillie A., Meany, Emily L., Yan, Jerry, Ou, Ben S., Grosskopf, Abigail K., Adamska, Julia, Picece, Vittoria C. T. M., d'Aquino, Andrea I., Pulendran, Bali, Kim, Peter S., Appel, Eric A.“…Together, these results suggest that slow delivery of RBD subunit vaccines with PNP hydrogels can significantly enhance the immunogenicity of RBD and induce neutralizing humoral immunity.…”
Publicado 2021
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1112por Zhou, Zhongcheng, Du, Peng, Li, Ning, Xiong, Xinxin, Tang, Shengjun, Dai, Qinjin, Wang, Taorui, Yu, Meixing, Man, Miao, Lam, Kelvin, Baptista‐Hon, Daniel T., Tai, Wa Hou, Monteiro, Olivia, Ng, Weng Sam, Lee, Un Man, Liu, Zhihai, Zhang, Kang, Li, Gen“…However, our results also show that nonhuman primates receiving a recombinant RBD protein vaccine show substantial neutralization activity. …”
Publicado 2022
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1113“…We found that the size and three-dimensional shape of epitopes significantly impacted the activity of antibodies produced against the RBD of Spike protein. Overall, because of the conformational changes between RBD and hACE2, it prevents viral entry. …”
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1114“…N440K, T478K, E484A, Q493R, and Q498R mutations in the RBD have been found to play a critical role in the stability of the RBD-hACE2 complex. …”
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1115por Gaurav, Rahul, Pyatigorskaya, Nadya, Biondetti, Emma, Valabrègue, Romain, Yahia‐Cherif, Lydia, Mangone, Graziella, Leu‐Semenescu, Smaranda, Corvol, Jean‐Christophe, Vidailhet, Marie, Arnulf, Isabelle, Lehéricy, Stéphane“…BACKGROUND: Isolated REM sleep behavior disorder (iRBD) is considered a prodromal stage of parkinsonism. …”
Publicado 2022
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1116por Khatri, Ritika, Parray, Hilal Ahmad, Siddiqui, Gazala, Chiranjivi, Adarsh Kumar, Raj, Sneha, Kaul, Rachel, Maithil, Vikas, Samal, Sweety, Ahmed, Shubbir“…Many of these variants have mutations in the receptor binding domain (RBD) of SARS-CoV-2 spike protein that interacts with the host cell receptor. …”
Publicado 2022
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1117por Zang, Yajie, Zhang, Hui, Li, Yuan, Cai, Yanning, Chhetri, Jagadish K., Chan, Piu, Mao, Wei“…This study aimed to investigate the prevalence and clinical characteristics of fatigue in patients with idiopathic/isolated REM sleep behavior disorders (iRBD). Methods: A total of 97 polysomnography-confirmed iRBD patients were enrolled in this study. …”
Publicado 2022
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1118por Schwarze, Mandy, Luo, Ji, Brakel, Alexandra, Krizsan, Andor, Lakowa, Nicole, Grünewald, Thomas, Lehmann, Claudia, Wolf, Johannes, Borte, Stephan, Milkovska-Stamenova, Sanja, Gabert, Jörg, Scholz, Markus, Hoffmann, Ralf“…The combination of two data sets, i.e., N- and RBD-, N- and M-, or RBD- and M-proteins increased the sensitivity to 85.8%, 77.9%, and 87.8%, respectively. …”
Publicado 2022
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1119por Wang, Wei Bu, Ma, Yi Bo, Lei, Ze Hua, Zhang, Xue Feng, Li, Jiao, Li, Shan Shan, Dong, Ze Yuan, Liang, Yu, Li, Qi Ming, Su, Ji Guo“…Moreover, fourteen neutralizing antibodies/nanobodies complexed with RBD were used to explore the effects of the mutations in Omicron RBD on their binding affinities. …”
Publicado 2023
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1120por Adnan, Nihad, Haq, Md Ahsanul, Tisha, Taslima Akter, Khandker, Shahad Saif, Jamiruddin, Mohd. Raeed, Sajal, SM Shafiul Alam, Akter, Salma, Ahmed, Md Firoz, Raqib, Rubhana, Khondoker, Mohib Ullah, Azmuda, Nafisa, Haque, Mainul“…Co-immobilization of S1 and RBD in different ratios revealed an 80:20 (S1:RBD) ratio as optimal for achieving an overall 96.2% sensitivity with the least cross-reaction to anti-dengue antibodies. …”
Publicado 2023
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