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1121por Seger, Aline, Ophey, Anja, Doppler, Christopher E. J., Kickartz, Johanna, Lindner, Marie-Sophie, Hommelsen, Maximilian, Fink, Gereon R., Sommerauer, Michael“…Isolated REM sleep behaviour disorder (iRBD) is the most specific marker of prodromal PD, but data on clinical subtyping of patients with iRBD remain scarce. …”
Publicado 2023
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1122por Jung, Ki-Young, Cho, Jae-Hyun, Ko, Deokwon, Seok, Hung Youl, Yoon, Ho-Kyoung, Lee, Heon-Jeong, Kim, Leen, Im, Chang-Hwan“…The authors hypothesized that if locomotor drive increases along with rapid eye movement (REM) sleep without atonia in idiopathic REM sleep behavior disorder (RBD), then RBD patients would have greater corticomuscular coherence (CMC) values during REM sleep than at other sleep stages and than in healthy control subjects during REM sleep. …”
Publicado 2012
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1123“…INTRODUCTION: Rapid eye movement sleep behavior disorder (RBD) is characterized by dream-enacting behavior (shouting, punching, and falling out of bed) related to unpleasant dreams and loss of normal rapid eye movement (REM) sleep muscle atonia. …”
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1124por Iyer, Anita S., Jones, Forrest K., Nodoushani, Ariana, Kelly, Meagan, Becker, Margaret, Slater, Damien, Mills, Rachel, Teng, Erica, Kamruzzaman, Mohammad, Garcia-Beltran, Wilfredo F., Astudillo, Michael, Yang, Diane, Miller, Tyler E., Oliver, Elizabeth, Fischinger, Stephanie, Atyeo, Caroline, Iafrate, A. John, Calderwood, Stephen B., Lauer, Stephen A., Yu, Jingyou, Li, Zhenfeng, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Branda, John A., Turbett, Sarah E., LaRocque, Regina C., Mellon, Guillaume, Barouch, Dan H., Schmidt, Aaron G., Azman, Andrew S., Alter, Galit, Ryan, Edward T, Harris, Jason B., Charles, Richelle C.“…IgG antibodies against RBD lasted longer and persisted through 75 days post-symptoms. …”
Publicado 2020
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1125“…Encouragingly, 6 drugs exhibited stable binding with RBD at the ACE2-RBD interface and 3 of them (gonadorelin, fondaparinux and atorvastatin) showed significantly enhanced binding after the MD simulations. …”
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1126por Kim, Ryul, Lee, Jee‐Young, Kim, Yu Kyeong, Kim, Heejung, Yoon, Eun Jin, Shin, Jung Hwan, Yoo, Dallah, Nam, Hyunwoo, Jeon, Beomseok“…BACKGROUND: It remains unclear whether and how the isolated rapid eye movement (REM) sleep behavior disorder (iRBD)‐related metabolic pattern (RBDRP) changes with disease progression in iRBD. …”
Publicado 2021
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1127por Zhou, Runhong, Wang, Pui, Wong, Yik-Chun, Xu, Haoran, Lau, Siu-Ying, Liu, Li, Mok, Bobo Wing-Yee, Peng, Qiaoli, Liu, Na, Woo, Kin-Fai, Deng, Shaofeng, Tam, Rachel Chun-Yee, Huang, Haode, Zhang, Anna Jinxia, Zhou, Dongyan, Zhou, Biao, Chan, Chun-Yin, Du, Zhenglong, Yang, Dawei, Au, Ka-Kit, Yuen, Kwok-Yung, Chen, Honglin, Chen, Zhiwei“…METHODS: Since mucosal immunity is critical for nasal prevention, we investigated the efficacy of an intramuscular PD1-based receptor-binding domain (RBD) DNA vaccine (PD1-RBD-DNA) and intranasal live attenuated influenza-based vaccines (LAIV-CA4-RBD and LAIV-HK68-RBD) against SARS-CoV-2. …”
Publicado 2021
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1128por Gilat, Moran, Marshall, Nathaniel S., Testelmans, Dries, Buyse, Bertien, Lewis, Simon J. G.“…Rapid Eye Movement sleep behavior disorder (RBD) is a parasomnia causing sufferers to physically act out their dreams. …”
Publicado 2021
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1129por Qin, Xi, Li, Shanhu, Li, Xiang, Pei, Dening, Liu, Yu, Ding, Youxue, Liu, Lan, Bi, Hua, Shi, Xinchang, Guo, Ying, Fang, Enyue, Huang, Fang, Yu, Lei, Zhu, Liuqiang, An, Yifang, Valencia, C. Alexander, Li, Yuhua, Dong, Biao, Zhou, Yong“…The vaccine candidate, named AAV9-RBD virus, was constructed by inserting a signal peptide to the N-terminus of two copies of RBD, spaced by a linker, into the genome of a type 9 adeno-associated virus. …”
Publicado 2022
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1130por Behera, Jyotirmaya, Ison, Jessica, Voor, Michael J., Tyagi, Suresh C., Tyagi, Neetu“…The data demonstrate that SARS-CoV-2-RBD treatment in pre-existing diabetes conditions in hACE2 (T2DM + RBD) mice results in the aggravated osteoblast inflammation and downregulation of Glucose transporter 4 (Glut4) expression via upregulation of miR-294–3p expression. …”
Publicado 2022
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1131“…RESULTS: At baseline analysis, individuals with early and prodromal PD, who had higher RBD screening questionnaire (RBDSQ) score, or who were considered as pRBD, or who manifested specific behaviors of RBD (things falling down when sleep or disturbance of sleep), showed significantly the higher score of depression-related questionnaires. …”
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1132por Nugraha, Jusak, Permatasari, Cynthia Ayu, Fitriah, Munawaroh, Tambunan, Betty Agustina, Fuadi, Muhamad Robi’ul“…Kinetics of antibody NAb decreased more rapidly than IgG S-RBD.…”
Publicado 2022
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1133“…The specific IgG antibody titers in serum after (W4) inoculation with homologous booster inactivated vaccine were 10.80 (S/CO).The anti-RBD antibody titers were 28.33. The anti-RBD omicron variant (B.1.1.529) antibody titers were 11.67. …”
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1134por Huang, Jui-Hsin, Shen, Zhe-Qing, Lien, Shu-Pei, Hsiao, Kuang-Nan, Leng, Chih-Hsiang, Chen, Chi-Chang, Siu, Leung-Kei, Chong, Pele Choi-Sing“…The C-terminal receptor-binding domain (RBD) of TcdA, which is responsible for the initial binding of the toxin to host glycoproteins, has been predicted to contain 7 potential oligosaccharide-binding sites. …”
Publicado 2015
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1135por Schaffner, Anna, Risch, Lorenz, Aeschbacher, Stefanie, Risch, Corina, Weber, Myriam C., Thiel, Sarah L., Jüngert, Katharina, Pichler, Michael, Grossmann, Kirsten, Wohlwend, Nadia, Lung, Thomas, Hillmann, Dorothea, Bigler, Susanna, Bodmer, Thomas, Imperiali, Mauro, Renz, Harald, Kohler, Philipp, Vernazza, Pietro, Kahlert, Christian R., Twerenbold, Raphael, Paprotny, Matthias, Conen, David, Risch, Martin“…Pan-immunoglobulin assays can simultaneously detect IgG, IgM and IgA directed against the receptor binding domain (RBD) of the S1 subunit of the spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 S1-RBD Ig). …”
Publicado 2020
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1136por Walls, Alexandra C., Miranda, Marcos C., Pham, Minh N., Schäfer, Alexandra, Greaney, Allison, Arunachalam, Prabhu S., Navarro, Mary-Jane, Tortorici, M. Alejandra, Rogers, Kenneth, O’Connor, Megan A., Shireff, Lisa, Ferrell, Douglas E., Brunette, Natalie, Kepl, Elizabeth, Bowen, John, Zepeda, Samantha K., Starr, Tyler, Hsieh, Ching-Lin, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, Sydeman, Claire, Johnson, Max, Blackstone, Alyssa, Ravichandran, Rashmi, Ogohara, Cassandra, Carter, Lauren, Tilles, Sasha W., Rappuoli, Rino, O’Hagan, Derek T., Van Der Most, Robbert, Van Voorhis, Wesley C., McLellan, Jason S., Kleanthous, Harry, Sheahan, Timothy P., Fuller, Deborah H., Villinger, Francois, Bloom, Jesse, Pulendran, Bali, Baric, Ralph, King, Neil, Veesler, David“…SARS-CoV-2 RBD-NP elicits high antibody titers in two non-human primate (NHP) models against multiple distinct RBD antigenic sites known to be recognized by neutralizing antibodies. …”
Publicado 2021
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1137por Scheiblauer, Heinrich, Nübling, Claudius Micha, Wolf, Timo, Khodamoradi, Yascha, Bellinghausen, Carla, Sonntagbauer, Michael, Esser-Nobis, Katharina, Filomena, Angela, Mahler, Vera, Maier, Thorsten Jürgen, Stephan, Christoph“…RESULTS: Sensitivity at 30–60 days post symptom onset (pso) for TAb-S/RBD, TAb-N, IgG-S, IgG-N, IgA-S, IgM-RBD, and NAb was 96.6%, 99.5%, 89.7%, 94.3%, 80.9%, 76.9% and 92.8%, respectively. …”
Publicado 2022
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1138por Chen, Junyu, Wang, Pui, Yuan, Lunzhi, Zhang, Liang, Zhang, Limin, Zhao, Hui, Chen, Congjie, Wang, Xijing, Han, Jinle, Chen, Yaode, Jia, Jizong, Lu, Zhen, Hong, Junping, Lu, Zicen, Wang, Qian, Chen, Rirong, Qi, Ruoyao, Ma, Jian, Zhou, Min, Yu, Huan, Zhuang, Chunlan, Liu, Xiaohui, Han, Qiangyuan, Wang, Guosong, Su, Yingying, Yuan, Quan, Cheng, Tong, Wu, Ting, Ye, Xiangzhong, Zhang, Tianying, Li, Changgui, Zhang, Jun, Zhu, Huachen, Chen, Yixin, Chen, Honglin, Xia, Ningshao“…To overcome the limitations of intramuscular vaccines, we constructed a nasal vaccine candidate based on an influenza vector by inserting a gene encoding the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2, named CA4-dNS1-nCoV-RBD (dNS1-RBD). …”
Publicado 2022
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1139por Ridgway, Harry, Chasapis, Christos T., Kelaidonis, Konstantinos, Ligielli, Irene, Moore, Graham J., Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Mavromoustakos, Thomas, Matsoukas, John M.“…Considered also are the structural hydropathy traits of the residues in the interface between SARS-CoV-2 RBD and ACE2 protein. Salt bridges and π-π interactions are critical forces that create stronger complexes between the RBD and ACE2. …”
Publicado 2022
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1140por Su, Chao, He, Juanhua, Han, Pengcheng, Bai, Bin, Li, Dedong, Cao, Jian, Tian, Mingxiong, Hu, Yu, Zheng, Anqi, Niu, Sheng, Chen, Qian, Rong, Xiaoyu, Zhang, Yanfang, Li, Weiwei, Qi, Jianxun, Zhao, Xin, Yang, Mengsu, Wang, Qihui, Gao, George Fu“…Cryo-electron microscopy structures of the mkACE2-RBD Y453F (with a Y-to-F change at position 453) and mkACE2-RBD F486L complexes helped identify the key residues that facilitate changes in mkACE2 binding affinity. …”
Publicado 2022
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