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1161por Pont-Sunyer, Claustre, Iranzo, Alex, Gaig, Carles, Fernández-Arcos, Ana, Vilas, Dolores, Valldeoriola, Francesc, Compta, Yaroslau, Fernández-Santiago, Ruben, Fernández, Manel, Bayés, Angels, Calopa, Matilde, Casquero, Pilar, de Fàbregues, Oriol, Jaumà, Serge, Puente, Victor, Salamero, Manel, José Martí, Maria, Santamaría, Joan, Tolosa, Eduard“…REM sleep behavior disorder (RBD) was diagnosed in three LRRK2-PD. EDS and RBD were always reported to start after the onset of parkinsonism in LRRK2-PD. …”
Publicado 2015
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1162por Premkumar, Lakshmanane, Segovia-Chumbez, Bruno, Jadi, Ramesh, Martinez, David R., Raut, Rajendra, Markmann, Alena, Cornaby, Caleb, Bartelt, Luther, Weiss, Susan, Park, Yara, Edwards, Caitlin E., Weimer, Eric, Scherer, Erin M., Rouphael, Nadine, Edupuganti, Srilatha, Weiskopf, Daniela, Tse, Longping V., Hou, Yixuan J., Margolis, David, Sette, Alessandro, Collins, Matthew H., Schmitz, John, Baric, Ralph S., de Silva, Aravinda M.“…As the receptor binding domain (RBD) of the spike protein is poorly conserved between SARS-CoVs and other pathogenic human coronaviruses, the RBD represents a promising antigen for detecting CoV-specific antibodies in people. …”
Publicado 2020
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1163por Salazar, Eric, Kuchipudi, Suresh V., Christensen, Paul A., Eagar, Todd N., Yi, Xin, Zhao, Picheng, Jin, Zhicheng, Long, S. Wesley, Olsen, Randall J., Chen, Jian, Castillo, Brian, Leveque, Christopher, Towers, Dalton M., Lavinder, Jason, Gollihar, Jimmy D., Cardona, Jose, Ippolito, Gregory C., Nissly, Ruth H., Bird, Ian M., Greenawalt, Denver, Rossi, Randall M., Gontu, Abinhay, Srinivasan, Sreenidhi, Poojary, Indira B., Cattadori, Isabella M., Hudson, Peter J., Joselyn, Nicole, Prugar, Laura, Huie, Kathleen, Herbert, Andrew, Bernard, David W., Dye, John, Kapur, Vivek, Musser, James M.“…Anti-RBD plasma IgG correlated slightly better than anti-ECD IgG titer with VN titer. …”
Publicado 2020
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1164por Mufti, Kheireddin, Yu, Eric, Rudakou, Uladzislau, Krohn, Lynne, Ruskey, Jennifer A., Asayesh, Farnaz, Laurent, Sandra B., Spiegelman, Dan, Arnulf, Isabelle, Hu, Michele T.M., Montplaisir, Jacques Y., Gagnon, Jean-François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Bernardini, Andrea, Högl, Birgit, Stefani, Ambra, Holzknecht, Evi, Sonka, Karel, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel-Döring, Friederike, Cochen De Cock, Valérie, Monaca, Christelle Charley, Heidbreder, Anna, Ferini-Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F., Trempe, Jean-François, Rouleau, Guy A., Postuma, Ronald B., Gan-Or, Ziv“…OBJECTIVE: To examine the role of genes identified through genome-wide association studies (GWASs) of Parkinson disease (PD) in the risk of isolated REM sleep behavior disorder (iRBD). METHODS: We fully sequenced 25 genes previously identified in GWASs of PD in a total of 1,039 patients with iRBD and 1,852 controls. …”
Publicado 2021
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1165por Liu, Zezhong, Zhou, Jie, Xu, Wei, Deng, Wei, Wang, Yanqun, Wang, Meiyu, Wang, Qian, Hsieh, Ming, Dong, Jingming, Wang, Xinling, Huang, Weijin, Xing, Lixiao, He, Miaoling, Tao, Chunlin, Xie, Youhua, Zhang, Yilong, Wang, Youchun, Zhao, Jincun, Yuan, Zhenghong, Qin, Chuan, Jiang, Shibo, Lu, Lu“…Here, we discovered a new STING agonist, CF501, and found that CF501-adjuvanted RBD-Fc vaccine (CF501/RBD-Fc) elicited significantly stronger neutralizing antibody (nAb) and T cell responses than Alum- and cGAMP-adjuvanted RBD-Fc in mice. …”
Publicado 2022
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1166por Malladi, Sameer Kumar, Patel, Unnatiben Rajeshbhai, Rajmani, Raju S., Singh, Randhir, Pandey, Suman, Kumar, Sahil, Khaleeq, Sara, van Vuren, Petrus Jansen, Riddell, Shane, Goldie, Sarah, Gayathri, Savitha, Chakraborty, Debajyoti, Kalita, Parismita, Pramanick, Ishika, Agarwal, Nupur, Reddy, Poorvi, Girish, Nidhi, Upadhyaya, Aditya, Khan, Mohammad Suhail, Kanjo, Kawkab, Bhat, Madhuraj, Mani, Shailendra, Bhattacharyya, Sankar, Siddiqui, Samreen, Tyagi, Akansha, Jha, Sujeet, Pandey, Rajesh, Tripathi, Shashank, Dutta, Somnath, McAuley, Alexander J., Singanallur, Nagendrakumar Balasubramanian, Vasan, Seshadri S., Ringe, Rajesh P., Varadarajan, Raghavan“…[Image: see text] The receptor binding domain (RBD) of SARS-CoV-2 is the primary target of neutralizing antibodies. …”
Publicado 2021
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1167por Pollet, Jeroen, Strych, Ulrich, Chen, Wen-Hsiang, Versteeg, Leroy, Keegan, Brian, Zhan, Bin, Wei, Junfei, Liu, Zhuyun, Lee, Jungsoon, Kundu, Rahki, Adhikari, Rakesh, Poveda, Cristina, Jose Villar, Maria, Rani Thimmiraju, Syamala, Lopez, Brianna, Gillespie, Portia M., Ronca, Shannon, Kimata, Jason T., Reers, Martin, Paradkar, Vikram, Hotez, Peter J., Elena Bottazzi, Maria“…We compared the immune response of mice vaccinated with RBD/alum to mice vaccinated with RBD/alum + CpG. …”
Publicado 2022
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1168por Yang, Zhongqian, Hua, Liangqun, Yang, Mengli, Li, Weiran, Ren, Zhaoling, Zheng, Xiao, Chen, Haoqian, Long, Qiong, Bai, Hongmei, Huang, Weiwei, Ma, Yanbing“…More importantly, the polymerized RBD displayed on the ClyA-RBD polymerized porin (RBD-PP) already displays some correct spatial conformational epitopes that can induce neutralizing antibodies. …”
Publicado 2022
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1169por Hasan, Muhammad, Moiz, Bushra, Qaiser, Shama, Masood, Kiran Iqbal, Ghous, Zara, Hussain, Areeba, Ali, Natasha, Simas, J. Pedro, Veldhoen, Marc, Alves, Paula, Abidi, Syed Hani, Ghias, Kulsoom, Khan, Erum, Hasan, Zahra“…Positive IgG antibodies to RBD were present in 16.7% (95% CI; 13.6–19.8) of individuals. …”
Publicado 2022
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1170por Maghsood, Faezeh, Amiri, Mohammad Mehdi, Zarnani, Amir-Hassan, Salimi, Vahid, Kardar, Gholam Ali, Khoshnoodi, Jalal, Mobini, Maryam, Ahmadi Zare, Hengameh, Ghaderi, Abbas, Jeddi-Tehrani, Mahmood, Schmidt, Sylvie, Laumond, Géraldine, Moog, Christiane, Shokri, Fazel“…Here, we generated and characterized a panel of anti-RBD monoclonal antibodies (MAbs) isolated from eukaryotic recombinant RBD-immunized mice by hybridoma technology. …”
Publicado 2022
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1171por Chen, Ying, Xue, Nai‐Jia, Fang, Yi, Jin, Chong‐Yao, Li, Yao‐Lin, Tian, Jun, Yan, Ya‐Ping, Yin, Xin‐Zhen, Zhang, Bao‐Rong, Pu, Jia‐Li“…OBJECTIVES: To identify whether the concurrent presence of OD and probable RBD (pRBD) in PD (Dual hit in PD, PD‐DH) is associated with disease progression. …”
Publicado 2022
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1172por Puligheddu, Monica, Figorilli, Michela, Antelmi, Elena, Arnaldi, Dario, Casaglia, Elisa, d’Aloja, Ernesto, Ferini-Strambi, Luigi, Ferri, Raffaele, Gigli, Gian Luigi, Ingravallo, Francesca, Maestri, Michelangelo, Terzaghi, Michele, Plazzi, Giuseppe“…Most patients with idiopathic REM sleep behavior disorder (iRBD) will develop an overt α-synucleinopathy over time, with a rate of phenoconversion of 73.5% after 12 years from diagnosis. …”
Publicado 2022
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1173por Krohn, Lynne, Heilbron, Karl, Blauwendraat, Cornelis, Reynolds, Regina H., Yu, Eric, Senkevich, Konstantin, Rudakou, Uladzislau, Estiar, Mehrdad A., Gustavsson, Emil K., Brolin, Kajsa, Ruskey, Jennifer A., Freeman, Kathryn, Asayesh, Farnaz, Chia, Ruth, Arnulf, Isabelle, Hu, Michele T. M., Montplaisir, Jacques Y., Gagnon, Jean-François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Bernardini, Andrea, Högl, Birgit, Stefani, Ambra, Ibrahim, Abubaker, Šonka, Karel, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Biscarini, Francesco, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel-Döring, Friederike, Cochen De Cock, Valérie, Monaca, Christelle Charley, Heidbreder, Anna, Ferini-Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F., Scholz, Sonja W., Ryten, Mina, Bandres-Ciga, Sara, Noyce, Alastair, Cannon, Paul, Pihlstrøm, Lasse, Nalls, Mike A., Singleton, Andrew B., Rouleau, Guy A., Postuma, Ronald B., Gan-Or, Ziv“…Here, we perform a genome-wide association study of RBD, identifying five RBD risk loci near SNCA, GBA, TMEM175, INPP5F, and SCARB2. …”
Publicado 2022
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1174por Wang, Chaojie, He, Fengming, Sun, Ke, Guo, Kaiqiang, Lu, Sheng, Wu, Tong, Gao, Xiang, Fang, Meijuan“…The entry of SARS-CoV-2 into host cells is facilitated by the binding of its spike protein (S1-RBD) to the host receptor hACE2. Small molecule compounds targeting S1-RBD-hACE2 interaction could provide an alternative therapeutic strategy sensitive to viral mutations. …”
Publicado 2023
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1175por Plikusiene, Ieva, Maciulis, Vincentas, Juciute, Silvija, Ramanavicius, Arunas, Ramanaviciene, Almira“…The spike (S) protein and its receptor-binding domain (RBD) of the coronavirus SARS-CoV-2 have been continually evolving, yielding the majority of significant missense mutations and new variants of concern. …”
Publicado 2023
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1176“…Using peptides to inhibit binding interactions (BIs) between ACE2-PD and SARS-CoV-2-RBD is one of promising COVID-19 therapies. Employing computational protein design (CPD) as well as molecular dynamics (MD), this study used ACE2-PD’s α1 helix to generate novel 25-mer peptide binders (SPB25) of Omicron RBD that have predicted binding affinities (ΔG(bind (MM‑GBSA))) better than ACE2 by increasing favorable BIs between SPB25 and the conserved residues of RBD. …”
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1177por Rabenalt, Robert, Winter, Christian, Potthoff, Sebastian A., Eisenberger, Claus-Ferdinand, Grabitz, Klaus, Albers, Peter, Giessing, Markus“…When the first RBD was unsuccessful there was no improvement with a second. …”
Publicado 2011
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1178“…BACKGROUND: To evaluate the risk of premotor symptoms, namely rapid eye movement behavior disorder (RBD), constipation, and depression among patients with newly diagnosed Parkinson disease (PD). …”
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1179por Du, Lanying, He, Yuxian, Wang, Yijia, Zhang, Haojie, Ma, Selene, Wong, Charlotte K.L., Wu, Sharon H.W., Ng, Fai, Huang, Jian-Dong, Yuen, Kwok-Yung, Jiang, Shibo, Zhou, Yusen, Zheng, Bo-Jian“…We previously demonstrated that the receptor-binding domain (RBD) of SARS-CoV S protein is a major target of neutralizing antibodies. …”
Publicado 2006
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1180“…We analyzed the mechanisms by which HBD 2 primes innate antiviral immunity and polarized activation of macrophage-like THP-1 cells using the receptor-binding domain (RBD) of Middle East respiratory syndrome coronavirus (MERS-CoV) spike protein (S RBD) as a model antigen. …”
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