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101por Kudriavtsev, Aleksandr V., Vakhrusheva, Anna V., Novoseletsky, Valery N., Bozdaganyan, Marine E., Shaitan, Konstantin V., Kirpichnikov, Mikhail P., Sokolova, Olga S.Enlace del recurso
Publicado 2022
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102por Britton, Dustin, Punia, Kamia, Mahmoudinobar, Farbod, Tada, Takuya, Jiang, Xunqing, Renfrew, P. Douglas, Bonneau, Richard, Landau, Nathaniel R., Kong, Xiang-Peng, Montclare, Jin Kim“…One such solution to both of these prevailing issues is targeting the interaction of SARS-CoV-2 spike receptor binding domain (RBD) with the human angiotensin-converting enzyme 2 (ACE2) receptor protein. …”
Publicado 2022
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103por Dickey, Thayne H., Tang, Wai Kwan, Butler, Brandi, Ouahes, Tarik, Orr-Gonzalez, Sachy, Salinas, Nichole D., Lambert, Lynn E., Tolia, Niraj H.“…The receptor binding domain (RBD) of the SARS-CoV-2 spike protein is the primary target of neutralizing antibodies and is a component of almost all current vaccines. …”
Publicado 2022
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104por Masoomi Nomandan, Seyedeh Zeinab, Azimzadeh Irani, Maryam, Hosseini, Seyed Masoud“…It was shown that the ferritin–RBD complex becomes more stable when glycans are added to the ferritin–RBD interface and optimal performance of this nanoparticle can be achieved. …”
Publicado 2022
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105por Valério, Mariana, Borges-Araújo, Luís, Melo, Manuel N., Lousa, Diana, Soares, Cláudio M.“…The spike glycoprotein binds to angiotensin-converting enzyme 2 (ACE2) via its receptor binding domain (RBD) initiating the infection process. Attempting to understand the effect of RBD mutations in VOCs, a lot of attention has been given to the RBD-ACE2 interaction. …”
Publicado 2022
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106por Singh, Jaikee Kumar, Dubey, Saumya, Srivastava, Gaurava, Siddiqi, Mohammad Imran, Srivastava, Sandeep Kumar“…Key residual differences in the RBD interface of these variants form the basis for differential interaction affinities with neohesperidin as drug binding site overlaps with RBD-human ACE2 interface. …”
Publicado 2023
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107por Vetráková, A., Chovanová, R. Kalianková, Rechtoríková, R., Krajčíková, D., Barák, I.“…The RBD was attached to the N-terminus or C-terminus of the coat proteins. …”
Publicado 2023
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108por Alkayyal, Almohanad A., Ajina, Reham, Cacciabue, Marco, Alkayyal, Aaesha A., Saeedi, Nizar H., Hussain Alshehry, Taofik, Kaboha, Feras, Alotaibi, Mohammed A., Zaidan, Nada, Shah, Khalid, Alroqi, Fayhan, Bakur Mahmoud, Ahmad“…To test this hypothesis, we first generated a novel VSV-Δ51 mutant that encoded the SARS-COV-2 RBD and compared viral spreading and viral yield between VSV-Δ51-RBD and VSV-Δ51 in vitro. …”
Publicado 2023
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109por Cao, Yunlong, Jian, Fanchong, Wang, Jing, Yu, Yuanling, Song, Weiliang, Yisimayi, Ayijiang, Wang, Jing, An, Ran, Chen, Xiaosu, Zhang, Na, Wang, Yao, Wang, Peng, Zhao, Lijuan, Sun, Haiyan, Yu, Lingling, Yang, Sijie, Niu, Xiao, Xiao, Tianhe, Gu, Qingqing, Shao, Fei, Hao, Xiaohua, Xu, Yanli, Jin, Ronghua, Shen, Zhongyang, Wang, Youchun, Xie, Xiaoliang Sunney“…Despite their divergent evolutionary courses, mutations on their receptor-binding domain (RBD) converge on several hotspots. The driving force and destination of such sudden convergent evolution and its effect on humoral immunity remain unclear. …”
Publicado 2022
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110por Miao, Lu, Yan, Chunyu, Chen, Yingzhu, Zhou, Wei, Zhou, Xuelian, Qiao, Qinglong, Xu, Zhaochao“…Here, RBD and ACE2 were genetically coded and labeled with organic dyes to track RBD endocytosis in living cells. …”
Publicado 2023
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111por Addala, Santhinissi, Vissapragada, Madhuri, Aggunna, Madhumita, Mukala, Niharikha, Lanka, Manisha, Gampa, Shyamkumar, Sodasani, Manikanta, Chintalapati, Jahnavi, Kamidi, Akhila, Veeranna, Ravindra P., Yedidi, Ravikiran S.“…To evaluate the risk involved from such mutant viral strains, we performed a systematic in silico amino acid substitution of critical residues in the receptor binding domain (RBD) of the spike protein. Our molecular modeling analysis revealed significant topological changes in the RBD of spike protein suggesting that they could potentially contribute to the loss of antigen specificity for the currently existing therapeutic antibodies/vaccines, thus posing a challenge to the current vaccine strategies that are based on wild type viral spike protein epitopes. …”
Publicado 2022
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112“…Here, using structural modelling and molecular dynamics (MD) simulations, we show that the Omicron mutations increases the affinity of S1-RBD for ACE2, and a reversal of the unique Q493R mutation further increases the ACE2-S1-RBD affinity. …”
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113por Su, Rina, Shi, Zhuangzhuang, Li, Entao, Zhu, Menghan, Li, Dongxu, Liu, Xiawei, Sun, Yue, Feng, Na, Wang, Jianzhong, Wang, Tiecheng, Xia, Xianzhu, Sun, Weiyang, Gao, Yuwei“…In this study, we developed a bacterium-like particle vaccine that displays the SARS-CoV-2 receptor binding domain (RBD) (named Trim-RBD-GEM) using the GEM-PA system. …”
Publicado 2023
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114por Dormeshkin, Dmitri, Katsin, Mikalai, Stegantseva, Maria, Golenchenko, Sergey, Shapira, Michail, Dubovik, Simon, Lutskovich, Dzmitry, Kavaleuski, Anton, Meleshko, Alexander“…These data identify the RBD-PVXCP DNA vaccine platform as a promising solution for robust and effective SARS-CoV-2 protection, supporting further translational study.…”
Publicado 2023
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115por Kaewchim, Kanasap, Glab-ampai, Kittirat, Mahasongkram, Kodchakorn, Saenlom, Thanatsaran, Thepsawat, Watayagorn, Chulanetra, Monrat, Choowongkomon, Kiattawee, Sookrung, Nitat, Chaicumpa, Wanpen“…Engineered nanobodies (VHs) to the SARS-CoV-2 receptor-binding domain (RBD) were generated using phage display technology. …”
Publicado 2023
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116por Haycroft, Ebene R., Davis, Samantha K., Ramanathan, Pradhipa, Lopez, Ester, Purcell, Ruth A., Tan, Li Lynn, Pymm, Phillip, Wines, Bruce D., Hogarth, P. Mark, Wheatley, Adam K., Juno, Jennifer A., Redmond, Samuel J., Gherardin, Nicholas A., Godfrey, Dale I., Tham, Wai-Hong, Selva, Kevin John, Kent, Stephen J., Chung, Amy W.“…The SARS-CoV-2 receptor-binding domain (RBD) is a hotspot for mutations, reflecting its critical role at the ACE2 interface during viral entry. …”
Publicado 2023
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117por Wu, Yan, Shi, Jian, He, Xiaoxue, Lu, Jia, Gao, Xiao, Zhu, Xuerui, Chen, Xinlan, Zhang, Man, Fang, Lijuan, Zhang, Jing, Yuan, Zhiming, Xiao, Gengfu, Zhou, Pengfei, Pan, Xiaoyan“…Here, we report that the RBD homodimers of ancestral SARS-CoV-2 as well as the variant RBD dimers from the Beta, Delta, Lambda, Omicron, and Omicron sublineages, which were rapidly prepared using our universal dimeric protein platform, elicit both strong immunogenicity and good protection in vivo. …”
Publicado 2023
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118por Kawai, Atsushi, Tokunoh, Nagisa, Kawahara, Eigo, Tamiya, Shigeyuki, Okamura, Shinya, Ono, Chikako, Anindita, Jessica, Tanaka, Hiroki, Akita, Hidetaka, Yamasaki, Sho, Kunisawa, Jun, Okamoto, Toru, Matsuura, Yoshiharu, Hirai, Toshiro, Yoshioka, Yasuo“…Intranasal immunization of previously IAV-infected mice with RBD-HA without an adjuvant elicited robust production of RBD-specific systemic IgG and mucosal IgA by utilizing both HA-specific preexisting IgG and CD4(+) T cells. …”
Publicado 2023
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119por Kim, Felix J, Lavanya, Madakasira, Gessain, Antoine, Gallego, Sandra, Battini, Jean-Luc, Sitbon, Marc, Courgnaud, Valérie“…The PTLV envelope glycoprotein surface component (SUgp46) comprises a receptor-binding domain (RBD) that alternates hypervariable and highly conserved sequences. …”
Publicado 2006
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120por Kopra, Kari, Vuorinen, Emmiliisa, Abreu-Blanco, Maria, Wang, Qi, Eskonen, Ville, Gillette, William, Pulliainen, Arto T., Holderfield, Matthew, Härmä, Harri“…[Image: see text] We have developed a rapid and sensitive single-well dual-parametric method introduced in linked RAS nucleotide exchange and RAS/RAF-RBD interaction assays. RAS mutations are frequent drivers of multiple different human cancers, but the development of therapeutic strategies has been challenging. …”
Publicado 2020
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