Mostrando 1,181 - 1,200 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.27s Limitar resultados
  1. 1181
    “…All three antigens (S1+S2 ectodomain, S1 domain, and RBD), but not S2, generated strong neutralizing antibodies against SARS-CoV-2. …”
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    Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits
  2. 1182
    “…We detected S-RBD-specific class-switched MBC in 13 out of 14 participants, including 4 of the 5 participants with lowest plasma levels of anti-S-RBD IgG and neutralizing antibodies. …”
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    Durable SARS-CoV-2 B cell immunity after mild or severe disease
  3. 1183
    por Chakraborty, Sandipan
    Publicado 2021
    “…The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates host cell entry. …”
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    Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity
  4. 1184
    Publicado 2020
    “…RBD obtained from both yeast and mammalian cells was properly folded, as indicated by UV-absorption, circular dichroism and tryptophan fluorescence. …”
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    Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells
  5. 1185
    “…We hypothesized that the spike (S) protein or receptor-binding domain (RBD) from these SpDCoVs would alter the host and tissue tropism of PDCoV. …”
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    Chimeric Porcine Deltacoronaviruses with Sparrow Coronavirus Spike Protein or the Receptor-Binding Domain Infect Pigs but Lose Virulence and Intestinal Tropism
  6. 1186
    por Chakraborty, Sandipan
    Publicado 2021
    “…The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates host cell entry. …”
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    Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity
  7. 1187
    “…A human synthetic Fab phage display library was panned against the RBD of the SARS-CoV-2 spike protein (SARS-2 RBD), yielding ten unique Fabs with moderate apparent affinities (EC(50) = 19–663 nM) for the SARS-2 RBD. …”
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    Neutralizing Human Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 Isolated from a Human Synthetic Fab Phage Display Library
  8. 1188
    “…All three use VH1-2-encoded motifs to recognize the receptor-binding domain (RBD), with heavy-chain N53I-enhancing binding and light-chain tyrosines recognizing F486(RBD). …”
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    Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class
  9. 1189
    “…Mutations and transient conformational movements of the receptor binding domain (RBD) that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
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    A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2
  10. 1190
    “…The plant-produced RBD-Fc fusion protein was purified from the crude extract by using protein A affinity column chromatography. …”
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    Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human Primates
  11. 1191
    “…We initially characterized RBD(330-526 )biochemically and( )investigated its thermal stability, humoral and T cell immune response of various RBD protein formulations (with or without adjuvant) to evaluate the inherent immunogenicity and immunomodulatory effect. …”
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    Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model
  12. 1192
    “…The objective of the present investigation was to repurpose the drugs with potential antiviral activity against receptor-binding domain (RBD) of SARS-CoV-2 spike (S) protein among 56 commercially available drugs. …”
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    Drug repurposing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain: An in silico approach
  13. 1193
    “…This result is consistent with the fact that the binding affinity of RBD to dACE2 is lower than that of hACE2. We further show that a few important mutations in the RBD binding interface play a pivotal role in the binding affinity of RBD to both dACE2 and hACE2. …”
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    The molecular basis for SARS-CoV-2 binding to dog ACE2
  14. 1194
    “…Results: Before vaccination, 59 individuals were seronegative, and 27 seropositive for NP and/or RBD. Of the seronegative cohort, 42% did not develop an IgG immune response against RBD after the first vaccine dose, but 100% had a strong IgG response after 2 doses. …”
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    Immunoglobulin G antibody response to the Sputnik V vaccine: previous SARS-CoV-2 seropositive individuals may need just one vaccine dose
  15. 1195
    “…In this study, four rapid methods (ACE2-RBD inhibition assay, S1-IgG detection, RBD-IgG detection, and N-IgG detection) were established and evaluated based on chemiluminescence technology. …”
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    Chemiluminescence Immunoassay Based Serological Immunoassays for Detection of SARS-CoV-2 Neutralizing Antibodies in COVID-19 Convalescent Patients and Vaccinated Population
  16. 1196
    “…We constructed a vaccine candidate CoV-RBD121-NP, which is comprised of the SARS-CoV-2 receptor-binding domain (RBD) of the spike glycoprotein (S) fused to a human IgG1 Fc domain (CoV-RBD121) and conjugated to a modified tobacco mosaic virus (TMV) nanoparticle. …”
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    Development of a SARS-CoV-2 Vaccine Candidate Using Plant-Based Manufacturing and a Tobacco Mosaic Virus-Like Nano-Particle
  17. 1197
    por Zhu, Qian, Zhou, Xiaohong
    Publicado 2022
    “…The metallopeptidase angiotensin-converting enzyme 2 (ACE2) is the SARS-CoV-2 receptor required for viral entry based on its specific recognition of the spike protein receptor binding domain (S(_RBD)) on SARS-CoV-2. We constructed a human ACE2 (hACE2)-based peptide pair by ligating discontinuous key residues involved in the hACE2–S(_RBD) interaction. …”
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    A colorimetric sandwich-type bioassay for SARS-CoV-2 using a hACE2-based affinity peptide pair
  18. 1198
    “…A comparison of synthesized and mammalian expressed RBD proteins revealed clear advantages of mammalian expression. …”
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    Development of a quantitative COVID-19 multiplex assay and its use for serological surveillance in a low SARS-CoV-2 incidence community
  19. 1199
    “…In both autoinhibited, monomeric structures, the RAS binding domain (RBD) of BRAF is resolved, revealing that the RBD forms an extensive contact interface with the 14-3-3 protomer bound to the BRAF C-terminal site and that key basic residues required for RBD-RAS binding are exposed. …”
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    Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding
  20. 1200
    “…Moreover, conformational dynamics simulations of RBD motions in SARS-CoV-2 and SARS-CoV-1 point to the role in modification of the RBD dynamics and their impact on infectivity.…”
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    Site Density Functional Theory and Structural Bioinformatics Analysis of the SARS-CoV Spike Protein and hACE2 Complex
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