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1181por Ravichandran, Supriya, Coyle, Elizabeth M., Klenow, Laura, Tang, Juanjie, Grubbs, Gabrielle, Liu, Shufeng, Wang, Tony, Golding, Hana, Khurana, Surender“…All three antigens (S1+S2 ectodomain, S1 domain, and RBD), but not S2, generated strong neutralizing antibodies against SARS-CoV-2. …”
Publicado 2020
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1182por Ogega, Clinton O., Skinner, Nicole E., Blair, Paul W., Park, Han-Sol, Littlefield, Kirsten, Ganesan, Abhinaya, Ladiwala, Pranay, Antar, Annukka AR, Ray, Stuart C., Betenbaugh, Michael J., Pekosz, Andrew, Klein, Sabra L., Manabe, Yukari C., Cox, Andrea L., Bailey, Justin R.“…We detected S-RBD-specific class-switched MBC in 13 out of 14 participants, including 4 of the 5 participants with lowest plasma levels of anti-S-RBD IgG and neutralizing antibodies. …”
Publicado 2020
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1183por Chakraborty, Sandipan“…The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates host cell entry. …”
Publicado 2021
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1184Publicado 2020“…RBD obtained from both yeast and mammalian cells was properly folded, as indicated by UV-absorption, circular dichroism and tryptophan fluorescence. …”
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1185por Niu, Xiaoyu, Hou, Yixuan J., Jung, Kwonil, Kong, Fanzhi, Saif, Linda J., Wang, Qiuhong“…We hypothesized that the spike (S) protein or receptor-binding domain (RBD) from these SpDCoVs would alter the host and tissue tropism of PDCoV. …”
Publicado 2021
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1186por Chakraborty, Sandipan“…The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates host cell entry. …”
Publicado 2021
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1187por Kim, Yu Jung, Lee, Min Ho, Lee, Se-Ra, Chung, Hyo-Young, Kim, Kwangmin, Lee, Tae Gyu, Kim, Dae Young“…A human synthetic Fab phage display library was panned against the RBD of the SARS-CoV-2 spike protein (SARS-2 RBD), yielding ten unique Fabs with moderate apparent affinities (EC(50) = 19–663 nM) for the SARS-2 RBD. …”
Publicado 2021
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1188por Rapp, Micah, Guo, Yicheng, Reddem, Eswar R., Yu, Jian, Liu, Lihong, Wang, Pengfei, Cerutti, Gabriele, Katsamba, Phinikoula, Bimela, Jude S., Bahna, Fabiana A., Mannepalli, Seetha M., Zhang, Baoshan, Kwong, Peter D., Huang, Yaoxing, Ho, David D., Shapiro, Lawrence, Sheng, Zizhang“…All three use VH1-2-encoded motifs to recognize the receptor-binding domain (RBD), with heavy-chain N53I-enhancing binding and light-chain tyrosines recognizing F486(RBD). …”
Publicado 2021
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1189por Zhang, Li, Cao, Lei, Gao, Xing-Su, Zheng, Bin-Yang, Deng, Yong-Qiang, Li, Jing-Xin, Feng, Rui, Bian, Qian, Guo, Xi-Ling, Wang, Nan, Qiu, Hong-Ying, Wang, Lei, Cui, Zhen, Ye, Qing, Chen, Geng, Lu, Kui-Kui, Chen, Yin, Chen, Yu-Tao, Pan, Hong-Xing, Yu, Jiaping, Yao, Wenrong, Zhu, Bao-Li, Chen, Jianping, Liu, Yong, Qin, Cheng-Feng, Wang, Xiangxi, Zhu, Feng-Cai“…Mutations and transient conformational movements of the receptor binding domain (RBD) that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
Publicado 2021
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1190por Siriwattananon, Konlavat, Manopwisedjaroen, Suwimon, Shanmugaraj, Balamurugan, Rattanapisit, Kaewta, Phumiamorn, Supaporn, Sapsutthipas, Sompong, Trisiriwanich, Sakalin, Prompetchara, Eakachai, Ketloy, Chutitorn, Buranapraditkun, Supranee, Wijagkanalan, Wassana, Tharakhet, Kittipan, Kaewpang, Papatsara, Leetanasaksakul, Kantinan, Kemthong, Taratorn, Suttisan, Nutchanat, Malaivijitnond, Suchinda, Ruxrungtham, Kiat, Thitithanyanont, Arunee, Phoolcharoen, Waranyoo“…The plant-produced RBD-Fc fusion protein was purified from the crude extract by using protein A affinity column chromatography. …”
Publicado 2021
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1191por Shrivastava, Tripti, Singh, Balwant, Rizvi, Zaigham Abbas, Verma, Rohit, Goswami, Sandeep, Vishwakarma, Preeti, Jakhar, Kamini, Sonar, Sudipta, Mani, Shailendra, Bhattacharyya, Sankar, Awasthi, Amit, Surjit, Milan“…We initially characterized RBD(330-526 )biochemically and( )investigated its thermal stability, humoral and T cell immune response of various RBD protein formulations (with or without adjuvant) to evaluate the inherent immunogenicity and immunomodulatory effect. …”
Publicado 2021
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1192por Behera, Santosh Kumar, Mahapatra, Namita, Tripathy, Chandra Sekhar, Pati, Sanghamitra“…The objective of the present investigation was to repurpose the drugs with potential antiviral activity against receptor-binding domain (RBD) of SARS-CoV-2 spike (S) protein among 56 commercially available drugs. …”
Publicado 2021
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1193por Zhang, Zengyuan, Zhang, Yanfang, Liu, Kefang, Li, Yan, Lu, Qiong, Wang, Qingling, Zhang, Yuqin, Wang, Liang, Liao, Hanyi, Zheng, Anqi, Ma, Sufang, Fan, Zheng, Li, Huifang, Huang, Weijin, Bi, Yuhai, Zhao, Xin, Wang, Qihui, Gao, George F., Xiao, Haixia, Tong, Zhou, Qi, Jianxun, Sun, Yeping“…This result is consistent with the fact that the binding affinity of RBD to dACE2 is lower than that of hACE2. We further show that a few important mutations in the RBD binding interface play a pivotal role in the binding affinity of RBD to both dACE2 and hACE2. …”
Publicado 2021
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1194por Claro, Franklin, Silva, Douglas, Rodriguez, Melissa, Rangel, Hector Rafael, de Waard, Jacobus H.“…Results: Before vaccination, 59 individuals were seronegative, and 27 seropositive for NP and/or RBD. Of the seronegative cohort, 42% did not develop an IgG immune response against RBD after the first vaccine dose, but 100% had a strong IgG response after 2 doses. …”
Publicado 2021
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1195por Yin, Qiangling, Zhang, Yecheng, Lian, Lijun, Qu, Yuanyuan, Wu, Wei, Chen, Zhen, Pei, Rongjuan, Chen, Tingyou, Sun, Lina, Li, Chuan, Li, Aqian, Li, Jiandong, Li, Dexin, Wang, Shiwen, Guan, Wuxiang, Liang, Mifang“…In this study, four rapid methods (ACE2-RBD inhibition assay, S1-IgG detection, RBD-IgG detection, and N-IgG detection) were established and evaluated based on chemiluminescence technology. …”
Publicado 2021
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1196por Royal, Joshua M., Simpson, Carrie A., McCormick, Alison A., Phillips, Amanda, Hume, Steve, Morton, Josh, Shepherd, John, Oh, Youngjun, Swope, Kelsi, DeBeauchamp, Jennifer L., Webby, Richard J., Cross, Robert W., Borisevich, Viktoriya, Geisbert, Thomas W., Demarco, Jennifer K., Bratcher, Barry, Haydon, Hugh, Pogue, Gregory P.“…We constructed a vaccine candidate CoV-RBD121-NP, which is comprised of the SARS-CoV-2 receptor-binding domain (RBD) of the spike glycoprotein (S) fused to a human IgG1 Fc domain (CoV-RBD121) and conjugated to a modified tobacco mosaic virus (TMV) nanoparticle. …”
Publicado 2021
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1197“…The metallopeptidase angiotensin-converting enzyme 2 (ACE2) is the SARS-CoV-2 receptor required for viral entry based on its specific recognition of the spike protein receptor binding domain (S(_RBD)) on SARS-CoV-2. We constructed a human ACE2 (hACE2)-based peptide pair by ligating discontinuous key residues involved in the hACE2–S(_RBD) interaction. …”
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1198por Guarino, Cassandra, Larson, Elisabeth, Babasyan, Susanna, Rollins, Alicia, Joshi, Lok R., Laverack, Melissa, Parrilla, Lara, Plocharczyk, Elizabeth, Diel, Diego G., Wagner, Bettina“…A comparison of synthesized and mammalian expressed RBD proteins revealed clear advantages of mammalian expression. …”
Publicado 2022
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1199por Martinez Fiesco, Juliana A., Durrant, David E., Morrison, Deborah K., Zhang, Ping“…In both autoinhibited, monomeric structures, the RAS binding domain (RBD) of BRAF is resolved, revealing that the RBD forms an extensive contact interface with the 14-3-3 protomer bound to the BRAF C-terminal site and that key basic residues required for RBD-RAS binding are exposed. …”
Publicado 2022
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1200por Kumawat, Nitesh, Tucs, Andrejs, Bera, Soumen, Chuev, Gennady N., Valiev, Marat, Fedotova, Marina V., Kruchinin, Sergey E., Tsuda, Koji, Sljoka, Adnan, Chakraborty, Amit“…Moreover, conformational dynamics simulations of RBD motions in SARS-CoV-2 and SARS-CoV-1 point to the role in modification of the RBD dynamics and their impact on infectivity.…”
Publicado 2022
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