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1201por Nguyen, Hung, Lan, Pham Dang, Nissley, Daniel A., O’Brien, Edward P., Li, Mai Suan“…The dissociation constants of REGN10987-RBD and REGN10933-RBD complexes calculated from the coarse-grained simulations are in good agreement with the experimental data. …”
Publicado 2022
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1202por Velappan, Nileena, Nguyen, Hau B., Micheva-Viteva, Sofiya, Bedinger, Daniel, Ye, Chunyan, Mangadu, Betty, Watts, Austin J., Meagher, Robert, Bradfute, Steven, Hu, Bin, Waldo, Geoffrey S., Lillo, Antonietta M.“…We report antibodies’ RBD2 recognition specificity, binding affinity, and epitope diversity, as well as ability to block RBD2 binding to the human receptor angiotensin-converting enzyme 2 (ACE2) and to neutralize authentic SARS-CoV-2 virus infection in vitro. …”
Publicado 2022
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1203por Bramich, Samantha, King, Anna, Kuruvilla, Maneesh, Naismith, Sharon L., Noyce, Alastair, Alty, Jane“…Isolated REM sleep behaviour disorder (iRBD) is characterised by dream enactment behaviours, such as kicking and punching while asleep, and vivid/violent dreams. …”
Publicado 2022
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1204por Roden, Christine A, Dai, Yifan, Giannetti, Catherine A, Seim, Ian, Lee, Myungwoon, Sealfon, Rachel, McLaughlin, Grace A, Boerneke, Mark A, Iserman, Christiane, Wey, Samuel A, Ekena, Joanne L, Troyanskaya, Olga G, Weeks, Kevin M, You, Lingchong, Chilkoti, Ashutosh, Gladfelter, Amy S“…RBD2 prefers long stretches of dsRNA, independent of sequence. …”
Publicado 2022
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1205por Suntronwong, Nungruthai, Assawakosri, Suvichada, Kanokudom, Sitthichai, Yorsaeng, Ritthideach, Auphimai, Chompoonut, Thongmee, Thanunrat, Vichaiwattana, Preeyaporn, Duangchinda, Thaneeya, Chantima, Warangkana, Pakchotanon, Pattarakul, Chansaenroj, Jira, Nilyanimit, Pornjarim, Srimuan, Donchida, Thatsanatorn, Thaksaporn, Sudhinaraset, Natthinee, Wanlapakorn, Nasamon, Mongkolsapaya, Juthathip, Poovorawan, Yong“…This study examined the neutralizing activity and receptor-binding domain (RBD) antibody levels against wild-type and omicron BA.1 and BA.2 variants in individuals who received three doses of COVID-19 vaccination. …”
Publicado 2022
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1206por Chen, Liqing, Qi, Xiaoxiao, Liang, Dan, Li, Guiqi, Peng, Xiaofang, Li, Xiaohui, Ke, Bixia, Zheng, Huanying, Liu, Zhongqiu, Ke, Changwen, Liao, Guochao, Liu, Liang, Feng, Qian“…We found that a longer recombinant RBD protein (residues 319–583; RBD-Plus-hFc) containing a small alanine linker (AAA) was able to trigger long-lasting, high-titer neutralizing antibodies in mice. …”
Publicado 2022
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1207por Maltoni, Giulia, Scutteri, Lorenzo, Mensitieri, Francesca, Piaz, Fabrizio Dal, Hochkoeppler, Alejandro“…RESULTS: We overexpressed in E. coli BL21(DE3) a synthetic gene coding for CRM197-RBD, and the target protein was detected in inclusion bodies. …”
Publicado 2022
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1208“…In this study, we performed all-atom MD simulations of RBD–ACE2 complexes for BA.1, BA.1.1, BA.2, and BA.3 Omicron subvariants, conducted a systematic mutational scanning of the RBD–ACE2 binding interfaces and analysis of electrostatic effects. …”
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1209por Song, Rui, Liu, Li, Pan, Qingbo, Liu, Jin, Tan, Jiahe, Deng, Juan, Deng, Qin, Lin, Zijin, Chen, Min, Peng, Mingli, Ren, Hong, Ming, Jia“…Responses to receptor-binding domain IgG antibody (anti-RBD-IgG), neutralizing antibodies (NAbs) and RBD+ memory B cells (MBCs) were evaluated. …”
Publicado 2022
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1210por Xiang, Yusen, Zhai, Guanglei, Li, Yaozong, Wang, Mengge, Chen, Xixiang, Wang, Ruyu, Xie, Hang, Zhang, Weidong, Ge, Guangbo, Zhang, Qian, Xu, Yechun, Caflisch, Amedeo, Xu, Jianrong, Chen, Hongzhuan, Chen, Lili“…Site-directed mutagenesis and surface plasmon resonance revealed that GA171 specifically binds to the pocket near R403 and Y505, critical residues of S-RBD for S-RBD interacting with ACE2. Thus, we provide structural insights into developing new small-molecule inhibitors and vaccines against the proposed S-RBD binding site.…”
Publicado 2023
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1211“…The seropositivity rates and titers of two Abs (anti-RBD IgG and CoV-2 NAbs) were lower in HLD patients than in HCs (all, p < 0.05). …”
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1212por Jung, Youngsin, Boot, Brendon P., Mielke, Michelle M., Ferman, Tanis J., Geda, Yonas E., McDade, Eric, Christianson, Teresa J.H., Knopman, David S., St Louis, Erik K., Silber, Michael H., Petersen, Ronald C., Boeve, Bradley F.“…INTRODUCTION: Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. …”
Publicado 2017
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1213por Chuck, Chi-Pang, Wong, Chi-Hang, Chow, Larry Ming-Cheung, Fung, Kwok-Pui, Waye, Mary Miu-Yee, Tsui, Stephen Kwok-Wing“…Pull-down assay revealed that ACE2 was specifically captured from cell lysate, indicating that the RBD was biologically active. The glycosylated and deglycosylated RBD was then subjected to SEC and results showed that deglycosylated RBD formed soluble aggregates again. …”
Publicado 2008
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1214por Kim, Hyun, Hong, Yeongjin, Shibayama, Keigo, Suzuki, Yasuhiko, Wakamiya, Nobutaka, Kim, Youn Uck“…Additionally, monoclonal RBD antibodies were prepared to confirm RBD binding to target cells through ACE2. …”
Publicado 2014
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1215por Lee, EunYoung, Kim, Kiwon, So, Hyung Seok, Choi, Jin Hee, Yoon, In-Young, Choi, Hayun“…The purpose of this study was to determine whether the frequency of RBD differs depending on the presence of PTSD or trauma. …”
Publicado 2020
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1216por Azad, Taha, Singaravelu, Ragunath, Taha, Zaid, Jamieson, Taylor R., Boulton, Stephen, Crupi, Mathieu J.F., Martin, Nikolas T., Brown, Emily E.F., Poutou, Joanna, Ghahremani, Mina, Pelin, Adrian, Nouri, Kazem, Rezaei, Reza, Marshall, Christopher Boyd, Enomoto, Masahiro, Arulanandam, Rozanne, Alluqmani, Nouf, Samson, Reuben, Gingras, Anne-Claude, Cameron, D. William, Greer, Peter A., Ilkow, Carolina S., Diallo, Jean-Simon, Bell, John C.“…Our study demonstrates the versatility of our bioreporter in mapping key residues mediating viral entry as well as screening inhibitors of the ACE2-RBD interaction. Our findings point toward targeting RBD glycosylation for therapeutic and vaccine strategies against SARS-CoV-2.…”
Publicado 2021
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1217“…The FP was used to immunize BALB/c mice, and humoral- and T cell-mediated immune responses were investigated. SARS-CoV-2 RBD-specific T cells were induced at a high quantity; however, no RBD or S-specific antibodies were detected. …”
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1218por Nidzam, Mohammad Saiful, Hossain, Md. Sohrab, Ismail, Norli, Abdul Latip, Razam, Mohammad Ilias, Muhammad Khalish, Mobin Siddique, Md. Bazlul, Zulkifli, Muzafar“…The presence of glyceryl esters (GE) and 3-monochloropropane-1,2-diol esters (3-MCPDE) in refined, bleached, and deodorized (RBD) palm oil is severely concerning to the palm oil consumer. …”
Publicado 2022
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1219“…However, when in conjunction with the RBD–N501Y mutation, viral infectivity is enhanced. …”
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1220“…Here, we discuss different reported mutations of concern in RBD, physicochemical characteristic changes resulting from mutated amino acids and their effect on binding between the RBD and ACE2. …”
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