-
1221“…The antibody titers against RBD in health care workers in Thailand receiving two doses of CoronaVac, followed by a booster dose of BNT162b2, were significantly increased. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1222por Hirunpattarasilp, Chanawee, James, Greg, Kwanthongdee, Jaturon, Freitas, Felipe, Huo, Jiandong, Sethi, Huma, Kittler, Josef T, Owens, Raymond J, McCoy, Laura E, Attwell, David“…In brain slices from hamster, which has an ACE2 sequence similar to human ACE2, angiotensin II evoked a small pericyte-mediated capillary constriction via AT1 receptors, but evoked a large constriction when the SARS-CoV-2 receptor binding domain (RBD, original Wuhan variant) was present. A mutated non-binding RBD did not potentiate constriction. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1223por Hauser, Blake M., Sangesland, Maya, Lam, Evan C., Feldman, Jared, Balazs, Alejandro B., Lingwood, Daniel, Schmidt, Aaron G.“…Boosting with the SARS-2 RBD resulted in increased reactivity to RBD epitopes, but both immunization regimens resulted in similarly broad neutralization across diverse sarbecoviruses. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1224“…The ncRBD elicits broad RNA-binding ability and binds to multiple reporter mRNAs and all four homopolymeric RNAs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1225por Mamchur, Aleksandra A., Stanishneva-Konovalova, Tatiana B., Mokrushina, Yuliana A., Abrikosova, Viktoria A., Guo, Yu, Zhang, Hongkai, Terekhov, Stanislav S., Smirnov, Ivan V., Yaroshevich, Igor A.“…Effective new approaches in drug development are based on the binding of agents, such as neutralizing monoclonal antibodies to a receptor-binding domain (RBD) of SARS-CoV-2 spike protein. However, mutations in RBD may lower the affinity of previously developed antibodies. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1226por Merid, Yared, Tekleselasie, Wondwosen, Tesfaye, Emnet, Gadisa, Anteneh, Fentahun, Dessalegn, Abate, Alegntaw, Alemu, Aynalem, Mihret, Adane, Mulu, Andargachew, Gelanew, Tesfaye“…Irrespective of schoolchildren’s vaccination status, we observed a similar pattern of significantly higher levels of IgA antibodies to Delta-RBD than to Omicron-RBD (p < 0.001) in a randomly selected subset of schoolchildren, yet comparable to Wuhan-RBD, suggesting these schoolchildren were more likely to have had SARS-CoV-2 infection with Delta variant. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1227por Pallett, Scott J. C., Heskin, Joseph, Keating, Fergus, Mazzella, Andrea, Taylor, Hannah, Patel, Aatish, Lamb, Georgia, Sturdy, Deborah, Eisler, Natalie, Denny, Sarah, Charani, Esmita, Randell, Paul, Mughal, Nabeela, Parker, Eleanor, de Oliveira, Carolina Rosadas, Rayment, Michael, Jones, Rachael, Tedder, Richard, McClure, Myra, Groppelli, Elisabetta, Davies, Gary W., O’Shea, Matthew K., Moore, Luke S. P.“…A strong association is observed between antibody titre: neutralising activity (p < 0.00001) and rising anti-RBD antibody titre: RBD antibody-binding inhibition (p < 0.001), although 18/169 (10.7%) participants with high anti-RBD titre (>100BAU/ml), show inhibition <75%. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1228por Liang, Kang-Hao, Chiang, Pao-Yin, Ko, Shih-Han, Chou, Yu-Chi, Lu, Ruei-Min, Lin, Hsiu-Ting, Chen, Wan-Yu, Lin, Yi-Ling, Tao, Mi-Hua, Jan, Jia-Tsrong, Wu, Han-Chung“…However, only RBD-chAb-45 and -51 retained neutralizing activities; RBD-chAb-1, -15, -25 and -28 exhibited diminished neutralization for all SARS-CoV-2 variants. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1229por Fresco-Taboada, A., Garcia-Duran, M., Aira, C., López, L., Sastre, P., Van der Hoek, L., Van Gils, M., Brouwer, P.J.M., Sanders, R.W., Holzer, B., Zimpernik, I., López-Collazo, E., Muñoz, P., Rueda, P., Vela, C.“…METHODS & MATERIALS: A total of 1272 human serum samples collected from volunteers (SARS-CoV-2 infected, non-infected or vaccinated) were evaluated by the two assays. For the RBD-ELISA, plates were coated with RBD, sera were added at 1/5 dilution and bound antibodies were detected with RBD labelled with Horseradish Peroxidase. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1230por Thomas, Stefani N., Karger, Amy B., Altawallbeh, Ghaith, Nelson, Kathryn M., Jacobs, David R., Gorlin, Jed, Barcelo, Helene, Thyagarajan, Bharat“…The performance of the method was compared to a laboratory-developed SARS-CoV-2 RBD total antibody enzyme-linked immunosorbent assay (ELISA). …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1231por Lan, Jiaming, Yao, Yanfeng, Deng, Yao, Chen, Hong, Lu, Guangwen, Wang, Wen, Bao, Linlin, Deng, Wei, Wei, Qiang, Gao, George F., Qin, Chuan, Tan, Wenjie“…We herein report of evaluating a recombinant receptor-binding domain (rRBD) protein vaccine in a rhesus macaque model. …”
Publicado 2015
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1232por Pan, Ting, Zhang, Yiwen, Zhou, Nan, He, Xin, Chen, Cancan, Liang, Liting, Duan, Xiaobing, Lin, Yingtong, Wu, Kang, Zhang, Hui“…We thus constructed several chimeric proteins by connecting the C-terminal domains of several adaptor proteins of E3 ubiquitin ligases such as CBL, CHIP, E6AP, and VHL, as well as VIF encoded by human immunodeficiency virus type 1 (HIV-1), to the Ras binding domain (RBD) of Raf. Although all of these chimeric proteins caused the degradation of mutant KRAS and the death of KRAS-mutant-tumor cell lines, the RBD-VIF with a protein transduction domain (PTD), named PTD-RBD-VIF, had the strongest tumor-killing effect. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1233por Zhao, Lianping, Wang, Ying, Jia, Yanbin, Zhong, Shuming, Sun, Yao, Qi, Zhangzhang, Zhang, Zhongping, Huang, Li“…However, alterations of remitted BD (RBD) in functional connectivity between the cerebral hemispheres are still not well understood. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1234por Byeon, Haewon“…The rapid eye movement sleep behavior disorder (RBD) of Parkinson’s disease (PD) patients can be improved with medications such as donepezil as long as it is diagnosed with a thorough medical examination, since identifying a high-risk group of RBD is a critical issue to treat PD. …”
Publicado 2020
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1235por Bouwman, Kim M., Tomris, Ilhan, Turner, Hannah L., van der Woude, Roosmarijn, Shamorkina, Tatiana M., Bosman, Gerlof P., Rockx, Barry, Herfst, Sander, Snijder, Joost, Haagmans, Bart L., Ward, Andrew B., Boons, Geert-Jan, de Vries, Robert P.“…We hypothesized that trimeric Receptor Binding Domain (RBD) proteins would be suitable candidates to study receptor binding properties of SARS-CoV-1 and -2. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1236por Liu, Haolin, Wei, Pengcheng, Zhang, Qianqian, Chen, Zhongzhou, Aviszus, Katja, Downing, Walter, Peterson, Shelley, Reynoso, Lyndon, Downey, Gregory P., Frankel, Stephen K., Kappler, John, Marrack, Philippa, Zhang, Gongyi“…Mutation of E484K leads to the loss of bamlanivimab binding to RBD, although this mutation does not affect the binding between RBD and ACE2.…”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1237por David, Alon Ben, Diamant, Eran, Dor, Eyal, Barnea, Ada, Natan, Niva, Levin, Lilach, Chapman, Shira, Mimran, Lilach Cherry, Epstein, Eyal, Zichel, Ran, Torgeman, Amram“…Here, we describe the development of an in vitro RBD-ACE2 binding assay and its application to identify inhibitors of the interaction of the SARS-CoV-2 RBD to ACE2 by the high-throughput screening of two compound libraries (LOPAC(®)1280 and DiscoveryProbeTM). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1238por Xu, Lingqing, Doyle, Joshua, Barbeau, Dominique J., Le Sage, Valerie, Wells, Alan, Duprex, W. Paul, Shurin, Michael R., Wheeler, Sarah E., McElroy, Anita K.“…Our results showed a seroprevalence of 5.5% by RBD ELISA, 4.5% by N ELISA, and 2.5% for both in Fall 2020, which increased to 24.7% by RBD ELISA, 14.9% by N ELISA, and 12.9% for both in February 2021. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1239por Choi, Kwang-Eun, Kim, Jeong-Min, Rhee, JeeEun, Park, Ae Kyung, Kim, Eun-Jin, Kang, Nam Sook“…Because RBD in spike protein is related to direct interaction with ACE2, almost all researches were focused on the RBD region or ACE2-free whole domain region. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1240“…OBJECTIVE: This study compared the convergent validity of commonly used anxiety scales across PD, DLB and iRBD patients. METHODS: Anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS-A), State-Trait Anxiety Inventory (STAI), MDS-UPDRS Anxiety item, and the Parkinson Anxiety Scale (PAS) in 57 participants (17 PD, 16 DLB, and 23 iRBD). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto