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1241por Leonard, Alison C., Weinstein, Jonathan J., Steiner, Paul J., Erbse, Annette H., Fleishman, Sarel J., Whitehead, Timothy A.“…Our most successful design encodes I358F, Y365W, T430I, and I513L RBD mutations, maintains recognition by the receptor ACE2 and a panel of different anti-RBD monoclonal antibodies, is between 1–2°C more thermally stable than the original RBD using a thermal shift assay, and is less proteolytically sensitive to chymotrypsin and thermolysin than the original RBD. …”
Publicado 2021
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1242por Shinnakasu, Ryo, Sakakibara, Shuhei, Yamamoto, Hiromi, Wang, Po-hung, Moriyama, Saya, Sax, Nicolas, Ono, Chikako, Yamanaka, Atsushi, Adachi, Yu, Onodera, Taishi, Sato, Takashi, Shinkai, Masaharu, Suzuki, Ryosuke, Matsuura, Yoshiharu, Hashii, Noritaka, Takahashi, Yoshimasa, Inoue, Takeshi, Yamashita, Kazuo, Kurosaki, Tomohiro“…The SARS-CoV-2 spike receptor-binding domain (RBD) comprises two regions, the core-RBD and the receptor-binding motif (RBM); the former is structurally conserved between SARS-CoV-2 and SARS-CoV. …”
Publicado 2021
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1243por Luedemann, Max, Stadler, Daniela, Cheng, Cho-Chin, Protzer, Ulrike, Knolle, Percy A., Donakonda, Sainitin“…Molecular dynamics simulation of candidate molecules with high RBD binding-scores in docking analysis predicted montelukast, an antagonist of the cysteinyl-leukotriene-receptor, to disturb the RBD structure, and infection experiments demonstrated inhibition of SARS-CoV-2 infection, although montelukast binding was outside the ACE2-binding site. …”
Publicado 2022
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1244por Yin, Wanchao, Xu, Youwei, Xu, Peiyu, Cao, Xiaodan, Wu, Canrong, Gu, Chunyin, He, Xinheng, Wang, Xiaoxi, Huang, Sijie, Yuan, Qingning, Wu, Kai, Hu, Wen, Huang, Zifu, Liu, Jia, Wang, Zongda, Jia, Fangfang, Xia, Kaiwen, Liu, Peipei, Wang, Xueping, Song, Bin, Zheng, Jie, Jiang, Hualiang, Cheng, Xi, Jiang, Yi, Deng, Su-Jun, Xu, H. Eric“…In the ACE2 binding site, compensating mutations strengthen RBD binding to ACE2. Both the RBD and the apo form of the Omicron spike trimer are thermodynamically unstable. …”
Publicado 2022
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1245por Su, Qianling, Shi, Wei, Huang, Xianing, Wan, Yakun, Li, Guanghui, Xing, Bengang, Xu, Zhi Ping, Liu, Hongbo, Hammock, Bruce D., Yang, Xiaomei, Yin, Shihua, Lu, Xiaoling“…The four purified nanobodies showed specific high-affinity binding SARS-CoV-2 S-RBD. Among these, the antigen binding affinity of Nb61 was more comparable to that of commercial rabbit anti-SARS-CoV-2 S-RBD antibodies. …”
Publicado 2022
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1246“…RESULTS: We analyzed the clinical remission or cure rate, IBS-SSS, quality of life, anxiety, depression, total adverse effects, and total severe adverse effects (TSAE) in patients with RBD. CONCLUSION: This systematic review evaluated the efficacy and safety of oFMT in the treatment of RBD to provide more comprehensive evidence.…”
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1247por Suleman, Muhammad, Murtaza, Aneela, Khan, Haji, Rashid, Farooq, Alshammari, Abdulrahman, Ali, Liaqat, Khan, Abbas, Wei, Dong-Qing“…On the other hand, wild-type RBD and XBB RBD with ACE2 receptor demonstrated docking scores of −115.0 ± 1.5 kcal/mol and −120.8 ± 3.4 kcal/mol respectively. …”
Publicado 2023
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1248por Kunz, Dieter, Stotz, Sophia, de Zeeuw, Jan, Papakonstantinou, Alexandra, Dümchen, Susanne, Haberecht, Martin, Plotkin, Michail, Bes, Frederik“…BACKGROUND: Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is a prodromal state of clinical α-synucleinopathies such as Parkinson’s disease and Lewy body dementia. …”
Publicado 2023
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1249por Romero, Maritza J., Yue, Qian, Singla, Bhupesh, Hamacher, Jürg, Sridhar, Supriya, Moseley, Auriel S., Song, Chang, Mraheil, Mobarak A., Fischer, Bernhard, Zeitlinger, Markus, Chakraborty, Trinad, Fulton, David, Gan, Lin, Annex, Brian H., Csanyi, Gabor, Eaton, Douglas C., Lucas, Rudolf“…It remains obscure how the SARS-CoV2 RBD exerts its deleterious actions in lung endothelium and whether there are mechanisms to mitigate this. …”
Publicado 2023
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1250por Goo, Junghyun, Jeong, Yuji, Park, Young-Shin, Yang, Eunji, Jung, Dae-Im, Rho, Semi, Park, Uni, Sung, Hyeyeong, Park, Pil-Gu, Choi, Jung-ah, Seo, Sang Hwan, Cho, Nam Hyuck, Lee, Hyeja, Lee, Jae Myun, Kim, Jae-Ouk, Song, Manki“…Interestingly, all five neutralizing mAbs have binding affinity to RBD, although most mAbs generated by RBD did not have neutralizing activity. …”
Publicado 2020
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1251por Castro, Rute, Nobre, Lígia S., Eleutério, Rute P., Thomaz, Mónica, Pires, António, Monteiro, Sandra M., Mendes, Sónia, Gomes, Ricardo A., Clemente, João J., Sousa, Marcos F. Q., Pinto, Filipe, Silva, Ana C., Freitas, Micael C., Lemos, Ana R., Akpogheneta, Onome, Kosack, Lindsay, Bergman, Marie‐Louise, Duarte, Nadia, Matoso, Paula, Costa, Júlia, Bandeiras, Tiago M., Gomes‐Alves, Patricia, Gonçalves, Carlos P., Demengeot, Jocelyne, Alves, Paula M.“…SARS‐CoV‐2 Spike protein and its receptor binding domain (RBD) are the antigens with higher potential to develop SARS‐CoV‐2 serological assays. …”
Publicado 2021
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1252por Papenburg, Jesse, Cheng, Matthew P, Corsini, Rachel, Caya, Chelsea, Mendoza, Emelissa, Manguiat, Kathy, Lindsay, L Robbin, Wood, Heidi, Drebot, Michael A, Dibernardo, Antonia, Zaharatos, Gerasimos, Bazin, Reneé, Gasser, Romain, Benlarbi, Mehdi, Gendron-Lepage, Gabrielle, Beaudoin-Bussières, Guillaume, Prévost, Jérémie, Finzi, Andrés, Ndao, Momar, Yansouni, Cedric P“…Against PRNT-50, results of cPass and anti-RBD IgG were nearly identical. CONCLUSIONS: The added value of cPass compared with an IgG anti-RBD ELISA was modest.…”
Publicado 2021
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1253GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2por Tsai, Ming-Shao, Yang, Yao-Hsu, Lin, Yu-Shih, Chang, Geng-He, Hsu, Cheng-Ming, Yeh, Reming-Albert, Shu, Li-Hsin, Cheng, Yu-Ching, Liu, Hung-Te, Wu, Yu-Huei, Wu, Yu-Heng, Shen, Rou-Chen, Wu, Ching-Yuan“…In the compositions of GB-2, glycyrrhiza uralensis Fisch. ex DC., theaflavin and (+)-catechin cannot inhibit the binding between ACE2 and wild-type RBD spike protein. Theaflavin 3-gallate can inhibit the binding between ACE2 and wild-type RBD spike protein. …”
Publicado 2021
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1254por Moura, Andrew D., da Costa, Hernan H. M., Correa, Victor A., de S. Lima, Ana K., Lindoso, José A. L., De Gaspari, Elizabeth, Hong, Marisa A., Cunha-Junior, Jair P., Prudencio, Carlos R.“…This work aimed to assess the antibody levels, avidity, and subclasses of IgG to RBD protein, in symptomatic patients with severe and mild forms of COVID-19 in Brazil using an adapted in-house RBD-IgG ELISA. …”
Publicado 2021
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1255por Salem, Reda, El-Kholy, Alaa A., Waly, Fatma R., Ayman, Dalia, Sakr, Aya, Hussein, Mai“…The recombinant RBD (rRBD) was ascertained to be at the proper encoding size of ∼ 600bp and expressed protein of the molecular weight of ∼ 21KDa. …”
Publicado 2022
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1256por Miluzio, Annarita, Cuomo, Alessandro, Cordiglieri, Chiara, Donnici, Lorena, Pesce, Elisa, Bombaci, Mauro, Conti, Matteo, Fasciani, Alessandra, Terracciano, Luigi, Manganaro, Lara, Toccafondi, Mirco, Scagliola, Alessandra, Oliveto, Stefania, Ricciardi, Sara, Grifantini, Renata, De Francesco, Raffaele, Abrignani, Sergio, Manfrini, Nicola, Biffo, Stefano“…The first step of SARS-CoV-2 infection is the recognition of angiotensin-converting enzyme 2 (ACE2) receptors by the receptor-binding domain (RBD) of the viral Spike (S) glycoprotein. Although the molecular and structural bases of the SARS-CoV-2-RBD/hACE2 interaction have been thoroughly investigated in vitro, the relationship between hACE2 expression and in vivo infection is less understood. …”
Publicado 2022
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1257por Cosentino, Filomena I. I., Distefano, Angela, Plazzi, Giuseppe, Schenck, Carlos H., Ferri, Raffaele“…A patient is reported in whom signs and symptoms of REM sleep behavior disorder (RBD) and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. …”
Publicado 2014
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1258“…In addition, the structures of the Rab14–FIP1 and Rab25–FIP2 complexes have been determined. All of the RBD structures contain a central parallel coiled coil in the RBD that binds to the switch 1 and switch 2 regions of the Rab. …”
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1259por Tian, Linhua, Elsheikh, Elzafir B., Patrone, Paul N., Kearsley, Anthony J., Gaigalas, Adolfas K., Inwood, Sarah, Lin-Gibson, Sheng, Esposito, Dominic, Wang, Lili“…The serology assays test the IgG and IgM against both the full-length spike antigens and the receptor binding domain (RBD) of the spike antigen. Benchmarking against an RBD-specific SARS-CoV IgG reference standard, the anti-SARS-CoV-2 RBD antibody titer was quantified in the range of 37.6 µg/mL to 31.0 ng/mL. …”
Publicado 2021
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1260por Jiménez-Jiménez, Félix Javier, Alonso-Navarro, Hortensia, García-Martín, Elena, Agúndez, José A. G.“…Dopaminergic deficiency, shown by many studies using functional neuroimaging with Single Photon Emission Computerized Tomography (SPECT) and Positron Emission Tomography (PET), is the most consistent neurochemical feature of rapid eye movement (REM) sleep behaviour disorder (RBD) and, together with transcranial ultrasonography, and determination of alpha-synuclein in certain tissues, should be considered as a reliable marker for the phenoconversion of idiopathic RBD (iRBD) to a synucleopathy (Parkinson’s disease –PD- or Lewy body dementia -LBD). …”
Publicado 2021
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