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1261por Grabovenko, Fedor, Nikiforova, Liudmila, Yanenko, Bogdan, Ulitin, Andrey, Loktyushov, Eugene, Zatsepin, Timofei, Zavyalova, Elena, Zvereva, Maria“…We propose glycosylation of the RBD as the main force for observed differences. …”
Publicado 2022
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1262“…Moreover, these models reveal key opposing impacts of RBD mutations on transmissibility, as many sets of RBD mutations predicted to increase antibody escape are also predicted to reduce receptor affinity and vice versa. …”
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1263por Okuda, Shinya, Nakayama, Takeo, Uemura, Norihito, Hikawa, Rie, Ikuno, Masashi, Yamakado, Hodaka, Inoue, Haruhisa, Tachibana, Naoko, Hayashi, Yu, Takahashi, Ryosuke, Egawa, Naohiro“…RBD is clinically confirmed by REM sleep without atonia (RWA) in polysomnography. …”
Publicado 2022
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1264por Lu, Qiuyang, Zhang, Baiyang, Sun, Mingzi, Lu, Lu, Chen, Baian, Wong, Hon Ho, Chan, Cheuk Hei, Wu, Tong, Huang, Bolong“…To supply a general understanding, in this work, we have carried out theoretical calculations to investigate the interaction between protein segments (RBD1, RBD2, RBD3) of SARS-Cov-2 spike protein and a series of noble metal (Au, Ag, Cu, Pd, Pt) surfaces regarding the binding strength, protein orientations, and electronic modulations. …”
Publicado 2023
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1265por Filippatos, Filippos, Tatsi, Elizabeth-Barbara, Papagiannopoulos, Christos, Syriopoulou, Vasiliki, Michos, Athanasios“…BACKGROUND: SARS-CoV-2 Spike protein Receptor Binding Domain neutralizing antibodies (NAbs-RBD) inhibit the viral binding to angiotensin-converting enzyme 2 (ACE2) receptors. …”
Publicado 2023
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1266por Yang, Lei, Xu, LingFang, Guo, Qiao, Deng, Bing, Hong, Yang, Wang, LiangLiang, Wang, YaLin, Jiang, DePeng, Ren, Hong“…Frequencies of memory B cells (MBCs) subsets and titers of SARS-CoV-2 neutralizing antibodies (NAbs) and anti-receptor binding domain (RBD) IgG antibodies (Abs) were analyzed. Results: As compared to the HCs, CRD patients had lower seropositivity rates and titers of both anti-RBD IgG Abs and NAbs, in addition to lower frequencies of RBD-specific MBCs (all, p < 0.05). …”
Publicado 2023
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1267“…The highest cord blood geometric mean concentration (GMC) of anti-RBD IgG was observed in infants who was born from the mother who received COVID-19 vaccine and were diagnosed with COVID-19 during pregnancy (n= 28; anti-RBD IgG: 7684.8 [95% confidential interval (CI) 4215.9-14007.8] AU/ml), while the lowest GMC was found in the infants born from mothers who received COVID-19 vaccination before pregnancy and did not have COVID-19 during pregnancy (n=18, anti-RBD IgG 1453.5 [95% CI 648.1-3259.6 AU/ml]. …”
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1268por He, Yuxian, Zhu, Qingyu, Liu, Shuwen, Zhou, Yusen, Yang, Baoan, Li, Jiaming, Jiang, Shibo“…In this study, we demonstrated that the receptor-binding domain (RBD) of S protein is an important immunogenic site in patients with SARS and rabbits immunized with inactivated SARS-CoV. …”
Publicado 2005
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1269por Santos, M.J.S., Canuto, K.M., de Aquino, C.C., Martins, C.S., Brito, G.A.C., Pessoa, T.M.R.P., Bertolini, L.R., de Sá Carneiro, I., Pinto, D.V., Nascimento, J.C.R., da Silva, B.B., Valença, J.T., Guedes, M.I.F., Owen, J.S., Oriá, R.B.“…The regional basic diet (RBD), produced to mimic the Brazilian northeastern dietary characteristics (rich in carbohydrate and low in protein) has been used in experimental malnutrition models, but few studies have explored the effect of chronic RBD on liver function, a central organ involved in cholesterol metabolism. …”
Publicado 2020
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1270por McAndrews, Kathleen M., Dowlatshahi, Dara P., Dai, Jianli, Becker, Lisa M., Hensel, Janine, Snowden, Laura M., Leveille, Jennifer M., Brunner, Michael R., Holden, Kylie W., Hopkins, Nikolas S., Harris, Alexandria M., Kumpati, Jerusha, Whitt, Michael A., Lee, J. Jack, Ostrosky-Zeichner, Luis L., Papanna, Ramesha, LeBleu, Valerie S., Allison, James P., Kalluri, Raghu“…Antibodies against N-protein were detected at a rate of 3.6% in healthy and non–COVID-19 sera collected during the pandemic in 2020, whereas 1.9% of these sera were positive for S-RBD. Approximately 86% of individuals positive for S-RBD–binding antibodies exhibited neutralizing capacity, but only 74% of N-protein–positive individuals exhibited neutralizing capacity. …”
Publicado 2020
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1271Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19por Li, Kening, Huang, Bin, Wu, Min, Zhong, Aifang, Li, Lu, Cai, Yun, Wang, Zhihua, Wu, Lingxiang, Zhu, Mengyan, Li, Jie, Wang, Ziyu, Wu, Wei, Li, Wanlin, Bosco, Bakwatanisa, Gan, Zhenhua, Qiao, Qinghua, Wu, Jian, Wang, Qianghu, Wang, Shukui, Xia, Xinyi“…The generation of S-, RBD-, and N-specific IgG occurs one week later in patients with severe/critical COVID-19 compared to patients with mild/moderate disease, while S- and RBD-specific IgG levels are 1.5-fold higher in severe/critical patients during hospitalization. …”
Publicado 2020
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1272por Bierig, Tobias, Collu, Gabriella, Blanc, Alain, Poghosyan, Emiliya, Benoit, Roger M.“…Complex formation with the peptidase domain of human angiotensin-converting enzyme 2 (ACE2), the receptor for the 2019-nCoV spike RBD, was confirmed by SEC, both for the YFP-fused spike RBD and for spike RBD alone, after removal of YFP by proteolytic cleavage. …”
Publicado 2020
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1273por Wasserman, Danielle, Bindman, Dorothea, Nesbitt, Alexander D, Cash, Diana, Milosevic, Milan, Francis, Paul T, Chaudhuri, K Ray, Leschziner, Guy D, Ferini-Strambi, Luigi, Ballard, Clive, Eccles, Amy, Rosenzweig, Ivana“…INTRODUCTION: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is increasingly recognised as an important precursor disease state of alpha-synucleinopathies. …”
Publicado 2021
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1274“…We have identified dominant molecular-level interactions, some attractive and some repulsive, between the receptor binding domain of SARS-CoV-1 spike proteins (S-RBD) and hACE2. We performed fragment-based quantum-biochemical calculations which directly relate biomolecular structure to the hACE2...S-RBD interaction energy. …”
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1275por Day, Christopher J., Bailly, Benjamin, Guillon, Patrice, Dirr, Larissa, Jen, Freda E.-C., Spillings, Belinda L., Mak, Johnson, von Itzstein, Mark, Haselhorst, Thomas, Jennings, Michael P.“…These combined screens identified compounds from these libraries that bind at K(D) (equilibrium dissociation constant) <3 μM affinity to their respective targets, 17 for ACE2 and 6 for SARS-CoV-2 RBD. Twelve ACE2 binders and six of the RBD binders compete with the RBD-ACE2 interaction in an SPR-based competition assay. …”
Publicado 2021
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1276por Nishiyama, Keine, Takahashi, Kazuki, Fukuyama, Mao, Kasuya, Motohiro, Imai, Ayuko, Usukura, Takumi, Maishi, Nako, Maeki, Masatoshi, Ishida, Akihiko, Tani, Hirofumi, Hida, Kyoko, Shigemura, Koji, Hibara, Akihide, Tokeshi, Manabu“…When the anti-RBD antibody in human serum binds to F-RBD, the degree of polarization (P) increases by suppressing the rotational diffusion of F-RBD. …”
Publicado 2021
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1277por Ellis, Daniel, Brunette, Natalie, Crawford, Katharine H. D., Walls, Alexandra C., Pham, Minh N., Chen, Chengbo, Herpoldt, Karla-Luise, Fiala, Brooke, Murphy, Michael, Pettie, Deleah, Kraft, John C., Malone, Keara D., Navarro, Mary Jane, Ogohara, Cassandra, Kepl, Elizabeth, Ravichandran, Rashmi, Sydeman, Claire, Ahlrichs, Maggie, Johnson, Max, Blackstone, Alyssa, Carter, Lauren, Starr, Tyler N., Greaney, Allison J., Lee, Kelly K., Veesler, David, Bloom, Jesse D., King, Neil P.“…Here, we used previously reported deep mutational scanning (DMS) data to guide the design of stabilized variants of the RBD. The selected mutations fill a cavity in the RBD that has been identified as a linoleic acid binding pocket. …”
Publicado 2021
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1278por Bibilashvili, R. Sh., Sidorova, M. V., Dudkina, U. S., Palkeeva, M. E., Molokoedov, A. S., Kozlovskaya, L. I., Egorov, A. M., Ishmukhametov, A. A., Parfyonova, E.V.“…The original RBD of the Chinese variant bound to three synthesized peptides: linear h2 and both chimeric variants. …”
Publicado 2021
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1279por Zhong, Min, Jiang, Xu, Zhu, Sha, Gu, Ruxin, Bai, Yu, He, Hong, Pan, Yang, Xu, Pingyi, Yan, Jun, Zhang, Li“…Depression, anxiety, and RBD are highly related to sleep disturbance. RBD has many comorbidities, which can influence the cognitive function and life quality of the patients.…”
Publicado 2021
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1280por Saker, Kahina, Escuret, Vanessa, Pitiot, Virginie, Massardier-Pilonchéry, Amélie, Paul, Stéphane, Mokdad, Bouchra, Langlois-Jacques, Carole, Rabilloud, Muriel, Goncalves, David, Fabien, Nicole, Guibert, Nicolas, Fassier, Jean-Baptiste, Bal, Antonin, Trouillet-Assant, Sophie, Trabaud, Mary-Anne“…Antibody titers were measured in 255 sera (from 150 HCW) with five quantitative immunoassays (Abbott RBD IgG II quant, bioMérieux RBD IgG, DiaSorin Trimeric spike IgG, Siemens Healthineers RBD IgG, Wantai RBD IgG). …”
Publicado 2022
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