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1301por Carino, Adriana, Moraca, Federica, Fiorillo, Bianca, Marchianò, Silvia, Sepe, Valentina, Biagioli, Michele, Finamore, Claudia, Bozza, Silvia, Francisci, Daniela, Distrutti, Eleonora, Catalanotti, Bruno, Zampella, Angela, Fiorucci, Stefano“…In detail, we provide evidence that potential binding sites exist in the RBD of the SARS CoV-2 Spike protein and that occupancy of these pockets reduces the ability of the RBD to bind to the ACE2 consensus in vitro. …”
Publicado 2020
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1302por Hattori, Takamitsu, Koide, Akiko, Panchenko, Tatyana, Romero, Larizbeth A., Teng, Kai Wen, Tada, Takuya, Landau, Nathaniel R., Koide, Shohei“…Consequently, antibodies targeting the ACE2-interacting surface (ACE2IS) located in the receptor-binding domain (RBD) of the spike protein can neutralize the virus. …”
Publicado 2020
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1303“…The receptor-binding domain (RBD) of SARS-CoV-2 S protein directly interacts with the human angiotensin-converting enzyme 2 (ACE2) on the host cell membrane. …”
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1304“…The RBD was fused to both a HiBIT tag and an IL6 secretion signal to enable facile collection from the cell culture media. …”
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1305por Zhu, Yuanmei, Yu, Danwei, Han, Yang, Yan, Hongxia, Chong, Huihui, Ren, Lili, Wang, Jianwei, Li, Taisheng, He, Yuxian“…All patient sera reacted strongly with the S1 subunit and receptor binding domain (RBD) of SARS-CoV; cross-reacted with the S ectodomain, S1, RBD, and S2 proteins of SARS-CoV-2; and neutralized both SARS-CoV and SARS-CoV-2 S protein–driven infections. …”
Publicado 2020
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1306por Malladi, Sameer Kumar, Singh, Randhir, Pandey, Suman, Gayathri, Savitha, Kanjo, Kawkab, Ahmed, Shahbaz, Khan, Mohammad Suhail, Kalita, Parismita, Girish, Nidhi, Upadhyaya, Aditya, Reddy, Poorvi, Pramanick, Ishika, Bhasin, Munmun, Mani, Shailendra, Bhattacharyya, Sankar, Joseph, Jeswin, Thankamani, Karthika, Raj, V. Stalin, Dutta, Somnath, Singh, Ramandeep, Nadig, Gautham, Varadarajan, Raghavan“…Neutralizing antibodies, the clearest known correlate of protection against SARS-CoV-2, are primarily directed against the receptor-binding domain (RBD) of the viral spike protein, suggesting that a suitable RBD construct might serve as a more accessible vaccine ingredient. …”
Publicado 2020
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1307por Hartley, Gemma E., Edwards, Emily S.J., Aui, Pei M., Varese, Nirupama, Stojanovic, Stephanie, McMahon, James, Peleg, Anton Y., Boo, Irene, Drummer, Heidi E., Hogarth, P. Mark, O’Hehir, Robyn E., van Zelm, Menno C.“…RBD- and NCP-specific Bmem cells predominantly expressed IgM(+) or IgG1(+) and continued to rise until 150 days. …”
Publicado 2020
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1308por Gai, Junwei, Ma, Linlin, Li, Guanghui, Zhu, Min, Qiao, Peng, Li, Xiaofei, Zhang, Haiwei, Zhang, Yanmin, Chen, Yadong, Ji, Weiwei, Zhang, Hao, Cao, Huanhuan, Li, Xionghui, Gong, Rui, Wan, Yakun“…Furthermore, seven Nbs were shown to block interaction of human angiotensin‐converting enzyme 2 (ACE2) with SARS‐CoV‐2‐RBD variants and two Nbs blocked the interaction of human ACE2 with bat‐SL‐CoV‐WIV1‐RBD and SARS‐CoV‐1‐RBD. …”
Publicado 2021
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1309por Graham, Carl, Seow, Jeffrey, Huettner, Isabella, Khan, Hataf, Kouphou, Neophytos, Acors, Sam, Winstone, Helena, Pickering, Suzanne, Galao, Rui Pedro, Dupont, Liane, Lista, Maria Jose, Jimenez-Guardeño, Jose M., Laing, Adam G., Wu, Yin, Joseph, Magdalene, Muir, Luke, van Gils, Marit J., Ng, Weng M., Duyvesteyn, Helen M.E., Zhao, Yuguang, Bowden, Thomas A., Shankar-Hari, Manu, Rosa, Annachiara, Cherepanov, Peter, McCoy, Laura E., Hayday, Adrian C., Neil, Stuart J.D., Malim, Michael H., Doores, Katie J.“…RBD is the dominant target for neutralizing antibodies, and several neutralizing epitopes on RBD have been molecularly characterized. …”
Publicado 2021
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1310“…In addition, we also modeled the RBD-ACE2 receptor complex for SARS-CoV-2 using the SARS-CoV RBD-ACE2 complex (3D0J) as a reference model. …”
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1311por Bellone, Maria Laura, Puglisi, Andrea, Dal Piaz, Fabrizio, Hochkoeppler, Alejandro“…However, the immunogenicity of RBD per se is limited by its low molecular mass, and by a structural rearrangement of full-length SP accompanied by the detachment of RBD. …”
Publicado 2021
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1312por Cai, Qiyong, Mu, Jingjing, Lei, Yang, Ge, Jia, Aryee, Aaron Albert, Zhang, Xiaoge, Li, Zhaohui“…It is a highly specific method for the simultaneous detection of S-RBD protein and N-protein and has minimal interference from other blood proteins. …”
Publicado 2021
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1313“…Group-A S protein's RBD bound imperceptibly to the two binding clefts of the hACE2 protein, on the other hand, Group-B S protein's RBD perfectly interacted inside the binding clefts of hACE2, with higher number of hydrogen and hydrophobic interactions. …”
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1314“…Thus, it is critical to investigate and predict the putative mutations of RBD that escape neutralizing immune responses. Here, we employed computational analyses to comprehensively investigate the mutational effects of RBD on binding to neutralizing antibodies and angiotensin-converting enzyme 2 (ACE2) and demonstrated that the RBD residues K417, L452, L455, F456, E484, G485, F486, F490, Q493, and S494 were consistent with clinically emerging variants or experimental observations of attenuated neutralizations. …”
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1315por Garcia, Pablo, Anand, Shuchi, Han, Jialin, Montez-Rath, Maria, Sun, Sumi, Shang, Tiffany, Parsonnet, Julie, Chertow, Glenn M, Schiller, Brigitte, Abra, Graham“…We defined “no seroconversion” as lack of change from negative to positive in total RBD Ig antibody, no detectable response on semiquantitative RBD IgG antibody (index value <1) as “no RBD IgG response”, and a semiquantitative RBD IgG index value <10 as “diminished RBD IgG response” RESULTS: Of the 2,099 fully vaccinated patients on dialysis, the proportion receiving the mRNA1273, BNT162b2, and Ad26.COV2.S were 62% (n=1316), 20% (n=416) and 18% (n=367), respectively. …”
Publicado 2021
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1316por Zhou, Wenyang, Xu, Chang, Wang, Pingping, Luo, Meng, Xu, Zhaochun, Cheng, Rui, Jin, Xiyun, Guo, Yu, Xue, Guangfu, Juan, Liran, Anashkina, Anastasia A., Nie, Huan, Jiang, Qinghua“…According to the molecular dynamics simulation, a key mutation N439K in the SARS-CoV-2 RBD region created a new salt bridge with Glu329 of hACE2, which resulted in greater electrostatic complementarity, and created a weak salt bridge with Asp442 of RBD. …”
Publicado 2021
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1317por D’Ippolito, Robert A., Drew, Matthew R., Mehalko, Jennifer, Snead, Kelly, Wall, Vanessa, Putman, Zoe, Esposito, Dominic, DeHart, Caroline J.“…[Image: see text] Previous work employing five SARS-CoV-2 spike protein receptor-binding domain (RBD) constructs, comprising versions originally developed by Mt. …”
Publicado 2021
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1318por Vogel, Monique, Augusto, Gilles, Chang, Xinyue, Liu, Xuelan, Speiser, Daniel, Mohsen, Mona O., Bachmann, Martin F.“…METHODS: We produced wild type RBD, RBD with single mutations (E484K, K417N, or N501Y) or with all three mutations combined and tested their binding to ACE2 by biolayer interferometry (BLI). …”
Publicado 2021
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1319“…The receptor binding domain (RBD) of the virus spike protein reacts with host ACE2, leading to the entry of the virus into the cell. …”
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1320por Matusali, Giulia, Sberna, Giuseppe, Meschi, Silvia, Gramigna, Giulia, Colavita, Francesca, Lapa, Daniele, Francalancia, Massimo, Bettini, Aurora, Capobianchi, Maria R., Puro, Vincenzo, Castilletti, Concetta, Vaia, Francesco, Bordi, Licia“…Despite the high correlation, results for anti-RBD and anti-Trimeric S IgG were numerically different even after recalculation to BAU/mL following WHO standards indications. …”
Publicado 2022
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