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1321por Othman, Houcemeddine, Messaoud, Haifa Ben, Khamessi, Oussema, Ben-Mabrouk, Hazem, Ghedira, Kais, Bharuthram, Avani, Treurnicht, Florette, Achilonu, Ikechukwu, Sayed, Yasien, Srairi-Abid, Najet“…The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-Asp tripeptide named RGD motif, which has also been identified in extracellular matrix proteins that bind integrins as well as other disintegrins and viruses. …”
Publicado 2022
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1322“…The RBD BA.2 was modeled after the BA.1. The results from molecular docking and molecular dynamics studies showed that RBD BA.2 has a higher and more stable affinity for hACE2 compared to RBD BA.1. …”
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1323por Zheng, Yuyuan, Ding, Lei, Meng, Xianhui, Potter, Meg, Kearney, Alison L., Zhang, Jie, Sun, Jie, James, David E., Yang, Guang, Zhou, Chun“…With structural comparison and competition fluorescence resonance energy transfer (FRET) assays we showed that HRas-SIN1 RBD association is much weaker than HRas-Raf1 RBD but is slightly stronger than HRas-PI3K RBD interaction, providing a possible explanation for the different outcome of insulin or EGF stimulation. …”
Publicado 2022
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1324por Li, Tingting, Zhou, Bingjie, Luo, Zhipu, Lai, Yanling, Huang, Suqiong, Zhou, Yuanze, Li, Yaning, Gautam, Anupriya, Bourgeau, Salome, Wang, Shurui, Bao, Juan, Tan, Jingquan, Lavillette, Dimitri, Li, Dianfan“…The virus recognizes the host cell by attaching its Spike (S) receptor-binding domain (RBD) to the host receptor, ACE2. Therefore, RBD is a primary target for neutralizing antibodies and vaccines. …”
Publicado 2022
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1325por Li, Hai-yun, Gao, Ning, Liu, Cheng-yang, Liu, Xiao-ling, Wu, Feng, Dai, Nini, Han, Jing, Li, Qiu-yu“…The receptor-binding domain (RBD) of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the human angiotensin-converting enzyme 2 (ACE2) receptor, which is a prerequisite for the virus to enter the cell. …”
Publicado 2022
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1326por Eweas, Ahmad F., Osman, Hosam-Eldin H., Naguib, Ibrahim A., Abourehab, Mohammed A. S., Abdel-Moneim, Ahmed S.“…Most of the interacting amino acid residues of the receptor fall within the RBD (438–506).…”
Publicado 2022
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1327por Singh, Swati, Banavath, Hemanth Naick, Godara, Priya, Naik, Biswajit, Srivastava, Varshita, Prusty, Dhaneswar“…The binding affinity of the best five peptide inhibitors with the RBD of omicron was validated further by molecular dynamics (MD) simulation. …”
Publicado 2022
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1328por Hussain, Mushtaq, Amanullah, Anusha, Aslam, Ayesha, Raza, Fozia, Arzoo, Shabana, Qureshi, Iffat Waqar, Waheed, Humera, Jabeen, Nusrat, Shabbir, Sanya, Sayeed, Muneeba Ahsan, Quraishy, Saeed“…Based on the assessment, a novel hypothetical NTD (h-NTD) and RBD (h-RBD) were designed to hold all overlapping immune escape variations. …”
Publicado 2022
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1329“…In addition, the RBD Q498Y mutant bound to ACE2 was crystallized. …”
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1330por Anzinger, Joshua J., Cameron-McDermott, Suzette M., Phillips, Yakima Z.R., Mendoza, Leshawn, Anderson, Mark, Cloherty, Gavin, Strachan-Johnson, Susan, Lindo, John F., Figueroa, J. Peter“…SARS-CoV-2 spike receptor binding domain (RBD) and/or nucleocapsid IgG antibodies were detected for 88.4% of the study population, with 77.0% showing evidence of previous SARS-CoV-2 infection. …”
Publicado 2022
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1331por Maltseva, Mariam, Galipeau, Yannick, Renner, Tyler M., Deschatelets, Lise, Durocher, Yves, Akache, Bassel, Langlois, Marc-André“…Furthermore, vaccination with adjuvanted spike led to superior mucosal IgA responses than with the RBD antigen and produced broadly targeting neutralizing plasma antibodies against ancestral, Delta and Omicron variants in vitro; whereas adjuvanted RBD elicited a narrower antibody response with neutralizing activity only against ancestral and Delta variants. …”
Publicado 2022
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1332por Ahuja, Rahul, Srichandan, Sudeepa, Meena, Jairam, Biswal, Bichitra Kumar, Panda, Amulya K.“…Receptor binding domain (RBD) of SARS-CoV-2 is a prime vaccine target against which neutralizing antibody responses are directed. …”
Publicado 2023
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1333“…In this work, we examine the modeling and analysis power of PTLs in the study of the protein structures of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor binding domain (RBD). First, we employ PTLs to study how the RBD mutation-induced structural changes of RBD-angiotensin-converting enzyme 2 (ACE2) binding complexes are captured in the changes of spectra of the PTLs among SARS-CoV-2 variants. …”
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1334“…This included, for example, a key RBD residue ARG357 in the Up-Down interaction and a three residue sequence ALA520-PRO521-ALA522, associated with a turn structure in the RBD of the Up state protomer, acting as a stabilizing interaction with the NTD of its neighbor protomer. …”
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1335por Song, Ruixin, Yang, Chao, Li, Qianqian, Wang, Jiayin, Chen, Jing, Sun, Kai, Lv, Hongmin, Yang, Yankai, Liang, Jing, Ye, Qing, Gao, YanYing, Li, Jun, Li, Ying, Yan, Junqing, Liu, Ying, Wang, Tao, Liu, Changen, Zhu, Ping, Wang, Fei, Yin, Weili, Xiang, Huiling“…After basic immunization, the time for nCoV NTAb and nCoV S-RBD to turn negative was 120 and 169 days, respectively, and the negative time of nCoV NTAb and nCoV S-RBD was significantly prolonged to 266 days and 329 days, respectively. …”
Publicado 2023
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1336por Beenhouwer, David O, Chintalacharuvu, Koteswara, Winnett, Alexander, Goldin, Evan, Bhattacharya, Debika, Graber, Christopher J, Goetz, Matthew B, Fulcher, Jennifer A“…Serum samples selected for analysis included first, last, and intermediaries spaced ≥ 5 days apart, as available. Anti-RBD IgG was detected with an enzyme immunoassay (EIA) using recombinant RBD protein. …”
Publicado 2020
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1337por L'Huillier, Arnaud G., Meyer, Benjamin, Andrey, Diego O., Arm-Vernez, Isabelle, Baggio, Stephanie, Didierlaurent, Arnaud, Eberhardt, Christiane S., Eckerle, Isabella, Grasset-Salomon, Carole, Huttner, Angela, Posfay-Barbe, Klara M., Royo, Irene Sabater, Pralong, Jacques A., Vuilleumier, Nicolas, Yerly, Sabine, Siegrist, Claire-Anne, Kaiser, Laurent“…Disease severity was associated with higher initial anti-RBD and RBD-ACE2-inhibiting antibody titres, but not with their kinetics. …”
Publicado 2021
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1338por Santiago, Llipsy, Uranga-Murillo, Iratxe, Arias, Maykel, González-Ramírez, Andrés Manuel, Macías-León, Javier, Moreo, Eduardo, Redrado, Sergio, García-García, Ana, Taleb, Víctor, Lira-Navarrete, Erandi, Hurtado-Guerrero, Ramón, Aguilo, Nacho, del Mar Encabo-Berzosa, Maria, Hidalgo, Sandra, Galvez, Eva M., Ramirez-Labrada, Ariel, de Miguel, Diego, Benito, Rafael, Miranda, Patricia, Fernández, Antonio, Domingo, José María, Serrano, Laura, Yuste, Cristina, Villanueva-Saz, Sergio, Paño-Pardo, José Ramón, Pardo, Julián“…Anti-RBD IgG plasma concentration significantly correlated with the plasma/serum VN activity against SARS-CoV-2 in vitro. …”
Publicado 2021
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1339por Lubin, Joseph H., Markosian, Christopher, Balamurugan, D., Pasqualini, Renata, Arap, Wadih, Burley, Stephen K., Khare, Sagar D.“…Examination of ACE2-bound omRBD models reveals an interdigitated multi-residue interaction network formed by omRBD-specific substituted residues (R493, S496, Y501, R498) and ACE2 residues at the interface, which was not present in the original Wuhan-Hu-1 RBD-ACE2 complex. …”
Publicado 2021
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1340por Smirnov, Vyacheslav S., Lyalina, Liudmila V., Milichkina, Anzhelika M., Khamitova, Irina V., Zueva, Elena V., Ivanov, Valery A., Zaguzov, Vitaly S., Totolian, Areg A.“…Seropositivity levels (Nc, RBD) were assessed by quantitative and qualitative enzyme immunoassays. …”
Publicado 2022
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