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1361por Kim, Ji Woong, Kim, Hyun Jung, Heo, Kyun, Lee, Yoonwoo, Jang, Hui Jeong, Lee, Ho-Young, Park, Jun Won, Cho, Yea Bin, Lee, Ji Hyun, Shin, Ha Gyeong, Yang, Ha Rim, Choi, Hye Lim, Shim, Hyun Bo, Lee, Sukmook“…Furthermore, we generated K203.A, a new bsAb built in immunoglobulin G4-(single-chain variable fragment)(2) forms and demonstrating a high manufacturing yield and nanomolar affinity to both the RBD and FP, by fusing K102.1, our previously reported RBD-specific mAb, with K107.1. …”
Publicado 2023
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1362por Alhammad, Yousef M. O., Maharajh, Sanvir, Butcher, Rebecca, Eden, John-Sebastian, White, Peter A., Poumbourios, Pantelis, Drummer, Heidi E“…In the second patient, the ability of the week 36 RBD, just prior to viral clearance, to bind CD81 was reduced ~50% relative to RBD sequences obtained earlier. …”
Publicado 2015
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1363por Gould, Gillian Sandra, Bovill, Michelle, Chiu, Simon, Bonevski, Billie, Oldmeadow, Christopher“…The RBD Scale could have diagnostic potential to tailor health messages. …”
Publicado 2017
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1364por He, Yuxian, Li, Jingjing, Du, Lanying, Yan, Xuxia, Hu, Guangan, Zhou, Yusen, Jiang, Shibo“…Group D mAb (S25) was directed against a unique epitope by its competitive binding. Two anti-RBD mAbs recognizing the linear epitopes (Group E) were mapped to the RBD residues 335–352 and 442–458, respectively, and none of them inhibited the receptor binding and virus entry. …”
Publicado 2006
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1365por Du, Lanying, Zhao, Guangyu, He, Yuxian, Guo, Yan, Zheng, Bo-Jian, Jiang, Shibo, Zhou, Yusen“…In this study, BALB/c mice were vaccinated intramuscularly (i.m.) with 10 μg of RBD-Fc (RBD fused with human IgG1 Fc) and boosted twice at 3-week intervals and one more time at 12th month. …”
Publicado 2007
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1366por Krohn, Lynne, Ruskey, Jennifer A., Rudakou, Uladzislau, Leveille, Etienne, Asayesh, Farnaz, Hu, Michele T.M., Arnulf, Isabelle, Dauvilliers, Yves, Högl, Birgit, Stefani, Ambra, Monaca, Christelle Charley, Abril, Beatriz, Plazzi, Giuseppe, Antelmi, Elena, Ferini-Strambi, Luigi, Heidbreder, Anna, Boeve, Bradley F., Espay, Alberto J., De Cock, Valérie Cochen, Mollenhauer, Brit, Sixel-Döring, Friederike, Trenkwalder, Claudia, Sonka, Karel, Kemlink, David, Figorilli, Michela, Puligheddu, Monica, Dijkstra, Femke, Viaene, Mineke, Oertel, Wolfgang, Toffoli, Marco, Gigli, Gian Luigi, Valente, Mariarosaria, Gagnon, Jean-François, Desautels, Alex, Montplaisir, Jacques Y., Postuma, Ronald B., Rouleau, Guy A., Gan-Or, Ziv“…OBJECTIVE: To study the role of GBA variants in the risk for isolated REM sleep behavior disorder (iRBD) and conversion to overt neurodegeneration. …”
Publicado 2020
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1367por Dash, Pujarini, Turuk, Jyotirmayee, Behera, Santosh K., Palo, Subrata Kumar, Raghav, Sunil K., Ghosh, Arup, Sabat, Jyotsnamayee, Rath, Sonalika, Subhadra, Subhra, Rana, Khokan, Bhattacharya, Debdutta, Kanungo, Srikanta, Kshatri, Jaya Singh, Mishra, Bijaya Kumar, Dash, Saroj, Parida, Ajay, Pati, Sanghamitra“…Sequence analysis and phylogenetic analysis were performed for the spike region and the RBD region of all isolates. The interaction between the RBD and ACE2 of five different species was also analysed. …”
Publicado 2021
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1368por Heaney, Christopher D., Pisanic, Nora, Randad, Pranay R., Kruczynski, Kate, Howard, Tyrone, Zhu, Xianming, Littlefield, Kirsten, Patel, Eshan U., Shrestha, Ruchee, Laeyendecker, Oliver, Shoham, Shmuel, Sullivan, David, Gebo, Kelly, Hanley, Daniel, Redd, Andrew D., Quinn, Thomas C., Casadevall, Arturo, Zenilman, Jonathan M., Pekosz, Andrew, Bloch, Evan M., Tobian, Aaron A. R.“…Compared to a plasma nAb assay, the multiplex salivary assay PPA ranged from 62.3% (N) and 98.6% (RBD) and NPA ranged from 18.8% (RBD) to 96.9% (S). …”
Publicado 2021
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1369por Chen, Wen-Hsiang, Wei, Junfei, Kundu, Rakhi Tyagi, Adhikari, Rakesh, Liu, Zhuyun, Lee, Jungsoon, Versteeg, Leroy, Poveda, Cristina, Keegan, Brian, Villar, Maria Jose, de Araujo Leao, Ana C., Rivera, Joanne Altieri, Gillespie, Portia M., Pollet, Jeroen, Strych, Ulrich, Zhan, Bin, Hotez, Peter J., Bottazzi, Maria Elena“…METHOD: We constructed three variants of the recombinant receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein (residues 331–549) in yeast as follows: (1) a “wild type” RBD (RBD219-WT), (2) a deglycosylated form (RBD219-N1) by deleting the first N-glycosylation site, and (3) a combined deglycosylated and cysteine-mutagenized form (C538A-mutated variant (RBD219-N1C1)). …”
Publicado 2021
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1370por Lin, Jun-Yu, Zhang, Ling-Yu, Cao, Bei, Wei, Qian-Qian, Ou, Ru-Wei, Hou, Yan-Bing, Liu, Kun-Cheng, Xu, Xin-Ran, Jiang, Zheng, Gu, Xiao-Jing, Liu, Jiao, Shang, Hui-Fang“…Three sleep-related symptoms, namely Parkinson's disease (PD)-related sleep problems (PD-SP), excessive daytime sleepiness (EDS), and rapid eye movement sleep behavior disorder (RBD), were evaluated using the PD Sleep Scale-2 (PDSS-2), Epworth Sleepiness Scale (ESS), and RBD Screening Questionnaire (RBDSQ), respectively. …”
Publicado 2021
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1371por Rusz, Jan, Hlavnička, Jan, Novotný, Michal, Tykalová, Tereza, Pelletier, Amelie, Montplaisir, Jacques, Gagnon, Jean‐Francois, Dušek, Petr, Galbiati, Andrea, Marelli, Sara, Timm, Paul C., Teigen, Luke N., Janzen, Annette, Habibi, Mahboubeh, Stefani, Ambra, Holzknecht, Evi, Seppi, Klaus, Evangelista, Elisa, Rassu, Anna Laura, Dauvilliers, Yves, Högl, Birgit, Oertel, Wolfgang, St. Louis, Erik K., Ferini‐Strambi, Luigi, Růžička, Evžen, Postuma, Ronald B., Šonka, Karel“…A total of 448 participants (337 males), including 150 with iRBD (mean duration of iRBD across language groups 0.5–3.4 years), 149 with PD (mean duration of disease across language groups 1.7–2.5 years), and 149 healthy controls were recorded; 350 of the participants completed the 12‐month follow‐up. …”
Publicado 2021
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1372por Firinu, Davide, Perra, Andrea, Campagna, Marcello, Littera, Roberto, Meloni, Federico, Sedda, Francesca, Conti, Maria, Costanzo, Giulia, Erbi, Monica, Usai, Gianmario, Locci, Carlotta, Carta, Mauro Giovanni, Cappai, Riccardo, Orrù, Germano, Del Giacco, Stefano, Coghe, Ferdinando, Chessa, Luchino“…Results: The median IgG anti-S-RBD levels at T(FULL) of Chad/BNT group were significantly higher than the BNT/BNT group and ChAd/ChAd. …”
Publicado 2021
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1373por Li, Dapeng, Martinez, David R., Schäfer, Alexandra, Chen, Haiyan, Barr, Maggie, Sutherland, Laura L., Lee, Esther, Parks, Robert, Mielke, Dieter, Edwards, Whitney, Newman, Amanda, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Gagne, Matthew, Douek, Daniel C., DeMarco, C. Todd, Denny, Thomas N., Oguin, Thomas H., Brown, Alecia, Rountree, Wes, Wang, Yunfei, Mansouri, Katayoun, Edwards, Robert J., Ferrari, Guido, Sempowski, Gregory D., Eaton, Amanda, Tang, Juanjie, Cain, Derek W., Santra, Sampa, Pardi, Norbert, Weissman, Drew, Tomai, Mark A., Fox, Christopher B., Moore, Ian N., Andersen, Hanne, Lewis, Mark G., Golding, Hana, Seder, Robert, Khurana, Surender, Baric, Ralph S., Montefiori, David C., Saunders, Kevin O., Haynes, Barton F.“…We previously reported a receptor-binding domain (RBD) sortase A-conjugated ferritin nanoparticle (RBD-scNP) vaccine that induced neutralizing antibodies against SARS-CoV-2 and pre-emergent sarbecoviruses and protected monkeys from SARS-CoV-2 WA-1 infection. …”
Publicado 2022
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1374por Guiomar, Raquel, Santos, Ana João, Melo, Aryse Martins, Costa, Inês, Matos, Rita, Rodrigues, Ana Paula, Kislaya, Irina, Silva, Anabela Santos, Roque, Carla, Nunes, Carla, Aguiar, Joaquim, Graça, Fátima, Silva Graça, Antônio, Machado, Ausenda“…The increase of nAb titers was correlated with IgG (anti-RBD/S) antibodies titers; however, in contrast to IgG (anti-RBD/S) antibodies titers, we did not detect a decrease in the nAb titer 36 days after a second vaccine dose uptake. …”
Publicado 2022
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1375por He, Qian, Mao, Qunying, Peng, Xiaozhong, He, Zhanlong, Lu, Shuaiyao, Zhang, Jialu, Gao, Fan, Bian, Lianlian, An, Chaoqiang, Yu, Wenhai, Yang, Fengmei, Zhou, Yanan, Yang, Yun, Li, Yanyan, Yuan, Yadi, Yan, Xujia, Yang, Jinghuan, Wu, Xing, Huang, Weijin, Li, Changgui, Wang, Junzhi, Liang, Zhenglun, Xu, Miao“…To investigate the potential protective effect of the recombinant protein subunit COVID-19 vaccine targeting receptor-binding domain (RBD) (PS-RBD) and whole inactivated virus particle vaccine (IV) against the variant strains, in this study, rhesus macaques were immunized with PS-RBD or IV vaccine, followed by a Beta variant (B.1.351) challenge. …”
Publicado 2022
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1376por Ganapathy S., Ranjani, Levová, Kateřina, Kotačková, Lenka, Trnka, Jiří, Zogala, David, Rusz, Jan, Zima, Tomáš, Devos, David, Šonka, Karel, Růžička, Evžen, Kalousová, Marta, Dušek, Petr“…After a median 44‐month follow‐up, 20% of iRBD patients progressed to a manifest disease. Although iRBD converters and nonconverters did not significantly differ in CDT(adj) levels (P = 0.189), low CDT(adj) increased the risk of phenoconversion with hazard ratio 3.2 (P = 0.045) but did not refine the phenoconversion risk associated with abnormal DaT‐SPECT yielding hazard ratio 15.8 (P < 0.001). …”
Publicado 2022
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1377por Nah, Eun‐Hee, Cho, Seon, Park, Hyeran, Kim, Suyoung, Noh, Dongwon, Kwon, Eunjoo, Cho, Han‐Ik“…Assaying of anti‐spike‐protein receptor‐binding domain (S‐RBD) antibodies are used to aid evaluations of the immune statuses of individuals. …”
Publicado 2022
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1378por Wang, Ting, Xu, Jie, Wang, Beibei, Wang, Yulian, Zhao, Wei, Xiang, Bin, Xue, Yuhua, Yuan, Quan, Wang, Yiqiang“…METHODS: Phage display (PhD)-12 peptide library was screened against recombinant spike trimer (S-trimer) or receptor-binding domain (S-RBD) proteins. The resulting enriched peptide sequences were obtained, and their potential binding sites on S-trimer and S-RBD 3D structure models were searched. …”
Publicado 2022
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1379por Cheng, Yandong, Shen, Ping, Tao, Yue, Zhang, Wenjun, Xu, Biyun, Bi, Yan, Han, Zhen, Zhou, Yi-Hua“…IgG antibodies against the nucleocapsid (N) and spike (S) proteins of SARS-CoV-2 (anti-N/S IgG) and receptor binding domain (RBD) proteins (anti-RBD IgG) were quantitatively evaluated by the electrochemiluminescence immunoassays, respectively. …”
Publicado 2022
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1380por Ismail, Mohamed, Martin, Stephen R., George, Roger, Houghton, Francesca, Kelly, Geoff, Chaleil, Raphaël A. G., Anastasiou, Panayiotis, Wang, Xinyue, O’Reilly, Nicola, Federico, Stefania, Joshi, Dhira, Nagaraj, Hemavathi, Cooley, Rachel, Hui, Ning Sze, Molina-Arcas, Miriam, Hancock, David C., Tavassoli, Ali, Downward, Julian“…We show that cyclo-CRVLIR binds selectively to the p110α-RBD but not to KRAS or the structurally-related RAF-RBD. …”
Publicado 2023
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