-
121por Liu, Bingfeng, Shi, Yaling, Zhang, Wanying, Li, Rong, He, Zhangping, Yang, Xiaofan, Pan, Yuejun, Deng, Xilong, Tan, Mingkai, Zhao, Lingzhai, Zou, Fan, Zhang, Yiwen, Pan, Ting, Zhang, Junsong, Zhang, Xu, Xiao, Fei, Li, Fang, Deng, Kai, Zhang, HuiEnlace del recurso
Publicado 2020
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
122por Mehalko, Jennifer, Drew, Matthew, Snead, Kelly, Denson, John-Paul, Wall, Vanessa, Taylor, Troy, Sadtler, Kaitlyn, Messing, Simon, Gillette, William, Esposito, Dominic“…The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a commonly used antigen for serology assays critical to determining the extent of SARS-CoV-2 exposure in the population. …”
Publicado 2020
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
123por Mehalko, Jennifer, Drew, Matthew, Snead, Kelly, Denson, John-Paul, Wall, Vanessa, Taylor, Troy, Sadtler, Kaitlyn, Messing, Simon, Gillette, William, Esposito, Dominic“…The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a commonly used antigen for serology assays critical to determining the extent of SARS-CoV-2 exposure in the population. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
124por Lu, Qizhong, Zhang, Zongliang, Li, Hexian, Zhong, Kunhong, Zhao, Qin, Wang, Zeng, Wu, Zhiguo, Yang, Donghui, Sun, Shuang, Yang, Nian, Zheng, Meijun, Chen, Qiang, Long, Cheng, Guo, Wenhao, Yang, Hui, Nie, Chunlai, Tong, Aiping“…RESULTS: Totally, four specific nanobodies against spike protein and its RBD domain were screened from a naïve VHH library. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
125
-
126
-
127por Urdaniz, Irene Francino, Steiner, Paul J., Kirby, Monica B., Zhao, Fangzhu, Haas, Cyrus M., Barman, Shawn, Rhodes, Emily R., Peng, Linghang, Sprenger, Kayla G., Jardine, Joseph G., Whitehead, Timothy A.“…Escape mutations predominantly mapped to the periphery of the ACE2 recognition site on the RBD with K417, D420, Y421, F486, and Q493 as notable hotspots. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
128por Nguyen, Kien, Chakraborty, Srirupa, Mansbach, Rachael A., Korber, Bette, Gnanakaran, Sandrasegaram“…To this end, we perform extensive all-atom simulations of the (i) RBD-ACE2 complex without glycans, (ii) RBD-ACE2 with oligomannose MAN9 glycans in ACE2, and (iii) RBD-ACE2 with complex FA2 glycans in ACE2. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
129por Li, Tingting, Cai, Hongmin, Yao, Hebang, Zhou, Bingjie, Zhang, Ning, van Vlissingen, Martje Fentener, Kuiken, Thijs, Han, Wenyu, GeurtsvanKessel, Corine H., Gong, Yuhuan, Zhao, Yapei, Shen, Quan, Qin, Wenming, Tian, Xiao-Xu, Peng, Chao, Lai, Yanling, Wang, Yanxing, Hutter, Cedric A. J., Kuo, Shu-Ming, Bao, Juan, Liu, Caixuan, Wang, Yifan, Richard, Audrey S., Raoul, Hervé, Lan, Jiaming, Seeger, Markus A., Cong, Yao, Rockx, Barry, Wong, Gary, Bi, Yuhai, Lavillette, Dimitri, Li, Dianfan“…SARS-CoV-2, the causative agent of COVID-19(1), features a receptor-binding domain (RBD) for binding to the host cell ACE2 protein(1–6). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
130por Francino-Urdaniz, Irene M., Steiner, Paul J., Kirby, Monica B., Zhao, Fangzhu, Haas, Cyrus M., Barman, Shawn, Rhodes, Emily R., Leonard, Alison C., Peng, Linghang, Sprenger, Kayla G., Jardine, Joseph G., Whitehead, Timothy A.“…Escape mutations predominantly mapped to the periphery of the angiotensin-converting enzyme 2 (ACE2) recognition site on the RBD with K417, D420, Y421, F486, and Q493 as notable hotspots. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
131por Jia, Lina, Liu, Yan‐Ping, Tian, Li‐Fei, Xiong, Chao, Xu, Xin, Qu, Honge, Xiong, Weixi, Zhou, Dong, Wang, Feng, Liu, Zheng, Yan, Xiao‐Xue, Xu, Wenqing, Tang, Lin“…This study described the identification of neutralizing receptor‐binding domain (RBD)‐specific antibodies from mice through vaccination with a recombinant SARS‐CoV‐2 RBD. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
132“…Moreover, the binding free energy and hydrogen bond distribution analysis of RBD-ACE2 binding interface provided the binding motifs that may be critical to allosteric signal transmission and RBD binding. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
133por Jiang, Min, Zhang, Gaiping, Liu, Hongliang, Ding, Peiyang, Liu, Yunchao, Tian, Yuanyuan, Wang, Yanwei, Wang, Aiping“…In this study, the antibody response to the RBD of SARS-CoV-2 S protein was analyzed by a panel of sera from animals immunized with RBD-based antigens and four linear B-cell epitope peptides (R345, R405, R450 and R465) were revealed. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
134“…In this study, we developed a proximity-based AlphaScreen™ assay that can be utilized to quickly and efficiently screen for inhibitors that perturb the ACE2 : S1 RBD interaction. We then designed several peptides candidates from motifs in ACE2 and S1 RBD that play critical roles in the interaction, with and without modifications to the native sequences. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
135por Roy, Urmi“…The mutations in the more recently found B.1.617 lineage and its sub-lineages are explored, and the implications for multiple point mutations of the spike protein’s receptor-binding domain (RBD) are described. The selected S1 mutations within the highly contagious B.1.617.2 sub-lineage, also known as the delta variant, are examined as well. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
136por Huang, Kuan-Ying A., Zhou, Daming, Tan, Tiong Kit, Chen, Charles, Duyvesteyn, Helen M. E., Zhao, Yuguang, Ginn, Helen M., Qin, Ling, Rijal, Pramila, Schimanski, Lisa, Donat, Robert, Harding, Adam, Gilbert-Jaramillo, Javier, James, William, Tree, Julia A., Buttigieg, Karen, Carroll, Miles, Charlton, Sue, Lien, Chia-En, Lin, Meei-Yun, Chen, Cheng-Pin, Cheng, Shu-Hsing, Chen, Xiaorui, Lin, Tzou-Yien, Fry, Elizabeth E., Ren, Jingshan, Ma, Che, Townsend, Alain R., Stuart, David I.“…Background: Administration of potent anti-receptor-binding domain (RBD) monoclonal antibodies has been shown to curtail viral shedding and reduce hospitalization in patients with SARS-CoV-2 infection. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
137por Zhang, Hui, Liu, Xingtian, Liu, Qingzhi, Mei, Hongshuang, Wang, Yashu, Cui, Gang, Zhao, Shuping“…OBJECTIVES: This study aimed to explore the regularity of S-RBD domain antibody reactivity after immunization with inactivated SARS-CoV-2 vaccine and evaluate the effect of this vaccine on the immune response. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
138por Liang, Yu, Zhang, Jing, Yuan, Run Yu, Wang, Mei Yu, He, Peng, Su, Ji Guo, Han, Zi Bo, Jin, Yu Qin, Hou, Jun Wei, Zhang, Hao, Zhang, Xue Feng, Shao, Shuai, Hou, Ya Nan, Liu, Zhao Ming, Du, Li Fang, Shen, Fu Jie, Zhou, Wei Min, Xu, Ke, Gao, Ru Qin, Tang, Fang, Lei, Ze Hua, Liu, Shuo, Zhen, Wei, Wu, Jin Juan, Zheng, Xiang, Liu, Ning, Chen, Shi, Ma, Zhi Jing, Zheng, Fan, Ren, Si Yu, Hu, Zhong Yu, Huang, Wei Jin, Wu, Gui Zhen, Ke, Chang Wen, Li, Qi Ming“…The in vivo protective capability of mutI-tri-RBD was further validated in hACE2-transgenic mice challenged by the live virus, and the results showed that mutI-tri-RBD provided potent protection not only against the SARS-CoV-2 prototype strain but also against the Delta and Beta variants.…”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
139por Hajizadeh, Faezeh, Khanizadeh, Sayyad, Khodadadi, Hamidreza, Mokhayeri, Yaser, Ajorloo, Mehdi, Malekshahi, Asra, Heydari, Ezatoallah“…An essential step in SARS-CoV-2 infection is binding the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the ACE2 receptor on the surface of host cells. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
140por da Costa, Clauber Henrique Souza, de Freitas, Camila Auad Beltrão, Alves, Cláudio Nahum, Lameira, Jerônimo“…Mutations on the Spike (S) protein receptor-binding domain (RBD) are critical for the antibody resistance and infectivity of the SARS-CoV-2 variants. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto