Mostrando 121 - 140 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.22s Limitar resultados
  1. 121
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    Recovered COVID-19 patients with recurrent viral RNA exhibit lower levels of anti-RBD antibodies
  2. 122
    “…The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a commonly used antigen for serology assays critical to determining the extent of SARS-CoV-2 exposure in the population. …”
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    Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays
  3. 123
    “…The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a commonly used antigen for serology assays critical to determining the extent of SARS-CoV-2 exposure in the population. …”
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    Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays
  4. 124
    “…RESULTS: Totally, four specific nanobodies against spike protein and its RBD domain were screened from a naïve VHH library. …”
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    Development of multivalent nanobodies blocking SARS-CoV-2 infection by targeting RBD of spike protein
  5. 125
    por Ferraz, Matheus, Lins, Roberto
    Publicado 2021
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    Characterizing Binding Kinetics and Thermodynamics of Computer-Designed Nanobodies Targeting SARS-CoV-2 RBD
  6. 126
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    Exploring the Role of Glycans in the Interaction of SARS-CoV-2 RBD and Human Receptor ACE2
  7. 127
    “…Escape mutations predominantly mapped to the periphery of the ACE2 recognition site on the RBD with K417, D420, Y421, F486, and Q493 as notable hotspots. …”
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    One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening
  8. 128
    “…To this end, we perform extensive all-atom simulations of the (i) RBD-ACE2 complex without glycans, (ii) RBD-ACE2 with oligomannose MAN9 glycans in ACE2, and (iii) RBD-ACE2 with complex FA2 glycans in ACE2. …”
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    Exploring the Role of Glycans in the Interaction of SARS-CoV-2 RBD and Human Receptor ACE2
  9. 129
    “…SARS-CoV-2, the causative agent of COVID-19(1), features a receptor-binding domain (RBD) for binding to the host cell ACE2 protein(1–6). …”
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    A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
  10. 130
    “…Escape mutations predominantly mapped to the periphery of the angiotensin-converting enzyme 2 (ACE2) recognition site on the RBD with K417, D420, Y421, F486, and Q493 as notable hotspots. …”
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    One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening
  11. 131
    “…This study described the identification of neutralizing receptor‐binding domain (RBD)‐specific antibodies from mice through vaccination with a recombinant SARS‐CoV‐2 RBD. …”
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    Potent neutralizing RBD‐specific antibody cocktail against SARS‐CoV‐2 and its mutant
  12. 132
    “…Moreover, the binding free energy and hydrogen bond distribution analysis of RBD-ACE2 binding interface provided the binding motifs that may be critical to allosteric signal transmission and RBD binding. …”
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    In silico study of intrinsic dynamics of full-length apo-ACE2 and RBD-ACE2 complex
  13. 133
    “…In this study, the antibody response to the RBD of SARS-CoV-2 S protein was analyzed by a panel of sera from animals immunized with RBD-based antigens and four linear B-cell epitope peptides (R345, R405, R450 and R465) were revealed. …”
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    Epitope Profiling Reveals the Critical Antigenic Determinants in SARS-CoV-2 RBD-Based Antigen
  14. 134
    “…In this study, we developed a proximity-based AlphaScreen™ assay that can be utilized to quickly and efficiently screen for inhibitors that perturb the ACE2 : S1 RBD interaction. We then designed several peptides candidates from motifs in ACE2 and S1 RBD that play critical roles in the interaction, with and without modifications to the native sequences. …”
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    ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics
  15. 135
    por Roy, Urmi
    Publicado 2021
    “…The mutations in the more recently found B.1.617 lineage and its sub-lineages are explored, and the implications for multiple point mutations of the spike protein’s receptor-binding domain (RBD) are described. The selected S1 mutations within the highly contagious B.1.617.2 sub-lineage, also known as the delta variant, are examined as well. …”
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    Comparative structural analyses of selected spike protein-RBD mutations in SARS-CoV-2 lineages
  16. 136
    “…Background: Administration of potent anti-receptor-binding domain (RBD) monoclonal antibodies has been shown to curtail viral shedding and reduce hospitalization in patients with SARS-CoV-2 infection. …”
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    Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2
  17. 137
    “…OBJECTIVES: This study aimed to explore the regularity of S-RBD domain antibody reactivity after immunization with inactivated SARS-CoV-2 vaccine and evaluate the effect of this vaccine on the immune response. …”
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    Serological reactivity of inactivated SARS-CoV-2 vaccine based on an S-RBD neutralizing antibody assay
  18. 138
    “…The in vivo protective capability of mutI-tri-RBD was further validated in hACE2-transgenic mice challenged by the live virus, and the results showed that mutI-tri-RBD provided potent protection not only against the SARS-CoV-2 prototype strain but also against the Delta and Beta variants.…”
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    Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2
  19. 139
    “…An essential step in SARS-CoV-2 infection is binding the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the ACE2 receptor on the surface of host cells. …”
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    SARS-COV-2 RBD (Receptor binding domain) mutations and variants (A sectional-analytical study)
  20. 140
    “…Mutations on the Spike (S) protein receptor-binding domain (RBD) are critical for the antibody resistance and infectivity of the SARS-CoV-2 variants. …”
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    Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants
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