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1381por Gerhards, Catharina, Kittel, Maximilian, Ast, Volker, Bugert, Peter, Froelich, Matthias F., Hetjens, Michael, Haselmann, Verena, Neumaier, Michael, Thiaucourt, Margot“…Moreover, variables that might influence an anti-RBD/S1 antibody decline and the existence of a post-COVID-syndrome (PCS) were addressed. …”
Publicado 2023
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1382por He, Cai, Chen, Li, Yang, Jingyun, Chen, Zimin, Lei, Hong, Hong, Weiqi, Song, Xiangrong, Yang, Li, Li, Jiong, Wang, Wei, Shen, Guobo, Lu, Guangwen, Wei, Xiawei“…Here, we investigated the immunogenic capacity of the vaccine candidate based on the receptor binding domain (RBD). An RBD(β)-HR self-assembled trimer vaccine including RBD of Beta variant (containing K417, E484 and N501) and heptad repeat (HR) subunits was developed using an insect cell expression platform. …”
Publicado 2023
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1383“…Surprisingly, the Up-Down, RBD-NTD interactions were overall stronger and more numerous than the Down-Down cross chain interactions, including the appearance of the three residue sequence ALA520-PRO521-ALA522 associated with a turn structure in the RBD of the Up state protomer. …”
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1384por Laham, Gustavo, Martínez, Alfredo P., Rojas Gimenez, Wanda, Amaya, Lucas, Abib, Anabel, Echegoyen, Natalia, Díaz, Carlos, Lucero, Alicia, Martelli, Antonella, Videla, Cristina, Neukam, Karin, Di Lello, Federico Alejandro“…Binding IgG antibodies against the spike (S) receptor-binding domain (RBD) of SARS-CoV-2 (anti-S-RBD) concentration was assessed between 3 and 16 weeks after the boost dose. …”
Publicado 2022
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1385“…In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy.…”
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1386por Zai, Xiaodong, Zhang, Zhiling, Zhou, Chuge, Zhao, Fangxin, Zhang, Yue, Wang, Xiaolin, Li, Ruihua, Li, Yaohui, Zhao, Xiaofan, Wang, Shuyi, Yang, Yilong, Yin, Ying, Zhang, Jun, Xu, Junjie, Chen, Wei“…On this basis, the wide applicability of this novel strategy to a series of representative pathogen antigens such as SARS-RBD, MERS-RBD, Mpox-M1, MenB-fHbp, and Tularemia-Tul4 was further confirmed. …”
Publicado 2023
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1387por Kanokudom, Sitthichai, Suntronwong, Nungruthai, Duangchinda, Thaneeya, Wanlapakorn, Nasamon, Poovorawan, Yong“…Booster doses, including AZD1222 (AZ), half-dose BNT162b2 (PF), and CO, increased the total RBD Ig levels, except for CV. The individual experienced a breakthrough infection by the Omicron BA.5 variant, leading to a substantial surge in total RBD Ig to over 10(5) U/mL. …”
Publicado 2023
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1388“…Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by dream enactment behavior resulting from a loss of REM skeletal muscle atonia. …”
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1389por Wu, Nicholas C., Yuan, Meng, Liu, Hejun, Lee, Chang-Chun D., Zhu, Xueyong, Bangaru, Sandhya, Torres, Jonathan L., Caniels, Tom G., Brouwer, Philip J.M., van Gils, Marit J., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.“…IGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S) protein. Such IGHV3-53 antibodies generally have a short CDR H3 because of structural constraints in binding the RBD (mode A). …”
Publicado 2020
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1390“…Out of six drugs characterized as putative RBD binders, the cephalosporin antibiotic cefsulodin was further assessed for its effect on the binding between the RBD and ACE2, suggesting that it is important to consider the dynamic formation of the heterodimer between RBD and ACE2 when judging any potential candidate. …”
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1391por Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.“…Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and are a major contributor to neutralizing antibody responses elicited by infection. …”
Publicado 2021
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1392por Moreira, Rodrigo A., Guzman, Horacio V., Boopathi, Subramanian, Baker, Joseph L., Poma, Adolfo B.“…We expect our result to foster the discussion of the number of RBD involved during recognition and the repurposing of new drugs to disable the recognition by discovering new hotspots for drug targets apart from the flexible loop in the RBD that binds the ACE2.…”
Publicado 2020
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1393por Pomplun, Sebastian, Jbara, Muhammad, Quartararo, Anthony J., Zhang, Genwei, Brown, Joseph S., Lee, Yen-Chun, Ye, Xiyun, Hanna, Stephanie, Pentelute, Bradley L.“…Nanomolar RBD concentrations in a biological matrix could be detected using the biotinylated lead peptide in ELISA format. …”
Publicado 2020
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1394por Bennett, Monique, Yoder, Sandra, Brady, Eric, Pulley, Jill M., Rhoads, Jillian P., Stewart, Thomas G., Bernard, Gordon R., Creech, C. Buddy, Wheeler, Allison P., Thomsen, Isaac“…We observed advantages over traditional ELISA for the detection and quantification of binding IgG against the receptor binding domain (RBD) of SARS-CoV-2. To determine whether COVID-19 symptom severity correlates with SARS-CoV-2 IgG, we measured anti-RBD IgG levels from 67 subjects recovered from PCR-confirmed COVID-19. …”
Publicado 2021
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1395por Yin, Rui, Guest, Johnathan D., Taherzadeh, Ghazaleh, Gowthaman, Ragul, Mittra, Ipsa, Quackenbush, Jane, Pierce, Brian G.“…With a dataset of nonredundant experimentally determined antibody-RBD structures, we classified antibodies by RBD residue binding determinants using unsupervised clustering. …”
Publicado 2021
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1396por Berndt, Anthony J., Smalley, Tressa N., Ren, Bijie, Simkovsky, Ryan, Badary, Amr, Sproles, Ashley E., Fields, Francis J., Torres-Tiji, Yasin, Heredia, Vanessa, Mayfield, Stephen P.“…Here we report the production of the SARS-CoV-2 spike protein Receptor Binding Domain (RBD) in the green algae Chlamydomonas. RBD fused to a fluorescent reporter protein accumulates as an intact protein when targeted for ER-Golgi retention or secreted from the cell, while a chloroplast localized version is truncated. …”
Publicado 2021
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1397por Harbison, Aoife M., Fogarty, Carl A., Phung, Toan K., Satheesan, Akash, Schulz, Benjamin L., Fadda, Elisa“…Furthermore, our results suggest that the loss of glycosylation at N370, a newly acquired modification in the SARS-CoV-2 S glycan shield's topology, may have contributed to increase the SARS-CoV-2 infectivity as we find that N-glycosylation at N370 stabilizes the closed RBD conformation by binding a specific cleft on the RBD surface. …”
Publicado 2021
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1398“…We predicted the structures of S, M, and N proteins of the Omicron variant using AlphaFold2 and investigated how the mutations have affected the S protein and its parts, S1 NTD and RBD, in detail. We found many amino acids on RBD were mutated, which may influence the interactions between the RBD and ACE2, while also showing the S309 antibody could still be capable of neutralizing Omicron RBD. …”
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1399“…Differences in the electrostatic potentials of the spike protein RBD (electropositive/basic) and ACE2 receptor (electronegative/acidic) play a key role in both the rapprochement and the recognition of the coronavirus by the cell receptors. …”
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1400por Yamaoka, Yutaro, Jeremiah, Sundararaj Stanleyraj, Funabashi, Rikako, Miyakawa, Kei, Morita, Takeshi, Mihana, Yusaku, Kato, Hideaki, Ryo, Akihide“…By adding protein disulfide isomerase (PDI) and endoplasmic reticulum oxidase (ERO1α) to the translational reaction mixture, we succeeded in synthesizing a functionally intact RBD protein that can interact with ACE2. Using this RBD protein, we have developed a high-throughput AlphaScreen assay to evaluate the RBD–ACE2 interaction, which can be applied for drug screening and mutation analysis. …”
Publicado 2022
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