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1401por Demone, Jordan, Maltseva, Mariam, Nourimand, Maryam, Nasr-Sharif, Mina, Galipeau, Yannick, Alarcon, Emilio I., Langlois, Marc-André, MacLean, Allyson M.“…We further demonstrate that binding of plant-expressed RBD to ACE2 is efficiently neutralized by these antibodies. …”
Publicado 2022
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1402“…Here, docking and all-atom molecular dynamics simulations were used to investigate the mechanism of HT against the receptor binding domain (RBD) of Spike, TMPRSS2, as well as the complex of RBD and angiotensin-converting enzyme 2 complex (RBD-ACE2). …”
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1403por He, Cai, Alu, Aqu, Lei, Hong, Yang, Jingyun, Hong, Weiqi, Song, Xiangrong, Li, Jiong, Yang, Li, Wang, Wei, Shen, Guobo, Lu, Guangwen, Wei, Xiawei“…By performing correlation analysis, we found that the NAbs titers were negatively correlated with the number of RBD mutations in the Omicron subvariants. Vaccines with more RBD mutations can effectively overcome the immune resistance caused by the accumulation of RBD mutations, making spike‐XBB.1.5 the most promising vaccine candidate against universal Omicron variants.…”
Publicado 2023
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1404“…Peripheral blood samples were collected. Anti-S-RBD IgG and surrogate neutralizing antibody levels were detected using the ELISA method. …”
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1405por Atıcı, Serkan, Soysal, Ahmet, Gönüllü, Erdem, Aydemir, Gökhan, Öner, Naci, Alan, Servet, Engin, Havva, Yıldız, Melek, Karaböcüoğlu, Metin“…Data on anti-receptor-binding domain (anti-RBD) IgG antibody titers and clinical characteristics were provided by infection control units. …”
Publicado 2023
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1406por Yu, Eric, Krohn, Lynne, Ruskey, Jennifer A., Asayesh, Farnaz, Spiegelman, Dan, Shah, Zalak, Chia, Ruth, Arnulf, Isabelle, Hu, Michele T. M., Montplaisir, Jacques Y., Gagnon, Jean‐François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Bernardini, Andrea, Högl, Birgit, Stefani, Ambra, Ibrahim, Abubaker, Heidbreder, Anna, Sonka, Karel, Dusek, Petr, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel‐Döring, Friederike, Cochen De Cock, Valérie, Ferini‐Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F., Rouleau, Guy A., Postuma, Ronald B., Scholz, Sonja W., Gan‐Or, Ziv“…In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27–1.93, p = 2.70e‐05). …”
Publicado 2023
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1407por Han, Qiuxue, Wang, Shen, Wang, Zhenshan, Zhang, Cheng, Wang, Xinyue, Feng, Na, Wang, Tiecheng, Zhao, Yongkun, Chi, Hang, Yan, Feihu, Xia, Xianzhu“…Here, we screened three alpacas-derived nanobodies (Nbs) with neutralizing activity from twenty RBD-specific Nbs. The three Nbs were fused with the Fc domain of human IgG, namely aVHH-11-Fc, aVHH-13-Fc and aVHH-14-Fc, which could specifically bind RBD protein and competitively inhibit the binding of ACE2 receptor to RBD. …”
Publicado 2023
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1408por Zirou, Christina, Gumeni, Sentiljana, Bellos, Ioannis, Ntanasis-Stathopoulos, Ioannis, Sklirou, Aimilia D., Bagratuni, Tina, Korompoki, Eleni, Apostolakou, Filia, Papassotiriou, Ioannis, Trougakos, Ioannis P., Terpos, Evangelos“…Conclusions: Severe COVID-19 is associated with higher anti-RBD and neutralizing antibodies up to 6 months after the infection. …”
Publicado 2023
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1409por Kerry, Philip S., Ayllon, Juan, Taylor, Margaret A., Hass, Claudia, Lewis, Andrew, García-Sastre, Adolfo, Randall, Richard E., Hale, Benjamin G., Russell, Rupert J.“…Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal ‘tail’. …”
Publicado 2011
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1410“…Its Rho GTPase binding domain (RBD) can associate with small Rho GTPases and can also self-bind to form a dimer. …”
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1411por Ma, Cuiqing, Li, Ye, Wang, Lili, Zhao, Guangyu, Tao, Xinrong, Tseng, Chien-Te K., Zhou, Yusen, Du, Lanying, Jiang, Shibo“…Our previous study has shown that subcutaneous (s.c.) vaccination of a recombinant protein containing receptor-binding domain (RBD) of MERS-CoV S fused with Fc of human IgG (RBD-Fc) induced strong systemic neutralizing antibody responses in vaccinated mice. …”
Publicado 2014
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1412por Acevedo, Roderico, Orench-Rivera, Nichole, Quarles, Kaycee A., Showalter, Scott A.“…Moreover, circular dichroism data shows that the number of dsRBD moieties bound to RNA at saturation is different for a tandem-dsRBD construct than for constructs with only one dsRBD per polypeptide, revealing another reason for the selective pressure to maintain multiple domains within a polypeptide chain. …”
Publicado 2015
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1413por Tanaka, Yoshihiro, Mizuno, Hirokazu, Akino, Yuichi, Isono, Masaru, Masai, Norimasa, Yamamoto, Toshijiro“…If the vendor's representative beam data (RBD) for TrueBeam linear accelerators are to be valid for use in clinical practice, the variations in the beam data used for beam modeling must be small. …”
Publicado 2019
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1414“…A multiple linear regression analysis showed that the OABSS was significantly influenced by the FAB score, H-Y stage, RBD, and age. CONCLUSIONS: The FAB score, H-Y stage, and RBD are accompanying factors for OAB. …”
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1415por Tian, Xiaolong, Li, Cheng, Huang, Ailing, Xia, Shuai, Lu, Sicong, Shi, Zhengli, Lu, Lu, Jiang, Shibo, Yang, Zhenlin, Wu, Yanling, Ying, Tianlei“…Here, we report for the first time that a SARS-CoV-specific human monoclonal antibody, CR3022, could bind potently with 2019-nCoV RBD (KD of 6.3 nM). The epitope of CR3022 does not overlap with the ACE2 binding site within 2019-nCoV RBD. …”
Publicado 2020
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1416por Guo, Li, Yao, Zhiqian, Yang, Lu, Zhang, Hao, Qi, Yu, Gou, Lu, Xi, Wang, Liu, Dingxin, Zhang, Lei, Cheng, Yilong, Wang, Xiaohua, Rong, Mingzhe, Chen, Hailan, Kong, Michael G.“…In this study, pseudoviruses with the SARS-CoV-2 S protein were used as a model, and plasma-activated water (PAW) effectively inhibited pseudovirus infection through S protein inactivation. The RBD was used to study the molecular details, and the RBD binding activity was inactivated by plasma-activated water through the RBD modification. …”
Publicado 2021
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1417por Graham, Carl, Seow, Jeffrey, Huettner, Isabella, Khan, Hataf, Kouphou, Neophytos, Acors, Sam, Winstone, Helena, Pickering, Suzanne, Galao, Rui Pedro, Lista, Maria Jose, Jimenez-Guardeno, Jose M, Laing, Adam G., Wu, Yin, Joseph, Magdalene, Muir, Luke, Ng, Weng M., Duyvesteyn, Helen M. E., Zhao, Yuguang, Bowden, Thomas A., Shankar-Hari, Manu, Rosa, Annachiara, Cherepanov, Peter, McCoy, Laura E., Hayday, Adrian C., Neil, Stuart J.D., Malim, Michael H., Doores, Katie J.“…RBD is the dominant target for neutralizing antibodies and several neutralizing epitopes on RBD have been molecularly characterized. …”
Publicado 2021
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1418“…In the absence of CDTa, CDTb assembles into two distinct di-heptameric states, a symmetric and an asymmetric form with both states having two surface-accessible host cell receptor-binding domains, termed RBD1 and RBD2. RBD1 has a unique amino acid sequence, when aligned to other well-studied binary toxins (i.e., anthrax), and it contains a novel Ca(2+)-binding site important for CDTb stability. …”
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1419por Huang, Kuan-Ying A., Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S., McCauley, John W., Rijal, Pramila, Townsend, Alain R.“…Fourteen of 32 anti-spike MAbs, including five anti-receptor-binding domain (RBD), three anti-non-RBD S1 and six anti-S2, neutralised wild-type SARS-CoV-2 in independent assays. …”
Publicado 2021
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1420“…Among these mutations are amino acid changes N501Y (lineage B.1.1.7, first identified in the UK), and the combination N501Y, E484K, K417N (B.1.351, first identified in South Africa), all located at the interface on the receptor binding domain (RBD). We experimentally establish that RBD containing the N501Y mutation results in 7-fold stronger binding to the hACE2 receptor than wild type RBD. …”
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