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1421“…Andrographolide which is largely present in the leaf extracts of Andrographis paniculata (AP) and is known to exhibit antiviral, antibacterial, and stabilizes Th1/Th2/Th17 responses; taking this clue, we used in silico approaches to see the binding of andrographolide to RBD and NSP12 molecules. Our docking results showed very strong affinity of andrographolide to RBD and NSP12 of the SARS-CoV-2 virus with dock scores of −10.3460 for RBD and −10.7313 for NSP12 indicating andrographolide acts as an inhibitor of RBD and NSP12. …”
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1422por Siriwattananon, Konlavat, Manopwisedjaroen, Suwimon, Shanmugaraj, Balamurugan, Prompetchara, Eakachai, Ketloy, Chutitorn, Buranapraditkun, Supranee, Tharakhet, Kittipan, Kaewpang, Papatsara, Ruxrungtham, Kiat, Thitithanyanont, Arunee, Phoolcharoen, Waranyoo“…This data revealed the adjuvants’ role in enhancing the immune response of RBD-Fc vaccination and the immune profiles elicited by different adjuvants, which could prove helpful for the rational development of next-generation SARS-CoV-2 RBD-Fc subunit vaccines. …”
Publicado 2021
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1423por Psichogiou, Mina, Karabinis, Andreas, Poulakou, Garyphallia, Antoniadou, Anastasia, Kotanidou, Anastasia, Degiannis, Dimitrios, Pavlopoulou, Ioanna D., Chaidaroglou, Antigoni, Roussos, Sotirios, Mastrogianni, Elpida, Eliadi, Irene, Basoulis, Dimitrios, Petsios, Konstantinos, Leontis, Konstantinos, Kakalou, Eleni, Protopapas, Konstantinos, Jahaj, Edison, Pratikaki, Maria, Syrigos, Konstantinos N., Lagiou, Pagona, Gogas, Helen, Tsiodras, Sotirios, Magiorkinis, Gkikas, Paraskevis, Dimitrios, Sypsa, Vana, Hatzakis, Angelos“…Immunogenicity was assessed by measuring anti-SARS-CoV-2 against the RBD domain of the spike protein (anti-RBD). Samples were collected 1–2 weeks after vaccination or 15–59 days post-onset of symptoms. …”
Publicado 2021
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1424por Grishin, Andrey M., Dolgova, Nataliya V., Landreth, Shelby, Fisette, Olivier, Pickering, Ingrid J., George, Graham N., Falzarano, Darryl, Cygler, Miroslaw“…Our research demonstrates the mechanism by which the disulfide bonds contribute to the molecular structure of the RBD of the Spike protein, allowing the RBD to execute its viral function.…”
Publicado 2022
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1425por Wang, Pan, Ding, Peiyang, Wei, Qiang, Liu, Hongliang, Liu, Yunchao, Li, Qingmei, Xing, Yunrui, Li, Ge, Zhou, Enmin, Zhang, Gaiping“…In this study, we report the generation, characterization and epitope mapping of several monoclonal antibodies against the spike receptor-binding domain (RBD) of MERS-CoV. Two monoclonal antibodies (4C7 and 6E8) that can react with linearized RBD have been selected for subsequent identification of RBD mAb-binding epitopes. …”
Publicado 2022
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1426por Valenti, Luca, Pelusi, Serena, Cherubini, Alessandro, Bianco, Cristiana, Ronzoni, Luisa, Uceda Renteria, Sara, Coluccio, Elena, Berzuini, Alessandra, Lombardi, Angela, Terranova, Leonardo, Malvestiti, Francesco, Lamorte, Giuseppe, Erba, Elisa, Oggioni, Massimo, Ceriotti, Ferruccio, Prati, Daniele“…The persistence of anti‐RBD antibodies was short‐lived.…”
Publicado 2021
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1427por Jeffery-Smith, Anna, Burton, Alice R., Lens, Sabela, Rees-Spear, Chloe, Davies, Jessica, Patel, Monika, Gopal, Robin, Muir, Luke, Aiano, Felicity, Doores, Katie J., Chow, J. Yimmy, Ladhani, Shamez N., Zambon, Maria, McCoy, Laura E., Maini, Mala K.“…Class-switched spike and receptor-binding domain (RBD) tetramer–binding MBCs persisted 5 months after mild or asymptomatic SARS-CoV-2 infection, irrespective of age. …”
Publicado 2022
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1428por Zhang, Meiyi, Wang, Haoqi, Foster, Emma R., Nikolov, Zivko L., Fernando, Sandun D., King, Maria D.“…At all the conditions, RBD exhibits lower dissociation capabilities than the full-length S trimer protein, indicating that the separated RBD formed stronger attachment to hydrophobic surfaces compared to when it was included in the S protein.…”
Publicado 2022
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1429“…Computational mutagenesis and free energy perturbation could confirm that Omicron RBD binds ACE2 ~2.5 times stronger than prototype SARS-CoV-2. …”
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1430“…Molecular dynamics simulation and Fpocket were applied to find the key sites on RBD(Omicron), and molecular docking was also used to reveal the interaction between A. tsao-ko essential oil (AEO) and RBD(Omicron). …”
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1431por Rothen, Dominik A., Krenger, Pascal S., Nonic, Aleksandra, Balke, Ina, Vogt, Anne‐Cathrine S., Chang, Xinyue, Manenti, Alessandro, Vedovi, Fabio, Resevica, Gunta, Walton, Senta M., Zeltins, Andris, Montomoli, Emanuele, Vogel, Monique, Bachmann, Martin F., Mohsen, Mona O.“…RESULTS: CuMV(TT)‐RBD vaccine elicited a strong systemic RBD‐ and spike‐IgG and IgA antibodies of high avidity. …”
Publicado 2022
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1432por Kopanja, Sonja, Gattinger, Pia, Schmidthaler, Klara, Sieber, Justyna, Niepodziana, Katarzyna, Schlederer, Thomas, Weseslindtner, Lukas, Stiasny, Karin, Götzinger, Florian, Pickl, Winfried F., Frischer, Thomas, Valenta, Rudolf, Szépfalusi, Zsolt“…The capacity of the antibody response to block RBD‐ACE2 binding and virus neutralization were assessed. …”
Publicado 2022
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1433por Nishimura, Masashi, Sugawa, Satoshi, Ota, Shinichiro, Suematsu, Etsuko, Shinoda, Masahiro, Shinkai, Masaharu“…For the detection of ongoing infection, periodical screening with IgG (RBD) in addition to PCR would be an effective measure. …”
Publicado 2022
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1434por Forest-Nault, Catherine, Koyuturk, Izel, Gaudreault, Jimmy, Pelletier, Alex, L’Abbé, Denis, Cass, Brian, Bisson, Louis, Burlacu, Alina, Delafosse, Laurence, Stuible, Matthew, Henry, Olivier, De Crescenzo, Gregory, Durocher, Yves“…Several key mutations in the Spike protein receptor binding domain (RBD) have been identified to influence its affinity for the human Angiotensin-Converting Enzyme 2 (ACE2). …”
Publicado 2022
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1435por Jaewjaroenwattana, Jutamas, Phoolcharoen, Waranyoo, Pasomsub, Ekawat, Teengam, Prinjaporn, Chailapakul, Orawon“…The current change of [Fe(CN)(6)](3-/4-) before and after the presence of target RBD could be clearly distinguished, providing a linear relationship with RBD concentration in the range from 0.1 pg/mL to 500 ng/mL with the minimum limit of detection of 2.0 fg/mL. …”
Publicado 2023
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1436por Peters, Michael H.“…In this study, we have examined the dynamics of the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein in detail. …”
Publicado 2022
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1437por Shi, Rui, Zeng, Jiawei, Xu, Ling, Wang, Fengze, Duan, Xiaomin, Wang, Yue, Wu, Zheng, Yu, Dandan, Huang, Qingrui, Yao, Yong-Gang, Yan, Jinghua“…Immunogenicity of SARS-CoV-2 RBD-trimer vaccine and H1N1 HA1-trimer antigens candidates were evaluated in mice. …”
Publicado 2022
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1438por Davis, Samantha K, Selva, Kevin John, Lopez, Ester, Haycroft, Ebene R, Lee, Wen Shi, Wheatley, Adam K, Juno, Jennifer A, Adair, Amy, Pymm, Phillip, Redmond, Samuel J, Gherardin, Nicholas A, Godfrey, Dale I, Tham, Wai‐Hong, Kent, Stephen J, Chung, Amy W“…Plasma IgA and IgG from this cohort broadly recognised similar RBD epitopes and had similar capacities to inhibit ACE2 from binding to 22 of the 23 prevalent RBD mutations assessed. …”
Publicado 2022
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1439“…We also coated streptavidin microspheres with SARS-CoV-2 delta variant RBD to determine if the streptavidin microsphere approach revealed any differences in binding of immune serum antibodies to wild-type (Wuhan) versus variant RBD (Delta). …”
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1440por Phillips, Joseph R., Matar, Elie, Ehgoetz Martens, Kaylena A., Moustafa, Ahmed A., Halliday, Glenda M., Lewis, Simon J. G.“…Thirteen iRBD patients demonstrated MCI (iRBD-MCI). In the iRBD-MCI group, one presented with parkinsonism and was thus classified as probable pDLB, whilst the remaining 12 were classified as only possible pDLB. …”
Publicado 2022
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