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  1. 1421
    “…Andrographolide which is largely present in the leaf extracts of Andrographis paniculata (AP) and is known to exhibit antiviral, antibacterial, and stabilizes Th1/Th2/Th17 responses; taking this clue, we used in silico approaches to see the binding of andrographolide to RBD and NSP12 molecules. Our docking results showed very strong affinity of andrographolide to RBD and NSP12 of the SARS-CoV-2 virus with dock scores of −10.3460 for RBD and −10.7313 for NSP12 indicating andrographolide acts as an inhibitor of RBD and NSP12. …”
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    Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug
  2. 1422
    “…This data revealed the adjuvants’ role in enhancing the immune response of RBD-Fc vaccination and the immune profiles elicited by different adjuvants, which could prove helpful for the rational development of next-generation SARS-CoV-2 RBD-Fc subunit vaccines. …”
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    Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant Formulations
  3. 1423
    “…Immunogenicity was assessed by measuring anti-SARS-CoV-2 against the RBD domain of the spike protein (anti-RBD). Samples were collected 1–2 weeks after vaccination or 15–59 days post-onset of symptoms. …”
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    Comparative Immunogenicity of BNT162b2 mRNA Vaccine with Natural SARS-CoV-2 Infection
  4. 1424
    “…Our research demonstrates the mechanism by which the disulfide bonds contribute to the molecular structure of the RBD of the Spike protein, allowing the RBD to execute its viral function.…”
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    Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen
  5. 1425
    “…In this study, we report the generation, characterization and epitope mapping of several monoclonal antibodies against the spike receptor-binding domain (RBD) of MERS-CoV. Two monoclonal antibodies (4C7 and 6E8) that can react with linearized RBD have been selected for subsequent identification of RBD mAb-binding epitopes. …”
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    Precise location of two novel linear epitopes on the receptor-binding domain surface of MERS-CoV spike protein recognized by two different monoclonal antibodies
  6. 1426
    “…The persistence of anti‐RBD antibodies was short‐lived.…”
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    Trends and risk factors of SARS‐CoV‐2 infection in asymptomatic blood donors
  7. 1427
    “…Class-switched spike and receptor-binding domain (RBD) tetramer–binding MBCs persisted 5 months after mild or asymptomatic SARS-CoV-2 infection, irrespective of age. …”
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    SARS-CoV-2–specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodies
  8. 1428
    “…At all the conditions, RBD exhibits lower dissociation capabilities than the full-length S trimer protein, indicating that the separated RBD formed stronger attachment to hydrophobic surfaces compared to when it was included in the S protein.…”
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    Binding behavior of spike protein and receptor binding domain of the SARS-CoV-2 virus at different environmental conditions
  9. 1429
    por Shah, Masaud, Woo, Hyun Goo
    Publicado 2022
    “…Computational mutagenesis and free energy perturbation could confirm that Omicron RBD binds ACE2 ~2.5 times stronger than prototype SARS-CoV-2. …”
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    Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies
  10. 1430
    “…Molecular dynamics simulation and Fpocket were applied to find the key sites on RBD(Omicron), and molecular docking was also used to reveal the interaction between A. tsao-ko essential oil (AEO) and RBD(Omicron). …”
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    Amomum tsao-ko essential oil, a novel anti-COVID-19 Omicron spike protein natural products: A computational study
  11. 1431
    “…RESULTS: CuMV(TT)‐RBD vaccine elicited a strong systemic RBD‐ and spike‐IgG and IgA antibodies of high avidity. …”
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    Intranasal administration of a VLP‐based vaccine induces neutralizing antibodies against SARS‐CoV‐2 and variants of concern
  12. 1432
    “…The capacity of the antibody response to block RBD‐ACE2 binding and virus neutralization were assessed. …”
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    Characterization of the antibody response to SARS‐CoV‐2 in a mildly affected pediatric population
  13. 1433
    “…For the detection of ongoing infection, periodical screening with IgG (RBD) in addition to PCR would be an effective measure. …”
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    Detection of silent infection of severe acute respiratory syndrome coronavirus 2 by serological tests
  14. 1434
    “…Several key mutations in the Spike protein receptor binding domain (RBD) have been identified to influence its affinity for the human Angiotensin-Converting Enzyme 2 (ACE2). …”
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    Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2
  15. 1435
    “…The current change of [Fe(CN)(6)](3-/4-) before and after the presence of target RBD could be clearly distinguished, providing a linear relationship with RBD concentration in the range from 0.1 pg/mL to 500 ng/mL with the minimum limit of detection of 2.0 fg/mL. …”
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    Electrochemical paper-based antigen sensing platform using plant-derived monoclonal antibody for detecting SARS-CoV-2
  16. 1436
    por Peters, Michael H.
    Publicado 2022
    “…In this study, we have examined the dynamics of the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein in detail. …”
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    Flap structure within receptor binding domain of SARS-CoV-2 spike periodically obstructs hACE2 Binding subdomain bearing similarities to HIV-1 protease flap
  17. 1437
    “…Immunogenicity of SARS-CoV-2 RBD-trimer vaccine and H1N1 HA1-trimer antigens candidates were evaluated in mice. …”
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    A combination vaccine against SARS-CoV-2 and H1N1 influenza based on receptor binding domain trimerized by six-helix bundle fusion core
  18. 1438
    “…Plasma IgA and IgG from this cohort broadly recognised similar RBD epitopes and had similar capacities to inhibit ACE2 from binding to 22 of the 23 prevalent RBD mutations assessed. …”
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    Heterologous SARS‐CoV‐2 IgA neutralising antibody responses in convalescent plasma
  19. 1439
    “…We also coated streptavidin microspheres with SARS-CoV-2 delta variant RBD to determine if the streptavidin microsphere approach revealed any differences in binding of immune serum antibodies to wild-type (Wuhan) versus variant RBD (Delta). …”
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    Monobiotinylated Proteins Tethered to Microspheres for Detection of Antigen-Specific Serum Antibodies
  20. 1440
    “…Thirteen iRBD patients demonstrated MCI (iRBD-MCI). In the iRBD-MCI group, one presented with parkinsonism and was thus classified as probable pDLB, whilst the remaining 12 were classified as only possible pDLB. …”
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    Exploring the Sensitivity of Prodromal Dementia with Lewy Bodies Research Criteria
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