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1461por He, Qingwen, Wu, Lili, Xu, Zepeng, Wang, Xiaoyun, Xie, Yufeng, Chai, Yan, Zheng, Anqi, Zhou, Jianjie, Qiao, Shitong, Huang, Min, Shang, Guijun, Zhao, Xin, Feng, Youjun, Qi, Jianxun, Gao, George Fu, Wang, Qihui“…Moreover, the complex structures of BA.2 RBD/BD-604/S304 and BA.4/5 RBD/BD-604/S304/S309 further elucidate the molecular mechanism of antibody evasion by these sub-variants. …”
Publicado 2023
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1462por Patil, Smital, Vijayanand, Sharon, Menon, Ipshita, Gomes, Keegan Braz, Kale, Akanksha, Bagwe, Priyal, Yacoub, Shadi, Uddin, Mohammad N., D’Souza, Martin J.“…The microparticles encapsulated a highly immunogenic subunit protein of the SARS-CoV-2 virus, such as the spike protein’s receptor binding domain (RBD). Adjuvants were also incorporated to enhance the spike RBD-specific immune response. …”
Publicado 2023
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1463“…OBJECTIVE: To validate, for the first time, the Risk Behaviour Diagnosis (RBD) Scale for Aboriginal Australian tobacco smokers, based on the Extended Parallel Process Model (EPPM). …”
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1464por Jakob, Leonhard, Treiber, Thomas, Treiber, Nora, Gust, Alexander, Kramm, Kevin, Hansen, Kerrin, Stotz, Mathias, Wankerl, Ludwig, Herzog, Franz, Hannus, Stefan, Grohmann, Dina, Meister, Gunter“…In addition, we show that the linker preceding dsRBD3 contributes significantly to dmDcr1 binding. …”
Publicado 2016
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1465“…In silico predictions and experimental results suggest that the RBD is structured as a rigid fold of three α-helices. …”
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1466“…The existence of these subtypes is supported by in vivo imaging studies of RBD-positive and RBD-negative patient groups and by histological evidence— reviewed herein. …”
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1467por Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.“…We find that the monoclonal antibody CR3022 binds the RBD tightly, neutralizing SARS-CoV-2, and report the crystal structure at 2.4 Å of the Fab/RBD complex. …”
Publicado 2020
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1468por Yu, Fei, Xiang, Rong, Deng, Xiaoqian, Wang, Lili, Yu, Zhengsen, Tian, Shijun, Liang, Ruiying, Li, Yanbai, Ying, Tianlei, Jiang, Shibo“…This review summarizes the structure and function of RBD and RBD-specific NMAbs against SARS-CoV and SARS-CoV-2 currently under development.…”
Publicado 2020
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1469por Greaney, Allison J., Starr, Tyler N., Barnes, Christopher O., Weisblum, Yiska, Schmidt, Fabian, Caskey, Marina, Gaebler, Christian, Cho, Alice, Agudelo, Marianna, Finkin, Shlomo, Wang, Zijun, Poston, Daniel, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J., Bloom, Jesse D.“…Here we use a yeast-display system to map all mutations to the viral spike receptor-binding domain (RBD) that escape binding by representatives of three potently neutralizing classes of anti-RBD antibodies with high-resolution structures. …”
Publicado 2021
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1470por Zha, Lisha, Chang, Xinyue, Zhao, Hongxin, Mohsen, Mona O., Hong, Liang, Zhou, Yuhang, Chen, Hongquan, Liu, Xuelan, Zhang, Jie, Li, Dong, Wu, Ke, Martina, Byron, Wang, Junfeng, Vogel, Monique, Bachmann, Martin F.“…The RBD displayed CuMV(TT) bound to ACE2, the viral receptor, demonstrating proper folding of RBD. …”
Publicado 2021
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1471por Norman, Alexander, Franck, Charlotte, Christie, Mary, Hawkins, Paige M. E., Patel, Karishma, Ashhurst, Anneliese S., Aggarwal, Anupriya, Low, Jason K. K., Siddiquee, Rezwan, Ashley, Caroline L., Steain, Megan, Triccas, James A., Turville, Stuart, Mackay, Joel P., Passioura, Toby, Payne, Richard J.“…We identified six high affinity molecules with dissociation constants (K(D)) in the nanomolar range (15–550 nM) to the RBD. The highest affinity ligand could be used as an affinity reagent to detect the spike protein in solution by ELISA, and the cocrystal structure of this molecule bound to the RBD demonstrated that it binds to a cryptic binding site, displacing a β-strand near the C-terminus. …”
Publicado 2021
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1472“…Since the viral entry into host cells depends on specific interactions between the receptor−binding domain (RBD) of the viral Spike protein and the membrane−bound monocarboxypeptidase angiotensin converting enzyme 2 (ACE2), the development of high affinity RBD binders to compete with human ACE2 represents a promising strategy for the design of therapeutics to prevent viral entry. …”
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1473“…Herein, we present a systematic analysis based on detailed molecular dynamics (MD) simulations in order to understand how the OV RBD mutations affect the ACE2 binding. We show that the OV RBD binds to ACE2 more efficiently and tightly predominantly because of strong electrostatic interactions, thereby promoting increased infectivity and transmissibility compared to other strains. …”
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1474por Starr, Tyler N., Greaney, Allison J., Hannon, William W., Loes, Andrea N., Hauser, Kevin, Dillen, Josh R., Ferri, Elena, Farrell, Ariana Ghez, Dadonaite, Bernadeta, McCallum, Matthew, Matreyek, Kenneth A., Corti, Davide, Veesler, David, Snell, Gyorgy, Bloom, Jesse D.“…SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its affinity for ACE2 receptor and recognition by antibodies. …”
Publicado 2022
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1475por Seraceni, Silva, Zocca, Elena, Cervone, Tamara Emanuela, Tomassetti, Flaminia, Polidori, Isabella, Valisi, Massimiliano, Broccolo, Francesco, Calugi, Graziella, Bernardini, Sergio, Pieri, Massimo“…Results: The data confirmed that RBD and RBD-ACE2 blocking ACE2 antibody levels of Group 1 were significantly lower than Group 2; p < 0.001. …”
Publicado 2022
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1476por Lagousi, Theano, Routsias, John, Mavrouli, Maria, Papadatou, Ioanna, Geropeppa, Maria, Spoulou, Vana“…Anti-RBD antibodies were strongly correlated with neutralizing and anti-S1 antibodies in both groups at all time-points. …”
Publicado 2022
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1477por Workman, Aspen M., McDaneld, Tara G., Harhay, Gregory P., Das, Subha, Loy, John Dustin, Hause, Benjamin M.“…The emergence of BCoV with structural variants in the RBD raises the possibility of further interspecies transmission.…”
Publicado 2022
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1478por Monroe, Jonathon M., Haralambieva, Iana H., Warner, Nathaniel D., Grill, Diane E., Quach, Huy Quang, Kennedy, Richard B.“…Across all humoral responses, ND(50) strongly associated with Spike S1 (R = 0.85, p = 2.7e−13) and RBD (R = 0.78, p = 2.9e−10) antibodies. Our findings provide longitudinal insight into humoral immune responses after infection and imply the potential of Spike S1/RBD antibody titer as surrogate correlates of protection.…”
Publicado 2022
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1479“…We developed an intranasal vaccine consisting of the SARS-CoV-2 receptor binding domain (RBD) fused to the antibody Fc fragment (RBD-Fc). …”
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1480por Wang, Gang, Shi, Juan, Verma, Abhishek K., Guan, Xiaoqing, Perlman, Stanley, Du, Lanying“…By contrast, other vaccination strategies, including RBD-mRNA first-dose plus BA1-S-mRNA two-boosts, RBD-mRNA or BA1-S-mRNA three-doses, or their combinations, failed to elicit high nAb titers against all of these viruses. …”
Publicado 2022
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