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  1. 1461
    “…Moreover, the complex structures of BA.2 RBD/BD-604/S304 and BA.4/5 RBD/BD-604/S304/S309 further elucidate the molecular mechanism of antibody evasion by these sub-variants. …”
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    An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB
  2. 1462
    “…The microparticles encapsulated a highly immunogenic subunit protein of the SARS-CoV-2 virus, such as the spike protein’s receptor binding domain (RBD). Adjuvants were also incorporated to enhance the spike RBD-specific immune response. …”
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    Adjuvanted-SARS-CoV-2 Spike Protein-Based Microparticulate Vaccine Delivered by Dissolving Microneedles Induces Humoral, Mucosal, and Cellular Immune Responses in Mice
  3. 1463
    “…OBJECTIVE: To validate, for the first time, the Risk Behaviour Diagnosis (RBD) Scale for Aboriginal Australian tobacco smokers, based on the Extended Parallel Process Model (EPPM). …”
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    Using the risk behaviour diagnosis scale to understand Australian Aboriginal smoking — A cross-sectional validation survey in regional New South Wales
  4. 1464
    “…In addition, we show that the linker preceding dsRBD3 contributes significantly to dmDcr1 binding. …”
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    Structural and functional insights into the fly microRNA biogenesis factor Loquacious
  5. 1465
    “…In silico predictions and experimental results suggest that the RBD is structured as a rigid fold of three α-helices. …”
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    The Receptor-Binding Domain in the VP1u Region of Parvovirus B19
  6. 1466
    “…The existence of these subtypes is supported by in vivo imaging studies of RBD-positive and RBD-negative patient groups and by histological evidence— reviewed herein. …”
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    Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis
  7. 1467
    “…We find that the monoclonal antibody CR3022 binds the RBD tightly, neutralizing SARS-CoV-2, and report the crystal structure at 2.4 Å of the Fab/RBD complex. …”
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    Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike
  8. 1468
    “…This review summarizes the structure and function of RBD and RBD-specific NMAbs against SARS-CoV and SARS-CoV-2 currently under development.…”
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    Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2
  9. 1469
    “…Here we use a yeast-display system to map all mutations to the viral spike receptor-binding domain (RBD) that escape binding by representatives of three potently neutralizing classes of anti-RBD antibodies with high-resolution structures. …”
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    Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies
  10. 1470
    “…The RBD displayed CuMV(TT) bound to ACE2, the viral receptor, demonstrating proper folding of RBD. …”
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    Development of a Vaccine against SARS-CoV-2 Based on the Receptor-Binding Domain Displayed on Virus-Like Particles
  11. 1471
    “…We identified six high affinity molecules with dissociation constants (K(D)) in the nanomolar range (15–550 nM) to the RBD. The highest affinity ligand could be used as an affinity reagent to detect the spike protein in solution by ELISA, and the cocrystal structure of this molecule bound to the RBD demonstrated that it binds to a cryptic binding site, displacing a β-strand near the C-terminus. …”
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    Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display
  12. 1472
    por Gao, Bin, Zhu, Shunyi
    Publicado 2021
    “…Since the viral entry into host cells depends on specific interactions between the receptor−binding domain (RBD) of the viral Spike protein and the membrane−bound monocarboxypeptidase angiotensin converting enzyme 2 (ACE2), the development of high affinity RBD binders to compete with human ACE2 represents a promising strategy for the design of therapeutics to prevent viral entry. …”
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    A Fungal Defensin Targets the SARS−CoV−2 Spike Receptor−Binding Domain
  13. 1473
    “…Herein, we present a systematic analysis based on detailed molecular dynamics (MD) simulations in order to understand how the OV RBD mutations affect the ACE2 binding. We show that the OV RBD binds to ACE2 more efficiently and tightly predominantly because of strong electrostatic interactions, thereby promoting increased infectivity and transmissibility compared to other strains. …”
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    Binding Interactions between Receptor-Binding Domain of Spike Protein and Human Angiotensin Converting Enzyme-2 in Omicron Variant
  14. 1474
    “…SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its affinity for ACE2 receptor and recognition by antibodies. …”
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    Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution
  15. 1475
    “…Results: The data confirmed that RBD and RBD-ACE2 blocking ACE2 antibody levels of Group 1 were significantly lower than Group 2; p < 0.001. …”
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    T-Cell Assay after COVID-19 Vaccination Could Be a Useful Tool? A Pilot Study on Interferon-Gamma Release Assay in Healthcare Workers
  16. 1476
    “…Anti-RBD antibodies were strongly correlated with neutralizing and anti-S1 antibodies in both groups at all time-points. …”
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    Comparative Characterization of Human Antibody Response Induced by BNT162b2 Vaccination vs. SARS-CoV-2 Wild-Type Infection
  17. 1477
    “…The emergence of BCoV with structural variants in the RBD raises the possibility of further interspecies transmission.…”
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    Recent Emergence of Bovine Coronavirus Variants with Mutations in the Hemagglutinin-Esterase Receptor Binding Domain in U.S. Cattle
  18. 1478
    “…Across all humoral responses, ND(50) strongly associated with Spike S1 (R = 0.85, p = 2.7e−13) and RBD (R = 0.78, p = 2.9e−10) antibodies. Our findings provide longitudinal insight into humoral immune responses after infection and imply the potential of Spike S1/RBD antibody titer as surrogate correlates of protection.…”
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    Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection
  19. 1479
    “…We developed an intranasal vaccine consisting of the SARS-CoV-2 receptor binding domain (RBD) fused to the antibody Fc fragment (RBD-Fc). …”
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    An intranasal vaccine targeting the receptor binding domain of SARS-CoV-2 elicits a protective immune response
  20. 1480
    “…By contrast, other vaccination strategies, including RBD-mRNA first-dose plus BA1-S-mRNA two-boosts, RBD-mRNA or BA1-S-mRNA three-doses, or their combinations, failed to elicit high nAb titers against all of these viruses. …”
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    mRNA vaccines elicit potent neutralization against multiple SARS-CoV-2 omicron subvariants and other variants of concern
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