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1481“…In order to design potential antibody drugs with high affinity, we used antibody S309 from patients with SARS-CoV as the target antibody and RBD of S protein as the target antigen. Systems with RBD glycosylated and non-glycosylated were constructed to study the influence of glycosylation. …”
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1482por Hu, Yu, Liu, Kefang, Han, Pu, Xu, Zepeng, Zheng, Anqi, Pan, Xiaoqian, Jia, Yunfei, Su, Chao, Tang, Lingfeng, Wu, Lili, Bai, Bin, Zhao, Xin, Tian, Di, Chen, Zhihai, Qi, Jianxun, Wang, Qihui, Gao, George F“…The RshSTT182/200 RBD broadly recognized 21 of 39 ACE2 orthologs, although its binding affinities for the orthologs were weaker than those of the RBD of SARS‐CoV‐2. …”
Publicado 2023
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1483por Byrne, Joanne, Gu, Lili, García-León, Alejandro, Gaillard, Colette Marie, Tomás-Cortázar, Julen, Negi, Riya, Alalwan, Dana, Saini, Gurvin, Donohue, Sean, Reynolds, Bearach, Kenny, Grace, Leamy, Kelly, O’Gorman, Tessa, O’Broin, Cathal, Savinelli, Stefano, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Sadlier, Corinna, Landay, Alan, Doran, Peter, Cox, Rebecca J, Olesen, Ole, Lelièvre, Jean-Daniel, Cornely, Oliver A, Gautier, Virginie, Mallon, Patrick“…In a subanalysis, we assessed SCV-2-specific plasma cell, memory B cell and T cell responses in peripheral blood mononuclear cells after stimulation with wild type (WT) RBD, WT full Spike antigen, Omicron RBD and Omicron S1 antigens by ELISpot (Mabtech ELISpot, Sweden, Fig 1). …”
Publicado 2023
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1484por Espi, M., Charmetant, X., Barba, T., Koppe, L., Pelletier, C., Kalbacher, E., Chalencon, E., Fouque, D., Juillard, L., Thaunat, O.“…RÉSULTATS: Dix à 14 jours après la 2nde injection, 19/106 (18 %) des patients n’avaient pas d’IgG anti-RBD, 47/106 (44 %) des IgG anti-RBD détectables mais inférieurs aux volontaires sains, et 40/106 (38 %) un titre d’IgG anti-RBD similaire aux volontaires sains. …”
Publicado 2021
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1485por Teyssou, Elisa, Zafilaza, Karen, Sayon, Sophie, Marot, Stéphane, Dropy, Margot, Soulie, Cathia, Abdi, Basma, Tubach, Florence, Hausfater, Pierre, Marcelin, Anne-Geneviève, Boutolleau, David“…METHODS: Serum samples from 92 HCWs were tested at month 0 (M0), M6, and M12 after SARS-CoV-2 infection for IgG targeting the nucleocapsid (N), IgG targeting the receptor-binding domain (RBD) of spike (S) protein, IgA targeting S, and anti-RBD neutralizing antibodies. …”
Publicado 2022
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1486por Goto, Atsushi, Okamoto, Takeshi, Matsumoto, Masaharu, Saito, Hiroyuki, Yanai, Hideo, Itoh, Hiroshi, sakaida, Isao“…The pathogenesis of RBD is discussed based on our experience with this case.…”
Publicado 2016
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1487“…Impaired glycinergic transmission in human HH could be involved in the pathophysiology of RBD and NREM parasomnias.…”
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1488por Baumann-Vogel, Heide, Hor, Hyun, Poryazova, Rositsa, Valko, Philipp, Werth, Esther, Baumann, Christian R.“…Thus, the prevalence of RBD in sporadic Parkinson disease might be higher than previously assumed, particularly in elderly patients.…”
Publicado 2020
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1489por Kuwentrai, Chaiyaporn, Yu, Jinming, Rong, Li, Zhang, Bao‐Zhong, Hu, Ye‐Fan, Gong, Hua‐Rui, Dou, Ying, Deng, Jian, Huang, Jian‐Dong, Xu, Chenjie“…This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. …”
Publicado 2020
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1490por Peng, Dandan, Zhao, Tingmei, Hong, Weiqi, Fu, Minyang, He, Cai, Chen, Li, Ren, Wenyan, Lei, Hong, Yang, Jingyun, Alu, Aqu, Ni, Yanghong, Liu, Jian, Li, Jiong, Wang, Wei, Shen, Guobo, Zhao, Zhiwei, Yang, Li, Yang, Jinliang, Wang, Zhenling, Tanaka, Yoshimasa, Lu, Guangwen, Song, Xiangrong, Wei, Xiawei“…In the present study, we prepared a Delta full‐length spike protein sequence‐based mRNA vaccine as the “priming” shot and developed a recombinant trimeric receptor‐binding domain (RBD) protein vaccine referred to as RBD–HR/trimer as a third heterologous booster. …”
Publicado 2023
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1491por Pavan, María Florencia, Bok, Marina, Juan, Rafael Betanzos San, Malito, Juan Pablo, Marcoppido, Gisela Ariana, Franco, Diego Rafael, Militello, Daniela Ayelen, Schammas, Juan Manuel, Bari, Sara, Stone, William B., López, Krisangel, Porier, Danielle L., Muller, John, Auguste, Albert J., Yuan, Lijuan, Wigdorovitz, Andrés, Parreño, Viviana, Ibañez, Lorena Itatí“…In this work, we developed llama-derived nanobodies (Nbs) directed to the receptor binding domain (RBD) and other domains of the Spike (S) protein of SARS-CoV-2. …”
Publicado 2023
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1492por Koros, Christos, Simitsi, Athina-Maria, Papagiannakis, Nikolaos, Bougea, Anastasia, Prentakis, Andreas, Papadimitriou, Dimitra, Pachi, Ioanna, Beratis, Ion, Stanitsa, Evangelia, Angelopoulou, Efthalia, Antonelou, Roubina, Bregianni, Marianna, Lourentzos, Konstantinos, Papageorgiou, Sokratis G., Bonakis, Anastasios, Trapali, Xenia Geronicola, Stamelou, Maria, Stefanis, Leonidas“…(Baseline RBD 6.07±1.6 vs. Baseline PD 5.35±1.3 mg/dL and Year-5 RBD 5.7±1.3 vs. …”
Publicado 2023
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1493por Sumner, Kelsey M., Yadav, Ruchi, Noble, Emma K., Sandford, Ryan, Joshi, Devyani, Tartof, Sara Y., Wernli, Karen J., Martin, Emily T, Gaglani, Manjusha, Zimmerman, Richard K., Talbot, H. Keipp, Grijalva, Carlos G., Chung, Jessie R., Rogier, Eric, Coughlin, Melissa M., Flannery, Brendan“…In the adjusted logistic regression, increasing levels of anti-RBD antibodies were associated with reduced odds of COVID-19 for both Delta and Omicron infections. …”
Publicado 2023
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1494“…We and others identified the receptor-binding domain (RBD) by using S fragments of various lengths but all including the amino acid residue 318 and two other potential glycosylation sites. …”
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1495por Du, Lanying, Zhao, Guangyu, Chan, Chris C.S., Sun, Shihui, Chen, Min, Liu, Zhonghua, Guo, Hongxiang, He, Yuxian, Zhou, Yusen, Zheng, Bo-Jian, Jiang, Shibo“…Our results show that all rRBD proteins expressed in the above systems maintained intact conformation, being able to induce highly potent neutralizing antibody responses and complete protective immunity against SARS-CoV challenge in mice, albeit the rRBD expressed in 293T cells elicited stronger humoral immune responses with significantly higher neutralizing activity (P < 0.05) than those expressed in Sf9 and E. coli cells. …”
Publicado 2009
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1496por Wang, Hui, Hota, Prasanta K., Tong, Yufeng, Li, Buren, Shen, Limin, Nedyalkova, Lyudmila, Borthakur, Susmita, Kim, SoonJeung, Tempel, Wolfram, Buck, Matthias, Park, Hee-Won“…The Rho GTPase binding domain (RBD) of plexin-A1 and -B1 can bind GTPases, including Rnd1. …”
Publicado 2011
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1497por Kuttappan, Vivek A., Vicuña, Eduardo A., Latorre, Juan D., Wolfenden, Amanda D., Téllez, Guillermo I., Hargis, Billy M., Bielke, Lisa R.“…Experiment 2 (n = 14 birds/treatment, leghorns, processed at 7 days) included CON, DSS, FRS, and rye-based diet (RBD). In experiments 3 and 4 (n = 15 birds/treatment, broilers, processed at 7 days), groups were CON, DSS, high fat diet (HFD), FRS, and RBD. …”
Publicado 2015
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1498por Chahine, Lana M., Urbe, Liz, Caspell-Garcia, Chelsea, Aarsland, Dag, Alcalay, Roy, Barone, Paolo, Burn, David, Espay, Alberto J., Hamilton, Jamie L., Hawkins, Keith A., Lasch, Shirley, Leverenz, James B., Litvan, Irene, Richard, Irene, Siderowf, Andrew, Coffey, Christopher S., Simuni, Tanya, Weintraub, Daniel“…Inclusion criteria enriched the RBD and hyposmia cohorts, but not the NMC cohort, with individuals with dopamine transporter binding deficit. …”
Publicado 2018
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1499por Wang, Chong, Zheng, Xuexing, Gai, Weiwei, Wong, Gary, Wang, Hualei, Jin, Hongli, Feng, Na, Zhao, Yongkun, Zhang, Weijiao, Li, Nan, Zhao, Guoxing, Li, Junfu, Yan, Jinghua, Gao, Yuwei, Hu, Guixue, Yang, Songtao, Xia, Xianzhu“…IFN-γ, IL-4 and IL-2 secreting cells induced by the RBD were detected in the splenocytes of vaccinated mice by ELISpot. …”
Publicado 2017
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1500por New, R.R.C., Moore, B.D., Butcher, W., Mahood, R., Lever, M.S., Smither, S., O'Brien, L., Weller, S.A., Bayliss, M., Gibson, L.C.D., Macleod, C., Bogus, M., Harvey, R., Almond, N., Williamson, E.D.“…The murine antisera used were derived from mice which had been primed sub-cutaneously with a recombinant fusion of RBD with a human IgG Fc tag (RBD-Fc), adsorbed to calcium phosphate microcrystals and then boosted by the oral route with the same fusion protein in reverse micelles. …”
Publicado 2019
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