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1521por Liang, Boyun, Xiang, Tiandan, Wang, Hua, Li, Ziwei, Quan, Xufeng, Feng, Xuemei, Li, Sumeng, Lu, Sihong, Fan, Lei, Xu, Ling, Wang, Tong, Wang, Xiaoyan, Zhu, Bin, Wang, Junzhong, Yang, Dongliang, Liu, Jia, Zheng, Xin“…Here, we characterized SARS-CoV-2 RBD-specific IgG (anti-S-RBD IgG) and neutralizing antibodies (NAbs) against SARS-CoV-2 wild type and variants of concerns (VOCs), as well as RBD-specific IgG-secreting B cells and antigen-specific T cells respectively in 51 SARS-CoV-2 recovered subjects and 63 healthy individuals. …”
Publicado 2022
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1522por Boccalini, Cecilia, Bortolin, Elisa, Carli, Giulia, Pilotto, Andrea, Galbiati, Andrea, Padovani, Alessandro, Ferini-Strambi, Luigi, Perani, Daniela“…This suggests and confirms iRBD as a risk condition for progression to the severe LB disease phenotype. …”
Publicado 2022
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1523por Skrabal, Dominik, Rusz, Jan, Novotny, Michal, Sonka, Karel, Ruzicka, Evzen, Dusek, Petr, Tykalova, Tereza“…Compared to controls, VSA was smaller in both iRBD (p = 0.01) and PD (p = 0.001) while VAI was lower only in PD (p = 0.002). iRBD subgroup with abnormal olfactory function had smaller VSA compared to iRBD subgroup with preserved olfactory function (p = 0.02). …”
Publicado 2022
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1524por Bhullar, Khushwant S., Nael, Manal A., Elokely, Khaled M., Drews, Steven J., Wu, Jianping“…Given the importance of SARS-CoV-2 S receptor binding domain (RBD)-ACE2 interaction in SARS-CoV-2 pathophysiology, we synthesized various IRW analogs intending to mitigate the RBD-ACE-2 interaction. …”
Publicado 2022
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1525por Anzinger, Joshua J., Cameron-McDermott, Suzette M., Phillips, Yakima Z.R., Mendoza, Leshawn, Anderson, Mark, Cloherty, Gavin, Strachan-Johnson, Susan, Lindo, John F., Figueroa, J. Peter“…SARS-CoV-2 spike receptor binding domain (RBD) and/or nucleocapsid IgG antibodies were detected for 88.4% of the study population, with 77.0% showing evidence of previous SARS-CoV-2 infection. …”
Publicado 2022
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1526por Chakraborti, Soumyananda, Gill, Jasmita, Goswami, Ritu, Kumar, Sanjeev, Chandele, Anmol, Sharma, Amit“…Structural visualization and analysis of important mutations of alpha, delta, Omicron and its sub-variants of SARS-CoV-2 Receptor-Binding Domain (RBD) was performed and our analysis clearly shows that mutations occur throughout the RBD, including the RBD surface responsible for human angiotensin-converting enzyme 2 (hACE-2) receptor-binding. …”
Publicado 2022
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1527por Assad, Mohammad, Parveen, Zahida, Farman, Saira, Khurshid, Beenish, Hashmi, Muhammad Ali, Khan, Khalid Mohammed, Khurshid, Akif“…The key interacting residues of the RBD involved in binding included Leu441, Lys444, and Tyr449. …”
Publicado 2022
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1528por Chinnadurai, Raj Kumar, Ponne, Saravanaraman, Chitra, Loganathan, Kumar, Rajender, Thayumanavan, Palvannan, Subramanian, Balanehru“…The receptor-binding domain (RBD) of the S protein mediates the binding and is more prone to mutations resulting in the generation of different variants. …”
Publicado 2022
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1529por Han, Lu, An, Chaoqiang, Liu, Dong, Wang, Zejun, Bian, Lianlian, He, Qian, Liu, Jianyang, Wang, Qian, Liu, Mingchen, Mao, Qunying, Hang, Taijun, Wang, Aiping, Gao, Fan, Tan, Dejiang, Liang, Zhenglun“…A porcine anti-RBD polyclonal antibody was selected as the coating antibody. …”
Publicado 2022
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1530The safety and immunogenicity of inactivated COVID-19 vaccine in old pulmonary tuberculosis patientspor Yang, Lei, Xiang, Feng, Wang, Dian, Guo, Qiao, Deng, Bing, Jiang, DePeng, Ren, Hong“…Concentrations of Abs against RBD-IgG and CoV-2 neutralizing Abs in addition to the frequencies of RBD-specific memory B cells proportions were lower in OPTB patients than the healthy controls (all, p < 0.05), while the frequencies of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4(+)) cells were higher (p = 0.023). …”
Publicado 2023
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1531por Cesari, Matteo, Heidbreder, Anna, Gaig, Carles, Bergmann, Melanie, Brandauer, Elisabeth, Iranzo, Alex, Holzknecht, Evi, Santamaria, Joan, Högl, Birgit, Stefani, Ambra“…METHODS: We analyzed 36 video-polysomnographies (v-PSGs) of isolated REM sleep behavior disorder (iRBD) patients and 35 controls’ v-PSGs. Patients diagnosed with RBD had: i) RWA, quantified with a reference method, i.e. automatic and artifact-corrected 3-s Sleep Innsbruck Barcelona (SINBAR) index in REM sleep periods (RSPs, i.e. manually selected portions of REM sleep); and ii) v-PSG-documented RBD behaviors. …”
Publicado 2022
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1532por Dyankov, Georgi, Genova-Kalou, Petia, Eftimov, Tinko, Ghaffari, Sanaz Shoar, Mankov, Vihar, Kisov, Hristo, Veselinov, Petar, Hikova, Evdokia, Malinowski, Nikola“…The binding activity of S/N- and RBD proteins was assessed. It was found that protein binding fully inhibited heme functionality. …”
Publicado 2023
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1533“…SARS-CoV-2 employs its spike protein’s receptor binding domain (RBD) to enter host cells. The RBD is constantly subjected to immune responses, while requiring efficient binding to host cell receptors for successful infection. …”
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1534por Joza, Stephen, Iranzo, Alex, Stefani, Ambra, Pelletier, Amelie, Serradell, Monica, Muñoz‐Lopetegi, Amaia, Ibrahim, Abubaker, Holzknecht, Evi, Montplaisir, Jacques Y., Mayà, Gerard, Santamaria, Joan, Gaig, Carles, Bergmann, Melanie, Brandauer, Elisabeth, Högl, Birgit, Gagnon, Jean‐François, Postuma, Ronald B.“…BACKGROUND: Since 2014, there has been increasing public outreach effort regarding isolated/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) in Montreal. OBJECTIVE: To assess if, over time, milder iRBD cases are presenting earlier. …”
Publicado 2023
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1535por Salgado, Bárbara Batista, Barbosa, Aguyda Rayany Cavalcante, Arcanjo, Ana Ruth, de Castro, Daniel Barros, Ramos, Tatyana Costa Amorim, Naveca, Felipe, Altmann, Daniel M., Boyton, Rosemary J., Lalwani, Jaila Dias Borges, Lalwani, Pritesh“…Antibody responses were measured by standard serological immunoassays. Peak anti-S-RBD and neutralizing RBD-ACE2 blocking antibody responses after two doses of CoronaVac vaccine were similar in vaccine breakthrough cases (n = 9) and matched controls (n = 45). …”
Publicado 2023
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1536“…Here, we report the crystal structures of human RNA helicase A (RHA) dsRBD1 and dsRBD2 domains in complex with dsRNAs, respectively. …”
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1537por Doyle, Michael, Badertscher, Lukas, Jaskiewicz, Lukasz, Güttinger, Stephan, Jurado, Sabine, Hugenschmidt, Tabea, Kutay, Ulrike, Filipowicz, Witold“…In the context of full-length Dicer, the dsRBD-NLS is masked. However, duplication of the dsRBD localizes the full-length protein to the nucleus. …”
Publicado 2013
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1538por Jia, Min, Shan, Zelin, Yang, Ying, Liu, Chunhua, Li, Jianchao, Luo, Zhen-Ge, Zhang, Mingjie, Cai, Yu, Wen, Wenyu, Wang, Wenning“…The crystal structure of Mira514–595/Stau dsRBD5 complex illustrates that Mira forms an elongated parallel coiled-coil dimer, and two dsRBD5 symmetrically bind to the Mira dimer through their exposed β-sheet faces, revealing a previously unrecognized protein interaction mode for dsRBDs. …”
Publicado 2015
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1539por Sprenger, Fabienne S., Stefanova, Nadia, Gelpi, Ellen, Seppi, Klaus, Navarro-Otano, Judith, Offner, Felix, Vilas, Dolores, Valldeoriola, Francesc, Pont-Sunyer, Claustre, Aldecoa, Iban, Gaig, Carles, Gines, Angels, Cuatrecasas, Miriam, Högl, Birgit, Frauscher, Birgit, Iranzo, Alex, Wenning, Gregor K., Vogel, Wolfgang, Tolosa, Eduardo, Poewe, Werner“…OBJECTIVE: To investigate the expression of α-synuclein in colonic biopsies of patients with idiopathic REM sleep behavior disorder (iRBD) and address if α-synuclein immunostaining of tissue obtained via colonic biopsies holds promise as a diagnostic biomarker for prodromal Parkinson disease (PD). …”
Publicado 2015
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1540por Wang, Wenling, Wang, Huijuan, Deng, Yao, Song, Tie, Lan, Jiaming, Wu, Guizhen, Ke, Changwen, Tan, Wenjie“…The S and RBD ELISAs were highly correlated with the commercial S1 ELISA. …”
Publicado 2016
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