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  1. 1541
    “…Another major clinical RBD feature is its prevalent phenoconversion into synucleinopathies as Parkinson’s disease in a delay of 10-15 years after diagnosis. …”
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    A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep
  2. 1542
    “…These mAbs bind epitopes within the receptor binding domain (RBD) or upstream of the RBD. We show that mAbs recognizing epitopes within the RBD inhibit infection by preventing viral attachment to the cellular receptor. …”
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    Human monoclonal antibodies to SARS-coronavirus inhibit infection by different mechanisms
  3. 1543
    “…The most potent antibody bound the RBD in a manner that prevented binding to the ACE2 receptor, while the other bound outside the RBD. …”
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    Characterization of neutralizing antibodies from a SARS-CoV-2 infected individual
  4. 1544
    “…Built on the fact that SARS-CoV-2 initiates its entry into human cells by the receptor binding domain (RBD) of its spike protein binding to the angiotensin-converting enzyme 2 (hACE2), we extended a recently developed approach, EvoDesign, to design multiple peptide sequences that can competitively bind to the SARS-CoV-2 RBD to inhibit the virus from entering human cells. …”
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    De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2
  5. 1545
    “…DPP4 expressed on human cells is the main attaching site for RBD in S protein of MERS CoV. Folding of RBD plays a crucial role in its pathogenesis. …”
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    Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2)
  6. 1546
    “…Our data are consistent with more than one mode of interaction of NS1′s RBD with RNAs, recognizing both structure and sequence determinants.…”
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    Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1
  7. 1547
    “…We found that immunization of human dipeptidyl peptidase 4 (hDPP4)-transgenic (hDPP4-Tg) mice with spike protein receptor-binding domain (S RBD) conjugated with HBD 2 (S RBD-HBD 2) induced potent antigen (Ag)-specific adaptive immune responses and protected against MERS-CoV infection. …”
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    Conjugation of Human β-Defensin 2 to Spike Protein Receptor-Binding Domain Induces Antigen-Specific Protective Immunity against Middle East Respiratory Syndrome Coronavirus Infection in Human Dipeptidyl Peptidase 4 Transgenic Mice
  8. 1548
    “…SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded “down” to an exposed “up” state in order to bind the human ACE2 receptor and infect cells. …”
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    A glycan gate controls opening of the SARS-CoV-2 spike protein
  9. 1549
    “…The antigenic properties of the resulting product are similar, but not identical to the RBD-containing fragment expressed in human cells.…”
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    Expression of SARS-CoV-2 surface glycoprotein fragment 319–640 in E. coli, and its refolding and purification
  10. 1550
    “…Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). …”
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    Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2
  11. 1551
    “…This engineered strain is now used to produce an RBD-based vaccine antigen that is currently in clinical trials and could be used to produce other variants of RBD as needed for future vaccines.…”
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    Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii
  12. 1552
    “…Antibodies binding to either JS7 or the SARS-CoV-2 recombinant RBD, as well as those that disrupt binding between a fragment of the ACE2 receptor and the RBD, are proportional to disease severity and clinical outcome. …”
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    Synthetic proteins for COVID-19 diagnostics
  13. 1553
    “…We also designed some mutations in meucin-18 and investigated their interactions with the RBD domain. The results revealed that the A9T mutation had more effective interaction with the RBD domain than the meucin-18 and was able to inhibit spike protein's interaction with ACE2 receptor. …”
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    Examining the interactions scorpion venom peptides (HP1090, Meucin-13, and Meucin-18) with the receptor binding domain of the coronavirus spike protein to design a mutated therapeutic peptide
  14. 1554
    “…We find that the spike protein receptor‐binding domain (RBD) of pangolin CoVs binds to hACE2 as efficiently as the SARS‐CoV‐2 RBD in vitro. …”
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    Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin
  15. 1555
    “…Here, we developed an RBD-ACE2 binding assay that is based on time-resolved FRET, which reliably monitors the interaction in a physiologically relevant and cellular context. …”
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    SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET
  16. 1556
    “…Peptides can inhibit the S-RBD:ACE2 interaction by interacting with the protein–protein interface. …”
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    Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein
  17. 1557
    “…This review’s objective is to highlight the significance of RBD as a prodromal premotor marker for the early detection of PD. …”
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    The Correlation Between Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: A Systematic Review
  18. 1558
    “…These results reveal the potential of RBD‐SpyCatcher‐mi3 as a broadly protective vaccination strategy.…”
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    Potent neutralization of SARS‐CoV‐2 including variants of concern by vaccines presenting the receptor‐binding domain multivalently from nanoscaffolds
  19. 1559
    “…SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded “down” to an exposed “up” state in order to bind the human ACE2 receptor and infect cells. …”
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    A glycan gate controls opening of the SARS-CoV-2 spike protein
  20. 1560
    “…This engineered strain is now used to produce an RBD‐based vaccine antigen that is currently in clinical trials and could be used to produce other variants of RBD as needed for future vaccines.…”
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    Scalable, methanol‐free manufacturing of the SARS‐CoV‐2 receptor‐binding domain in engineered Komagataella phaffii
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