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1541“…Another major clinical RBD feature is its prevalent phenoconversion into synucleinopathies as Parkinson’s disease in a delay of 10-15 years after diagnosis. …”
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1542“…These mAbs bind epitopes within the receptor binding domain (RBD) or upstream of the RBD. We show that mAbs recognizing epitopes within the RBD inhibit infection by preventing viral attachment to the cellular receptor. …”
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1543por Seydoux, Emilie, Homad, Leah J., MacCamy, Anna J., Parks, K. Rachael, Hurlburt, Nicholas K., Jennewein, Madeleine F., Akins, Nicholas R., Stuart, Andrew B., Wan, Yu-Hsin, Feng, Junli, Nelson, Rachael E., Singh, Suruchi, Cohen, Kristen W., McElrath, M. Juliana, Englund, Janet A., Chu, Helen Y., Pancera, Marie, McGuire, Andrew T., Stamatatos, Leonidas“…The most potent antibody bound the RBD in a manner that prevented binding to the ACE2 receptor, while the other bound outside the RBD. …”
Publicado 2020
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1544“…Built on the fact that SARS-CoV-2 initiates its entry into human cells by the receptor binding domain (RBD) of its spike protein binding to the angiotensin-converting enzyme 2 (hACE2), we extended a recently developed approach, EvoDesign, to design multiple peptide sequences that can competitively bind to the SARS-CoV-2 RBD to inhibit the virus from entering human cells. …”
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1545por Masood, Nosheen, Malik, Saima Shakil, Raja, Muhammad Naqqi, Mubarik, Sumaira, Yu, Chuanhua“…DPP4 expressed on human cells is the main attaching site for RBD in S protein of MERS CoV. Folding of RBD plays a crucial role in its pathogenesis. …”
Publicado 2020
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1546por Wacquiez, Alan, Coste, Franck, Kut, Emmanuel, Gaudon, Virginie, Trapp, Sascha, Castaing, Bertrand, Marc, Daniel“…Our data are consistent with more than one mode of interaction of NS1′s RBD with RNAs, recognizing both structure and sequence determinants.…”
Publicado 2020
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1547“…We found that immunization of human dipeptidyl peptidase 4 (hDPP4)-transgenic (hDPP4-Tg) mice with spike protein receptor-binding domain (S RBD) conjugated with HBD 2 (S RBD-HBD 2) induced potent antigen (Ag)-specific adaptive immune responses and protected against MERS-CoV infection. …”
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1548por Sztain, Terra, Ahn, Surl-Hee, Bogetti, Anthony T., Casalino, Lorenzo, Goldsmith, Jory A., Seitz, Evan, McCool, Ryan S., Kearns, Fiona L., Acosta-Reyes, Francisco, Maji, Suvrajit, Mashayekhi, Ghoncheh, McCammon, J. Andrew, Ourmazd, Abbas, Frank, Joachim, McLellan, Jason S., Chong, Lillian T., Amaro, Rommie E.“…SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded “down” to an exposed “up” state in order to bind the human ACE2 receptor and infect cells. …”
Publicado 2021
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1549por Fitzgerald, Gabriel A., Komarov, Andrei, Kaznadzey, Anna, Mazo, Ilya, Kireeva, Maria L.“…The antigenic properties of the resulting product are similar, but not identical to the RBD-containing fragment expressed in human cells.…”
Publicado 2021
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1550por Lim, Shion A., Gramespacher, Josef A., Pance, Katarina, Rettko, Nicholas J., Solomon, Paige, Jin, Jing, Lui, Irene, Elledge, Susanna K., Liu, Jia, Bracken, Colton J., Simmons, Graham, Zhou, Xin X., Leung, Kevin K., Wells, James A.“…Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). …”
Publicado 2021
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1551por Dalvie, Neil C., Biedermann, Andrew M., Rodriguez-Aponte, Sergio A., Naranjo, Christopher A., Rao, Harish D., Rajurkar, Meghraj P., Lothe, Rakesh R., Shaligram, Umesh S., Johnston, Ryan S., Crowell, Laura E., Castelino, Seraphin, Tracey, Mary Kate, Whittaker, Charles A., Love, J. Christopher“…This engineered strain is now used to produce an RBD-based vaccine antigen that is currently in clinical trials and could be used to produce other variants of RBD as needed for future vaccines.…”
Publicado 2021
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1552por Schein, Catherine H., Levine, Corri B., McLellan, Susan L.F., Negi, Surendra S., Braun, Werner, Dreskin, Stephen C., Anaya, Elizabeth S., Schmidt, Jurgen“…Antibodies binding to either JS7 or the SARS-CoV-2 recombinant RBD, as well as those that disrupt binding between a fragment of the ACE2 receptor and the RBD, are proportional to disease severity and clinical outcome. …”
Publicado 2021
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1553“…We also designed some mutations in meucin-18 and investigated their interactions with the RBD domain. The results revealed that the A9T mutation had more effective interaction with the RBD domain than the meucin-18 and was able to inhibit spike protein's interaction with ACE2 receptor. …”
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1554por Niu, Sheng, Wang, Jia, Bai, Bin, Wu, Lili, Zheng, Anqi, Chen, Qian, Du, Pei, Han, Pengcheng, Zhang, Yanfang, Jia, Yunfei, Qiao, Chengpeng, Qi, Jianxun, Tian, Wen‐xia, Wang, Hong‐Wei, Wang, Qihui, Gao, George Fu“…We find that the spike protein receptor‐binding domain (RBD) of pangolin CoVs binds to hACE2 as efficiently as the SARS‐CoV‐2 RBD in vitro. …”
Publicado 2021
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1555por Cecon, Erika, Burridge, Matilda, Cao, Longxing, Carter, Lauren, Ravichandran, Rashmi, Dam, Julie, Jockers, Ralf“…Here, we developed an RBD-ACE2 binding assay that is based on time-resolved FRET, which reliably monitors the interaction in a physiologically relevant and cellular context. …”
Publicado 2022
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1556por Sadremomtaz, Afsaneh, Al-Dahmani, Zayana M., Ruiz-Moreno, Angel J., Monti, Alessandra, Wang, Chao, Azad, Taha, Bell, John C., Doti, Nunzianna, Velasco-Velázquez, Marco A., de Jong, Debora, de Jonge, Jørgen, Smit, Jolanda, Dömling, Alexander, van Goor, Harry, Groves, Matthew R.“…Peptides can inhibit the S-RBD:ACE2 interaction by interacting with the protein–protein interface. …”
Publicado 2021
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1557por Shrestha, Niki, Abe, Rose Anne M, Masroor, Anum, Khorochkov, Arseni, Prieto, Jose, Singh, Karan B, Nnadozie, Maduka C, Abdal, Muhammad, Mohammed, Lubna“…This review’s objective is to highlight the significance of RBD as a prodromal premotor marker for the early detection of PD. …”
Publicado 2021
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1558por Halfmann, Peter J., Castro, Ana, Loeffler, Kathryn, Frey, Steven J., Chiba, Shiho, Kawaoka, Yoshihiro, Kane, Ravi S.“…These results reveal the potential of RBD‐SpyCatcher‐mi3 as a broadly protective vaccination strategy.…”
Publicado 2021
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1559por Sztain, Terra, Ahn, Surl-Hee, Bogetti, Anthony T., Casalino, Lorenzo, Goldsmith, Jory A., Seitz, Evan, McCool, Ryan S., Kearns, Fiona L., Acosta-Reyes, Francisco, Maji, Suvrajit, Mashayekhi, Ghoncheh, McCammon, J. Andrew, Ourmazd, Abbas, Frank, Joachim, McLellan, Jason S., Chong, Lillian T., Amaro, Rommie E.“…SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded “down” to an exposed “up” state in order to bind the human ACE2 receptor and infect cells. …”
Publicado 2021
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1560por Dalvie, Neil C., Biedermann, Andrew M., Rodriguez‐Aponte, Sergio A., Naranjo, Christopher A., Rao, Harish D., Rajurkar, Meghraj P., Lothe, Rakesh R., Shaligram, Umesh S., Johnston, Ryan S., Crowell, Laura E., Castelino, Seraphin, Tracey, Mary K., Whittaker, Charles A., Love, J. Christopher“…This engineered strain is now used to produce an RBD‐based vaccine antigen that is currently in clinical trials and could be used to produce other variants of RBD as needed for future vaccines.…”
Publicado 2021
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