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1561“…Finally, for several Omicron mutations that do not appear to contribute meaningfully to antibody escape, we find evidence for a plausible role in enhanced transmissibility via disruption of RBD-down conformational stability at the RBD-RBD interface.…”
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1562“…It is composed of a heparin binding domain (HBD) and a receptor binding domain (RBD), which are connected by a flexible linker. …”
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1563por Rechichi, Irene, Iadarola, Antonella, Zibetti, Maurizio, Cicolin, Alessandro, Olmo, Gabriella“…Objectives: Rapid Eye Movement Sleep Behaviour Disorder (RBD) is regarded as a prodrome of neurodegeneration, with a high conversion rate to [Formula: see text] –synucleinopathies such as Parkinson’s Disease (PD). …”
Publicado 2021
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1564por Chang, Xinyue, Liu, Xuelan, Mohsen, Mona O., Zeltins, Andris, Martina, Byron, Vogel, Monique, Bachmann, Martin F.“…Here, we present a vaccine candidate which displays receptor-binding domain (RBD) of SARS-CoV-2 on virus-like particles (VLP) that, in mice, not only induce strong antibody responses against RBD but also bind RBDs from other variants of concern (VOCs). …”
Publicado 2022
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1565por Choudhury, Parichita, Graff‐Radford, Jonathan, Aakre, Jeremiah A., Wurtz, Lincoln, Knopman, David S., Graff‐Radford, Neill R., Kantarci, Kejal, Forsberg, Leah K., Fields, Julie A., Pedraza, Otto, Chen, Qin, Miyagawa, Toji, Day, Gregory S., Tipton, Philip, Savica, Rodolfo, Botha, Hugo, Lachner, Christian, Dredla, Brynn, Reichard, R. Ross, Petersen, Ronald C., Dickson, Dennis W., Boeve, Bradley F., Ferman, Tanis J.“…Men were more likely to have RBD and were diagnosed with probable DLB earlier than women. …”
Publicado 2021
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1566por Laroche, Adrien, Orsini Delgado, Maria Lucia, Chalopin, Benjamin, Cuniasse, Philippe, Dubois, Steven, Sierocki, Raphaël, Gallais, Fabrice, Debroas, Stéphanie, Bellanger, Laurent, Simon, Stéphanie, Maillère, Bernard, Nozach, Hervé“…Here, we report the molecular engineering of nanobodies that bind with picomolar affinity to both SARS-CoV-1 and SARS-CoV-2 receptor-binding domains (RBD) and are highly neutralizing. We applied deep mutational engineering to VHH72, a nanobody initially specific for SARS-CoV-1 RBD with little cross-reactivity to SARS-CoV-2 antigen. …”
Publicado 2022
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1567por Tang, Lingfeng, Zhang, Di, Han, Pu, Kang, Xinrui, Zheng, Anqi, Xu, Zepeng, Zhao, Xin, Wang, Vivien Ya-Fan, Qi, Jianxun, Wang, Qihui, Liu, Kefang, Gao, George F.“…We report the binding between intermediate horseshoe bat ACE2 (bACE2-Ra) and SARS-CoV-2 receptor-binding domain (RBD), supporting the pseudotyped SARS-CoV-2 viral infection. …”
Publicado 2022
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1568por Mangone, Graziella, Houot, Marion, Gaurav, Rahul, Boluda, Susana, Pyatigorskaya, Nadya, Chalancon, Alizé, Seilhean, Danielle, Prigent, Annick, Lehéricy, Stéphane, Arnulf, Isabelle, Corvol, Jean-Christophe, Vidailhet, Marie, Duyckaerts, Charles, Degos, Bertrand“…Deposits of α-Syn were found in 15 (55.6%) PD, 7 (43.8%) iRBD, and 7 (38.9%) controls using the anti-aggregated α-Syn clone 5G4 antibody and in 4 (14.8%) PD, 3 (18.8%) iRBD and no control using the purified mouse anti-α-Syn clone 42 antibody. …”
Publicado 2022
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1569por Yamamoto, Yuichiro, Nakano, Yoshio, Murae, Mana, Shimizu, Yoshimi, Sakai, Shota, Ogawa, Motohiko, Mizukami, Tomoharu, Inoue, Tetsuya, Onodera, Taishi, Takahashi, Yoshimasa, Wakita, Takaji, Fukasawa, Masayoshi, Miyazaki, Satoru, Noguchi, Kohji“…Enzyme-linked immunosorbent assay showed direct inhibition of RBD-ACE2 interactions by PAA. In conclusion, the PAA treatment suppressed SARS-CoV-2 infection, which was dependent on the inhibition of the interaction between the spike RBD and ACE2 by inducing spike protein destabilization. …”
Publicado 2022
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1570por Monteiro, Fernanda Pereira, Tavares, Victor de Souza, Souza, Rayane da Silva Oliveira, Venâncio, Larissa Paola Rodrigues, Fabres-Klein, Mary Hellen, do Carmo, Rodrigo Feliciano, Klein, Raphael Contelli, Lima, Jonilson Berlink, Araújo-Santos, Théo“…FINDINGS: Patients with severe disease had a coagulation disorder with high levels of D-dimer as well as circulating IgG against the NP but not the RBD compared to other groups of patients. In addition, high levels of D-dimer and IgG against the NP and RBD were associated with disease severity among the patients in this study. …”
Publicado 2023
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1571“…The open-form spike protein with one RBD up is dominant, followed by the open-form spike protein with two RBD up, and the closed-form spike protein with the RBD down. …”
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1572por Pezzati, Laura, Milazzo, Laura, Carrozzo, Giorgia, Kullmann, Cristina, Oreni, Letizia, Beltrami, Martina, Caronni, Stefania, Lai, Alessia, Caberlotto, Livio, Ottomano, Cosimo, Antinori, Spinello, Ridolfo, Anna Lisa“…In this cross-sectional study, plasma samples were screened for anti-RBD IgG using a quantitative method. The neutralizing capacity for each sample was estimated by means of a surrogate virus neutralizing test (sVNT) and results expressed as the percentage of inhibition (%IH) of the interaction between RBD and the angiotensin-converting enzyme. …”
Publicado 2023
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1573por Werbel, William A., Karaba, Andrew H., Chiang, Teresa Po-Yu, Massie, Allan B., Brown, Diane M., Watson, Natasha, Chahoud, Maggie, Thompson, Elizabeth A., Johnson, Aileen C., Avery, Robin K., Cochran, Willa V., Warren, Daniel, Liang, Tao, Fribourg, Miguel, Huerta, Christopher, Samaha, Hady, Klein, Sabra L., Bettinotti, Maria P., Clarke, William A., Sitaras, Ioannis, Rouphael, Nadine, Cox, Andrea L., Bailey, Justin R., Pekosz, Andrew, Tobian, Aaron A.R., Durand, Christine M., Bridges, Nancy D., Larsen, Christian P., Heeger, Peter S., Segev, Dorry L.“…We administered third monovalent mRNA vaccines to n = 81 KTRs with negative or low-titer anti-receptor binding domain (RBD) antibody (n = 39 anti-RBD(NEG); n = 42 anti-RBD(LO)), compared with healthy controls (HCs, n = 19), measuring anti-RBD, Omicron neutralization, spike-specific CD8(+)%, and SARS-CoV-2–reactive T cell receptor (TCR) repertoires. …”
Publicado 2023
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1574por Serwanga, Jennifer, Ankunda, Violet, Sembera, Jackson, Kato, Laban, Oluka, Gerald Kevin, Baine, Claire, Odoch, Geoffrey, Kayiwa, John, Auma, Betty Oliver, Jjuuko, Mark, Nsereko, Christopher, Cotten, Matthew, Onyachi, Nathan, Muwanga, Moses, Lutalo, Tom, Fox, Julie, Musenero, Monica, Kaleebu, Pontiano“…Spike- and RBD-directed IgG antibodies were positively correlated until 14 months (Spearman’s rank correlation test, p-values 0.0001 to 0.05), although RBD diminished faster. …”
Publicado 2023
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1575por Zhang, Lingyu, Hou, Yanbing, Li, Chunyu, Wei, Qianqian, Ou, Ruwei, Liu, Kuncheng, Lin, Junyu, Yang, Tianmi, Xiao, Yi, Jiang, Qirui, Zhao, Bi, Shang, Huifang“…Sleep disturbances including RBD, EDS, and PD-SP were assessed using the RBD Screening Questionnaire, Epworth sleepiness scale, and PD sleep scale-2, respectively. …”
Publicado 2023
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1576por Wang, Wenling, Wang, Tianyu, Deng, Yao, Niu, Peihua, A, Ruhan, Zhao, Jincun, Peiris, Malik, Tang, Shixing, Tan, Wenjie“…Furthermore, the S1-, RBD-, and NP-LISAs were more sensitive (by at least 16-fold) than the commercially available S1-ELISA. …”
Publicado 2019
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1577por Prajapat, Manisha, Shekhar, Nishant, Sarma, Phulen, Avti, Pramod, Singh, Sanjay, Kaur, Hardeep, Bhattacharyya, Anusuya, Kumar, Subodh, Sharma, Saurabh, Prakash, Ajay, Medhi, Bikash“…In this study we tend to repurpose already approved drugs as inhibitors of the interaction between S1-RBD and the ACE2 receptor. METHODS: 2456 approved drugs were screened against the RBD of S1 protein of SARS-CoV-2 (target PDB ID: 6M17). …”
Publicado 2020
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1578por Heaney, Christopher D., Pisanic, Nora, Randad, Pranay R., Kruczynski, Kate, Howard, Tyrone, Zhu, Xianming, Littlefield, Kirsten, Patel, Eshan U., Shrestha, Ruchee, Laeyendecker, Oliver, Shoham, Shmuel, Sullivan, David, Gebo, Kelly, Hanley, Daniel, Redd, Andrew D., Quinn, Thomas C., Casadevall, Arturo, Zenilman, Jonathan M., Pekosz, Andrew, Bloch, Evan M., Tobian, Aaron A.R.“…Compared to a plasma nAb assay, the multiplex salivary assay PPA ranged from 62.3% (N) and 98.6% (RBD) and NPA ranged from 18.8% (RBD) to 96.9% (S). …”
Publicado 2021
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1579“…We found that the intracellular uptake of the RBD-S19-TAT/siRNA complex was increased compared to that of the RBD-TAT/siRNA complex, and the expression level of the target mRNA was decreased. …”
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1580por Deliyannis, Georgia, Gherardin, Nicholas A., Wong, Chinn Yi, Grimley, Samantha L., Cooney, James P., Redmond, Samuel J., Ellenberg, Paula, Davidson, Kathryn C., Mordant, Francesca L., Smith, Tim, Gillard, Marianne, Lopez, Ester, McAuley, Julie, Tan, Chee Wah, Wang, Jing J., Zeng, Weiguang, Littlejohn, Mason, Zhou, Runhong, Fuk-Woo Chan, Jasper, Chen, Zhi-wei, Hartwig, Airn E., Bowen, Richard, Mackenzie, Jason M., Vincan, Elizabeth, Torresi, Joseph, Kedzierska, Katherine, Pouton, Colin W., Gordon, Tom P., Wang, Lin-fa, Kent, Stephen J., Wheatley, Adam K., Lewin, Sharon R., Subbarao, Kanta, Chung, Amy W., Pellegrini, Marc, Munro, Trent, Nolan, Terry, Rockman, Steven, Jackson, David C., Purcell, Damian F.J., Godfrey, Dale I.“…These were tested in conjunction with three different adjuvants: a TLR2 agonist R4-Pam2Cys, an NKT cell agonist glycolipid α-Galactosylceramide, or MF59® squalene oil-in-water adjuvant, using mice, rats and hamsters. We also developed an RBD-human IgG1 Fc vaccine with an RBD sequence of the immuno-evasive beta variant (N501Y, E484K, K417N). …”
Publicado 2023
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