Mostrando 141 - 160 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.19s Limitar resultados
  1. 141
    “…Currently, SARS-CoV-2 spike receptor-binding-domain (RBD)-based vaccines are considered one of the most effective weapons against COVID-19. …”
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    Are Hamsters a Suitable Model for Evaluating the Immunogenicity of RBD-Based Anti-COVID-19 Subunit Vaccines?
  2. 142
    “…METHODS: An in-house ELISA was developed and standardized to screen for serum IgG antibodies against the SARS-CoV-2 S1-RBD protein as an antigen. This study aims to investigate the seroprevalence of serum antibodies against S1-RBD antigen in pre-pandemic (n = 120) and during the early pandemic period (n = 120) in subjects from the Hail region, KSA and to correlate it with clinical and demographic factors. …”
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    Seroprevalence of Anti-S1-RBD Antibodies in Pre-pandemic and Pandemic Subjects From Hail Region, KSA
  3. 143
    “…Results show that RBD-ACE2 binding site may drastically relocate with an enlarged interface. …”
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    Large interfacial relocation in RBD-ACE2 complex may explain fast-spreading property of Omicron
  4. 144
    “…METHODS: A preclinical study used a potential vaccine candidate (RBD, SARS-CoV-2). Four groups of BALB/c mice were used, a control group, an adjuvant group, a group inoculated with one dose of RBD subunit protein, and the fourth group inoculated with two doses of RBD subunit protein. …”
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    Immunogenicity and safety of a RBD vaccine against SARS-CoV-2 in a murine model
  5. 145
    “…BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) predicts cognitive decline in Parkinson’s disease (PD) patients without dementia. …”
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    Blood neuroexosomal excitatory amino acid transporter-2 is associated with cognitive decline in Parkinson’s disease with RBD
  6. 146
    “…The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the major target for antibody therapeutics. …”
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    Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD Protein
  7. 147
    “…Importantly, combining neutralizing antibodies targeting RBD conserved regions and stem helix synergistically prevented the emergence of escape mutations. …”
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    Mutational escape prevention by combination of four neutralizing antibodies that target RBD conserved regions and stem helix
  8. 148
    “…SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host’s cellular receptor. As RBD is required for many applications, in the context of pandemic it is important to meet the challenge of producing a high amount of recombinant RBD (rRBD). …”
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    Improved Expression of SARS-CoV-2 Spike RBD Using the Insect Cell-Baculovirus System
  9. 149
    “…A subsequent biolayer interferometry assay indicated that flavonoids bind to viral spike RBD to block viral interaction with ACE2 receptor, and a molecular docking study also revealed that flavonols could bind to Pocket 3, the non-mutant regions of SARS-CoV-2 variants, suggesting that flavonols might be also active against virus variants. …”
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    Anti-Entry Activity of Natural Flavonoids against SARS-CoV-2 by Targeting Spike RBD
  10. 150
    “…Free energy calculations were performed for different FA-bound RBD complexes. The results suggest that the interaction of FA with the cryptic binding site of RBD alters the conformation of the binding loop of RBD and effectively reduces its binding affinity towards ACE2. …”
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    Novel Inhibitory Role of Fenofibric Acid by Targeting Cryptic Site on the RBD of SARS-CoV-2
  11. 151
    “…In this work, we tested 18 triterpene derivatives as potential inhibitors of SARS-CoV-2 against the receptor-binding domain (RBD) of the spike protein by means of molecular docking and molecular dynamics simulations, modeling the RBD S1 subunit from the X-ray structure of the RBD-ACE2 complex (PDB ID: 6M0J). …”
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    Triterpene Derivatives as Potential Inhibitors of the RBD Spike Protein from SARS-CoV-2: An In Silico Approach
  12. 152
    “…This creates a plethora of unmet needs for people with RBDs as well as their families and care providers, including diagnostic delays, limited access to expert care, and a lack of specialized treatments. The RBD Summit, which took place across 2 days in November 2021, was a virtual meeting of 65 RBD experts from clinical, academic, and patient communities as well as the pharmaceutical industry. …”
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    Improving care pathways for people living with rare bone diseases (RBDs): outcomes from the first RBD Summit
  13. 153
    “…Here we report the safety, tolerability, and immunogenicity of a recombinant protein RBD fusion heterodimeric vaccine against SARS-CoV-2 (PHH-1V) evaluated in a phase 1-2a dose-escalation, randomized clinical trial conducted in Catalonia, Spain. 30 young healthy adults were enrolled and received two intramuscular doses, 21 days apart of PHH-1V vaccine formulations [10 µg (n = 5), 20 µg (n = 10), 40 µg (n = 10)] or control [BNT162b2 (n = 5)]. …”
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    Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2
  14. 154
    “…The structure reveals an unusual double-stranded RNA binding domain (dsRBD) fold embedding a novel zinc-binding motif that is conserved among dicers in yeast. …”
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    An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer
  15. 155
    “…KEY FINDINGS: 20 best compounds directed to interact in ACE2 with a high probability to be safe in humans, validated by web servers of prediction of ADME and toxicity (ProTox-II and PreADMET), to difficult the interaction between ACE2 and region binding domain (RBD) of SARS-CoV-2. SIGNIFICANCE: In this study, 20 compounds were determined by docking focused on the region of interaction between ACE2 and RBD of SARS-CoV-2 was carried out. …”
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    Potential inhibitors of the interaction between ACE2 and SARS-CoV-2 (RBD), to develop a drug
  16. 156
    “…The efficacy of the RBD in triggering antibody response in vivo was subsequently tested in both mice and equines, and the results showed that the RBD triggered high-titer neutralizing antibody production in vivo. …”
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    Immunoglobulin fragment F(ab’)(2) against RBD potently neutralizes SARS-CoV-2 in vitro
  17. 157
    “…To further investigate how peptides at the interface of RBD or ACE2 alter the binding between RBD and ACE2, protein–protein docking of RBD and ACE2 with and without peptides was performed. …”
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    Peptide modelling and screening against human ACE2 and spike glycoprotein RBD of SARS-CoV-2
  18. 158
    “…The insert and the receptor-binding domain, (RBD), are vital clues in the Sherlock Holmes-like investigation into the origin of the virus and in its zoonotic crossover. …”
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    The polybasic insert, the RBD of the SARS-CoV-2 spike protein, and the feline coronavirus – evolved or yet to evolve
  19. 159
    “…The RBD-ACE2 interaction is a crucial step to mediate the host cell entry of SARS-CoV-2. …”
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    Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction
  20. 160
    “…SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain (RBD) and N-terminal domain (NTD). Here we report the humoral immune response to circulating SARS-CoV-2 variants, such as 501Y.V2 (B.1.351), of the plasma and neutralizing antibodies (NAbs) elicited by CoronaVac (inactivated vaccine), ZF2001 (RBD-subunit vaccine) and natural infection. …”
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    Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines
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