-
141por Merkuleva, Iuliia A., Shcherbakov, Dmitry N., Borgoyakova, Mariya B., Isaeva, Anastasiya A., Nesmeyanova, Valentina S., Volkova, Natalia V., Aripov, Vazirbek S., Shanshin, Daniil V., Karpenko, Larisa I., Belenkaya, Svetlana V., Kazachinskaia, Elena I., Volosnikova, Ekaterina A., Esina, Tatiana I., Sergeev, Alexandr A., Titova, Kseniia A., Konyakhina, Yulia V., Zaykovskaya, Anna V., Pyankov, Oleg V., Kolosova, Evgeniia A., Viktorina, Olesya E., Shelemba, Arseniya A., Rudometov, Andrey P., Ilyichev, Alexander A.“…Currently, SARS-CoV-2 spike receptor-binding-domain (RBD)-based vaccines are considered one of the most effective weapons against COVID-19. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
142Seroprevalence of Anti-S1-RBD Antibodies in Pre-pandemic and Pandemic Subjects From Hail Region, KSApor Sherwani, Subuhi, Khan, Mohd Wajid Ali, Mallik, Arshi, Khan, Mahvish, Saleem, Mohd, Raafat, Mohamed, Shati, Ayed A., Alam, Noor“…METHODS: An in-house ELISA was developed and standardized to screen for serum IgG antibodies against the SARS-CoV-2 S1-RBD protein as an antigen. This study aims to investigate the seroprevalence of serum antibodies against S1-RBD antigen in pre-pandemic (n = 120) and during the early pandemic period (n = 120) in subjects from the Hail region, KSA and to correlate it with clinical and demographic factors. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
143“…Results show that RBD-ACE2 binding site may drastically relocate with an enlarged interface. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
144por Díaz, Andrés, Serrano-Coll, Héctor, Botero, Yesica, Calderón, Alfonso, Arteta-Cueto, Ariel, Gastelbondo, Bertha, Guzmán, Camilo, Rivero, Ricardo, Martínez, Caty, Marquez, Tania, Arrieta, Germán, Mattar, Salim“…METHODS: A preclinical study used a potential vaccine candidate (RBD, SARS-CoV-2). Four groups of BALB/c mice were used, a control group, an adjuvant group, a group inoculated with one dose of RBD subunit protein, and the fourth group inoculated with two doses of RBD subunit protein. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
145por Leng, Bing, Sun, Hairong, Li, Mengfan, Zhao, Junwu, Liu, Xiaoxiao, Yao, Ran, Shen, Tengqun, Li, Zhenguang, Zhang, Jinbiao“…BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) predicts cognitive decline in Parkinson’s disease (PD) patients without dementia. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
146por Chen, Yu-Lei, Lin, Jin-Jin, Ma, Huan, Zhong, Ning, Xie, Xin-Xin, Yang, Yunru, Zheng, Peiyi, Zhang, Ling-Jing, Jin, Tengchuan, Cao, Min-Jie“…The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the major target for antibody therapeutics. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
147por Tang, Haoneng, Ke, Yong, Liao, Yunji, Bian, Yanlin, Yuan, Yunsheng, Wang, Ziqi, Yang, Li, Ma, Hang, Sun, Tao, Zhang, Baohong, Zhang, Xiaoju, Wu, Mingyuan, Zhu, Jianwei“…Importantly, combining neutralizing antibodies targeting RBD conserved regions and stem helix synergistically prevented the emergence of escape mutations. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
148por Poodts, Joaquín, Smith, Ignacio, Birenbaum, Joaquín Manuel, Rodriguez, María Sol, Montero, Luciano, Wolman, Federico Javier, Marfía, Juan Ignacio, Valdez, Silvina Noemí, Alonso, Leonardo Gabriel, Targovnik, Alexandra Marisa, Miranda, María Victoria“…SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host’s cellular receptor. As RBD is required for many applications, in the context of pandemic it is important to meet the challenge of producing a high amount of recombinant RBD (rRBD). …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
149por Meng, Jie-Ru, Liu, Jiazheng, Fu, Lu, Shu, Tong, Yang, Lingzhi, Zhang, Xueji, Jiang, Zhi-Hong, Bai, Li-Ping“…A subsequent biolayer interferometry assay indicated that flavonoids bind to viral spike RBD to block viral interaction with ACE2 receptor, and a molecular docking study also revealed that flavonols could bind to Pocket 3, the non-mutant regions of SARS-CoV-2 variants, suggesting that flavonols might be also active against virus variants. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
150“…Free energy calculations were performed for different FA-bound RBD complexes. The results suggest that the interaction of FA with the cryptic binding site of RBD alters the conformation of the binding loop of RBD and effectively reduces its binding affinity towards ACE2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
151por Avelar, Mayra, Pedraza-González, Laura, Sinicropi, Adalgisa, Flores-Morales, Virginia“…In this work, we tested 18 triterpene derivatives as potential inhibitors of SARS-CoV-2 against the receptor-binding domain (RBD) of the spike protein by means of molecular docking and molecular dynamics simulations, modeling the RBD S1 subunit from the X-ray structure of the RBD-ACE2 complex (PDB ID: 6M0J). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
152por Chandran, Manju, Alves, Ines, Carpenter, Thomas, Davis, Michelle, Hsiao, Edward C., Petryk, Anna, Semler, Jorg Oliver, Sleiman, Marwan“…This creates a plethora of unmet needs for people with RBDs as well as their families and care providers, including diagnostic delays, limited access to expert care, and a lack of specialized treatments. The RBD Summit, which took place across 2 days in November 2021, was a virtual meeting of 65 RBD experts from clinical, academic, and patient communities as well as the pharmaceutical industry. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
153Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2por Leal, Lorna, Pich, Judit, Ferrer, Laura, Nava, Jocelyn, Martí-Lluch, Ruth, Esteban, Ignasi, Pradenas, Edwards, Raïch-Regué, Dàlia, Prenafeta, Antoni, Escobar, Karla, Pastor, Carmen, Ribas-Aulinas, Marc, Trinitè, Benjamin, Muñoz-Basagoiti, Jordana, Domenech, Gemma, Clotet, Bonaventura, Corominas, Júlia, Corpes-Comes, Aida, Garriga, Carme, Barreiro, Antonio, Izquierdo-Useros, Nuria, Arnaiz, Joan Albert, Soriano, Alex, Ríos, José, Nadal, Marga, Plana, Montserrat, Blanco, Julià, Prat, Teresa, Torroella, Elia, Ramos, Rafel“…Here we report the safety, tolerability, and immunogenicity of a recombinant protein RBD fusion heterodimeric vaccine against SARS-CoV-2 (PHH-1V) evaluated in a phase 1-2a dose-escalation, randomized clinical trial conducted in Catalonia, Spain. 30 young healthy adults were enrolled and received two intramuscular doses, 21 days apart of PHH-1V vaccine formulations [10 µg (n = 5), 20 µg (n = 10), 40 µg (n = 10)] or control [BNT162b2 (n = 5)]. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
154por Barraud, Pierre, Emmerth, Stephan, Shimada, Yukiko, Hotz, Hans-Rudolf, Allain, Frédéric H-T, Bühler, Marc“…The structure reveals an unusual double-stranded RNA binding domain (dsRBD) fold embedding a novel zinc-binding motif that is conserved among dicers in yeast. …”
Publicado 2011
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
155“…KEY FINDINGS: 20 best compounds directed to interact in ACE2 with a high probability to be safe in humans, validated by web servers of prediction of ADME and toxicity (ProTox-II and PreADMET), to difficult the interaction between ACE2 and region binding domain (RBD) of SARS-CoV-2. SIGNIFICANCE: In this study, 20 compounds were determined by docking focused on the region of interaction between ACE2 and RBD of SARS-CoV-2 was carried out. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
156por Pan, Xiaoyan, Zhou, Pengfei, Fan, Tiejiong, Wu, Yan, Zhang, Jing, Shi, Xiaoyue, Shang, Weijuan, Fang, Lijuan, Jiang, Xiaming, Shi, Jian, Sun, Yuan, Zhao, Shaojuan, Gong, Rui, Chen, Ze, Xiao, Gengfu“…The efficacy of the RBD in triggering antibody response in vivo was subsequently tested in both mice and equines, and the results showed that the RBD triggered high-titer neutralizing antibody production in vivo. …”
Publicado 2020
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
157por Rathod, Shravan B., Prajapati, Pravin B., Punjabi, Lata B., Prajapati, Kuntal N., Chauhan, Neha, Mansuri, Mohmedyasin F.“…To further investigate how peptides at the interface of RBD or ACE2 alter the binding between RBD and ACE2, protein–protein docking of RBD and ACE2 with and without peptides was performed. …”
Publicado 2020
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
158por Budhraja, Anshul, Pandey, Sakshi, Kannan, Srinivasaraghavan, Verma, Chandra S., Venkatraman, Prasanna“…The insert and the receptor-binding domain, (RBD), are vital clues in the Sherlock Holmes-like investigation into the origin of the virus and in its zoonotic crossover. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
159por Cao, Wenpeng, Dong, Chuqiao, Kim, Seonghan, Hou, Decheng, Tai, Wanbo, Du, Lanying, Im, Wonpil, Zhang, X. Frank“…The RBD-ACE2 interaction is a crucial step to mediate the host cell entry of SARS-CoV-2. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
160por Cao, Yunlong, Yisimayi, Ayijiang, Bai, Yali, Huang, Weijin, Li, Xiaofeng, Zhang, Zhiying, Yuan, Tianjiao, An, Ran, Wang, Jing, Xiao, Tianhe, Du, Shuo, Ma, Wenping, Song, Liyang, Li, Yongzheng, Li, Xiang, Song, Weiliang, Wu, Jiajing, Liu, Shuo, Li, Xuemei, Zhang, Yonghong, Su, Bin, Guo, Xianghua, Wei, Yangyang, Gao, Chuanping, Zhang, Nana, Zhang, Yifei, Dou, Yang, Xu, Xiaoyu, Shi, Rui, Lu, Bai, Jin, Ronghua, Ma, Yingmin, Qin, Chengfeng, Wang, Youchun, Feng, Yingmei, Xiao, Junyu, Xie, Xiaoliang Sunney“…SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain (RBD) and N-terminal domain (NTD). Here we report the humoral immune response to circulating SARS-CoV-2 variants, such as 501Y.V2 (B.1.351), of the plasma and neutralizing antibodies (NAbs) elicited by CoronaVac (inactivated vaccine), ZF2001 (RBD-subunit vaccine) and natural infection. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto