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1601por Becker, Matthias M. M., Lapouge, Karine, Segnitz, Bernd, Wild, Klemens, Sinning, Irmgard“…Despite their essential roles in the SRP pathway, structural information has been available only for the SRP68 RNA-binding domain (RBD). Here we present the crystal structures of the SRP68 protein-binding domain (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions of SRP72 within SRP. …”
Publicado 2017
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1602por Oladapo, Olulola Olutoyin, Ojora, Kehinde Adeyemi, Quadri, Oluwafemi Majeed, Ajani, Rotimi Sunday“…Diabetic animals fed on RBD-PO had a lower non-HDL-C, higher HDL-C, and lower AI than diabetic animals fed on olive oil or soya oil. …”
Publicado 2017
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1603por Charbonnel, Cyril, Niazi, Adnan K., Elvira-Matelot, Emilie, Nowak, Elżbieta, Zytnicki, Matthias, de Bures, Anne, Jobet, Edouard, Opsomer, Alisson, Shamandi, Nahid, Nowotny, Marcin, Carapito, Christine, Reichheld, Jean-Philippe, Vaucheret, Hervé, Sáez-Vásquez, Julio“…Furthermore, we demonstrate that RNase III and dsRNA binding domains (dsRBD) are both required for dsRNA cleavage. Interestingly, the four DCL and the three RTL that carry dsRBD share a conserved cysteine (C230 in Arabidopsis RTL1) in their dsRBD. …”
Publicado 2017
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1604por Heyam, Alex, Coupland, Claire E., Dégut, Clément, Haley, Ruth A., Baxter, Nicola J., Jakob, Leonhard, Aguiar, Pedro M., Meister, Gunter, Williamson, Michael P., Lagos, Dimitris, Plevin, Michael J.“…Double-stranded RNA-binding domains (dsRBDs) are commonly found in modular proteins that interact with RNA. Two varieties of dsRBD exist: canonical Type A dsRBDs interact with dsRNA, while non-canonical Type B dsRBDs lack RNA-binding residues and instead interact with other proteins. …”
Publicado 2017
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1605por Candini, M., Avanzi, S., Cantagallo, A., Zangoli, M.G., Benassi, M., Querzani, P., Lotti, E.M., Iachini, T., Frassinetti, F.“…By contrast, in the recognition task, both RBD and LBD patients were impaired and showed two different biases: RBD patients misattributed the other's voice to themselves, while LBD patients denied the ownership of their own voice. …”
Publicado 2018
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1606por Jun, Jin‐Sun, Kim, Ryul, Byun, Jung‐Ick, Kim, Tae‐Joon, Lim, Jung‐Ah, Sunwoo, Jun‐Sang, Lee, Soon‐Tae, Jung, Keun‐Hwa, Park, Kyung‐Il, Chu, Kon, Kim, Manho, Lee, Sang Kun, Jung, Ki‐Young“…OBJECTIVE: We investigated the effects of prolonged‐release melatonin (PRM) on idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). METHODS: In this 4‐week, randomized, double–blind, placebo–controlled pilot study, 30 participants with polysomnography–confirmed iRBD were assigned to receive PRM 2 mg per day, PRM 6 mg per day, or placebo. …”
Publicado 2019
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1607por Parsons, Lisa M., Bouwman, Kim M., Azurmendi, Hugo, de Vries, Robert P., Cipollo, John F., Verheije, Monique H.“…Ten single Asn–to–Ala substitutions at the predicted N-glycosylation sites of the M41–RBD were evaluated along with two control Val–to–Ala substitutions. …”
Publicado 2019
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1608por Joyce, M. Gordon, Sankhala, Rajeshwer S., Chen, Wei-Hung, Choe, Misook, Bai, Hongjun, Hajduczki, Agnes, Yan, Lianying, Sterling, Spencer L., Peterson, Caroline E., Green, Ethan C., Smith, Clayton, de Val, Natalia, Amare, Mihret, Scott, Paul, Laing, Eric D., Broder, Christopher C., Rolland, Morgane, Michael, Nelson L., Modjarrad, Kayvon“…Here we report the crystal structure of the SARS-CoV-2 S receptor-binding-domain (RBD) at a the highest resolution to date, of 1.95 Å. …”
Publicado 2020
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1609por Wu, Yan, Wang, Feiran, Shen, Chenguang, Peng, Weiyu, Li, Delin, Zhao, Cheng, Li, Zhaohui, Li, Shihua, Bi, Yuhai, Yang, Yang, Gong, Yuhuan, Xiao, Haixia, Fan, Zheng, Tan, Shuguang, Wu, Guizhen, Tan, Wenjie, Lu, Xuancheng, Fan, Changfa, Wang, Qihui, Liu, Yingxia, Zhang, Chen, Qi, Jianxun, Gao, George Fu, Gao, Feng, Liu, Lei“…Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. …”
Publicado 2020
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1610por Suthar, Mehul S., Zimmerman, Matthew G., Kauffman, Robert C., Mantus, Grace, Linderman, Susanne L., Hudson, William H., Vanderheiden, Abigail, Nyhoff, Lindsay, Davis, Carl W., Adekunle, Oluwaseyi, Affer, Maurizio, Sherman, Melanie, Reynolds, Stacian, Verkerke, Hans P., Alter, David N., Guarner, Jeannette, Bryksin, Janetta, Horwath, Michael C., Arthur, Connie M., Saakadze, Natia, Smith, Geoffrey H., Edupuganti, Srilatha, Scherer, Erin M., Hellmeister, Kieffer, Cheng, Andrew, Morales, Juliet A., Neish, Andrew S., Stowell, Sean R., Frank, Filipp, Ortlund, Eric, Anderson, Evan J., Menachery, Vineet D., Rouphael, Nadine, Mehta, Aneesh K., Stephens, David S., Ahmed, Rafi, Roback, John D., Wrammert, Jens“…RBD-specific IgG responses are detectable in all patients 6 days after PCR confirmation. …”
Publicado 2020
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1611por Jia, Ran, Wang, Xiangshi, Liu, Pengcheng, Liang, Xiaozhen, Ge, Yanling, Tian, He, Chang, Hailing, Zhou, Hao, Zeng, Mei, Xu, Jin“…Potent S-RBD IgA response was observed but N IgA seemed to be inconspicuous. …”
Publicado 2020
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1612por Parray, Hilal Ahmad, Chiranjivi, Adarsh Kumar, Asthana, Shailendra, Yadav, Naveen, Shrivastava, Tripti, Mani, Shailendra, Sharma, Chandresh, Vishwakarma, Preeti, Das, Supratik, Pindari, Kamal, Sinha, Subrata, Samal, Sweety, Ahmed, Shubbir, Kumar, Rajesh“…Herein, we use this technology to search for antibodies targeting the receptor-binding domain (RBD) of CoV-2. Specifically, we screened a naïve human semisynthetic phage library against RBD, leading to the identification of a high-affinity single-chain fragment variable region (scFv). …”
Publicado 2020
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1613por He, Linling, Lin, Xiaohe, Wang, Ying, Abraham, Ciril, Sou, Cindy, Ngo, Timothy, Zhang, Yi, Wilson, Ian A., Zhu, Jiang“…An antibody column specific for the RBD enabled tag-free vaccine purification. In mice, the 24-meric RBD-ferritin SApNP elicited a more potent neutralizing antibody (NAb) response than the RBD alone and the spike with two stabilizing proline mutations in S2 (S2P). …”
Publicado 2021
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1614por Bhattacharya, Rajarshi, Gupta, Aayatti Mallick, Mitra, Suranjita, Mandal, Sukhendu, Biswas, Swadesh R.“…Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. …”
Publicado 2021
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1615por Klingler, Jéromine, Weiss, Svenja, Itri, Vincenza, Liu, Xiaomei, Oguntuyo, Kasopefoluwa Y., Stevens, Christian, Ikegame, Satoshi, Hung, Chuan-Tien, Enyindah-Asonye, Gospel, Amanat, Fatima, Baine, Ian, Arinsburg, Suzanne, Bandres, Juan C., Kojic, Erna Milunka, Stoever, Jonathan, Jurczyszak, Denise, Bermudez-Gonzalez, Maria, Nádas, Arthur, Liu, Sean, Lee, Benhur, Zolla-Pazner, Susan, Hioe, Catarina E.“…Virus infection requires the receptor-binding domain (RBD) of the spike protein. Although studies have demonstrated anti-spike and - RBD antibodies to be protective in animal models, and convalescent plasma as a promising therapeutic option, little is known about immunoglobulin (Ig) isotypes capable of blocking infection. …”
Publicado 2020
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1616por Schasfoort, Richard B.M., van Weperen, Jos, van Amsterdam, Margot, Parisot, Judicaël, Hendriks, Jan, Koerselman, Michelle, Karperien, Marcel, Mentink, Anouk, Bennink, Martin, Krabbe, Hans, Terstappen, Leon WMM., Mulder, A.H. Leontine“…Surface Plasmon Resonance imaging (SPRi) was used to determine the presence and strength of binding of IgG, IgM and IgA against the Receptor Binding Domain (RBD) of SARS-CoV-2 in sera of 119 CoViD-19 patients. …”
Publicado 2021
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1617por Srivastava, Vikram, Niu, Ling, Phadke, Kruttika S., Bellaire, Bryan H., Cho, Michael W.“…In this study, immunogenicity of the receptor binding domain (RBD) of spike (S) glycoprotein was examined in mice. …”
Publicado 2021
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1618por Yuan, Yajie, Yu, Liang, Jin, Zi, Wang, Yongjun, Gao, Meng, Ding, Haojie, Zhuo, Xunhui, Zhu, Xiao, Gao, Fei, Zheng, Xiaojun, Ying, Guoqing, Xu, Xiaowei, Kong, Qingming, Lu, Shaohong, Lv, Hangjun“…Furthermore, ELISA-RBD IgG titers and pseudovirus-based NAb titers correlated significantly, with R(2) of 0.2564 (P < 0.0001). …”
Publicado 2021
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1619por Mishra, Pankaj Kumar, Bruiners, Natalie, Ukey, Rahul, Datta, Pratik, Onyuka, Alberta, Handler, Deborah, Hussain, Sabiha, Honnen, William, Singh, Sukhwinder, Guerrini, Valentina, Yin, Yue, Dewald, Hannah, Choudhary, Alok, Horton, Daniel B., Barrett, Emily S., Roy, Jason, Weiss, Stanley H., Fitzgerald-Bocarsly, Patricia, Blaser, Martin J., Carson, Jeffrey L., Panettieri, Reynold A., Lardizabal, Alfred, Chang, Theresa Li-Yun, Pinter, Abraham, Gennaro, Maria Laura“…Over time, neutralizing antibody responses, which are predominantly RBD specific, generally decreased, while RBD-specific memory B cells persisted. …”
Publicado 2021
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1620por Wagner, Teresa R, Ostertag, Elena, Kaiser, Philipp D, Gramlich, Marius, Ruetalo, Natalia, Junker, Daniel, Haering, Julia, Traenkle, Bjoern, Becker, Matthias, Dulovic, Alex, Schweizer, Helen, Nueske, Stefan, Scholz, Armin, Zeck, Anne, Schenke‐Layland, Katja, Nelde, Annika, Strengert, Monika, Walz, Juliane S, Zocher, Georg, Stehle, Thilo, Schindler, Michael, Schneiderhan‐Marra, Nicole, Rothbauer, Ulrich“…Here, we present 11 unique nanobodies (Nbs) specific for the SARS‐CoV‐2 spike receptor‐binding domain (RBD), of which 8 Nbs potently inhibit the interaction of RBD with angiotensin‐converting enzyme 2 (ACE2) as the major viral docking site. …”
Publicado 2021
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