Mostrando 1,601 - 1,620 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.18s Limitar resultados
  1. 1601
    “…Despite their essential roles in the SRP pathway, structural information has been available only for the SRP68 RNA-binding domain (RBD). Here we present the crystal structures of the SRP68 protein-binding domain (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions of SRP72 within SRP. …”
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    Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction
  2. 1602
    “…Diabetic animals fed on RBD-PO had a lower non-HDL-C, higher HDL-C, and lower AI than diabetic animals fed on olive oil or soya oil. …”
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    Lipidemic effects of common edible oils and risk of atherosclerosis in diabetic Wistar rats
  3. 1603
    “…Furthermore, we demonstrate that RNase III and dsRNA binding domains (dsRBD) are both required for dsRNA cleavage. Interestingly, the four DCL and the three RTL that carry dsRBD share a conserved cysteine (C230 in Arabidopsis RTL1) in their dsRBD. …”
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    The siRNA suppressor RTL1 is redox-regulated through glutathionylation of a conserved cysteine in the double-stranded-RNA-binding domain
  4. 1604
    “…Double-stranded RNA-binding domains (dsRBDs) are commonly found in modular proteins that interact with RNA. Two varieties of dsRBD exist: canonical Type A dsRBDs interact with dsRNA, while non-canonical Type B dsRBDs lack RNA-binding residues and instead interact with other proteins. …”
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    Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins
  5. 1605
    “…By contrast, in the recognition task, both RBD and LBD patients were impaired and showed two different biases: RBD patients misattributed the other's voice to themselves, while LBD patients denied the ownership of their own voice. …”
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    The lost ability to distinguish between self and other voice following a brain lesion
  6. 1606
    “…OBJECTIVE: We investigated the effects of prolonged‐release melatonin (PRM) on idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). METHODS: In this 4‐week, randomized, double–blind, placebo–controlled pilot study, 30 participants with polysomnography–confirmed iRBD were assigned to receive PRM 2 mg per day, PRM 6 mg per day, or placebo. …”
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    Prolonged–release melatonin in patients with idiopathic REM sleep behavior disorder
  7. 1607
    “…Ten single Asn–to–Ala substitutions at the predicted N-glycosylation sites of the M41–RBD were evaluated along with two control Val–to–Ala substitutions. …”
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    Glycosylation of the viral attachment protein of avian coronavirus is essential for host cell and receptor binding
  8. 1608
    “…Here we report the crystal structure of the SARS-CoV-2 S receptor-binding-domain (RBD) at a the highest resolution to date, of 1.95 Å. …”
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    A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein
  9. 1609
    “…Moreover, a therapeutic study in a mouse model validated that these antibodies can reduce virus titers in infected lungs. The RBD-B38 complex structure revealed that most residues on the epitope overlap with the RBD-ACE2 binding interface, explaining the blocking effect and neutralizing capacity. …”
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    A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
  10. 1610
    “…RBD-specific IgG responses are detectable in all patients 6 days after PCR confirmation. …”
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    Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients
  11. 1611
    “…Potent S-RBD IgA response was observed but N IgA seemed to be inconspicuous. …”
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    Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19
  12. 1612
    “…Herein, we use this technology to search for antibodies targeting the receptor-binding domain (RBD) of CoV-2. Specifically, we screened a naïve human semisynthetic phage library against RBD, leading to the identification of a high-affinity single-chain fragment variable region (scFv). …”
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    Identification of an anti–SARS–CoV-2 receptor-binding domain–directed human monoclonal antibody from a naïve semisynthetic library
  13. 1613
    “…An antibody column specific for the RBD enabled tag-free vaccine purification. In mice, the 24-meric RBD-ferritin SApNP elicited a more potent neutralizing antibody (NAb) response than the RBD alone and the spike with two stabilizing proline mutations in S2 (S2P). …”
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    Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates
  14. 1614
    “…Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. …”
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    A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2
  15. 1615
    “…Virus infection requires the receptor-binding domain (RBD) of the spike protein. Although studies have demonstrated anti-spike and - RBD antibodies to be protective in animal models, and convalescent plasma as a promising therapeutic option, little is known about immunoglobulin (Ig) isotypes capable of blocking infection. …”
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    Role of IgM and IgA Antibodies in the Neutralization of SARS-CoV-2
  16. 1616
    “…Surface Plasmon Resonance imaging (SPRi) was used to determine the presence and strength of binding of IgG, IgM and IgA against the Receptor Binding Domain (RBD) of SARS-CoV-2 in sera of 119 CoViD-19 patients. …”
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    Presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infection
  17. 1617
    “…In this study, immunogenicity of the receptor binding domain (RBD) of spike (S) glycoprotein was examined in mice. …”
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    Induction of Potent and Durable Neutralizing Antibodies Against SARS-CoV-2 Using a Receptor Binding Domain-Based Immunogen
  18. 1618
    “…Furthermore, ELISA-RBD IgG titers and pseudovirus-based NAb titers correlated significantly, with R(2) of 0.2564 (P < 0.0001). …”
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    Predictive Analysis of the Neutralization Activity in Convalescent Plasmas From COVID-19 Recovered Patients in Zhejiang Province, China, January-March, 2020
  19. 1619
    “…Over time, neutralizing antibody responses, which are predominantly RBD specific, generally decreased, while RBD-specific memory B cells persisted. …”
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    Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cells
  20. 1620
    “…Here, we present 11 unique nanobodies (Nbs) specific for the SARS‐CoV‐2 spike receptor‐binding domain (RBD), of which 8 Nbs potently inhibit the interaction of RBD with angiotensin‐converting enzyme 2 (ACE2) as the major viral docking site. …”
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    NeutrobodyPlex—monitoring SARS‐CoV‐2 neutralizing immune responses using nanobodies
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