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1621por Zhang, Bao-Zhong, Wang, Xiaolei, Yuan, Shuofeng, Li, Wenjun, Dou, Ying, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Chik, Kenn KaHeng, Tang, Kaiming, Chan, Chris Chun-Yiu, Hu, Ye-Fan, Hu, Jing-Chu, Badea, Smaranda Ruxandra, Gong, Hua-Rui, Lin, Xuansheng, Chu, Hin, Li, Xuechen, To, Kelvin Kai-Wang, Liu, Li, Chen, Zhiwei, Hung, Ivan Fan-Ngai, Yuen, Kwok Yung, Chan, Jasper Fuk-Woo, Huang, Jian-Dong“…We previously identified ten linear immunodominant sites on the SARS-CoV-2 spike protein of which four are located within the RBD. Therefore, we designed two linkerimmunodominant site (LIS) vaccine candidates which are composed of four immunodominant sites within the RBD (RBD-ID) or all the 10 immunodominant sites within the whole spike (S-ID). …”
Publicado 2021
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1622por Socher, Eileen, Conrad, Marcus, Heger, Lukas, Paulsen, Friedrich, Sticht, Heinrich, Zunke, Friederike, Arnold, Philipp“…This study also implies a reduced binding affinity for B.1.1.7 with ACE2, as the N501Y mutation restructures the RBD–ACE2 interface, significantly decreasing the linear interaction energy between the RBD and ACE2. …”
Publicado 2021
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1623“…Our predictions were validated by comparison with more than 1400 deep mutations on the S protein RBD. Our results show the urgent need to develop new mutation-resistant vaccines and antibodies and to prepare for seasonal vaccinations.…”
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1624“…From the Nextstrain global database, we identified prevalent mutations of S-RBD of SARS-CoV-2 from December 2019 to April 2021. …”
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1625por Schasfoort, Richard B.M., van Weperen, Jos, van Amsterdam, Margot, Parisot, Judicaël, Hendriks, Jan, Koerselman, Michelle, Karperien, Marcel, Mentink, Anouk, Bennink, Martin, Krabbe, Hans, Terstappen, Leon WMM, Mulder, A.H. Leontine“…Recovered patients all show high strength of binding of the IgG type to the RBD protein. The anti-RBD immunoglobulins SPRi assay provides additional insights in the immune status of patients recovering from CoViD-19. …”
Publicado 2021
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1626por Yang, Yong, Zang, Jinkai, Xu, Shiqi, Zhang, Xueyang, Yuan, Sule, Wang, Haikun, Lavillette, Dimitri, Zhang, Chao, Huang, Zhong“…We found that, at the same antigen dose, the RBD and S-trimer vaccines were more potent than the S1 vaccine in eliciting long-lasting, high-titer broadly neutralizing antibodies in mice. …”
Publicado 2021
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1627por Bayarri-Olmos, Rafael, Jarlhelt, Ida, Johnsen, Laust Bruun, Hansen, Cecilie Bo, Helgstrand, Charlotte, Rose Bjelke, Jais, Matthiesen, Finn, Nielsen, Susanne Dam, Iversen, Kasper Karmark, Ostrowski, Sisse Rye, Bundgaard, Henning, Frikke-Schmidt, Ruth, Garred, Peter, Skjoedt, Mikkel-Ole“…On the other hand, the two different 417 substitutions severely impair the RBD/ACE-2 affinity, but in the combined P.1 and B.1.351 RBD variants, this effect is partly counterbalanced by the effect of the E484K and N501Y. …”
Publicado 2021
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1628“…Thus masking of the RBD leads to the loss of receptor recognition property which can reduce the chance of infection host cells.…”
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1629“…The binding free energy of RBD and graphene shows that the adsorption is irreversible. …”
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1630por Pawłowski, Piotr H“…They had been found in the spike glycoprotein S, in the RBD and S1/S2 regions, crucial for initiation of viral infection. …”
Publicado 2021
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1631por Traboulsi, Hassan, Khedr, Mohammed A., Elgorashe, Rafea, Al-Faiyz, Yasair, Negm, Amr“…One of the proven methods to prevent and inhibit viral infections is to use antibodies to block the initial Receptor Binding Domain (RBD) of SARS-CoV-2 S protein and avoid its binding with the host cells. …”
Publicado 2022
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1632por Paiardi, Giulia, Richter, Stefan, Oreste, Pasqua, Urbinati, Chiara, Rusnati, Marco, Wade, Rebecca C.“…In simulations of the closed spike homotrimer, heparin binds the RBD and the N-terminal domain of two adjacent spike subunits and hinders opening. …”
Publicado 2021
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1633por Guerrieri, Mariapia, Francavilla, Beatrice, Fiorelli, Denise, Nuccetelli, Marzia, Passali, Francesco Maria, Coppeta, Luca, Somma, Giuseppina, Bernardini, Sergio, Magrini, Andrea, Di Girolamo, Stefano“…We detected anti-SARS-CoV-2 IgA-S1 and IgG-RBD in three study populations (healthy controls, vaccinated subjects, and subjects recovered from COVID-19 infection) on serum, saliva, and nasal secretions using two commercial immunoassays (ELISA for IgA-S1 and chemiluminescent assay for IgG-RBD). …”
Publicado 2021
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1634por Tubiana, Jérôme, Xiang, Yufei, Fan, Li, Wolfson, Haim J., Chen, Kong, Schneidman-Duhovny, Dina, Shi, Yi“…SARS-CoV-2 Omicron variant of concern (VOC) contains fifteen mutations on the receptor binding domain (RBD), evading most neutralizing antibodies from vaccinated sera. …”
Publicado 2022
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1635por Mason, Ashley E., Kasl, Patrick, Hartogensis, Wendy, Natale, Joseph L., Dilchert, Stephan, Dasgupta, Subhasis, Purawat, Shweta, Chowdhary, Anoushka, Anglo, Claudine, Veasna, Danou, Pandya, Leena S., Fox, Lindsey M., Puldon, Karena Y., Prather, Jenifer G., Gupta, Amarnath, Altintas, Ilkay, Smarr, Benjamin L., Hecht, Frederick M.“…Greater temperature deviation emerged as the strongest independent predictor of greater RBD antibody responses in multivariable models. …”
Publicado 2022
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1636“…The high binding affinity of RBD and ACE2 has provided a structural basis for future evaluation of antibodies and drug development. …”
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1637por Mashayekhi, Ghoncheh, Vant, John, Polavarapu, Abhigna, Ourmazd, Abbas, Singharoy, Abhishek“…Using experimental cryo-EM images, we present the energy landscape of the glycosylated spike protein, and identify the diversity of low-energy conformations in the vicinity of its open (so called 1RBD-up) state. The resulting atomic refinement reveal global and local molecular rearrangements that cannot be inferred from an average 1RBD-up cryo-EM model. …”
Publicado 2022
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1638por Tien, Ni, Chang, Yu-Chang, Chen, Po-Ku, Lin, Hui-Ju, Chang, Shih-Hsin, Lan, Joung-Liang, Hsueh, Po-Ren, Chang, Ching-Kun, Chen, Der-Yuan“…The positive rate and titers of anti-S/RBD-IgG were significantly higher in mRNA-1273 or BNT162b2 than in the AZD1222 vaccine. …”
Publicado 2022
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1639por Wnorowska, Sylwia, Targowska-Duda, Katarzyna, Kurzepa, Jacek, Wnorowski, Artur, Strzemski, Maciej“…Molecular docking suggested the presence of carlina oxide binding sites within the RBD and at the interface between RBD and ACE2. Finally, this study expands the list of potential applications of C. acaulis as a crop species.…”
Publicado 2022
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1640por Pape, Kathryn A., Dileepan, Thamotharampillai, Matchett, William E., Ellwood, Charles, Stresemann, Samuel, Kabage, Amanda J., Kozysa, Daria, Evert, Clayton, Matson, Michael, Lopez, Sharon, Krueger, Peter D., Graiziger, Carolyn T., Vaughn, Byron P., Shmidt, Eugenia, Rhein, Joshua, Schacker, Timothy W., Bold, Tyler D., Langlois, Ryan A., Khoruts, Alexander, Jenkins, Marc K.“…We assessed SARS-CoV-2 spike S1 receptor binding domain–specific (S1-RBD–specific) B lymphocytes to identify the underlying cellular defects. …”
Publicado 2022
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