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1701por Wang, Hongye, Yan, Dongshan, Li, Ya, Gong, Yanfei, Mai, Yulin, Li, Bingxiang, Zhu, Xiaoyong, Wan, Xinrui, Xie, Liyun, Jiang, HuaKe, Zhang, Min, Sun, Ming, Yao, Yufeng, Zhu, Yongzhang“…Additionally, CTD-IgG was strongly correlated with S-IgG in a non-severe group. Positive RBD-ACE2 binding inhibition was strongly associated with high titers of antibody (S-IgG1, S-IgG3, NTD-IgG, RBD-IgA, NTD-IgA, and CTD-IgA) especially RBD-IgG and CTD-IgG in the severe group, while in the non-severe group, S-IgG3, RBD-IgG, NTD-IgG, and NTD-IgM were correlated with ACE2 blocking rate. …”
Publicado 2022
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1702por Lippi, Giuseppe, Salvagno, Gian Luca, Henry, Brandon M., Pighi, Laura, De Nitto, Simone, Gianfilippi, Gianluca“…La tasa media de decrecimiento a los 6 meses fue de −95% para IgG anti- RBD, −85% para IgG contra la proteína trimérica espicular, −73% para IgA anti-S1 y −56% para los anticuerpos totales anti-RBD del SARS-CoV-2, respectivamente. …”
Publicado 2022
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1703por Hessel, Sofia Safitri, Dwivany, Fenny Martha, Zainuddin, Ima Mulyama, Wikantika, Ketut, Celik, Ismail, Emran, Talha Bin, Tallei, Trina Ekawati“…Molecular docking analysis demonstrated that both altered and wild-type BanLecs exhibited strong affinity with the RBD of different SARS-CoV-2 variants. Further analysis of the molecular docking results showed that the BanLec proteins interacted with the active site of RBD, particularly the key amino acids residues responsible for RBD’s binding to hACE2. …”
Publicado 2023
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1704“…The NP and S-RBD IgG antibodies’ levels declined to 44.6% (P=0.044) and 28.1% (P=0.18), respectively. 0 and 26.7% (4/15) of patients turned from NP and S-RBD IgG antibody positive to negative, respectively. …”
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1705por Peghin, Maddalena, De Martino, Maria, Palese, Alvisa, Gerussi, Valentina, Bontempo, Giulia, Graziano, Elena, Visintini, Erica, D'Elia, Denise, Dellai, Fabiana, Marrella, Francesco, Fabris, Martina, Curcio, Francesco, Sartor, Assunta, Isola, Miriam, Tascini, Carlo“…Vaccination status and two different serological assays to distinguish between response to vaccination (receptor-binding domain (RBD) SARS-CoV-2 IgG) and/or natural infection (non-RBD-SARS-CoV-2 IgG) were also assessed. …”
Publicado 2022
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1706“…RESULTS: Initial process development was done at 24 deep well plate (DWP) -scale to screen transient processes and stable clonal cell lines for recombinant SARS-CoV-2 receptor binding domain (rRBD) titer. Nine DNA vectors that drove rRBD production under different promoters and optionally contained Epstein-Barr virus (EBV) elements to promote episomal expression were screened for transient rRBD production at 37 °C or 32 °C. …”
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1707por Mattioli, Pietro, Orso, Beatrice, Liguori, Claudio, Famà, Francesco, Giorgetti, Laura, Donniaquio, Andrea, Massa, Federico, Giberti, Andrea, Vállez García, David, Meles, Sanne K., Leenders, Klaus L., Placidi, Fabio, Spanetta, Matteo, Chiaravalloti, Agostino, Camedda, Riccardo, Schillaci, Orazio, Izzi, Francesca, Mercuri, Nicola B., Pardini, Matteo, Bauckneht, Matteo, Morbelli, Silvia, Nobili, Flavio, Arnaldi, Dario“…BACKGROUND: Idiopathic rapid eye movement sleep behavior disorder (iRBD) represents the prodromal stage of α‐synucleinopathies. …”
Publicado 2022
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1708por Amellal, Houda, Assaid, Najlaa, Charoute, Hicham, Akarid, Khadija, Maaroufi, Abderrahmane, Ezzikouri, Sayeh, Sarih, M’hammed“…One month of symptom onset, most patients developed IgG, with 97% and 93% positivity for anti-RBD IgG and anti-N IgG, respectively. The anti-RBD IgG positivity rate remained high up to one year of follow-up. …”
Publicado 2023
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1709por Xu, Qin, Mudd, Pamela, Behzadpour, Hengameh, Bellusci, Lorenza, Grubbs, Gabrielle, Pourhashemi, Sara, Tang, Juanjie, Liu, Can, Newman, Daniel, Shi, Lihong, Milanez-Almeida, Pedro, Kardava, Lela, Tsang, John, Moir, Susan, Khurana, Surender, Schwartzberg, Pamela, Manthiram, Kalpana“…Tonsils and adenoids post-infection had a higher percentage of S1(+)RBD(+) memory B cells than post-vaccination, but differences in the percentage of S1(+)RBD(+) cells were not noted in the peripheral blood. …”
Publicado 2023
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1710por Moreno, Ana, Lelli, Davide, de Sabato, Luca, Zaccaria, Guendalina, Boni, Arianna, Sozzi, Enrica, Prosperi, Alice, Lavazza, Antonio, Cella, Eleonora, Castrucci, Maria Rita, Cicozzi, Massimo, Vaccari, Gabriele“…The comparison of the secondary and 3DMMS of the RBD of IT-batCoVs with MERS, HKU4 and HKU5 bat sequences showed two aa deletions located in a region corresponding to the external subdomain of MERS-RBD in IT-batCoV and HKU5 RBDs. …”
Publicado 2017
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1711por Trapp, Sascha, Soubieux, Denis, Lidove, Alexandra, Esnault, Evelyne, Lion, Adrien, Guillory, Vanaique, Wacquiez, Alan, Kut, Emmanuel, Quéré, Pascale, Larcher, Thibaut, Ledevin, Mireille, Nadan, Virginie, Camus-Bouclainville, Christelle, Marc, Daniel“…However it is still unclear to what extent each of its two structured domains (i.e. RNA-binding domain, RBD, and effector domain, ED) contribute to its various activities. …”
Publicado 2018
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1712“…The comparison of the concatenated domains within ORF1ab confirmed their classification into the MERS-CoV species. The 3D structure of RBD of Italian strains showed two amino acid deletions located in a region corresponding to the external subdomain of MERS-RBD. …”
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1713por de Bono, Johann, Lin, Chia-Chi, Chen, Li-Tzong, Corral, Jesus, Michalarea, Vasiliki, Rihawi, Karim, Ong, Michael, Lee, Jih-Hsiang, Hsu, Chih-Hung, Yang, James Chih-Hsin, Shiah, Her-Shyong, Yen, Chia-Jui, Anthoney, Alan, Jove, Maria, Buschke, Susanne, Fuertig, René, Schmid, Ulrike, Goeldner, Rainer-Georg, Strelkowa, Natalja, Huang, Dennis Chin-Lun, Bogenrieder, Thomas, Twelves, Chris, Cheng, Ann-Lii“…METHODS: These phase 1, open-label trials comprised dose-finding (part I; 3 + 3 design) and expansion cohorts (part II; selected tumours; RBD [weekly dosing]). Primary endpoints were MTD/RBD. …”
Publicado 2020
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1714por Gozalbo-Rovira, Roberto, Gimenez, Estela, Latorre, Víctor, Francés-Gómez, Clara, Albert, Eliseo, Buesa, Javier, Marina, Alberto, Blasco, María Luisa, Signes-Costa, Jaime, Rodríguez-Díaz, Jesús, Geller, Ron, Navarro, David“…CONCLUSIONS: The data presented herein do not support an association between SARS-CoV-2 RBD IgG or NtAb50 levels and COVID-19 severity.…”
Publicado 2020
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1715por Resman Rus, Katarina, Korva, Miša, Knap, Nataša, Avšič Županc, Tatjana, Poljak, Mario“…Antibodies against S protein receptor binding domain (RBD) have been shown to confer a neutralizing activity against SARS-CoV-2. …”
Publicado 2021
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1716por Rodriguez, Jorge H.“…However, recent quantum-biochemical calculations on the structurally related S-RBD of SARS-CoV-1 identified some contact-residue fragments as intrinsically attractive and others as repulsive. …”
Publicado 2021
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1717por Morgon, Nelson H., Grandini, Giulia S., Yoguim, Maurício I., Porto, Caio M., Santana, Lucas C., Biswas, Srijit, de Souza, Aguinaldo R.“…Molecular docking of the system (S)-Linezolid⋯RBD⋯ACE2 and (R)-Linezolid⋯RBD⋯ACE2 was performed, the analysis was made using LigPlot+ and NCIplot software packages, to understand the intermolecular interactions. …”
Publicado 2021
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1718por Rajpoot, Sajjan, Ohishi, Tomokazu, Kumar, Ashutosh, Pan, Qiuwei, Banerjee, Sreeparna, Zhang, Kam Y. J., Baig, Mirza S.“…METHODS: An in silico approach was employed to design a 13-amino acid peptide inhibitor (13AApi) against the RBD of the SARS-CoV-2 spike protein. Its binding specificity for RBD was confirmed by molecular docking using pyDockWEB, ClusPro 2.0, and HDOCK web servers. …”
Publicado 2021
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1719por Olea, Beatriz, Albert, Eliseo, Torres, Ignacio, Amat, Paula, Remigia, María José, Gozalbo-Rovira, Roberto, Rodríguez-Díaz, Jesús, Buesa, Javier, Blasco, María Luisa, Redón, Josep, Signes-Costa, Jaime, Navarro, David“…SARS-CoV-2 RBD-specific IgG serum levels were found to drop significantly over time. …”
Publicado 2021
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1720por Gallais, Floriane, Gantner, Pierre, Bruel, Timothée, Velay, Aurélie, Planas, Delphine, Wendling, Marie-Josée, Bayer, Sophie, Solis, Morgane, Laugel, Elodie, Reix, Nathalie, Schneider, Anne, Glady, Ludovic, Panaget, Baptiste, Collongues, Nicolas, Partisani, Marialuisa, Lessinger, Jean-Marc, Fontanet, Arnaud, Rey, David, Hansmann, Yves, Kling-Pillitteri, Laurence, Schwartz, Olivier, De Sèze, Jérome, Meyer, Nicolas, Gonzalez, Maria, Schmidt-Mutter, Catherine, Fafi-Kremer, Samira“…INTERPRETATION: Our study demonstrates a long-term persistence of anti-RBD antibodies that may reduce risk of reinfection. …”
Publicado 2021
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