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1741“…Molecular docking predicted the binding sites on the RBD-ACE2 complex and it showed similar binding abilities to both complex of variant Delta or Omicron RBD and ACE2. …”
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1742por Martinez, David R., Schafer, Alexandra, Gavitt, Tyler D., Mallory, Michael L., Lee, Esther, Catanzaro, Nicholas J., Chen, Haiyan, Gully, Kendra, Scobey, Trevor, Korategere, Pooja, Brown, Alecia, Smith, Lena, Parks, Rob, Barr, Maggie, Newman, Amanda, Bowman, Cindy, Powers, John M., Mansouri, Katayoun, Edwards, Robert J., Baric, Ralph S., Haynes, Barton F., Saunders, Kevin O.“…Specifically, a monovalent SARS-CoV-2 RBD scNP vaccine only protected against sarbecovirus challenge, whereas the trivalent RBD scNP vaccine protected against both merbecovirus and sarbecovirus challenge in highly pathogenic and lethal mouse models. …”
Publicado 2023
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1743por Rick, Anne-Marie, Lentscher, Anthony, Xu, Lingqing, Wilkins, Maris S., Nasser, Amro, Tuttle, Dylan J., Megli, Christina, Marques, Ernesto T. A., McElroy, Anita K., Williams, John V., Martin, Judith M.“…Anti-RBD IgG and IgA did not increase in infant blood after maternal booster. …”
Publicado 2023
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1744por Thangaleela, Subramanian, Sivamaruthi, Bhagavathi Sundaram, Kesika, Periyanaina, Mariappan, Subramanian, Rashmi, Subramanian, Choeisoongnern, Thiwanya, Sittiprapaporn, Phakkharawat, Chaiyasut, Chaiyavat“…RBD and associated emotional disorders are common non-motor symptoms of PD. …”
Publicado 2023
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1745“…OBJECTIVES: To present a REM sleep behavior disorder (RBD) case in a patient with Brunner syndrome. METHODS: The present study is a case report of a patient followed in our hospital’s outpatient care. …”
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1746por Ovcar, Eugen, Patyna, Sammy, Kohmer, Niko, Heckel-Kratz, Elisabeth, Ciesek, Sandra, Rabenau, Holger F., Hauser, Ingeborg A., de Groot, Kirsten“…The bivalent mRNA vaccine led to a 7.6-fold increase in S-RBD-ab levels and an augmented inhibition of the Omicron variant in SVNT by 35% (median). …”
Publicado 2023
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1747por Li, Haolong, Wang, Yao, Li, Xiaomeng, Wang, Siyu, Feng, Xinxin, Xiao, Xinhua, Li, Yongzhe“…Both HCs and patients with T2DM showed poor resistance against BA.4/5 due to the detected inhibition rates being lower than the positive threshold. The levels of anti‐RBD‐specific IgG were positively associated with the proportions of CD3(+)CD4(−)CD8(−) T cells (p = 0.045), and patients with T2DM who had anti‐RBD‐specific IgG positivity showed higher proportions of CD3(+)CD4(−)CD8(−) T cells compared to those negative (p = 0.005). …”
Publicado 2023
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1748“…When the purified RBD was mixed with pyocin S4 at different ratios, an inhibition of killing was observed, indicating that S2 RBD competes with the pyocin S4 for the binding to the FpvAI receptor. …”
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1749por Wang, Lingshu, Shi, Wei, Joyce, M. Gordon, Modjarrad, Kayvon, Zhang, Yi, Leung, Kwanyee, Lees, Christopher R., Zhou, Tongqing, Yassine, Hadi M., Kanekiyo, Masaru, Yang, Zhi-yong, Chen, Xuejun, Becker, Michelle M., Freeman, Megan, Vogel, Leatrice, Johnson, Joshua C., Olinger, Gene, Todd, John P., Bagci, Ulas, Solomon, Jeffrey, Mollura, Daniel J., Hensley, Lisa, Jahrling, Peter, Denison, Mark R., Rao, Srinivas S., Subbarao, Kanta, Kwong, Peter D., Mascola, John R., Kong, Wing-Pui, Graham, Barney S.“…Serological analysis and isolation of murine monoclonal antibodies revealed that immunization elicits NAbs to RBD and, non-RBD portions of S1 and S2 subunit. …”
Publicado 2015
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1750“…The Rvs161p binding domain (RBD) contains three predicted alpha-helices; structural modeling suggests that the RBD adopts an amphiphysin-like structure. …”
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1751“…To probe possible signaling from cell-to-cell, we utilized bimolecular luciferase complementation to examine the ability of K-Ras in exosomes to interact with the Raf-Ras Binding domain (Raf-RBD) expressed in a recipient cell line. Although the K-Ras/Raf-RBD interaction was readily detectable upon co-expression in a single cell line, or following lysis of co-cultured cell lines separately expressing K-Ras and RBD, bearing in mind the limitations of our assay, we were unable to detect the interaction in the intact, co-cultured cell lines or upon treatment of the Raf-RBD-expressing cells with exosomes containing K-Ras. …”
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1752“…We performed a structural analysis of the receptor binding domain (RBD) of spike glycoprotein responsible for entry of coronaviruses into host cells. …”
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1753“…In this study, we demonstrated that SARS-CoV inactivated by β-propiolactone elicited high titers of antibodies in the immunized mice and rabbits that recognize the spike (S) protein, especially the receptor-binding domain (RBD) in the S1 region. The antisera from the immunized animals efficiently bound to the RBD and blocked binding of RBD to angiotensin-converting enzyme 2, the functional receptor on the susceptible cells for SARS-CoV. …”
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1754por Lu, Guangwen, Hu, Yawei, Wang, Qihui, Qi, Jianxun, Gao, Feng, Li, Yan, Zhang, Yanfang, Zhang, Wei, Yuan, Yuan, Bao, Jinku, Zhang, Buchang, Shi, Yi, Yan, Jinghua, Gao, George F.“…Furthermore, binding between the RBD and CD26 is measured using real-time surface plasmon resonance with a dissociation constant of 16.7 nM. …”
Publicado 2013
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1755por Choi, Jang-Hoon, Woo, Hye-Min, Lee, Tae-young, Lee, So-young, Shim, Sang-Mu, Park, Woo-Jung, Yang, Jeong-Sun, Kim, Joo Ae, Yun, Mi-Ran, Kim, Dae-Won, Kim, Sung Soon, Zhang, Yi, Shi, Wei, Wang, Lingshu, Graham, Barney S., Mascola, John R., Wang, Nanshuang, McLellan, Jason S., Lee, Joo-Yeon, Lee, Hansaem“…We identified six receptor-binding domain (RBD)-specific and five S1 (non-RBD)-specific antibodies, among which, only the RBD-specific antibodies showed high neutralizing potency (IC(50) 0.006–1.787 μg/ml) as well as high affinity to RBD. …”
Publicado 2020
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1756por Byrnes, James R., Zhou, Xin X., Lui, Irene, Elledge, Susanna K., Glasgow, Jeff E., Lim, Shion A., Loudermilk, Rita, Chiu, Charles Y., Wilson, Michael R., Leung, Kevin K., Wells, James A.“…Sera are then supplemented with soluble ACE2-Fc to compete for RBD-binding serum antibodies, and antibody binding quantified. …”
Publicado 2020
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1757por Seydoux, Emilie, Homad, Leah J., MacCamy, Anna J., Parks, K. Rachael, Hurlburt, Nicholas K., Jennewein, Madeleine F., Akins, Nicholas R., Stuart, Andrew B., Wan, Yu-Hsin, Feng, Junli, Whaley, Rachael E., Singh, Suruchi, Boeckh, Michael, Cohen, Kristen W., McElrath, M. Juliana, Englund, Janet A., Chu, Helen Y., Pancera, Marie, McGuire, Andrew T., Stamatatos, Leonidas“…They had undergone minimal somatic mutation with limited clonal expansion, and three bound the receptor-binding domain (RBD). Two antibodies neutralized SARS-CoV-2. The most potent antibody bound the RBD and prevented binding to the ACE2 receptor, while the other bound outside the RBD. …”
Publicado 2020
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1758por Mou, Huihui, Quinlan, Brian D., Peng, Haiyong, Guo, Yan, Peng, Shoujiao, Zhang, Lizhou, Davis-Gardner, Meredith E., Gardner, Matthew R., Crynen, Gogce, Voo, Zhi Xiang, Bailey, Charles C., Alpert, Michael D., Rader, Christoph, Choe, Hyeryun, Farzan, Michael“…We observed that the SARS-CoV-2 RBD bound human, pangolin, and horseshoe bat (R. macrotis) ACE2 more efficiently than the SARS-CoV-1 or RaTG13 RBD. …”
Publicado 2020
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1759por Glasgow, Anum, Glasgow, Jeff, Limonta, Daniel, Solomon, Paige, Lui, Irene, Zhang, Yang, Nix, Matthew A., Rettko, Nicholas J., Lim, Shion A., Zha, Shoshana, Yamin, Rachel, Kao, Kevin, Rosenberg, Oren S., Ravetch, Jeffrey V., Wiita, Arun P., Leung, Kevin K., Zhou, Xin X., Hobman, Tom C., Kortemme, Tanja, Wells, James A.“…We first computationally designed the ACE2-RBD interface using a two-stage flexible protein backbone design process that improved affinity for the RBD by up to 12-fold. …”
Publicado 2020
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1760por Hanke, Leo, Vidakovics Perez, Laura, Sheward, Daniel J., Das, Hrishikesh, Schulte, Tim, Moliner-Morro, Ainhoa, Corcoran, Martin, Achour, Adnane, Karlsson Hedestam, Gunilla B., Hällberg, B. Martin, Murrell, Ben, McInerney, Gerald M.“…Ty1 binds the RBD with high affinity, occluding ACE2. A cryo-electron microscopy structure of the bound complex at 2.9 Å resolution reveals that Ty1 binds to an epitope on the RBD accessible in both the ‘up’ and ‘down’ conformations, sterically hindering RBD-ACE2 binding. …”
Publicado 2020
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