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161por Amanat, Fatima, Thapa, Mahima, Lei, Tinting, Ahmed, Shaza M. Sayed, Adelsberg, Daniel C., Carreño, Juan Manuel, Strohmeier, Shirin, Schmitz, Aaron J., Zafar, Sarah, Zhou, Julian Q., Rijnink, Willemijn, Alshammary, Hala, Borcherding, Nicholas, Reiche, Ana Gonzalez, Srivastava, Komal, Sordillo, Emilia Mia, van Bakel, Harm, Turner, Jackson S., Bajic, Goran, Simon, Viviana, Ellebedy, Ali H., Krammer, Florian“…Neutralizing activity of NTD mAbs but not RBD mAbs against a clinical viral isolate carrying E484K as well as extensive changes in the NTD was abolished, suggesting that a proportion of vaccine-induced RBD binding antibodies may provide substantial protection against viral variants carrying single E484K RBD mutations.…”
Publicado 2021
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162por Deshpande, Ashlesha, Harris, Bethany D., Martinez-Sobrido, Luis, Kobie, James J., Walter, Mark R.“…The SARS-CoV-2 S RBD is a major target of neutralizing antibodies (NAbs) that block RBD - ACE2 interactions. …”
Publicado 2021
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163por Voss, William N., Hou, Yixuan J., Johnson, Nicole V., Delidakis, George, Kim, Jin Eyun, Javanmardi, Kamyab, Horton, Andrew P., Bartzoka, Foteini, Paresi, Chelsea J., Tanno, Yuri, Chou, Chia-Wei, Abbasi, Shawn A., Pickens, Whitney, George, Katia, Boutz, Daniel R., Towers, Dalton M., McDaniel, Jonathan R., Billick, Daniel, Goike, Jule, Rowe, Lori, Batra, Dhwani, Pohl, Jan, Lee, Justin, Gangappa, Shivaprakash, Sambhara, Suryaprakash, Gadush, Michelle, Wang, Nianshuang, Person, Maria D., Iverson, Brent L., Gollihar, Jimmy D., Dye, John, Herbert, Andrew, Finkelstein, Ilya J., Baric, Ralph S., McLellan, Jason S., Georgiou, George, Lavinder, Jason J., Ippolito, Gregory C.“…These data show that “public” NTD-directed and other non-RBD plasma antibodies are prevalent and have implications for SARS-CoV-2 protection and antibody escape.…”
Publicado 2021
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164por Jearanaiwitayakul, Tuksin, Seesen, Mathurin, Chawengkirttikul, Runglawan, Limthongkul, Jitra, Apichirapokey, Suttikarn, Sapsutthipas, Sompong, Phumiamorn, Supaporn, Sunintaboon, Panya, Ubol, Sukathida“…In this study, we evaluated the immunogenicity of a receptor-binding domain (RBD) of SARS-CoV-2 spike glycoprotein loaded into N,N,N-trimethyl chitosan nanoparticles (RBD-TMC NPs). …”
Publicado 2021
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165por Kim, Seonghan, Liu, Yi, Lei, Zewei, Dicker, Jeffrey, Cao, Yiwei, Zhang, X. Frank, Im, Wonpil“…It is known that the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 interacts with the human angiotensin-converting enzyme 2 (ACE2) receptor, initiating the entry of SARS-CoV-2. …”
Publicado 2021
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166por Li, Bingqian, Wang, Lin, Ge, Huan, Zhang, Xianglei, Ren, Penxuan, Guo, Yu, Chen, Wuyan, Li, Jie, Zhu, Wei, Chen, Wenzhang, Zhu, Lili, Bai, FangEnlace del recurso
Publicado 2021
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167“…We found that the anti-Spike antibodies do not recognize PF4, on the contrary, the anti-PF4 antibodies show some cross-reactivity for Spike-RBD. More interestingly, we report for the first time that the PF4 and Spike-RBD proteins can bind each other. …”
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168por Xu, Hua, Wang, Bo, Zhao, Tian-Ning, Liang, Zi-Teng, Peng, Tian-Bo, Song, Xiao-Hui, Wu, Jia-Jing, Wang, You-Chun, Su, Xiao-DongEnlace del recurso
Publicado 2021
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169por Pan, Xiaoyan, Shi, Jian, Hu, Xue, Wu, Yan, Zeng, Liang, Yao, Yanfeng, Shang, Weijuan, Liu, Kunpeng, Gao, Ge, Guo, Weiwei, Peng, Yun, Chen, Shaohong, Gao, Xiaoxiao, Peng, Cheng, Rao, Juhong, Zhao, Jiaxuan, Gong, Cheng, Zhou, Hui, Lu, Yudong, Wang, Zili, Hu, Xiliang, Cong, WenJuan, Fang, Lijuan, Yan, Yongxiang, Zhang, Jing, Xiong, Hui, Yi, Jizu, Yuan, Zhiming, Zhou, Pengfei, Shan, Chao, Xiao, Gengfu“…Here, a novel SARS-CoV-2 receptor-binding domain (RBD) homodimer was developed as a SARS-CoV-2 vaccine candidate. …”
Publicado 2021
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170Identification of SARS-CoV-2 S RBD escape mutants using yeast screening and deep mutational scanningpor Haas, Cyrus M., Francino-Urdaniz, Irene M., Steiner, Paul J., Whitehead, Timothy A.“…Here, we describe a protocol to identify escape mutants on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) receptor-binding domain (RBD) using a yeast screen combined with deep mutational scanning. …”
Publicado 2021
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171por Villafañe, Luciana, Vaulet, Lucía Gallo, Viere, Florencia M., Klepp, Laura I., Forrellad, Marina A., Bigi, María M., Romano, María I., Magistrelli, Giovanni, Fermepin, Marcelo Rodríguez, Bigi, Fabiana“…In this study, we used a semi-stable mammalian episomal expression system to produce high quantities of the receptor-binding domain-RBD of SARS-CoV-2 in a simple and very economical way. …”
Publicado 2022
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172“…The angiotensin-converting enzyme 2 (ACE2) is the receptor used by SARS-CoV and SARS-CoV-2 coronaviruses to attach to cells via the receptor-binding domain (RBD) of their viral spike protein. Since the start of the COVID-19 pandemic, several structures of protein complexes involving ACE2 and RBD as well as monoclonal antibodies and nanobodies have become available. …”
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173por Traboulsi, Hassan, Khedr, Mohammed A., Al-Faiyz, Yasair S. S., Elgorashe, Rafea, Negm, Amr“…SARS-CoV-2 receptor-binding domain (RBD) plays fundamental roles related to cell infection. …”
Publicado 2021
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174por Zhao, Hui, Wang, Tie-Cheng, Li, Xiao-Feng, Zhang, Na-Na, Li, Liang, Zhou, Chao, Deng, Yong-Qiang, Cao, Tian-Shu, Yang, Guan, Li, Rui-Ting, Huang, Yi-Jiao, Li, Yuan-Guo, Zhang, Yi-Ming, Li, Fang-Xu, Zhou, Yu-Ren, Jiang, Yu-Hang, Lu, Xi-Shan, Sun, Shi-Hui, Cheng, Meng-Li, Gu, Kai-Ping, Zhang, Mei, Ma, Qing-Qing, Yang, Xiao, Ying, Bo, Gao, Yu-Wei, Qin, Cheng-Feng“…Recently, we have developed a lipid nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor-binding domain (RBD) of SARS-CoV-2 (termed ARCoV), which confers complete protection in mouse model. …”
Publicado 2021
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175“…BACKGROUND: Limited information is available on the effectiveness of the BBIBP-CorV (Sinopharm, Beijing CNBG) vaccine, especially in the elderly, despite the fact that it is approved in more than 50 countries. METHODS: RBD-specific antibody titres, as a rapidly available and highly predictive surrogate marker, were measured after two doses of the BBIBP-CorV vaccine in 450 subjects. …”
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176por Kim, Seonghan, Liu, Yi, Lei, Zewei, Dicker, Jeffrey, Cao, Yiwei, Zhang, Xiaohui, Im, WonpilEnlace del recurso
Publicado 2022
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177por Ma, Hang, Guo, Yingying, Tang, Haoneng, Tseng, Chien-Te K., Wang, Lei, Zong, Huifang, Wang, Zhenyu, He, Yang, Chang, Yunsong, Wang, Shusheng, Huang, Haiqiu, Ke, Yong, Yuan, Yunsheng, Wu, Mingyuan, Zhang, Yuanyuan, Drelich, Aleksandra, Kempaiah, Kempaiah Rayavara, Peng, Bi-Hung, Wang, Ailin, Yang, Kaiyong, Yin, Haiyang, Liu, Junjun, Yue, Yali, Xu, Wenbo, Zhu, Shuangli, Ji, Tianjiao, Zhang, Xiaoju, Wang, Ziqi, Li, Gang, Liu, Guangchun, Song, Jingjing, Mu, Lingling, Xiang, ZongShang, Song, Zhangyi, Chen, Hua, Bian, Yanlin, Zhang, Baohong, Chen, Hui, Zhang, Jiawei, Liao, Yunji, Zhang, Li, Yang, Li, Chen, Yi, Gilly, John, Xiao, Xiaodong, Han, Lei, Jiang, Hua, Xie, Yueqing, Zhou, Qiang, Zhu, Jianwei“…The epitope of 2G1 on RBD partially overlaps with angiotensin converting enzyme 2 (ACE2) interface, which enables 2G1 to block interaction between RBD and ACE2. …”
Publicado 2022
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178por Ranjan, Prashant, Neha, Devi, Chandra, Jain, Garima, Mallick, Chandana Basu, Das, Parimal“…RESULTS: We found that in seven of the 12 variants studied, there was a structural alteration in the RBD region, further affecting its stability and function. …”
Publicado 2022
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179por Li, Qianqian, Zhang, Mengyi, Liang, Ziteng, Zhang, Li, Wu, Xi, Yang, Chaoying, An, Yimeng, Tong, Jincheng, Liu, Shuo, Li, Tao, Cui, Qianqian, Nie, Jianhui, Wu, Jiajing, Huang, Weijin, Wang, Youchun“…The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants, particularly those with multiple mutations in receptor‐binding domain (RBD), pose a critical challenge to the efficacy of coronavirus disease 2019 (COVID‐19) vaccines and therapeutic neutralizing monoclonal antibodies (mAbs). …”
Publicado 2022
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180por Xu, Kun, Gao, Ping, Liu, Sheng, Lu, Shuaiyao, Lei, Wenwen, Zheng, Tianyi, Liu, Xueyuan, Xie, Yufeng, Zhao, Zhennan, Guo, Shuxin, Tang, Cong, Yang, Yun, Yu, Wenhai, Wang, Junbin, Zhou, Yanan, Huang, Qing, Liu, Chuanyu, An, Yaling, Zhang, Rong, Han, Yuxuan, Duan, Minrun, Wang, Shaofeng, Yang, Chenxi, Wu, Changwei, Liu, Xiaoya, She, Guangbiao, Liu, Yan, Zhao, Xin, Xu, Ke, Qi, Jianxun, Wu, Guizhen, Peng, Xiaozhong, Dai, Lianpan, Wang, Peiyi, Gao, George F.“…Previously, we developed the protein subunit vaccine ZF2001 based on the dimeric receptor-binding domain (RBD) of prototype SARS-CoV-2. Here, we developed a chimeric RBD-dimer vaccine approach to adapt SARS-CoV-2 variants. …”
Publicado 2022
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