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1801por Zhang, Biyan, Huo, Jianxin, Huang, Yuhan, Teo, Shuan Yong, Duan, Kaibo, Li, Yanfeng, Toh, Lim Kai, Lam, Kong Peng, Xu, Shengli“…Corroborating the antibody results, boosting with the mRNA vaccine increased the frequencies of Omicron RBD-binding B cells by (1.5–3.3 fold) regardless of priming vaccine types. …”
Publicado 2022
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1802por Fu, Ying, da Fonseca Rezende e Mello, Juliana, Fleming, Bryan D., Renn, Alex, Chen, Catherine Z., Hu, Xin, Xu, Miao, Gorshkov, Kirill, Hanson, Quinlin, Zheng, Wei, Lee, Emily M., Perera, Lalith, Petrovich, Robert, Pradhan, Manisha, Eastman, Richard T., Itkin, Zina, Stanley, Thomas B., Hsu, Allen, Dandey, Venkata, Sharma, Kedar, Gillette, William, Taylor, Troy, Ramakrishnan, Nitya, Perkins, Shelley, Esposito, Dominic, Oh, Eunkeu, Susumu, Kimihiro, Wolak, Mason, Ferrer, Marc, Hall, Matthew D., Borgnia, Mario J., Simeonov, Anton“…The most potent nanobody, RBD-1-2G(NCATS-BL8125), tolerates the N501Y RBD mutation and remains capable of neutralizing the B.1.1.7 (Alpha) variant. …”
Publicado 2022
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1803“…We also showed that the resistance mutations could greatly weaken the binding affinity of LCB1 to RBD and thus attenuated its blocking capacity on the interaction between RBD and the cell receptor ACE2. …”
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1804por Panizo, Nayara, Giménez, Estela, Albert, Eliseo, Zulaica, Joao, Rodríguez-Moreno, Alicia, Rusu, Luciana, Giménez-Civera, Elena, Puchades, Maria Jesús, D’Marco, Luis, Gandía-Salmerón, Lorena, Torres, Ignacio, Sancho, Asunción, Gavela, Eva, Gonzalez-Rico, Miguel, Montomoli, Marco, Perez-Baylach, Carmen Maria, Bonilla, Begoña, Solano, Camila, Alvarado, Mª Fernanda, Torregrosa, Isidro, Gonzales-Candia, Boris, Alcaraz, María Jesús, Geller, Ron, Górriz, José Luis, Navarro, David“…Anti-RBD antibodies were detected in 39/40 HD and 19/21 KTR. …”
Publicado 2022
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1805por Jia, Yunfei, Niu, Sheng, Hu, Yu, Chai, Yan, Zheng, Anqi, Su, Chao, Wu, Lili, Han, Pengcheng, Han, Pu, Lu, Dan, Liu, Zhimin, Yan, Xinxin, Tian, Di, Chen, Zhihai, Qi, Jianxun, Tian, Wen-xia, Wang, Qihui, Gao, George Fu“…Furthermore, we solve two complex structures of the GX/P2V/2017 RBD with MAbs belonging to RBD-1 and RBD-5, providing a structural basis for their different antigenicity. …”
Publicado 2022
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1806por Deptuła, Piotr, Fiedoruk, Krzysztof, Wasilewska, Monika, Suprewicz, Łukasz, Cieśluk, Mateusz, Żeliszewska, Paulina, Oćwieja, Magdalena, Adamczyk, Zbigniew, Pogoda, Katarzyna, Bucki, Robert“…The presence of specific interactions between vimentin and S1 RBD was also confirmed using in silico studies. …”
Publicado 2023
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1807por Nydegger, Damian T., Pujol-Giménez, Jonai, Kandasamy, Palanivel, Vogt, Bruno, Hediger, Matthias A.“…Here, we introduce microscale thermophoresis (MST) as a reliable and versatile tool for coronavirus research, which we demonstrate through three different applications described in this report: (1) binding of the SARS-CoV-2 spike receptor binding domain (RBD) to peptides as a strategy to prevent virus entry, (2) binding of the RBD to the viral receptor ACE2, and (3) binding of the RBD to ACE2 in complex with the amino acid transporter SLC6A20/SIT1 or its allelic variant rs61731475 (p.Ile529Val). …”
Publicado 2023
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1808“…Based on those complex structures, we conduct computational characterization and design of RBD-mediated receptor recognition and antibody neutralization. …”
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1809“…In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs.…”
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1810“…Here, we present cryo–electron microscopy structures of full-length human ACE2 in the presence of the neutral amino acid transporter B(0)AT1 with or without the receptor binding domain (RBD) of the surface spike glycoprotein (S protein) of SARS-CoV-2, both at an overall resolution of 2.9 angstroms, with a local resolution of 3.5 angstroms at the ACE2-RBD interface. …”
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1811por Liu, Hejun, Wu, Nicholas C., Yuan, Meng, Bangaru, Sandhya, Torres, Jonathan L., Caniels, Tom G., van Schooten, Jelle, Zhu, Xueyong, Lee, Chang-Chun D., Brouwer, Philip J.M., van Gils, Marit J., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.“…COVA1–16 binds to a flexible up conformation of the RBD on the spike and relies on antibody avidity for neutralization. …”
Publicado 2020
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1812“…Specifically, in silico method was employed to simulate protein degradation by gastrointestinal enzymes and to produce a large number of active peptides, then, the binding ability of these peptides to SARS-CoV-2 spike protein receptor-binding domain (RBD) was evaluated. The results showed that wheat-derived alpha/beta-gliadin, oat-derived avenin, and ribulose bisphosphate carboxylase small chain of different origin could be good protein source in generating potent binders to SARS-CoV-2 spike RBD. …”
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1813“…The protein/peptide array-identified receptor-binding domain (RBD) was considered as immunodominant. No linear epitopes were found in the RBD, although several linear epitopes were found in the C-terminal domain right after the RBD and heptad repeat regions. …”
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1814por Esmail, Sally, Knauer, Michael J., Abdoh, Husam, Voss, Courtney, Chin-Yee, Benjamin, Stogios, Peter, Seitova, Almagul, Hutchinson, Ashley, Yusifov, Farhad, Skarina, Tatiana, Evdokimova, Elena, Ackloo, Suzanne, Lowes, Lori, Hedley, Benjamin D., Bhayana, Vipin, Chin-Yee, Ian, Li, Shawn S.-C.“…Furthermore, we found that the strength of the S-RBD antibody response measured by the agglutination assay correlated with the efficiency of the plasma in blocking RBD binding to the angiotensin-converting enzyme 2 in a surrogate neutralization assay, suggesting that the agglutination assay might be used to identify individuals with virus-neutralizing antibodies. …”
Publicado 2021
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1815por Liu, Yanyan, Ke, Pu, Kuo, Yi-Chun, Wang, Yuxiao, Zhang, Xuewu, Song, Chen, Shan, Yibing“…Upon binding plexin at the Rho-GTPase-binding domain (RBD), RND1 and RhoD interact differently with the inner leaflet of the cell membrane and exert opposite effects on the dimerization interface via an allosteric network involving the RBD, RBD linkers, and a buttress segment adjacent to the dimerization interface. …”
Publicado 2021
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1816por Hedges, Jodi F., Thompson, Macy A., Snyder, Deann T., Robison, Amanda, Taylor, Matthew P., Jutila, Mark A.“…We also detected low and largely non-neutralizing anti-RBD IgG titers in a few participants with no known COVID-19 diagnosis. …”
Publicado 2021
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1817por Maharjan, Puna Maya, Cheon, Jinyeong, Jung, Jiyun, Kim, Haerim, Lee, Jaewon, Song, Minjeong, Jeong, Gi Uk, Kwon, Youngchan, Shim, Byoungshik, Choe, Sunghwa“…This recombinant RBD elicited humoral immunity in mice via induction of highly neutralizing antibodies. …”
Publicado 2021
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1818por Guo, Xueyang, Kazanova, Alexandra, Thurmond, Stephanie, Saragovi, H. Uri, Rudd, Christopher E.“…CAR-Ts further showed potent in vitro killing of target cells loaded with RBD, S1 peptide, or expressing the S1 protein. The efficacy of killing varied with different sized hinge regions, whereas time-lapse microscopy showed CAR-T cluster formation around RBD-expressing targets. …”
Publicado 2021
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1819por Akisawa, Kazuki, Hatada, Ryo, Okuwaki, Koji, Mochizuki, Yuji, Fukuzawa, Kaori, Komeiji, Yuto, Tanaka, Shigenori“…By two separate calculations for the RBD complexes with angiotensin-converting enzyme 2 (ACE2) (6M0J) and B38 Fab antibody (7BZ5), it was found that the binding with ACE2 or antibody partially compensated for this stabilization loss of RBD.…”
Publicado 2021
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1820“…Following I.N. immunization, antigen-presenting cells of the lungs took up liposomes displaying the RBD. K18 human ACE2-transgenic mice that were immunized I.M or I.N with sub-microgram doses of RBD liposomes and that were then challenged with SARS-CoV-2 had a reduced viral load in the early course of infection, with I.M. achieving complete viral clearance. …”
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